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H. Gobind Khorana, Ph.D.
The Nobel Prize in Physiology or Medicine 1968
National Medal of Sciences - Biological Sciences 1978
Co-Nobelists: Robert W. Holley, Marshall W. Nirenberg
Organic Chemist, Biochemist. 'Genetic code interpretation, function in protein synthesis. Pioneered synthesizing biologically active gene, determine codon triplets'
nucleotides order. Unraveled genetic code, how nucleic acids form proteins. Pioneered genetic engineering. Multidisciplinary work.
"Wife brought sense of purpose. In foreign country, I felt out of place everywhere, at home nowhere."
Patents
| Publication: | 1/3 |
| Publication No: | US2815342 A |
| Title: | Synthesis of pyrimidine nucleoside phosphates |
| Publication Type: | Grant |
| Publication Date: | Dec 3, 1957 |
| Filing Date: | Mar 4, 1955 |
| Inventors: | Khorana Har G |
| Assignee: | Canadian Patents Dev |
| Abstract: | This invention relates to the synthesis of pyrimidine nucleoside 5’-monophosphates and 2’,5’- and 3’,5’-diphosphates. |
| Representative Figure: | |
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| Family | None |
| Details | Google Patents |
| Publication: | 2/3 |
| Publication No: | US2795580 A |
| Title: | Synthesis of nucleoside polyphosphates |
| Publication Type: | Grant |
| Publication Date: | Jun 11,1957 |
| Filing Date: | May 27, 1955 |
| Inventors: | Gobind Khorana Har |
| Assignee: | Canadian Patents Dev |
| Abstract: | This invention relates to the synthesis of nucleoside phosphates. |
| Representative Figure: | |
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| Family Members | 437,006 |
| Details | Google Patents |
| Publication: | 3/3 |
| Publication No: | US20040029229 A1 |
| Title: | High level protein expression system |
| Publication Type: | Application |
| Publication Date: | Feb 12, 2004 |
| Filing Date: | May 20, 2003 |
| Inventors: | Philip Reeves, H. Khorana, Nico Callewaert, Roland Contreras |
| Assignee: | Reeves Philip J., Khorana H. Gobind, Nico Callewaert, Roland Contreras |
| Abstract: | The present application is directed to a system for expressing high levels of a protein of interest in a cell. Preferably the system includes introducing into a mammalian cell line an expression vector that comprises a gene encoding a selectable marker under the control of a weak promoter to facilitate integration of the expression vector into genomic areas that result in high levels of expression, along with a gene encoding the protein of interest. The gene of interest is linked to a strong promoter, which results in high levels of expression of the desired protein. In one embodiment, the protein of interest is detrimental or toxic to cells, and the promoter is an inducible promoter. In another embodiment, the protein of interest is a glycoprotein, including membrane proteins, and the cell line has been mutated to inactivate N-acetylglucosamine transferase I to ensure uniform glycosylation. Preferably the cell is a mammalian or an insect cell. |
| Representative Figure: | |
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| Family Members | 60/381,978 |
| Details | Google Patents |
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Name: Har Gobind Khorana
Birth: 9 January 1922, Raipur, India
Death: 9 November 2011, Concord, MA, USA
Institution: University of Wisconsin, Madison, WI, USA
Award: "for their interpretation of the genetic code and its function in protein synthesis."
Portion of Cash: 1/3
Education, Mentors: D.A.V. High School, Multan, India; Influential Teacher; Ratan Lal.
B.Sc. 1943 & M. Sc. 1945, Punjab University, Lahore, India; Supervisor: Mahan Singh.
Ph. D. University of Liverpool, UK 1948, Indian government scholarship; Mentor: Roger J. S. Beer.
Postdoc Eidgenössische Technische Hochschule, Zurich, 1948-1949; Mentor: Vladimir Prelog, Chemistry Nobelist 1975.
Postdoc Cambridge University, England 1949; Mentors: G. W. Kenner & A. R. Todd, Chemistry Nobelist 1957.
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