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Julius Axelrod Ph.D.

The Nobel Prize in Physiology or Medicine 1970
Co-Nobelists Sir Bernard Katz, Ulf von Euler

Pharmacologist. Neurophysiologist. Mechanism for storage, release, inactivation of humoral transmitters in nerve endings. Discovered drug metabolic pathways: hydroxylation, demethylation, deamination, conjugation. Led to liver’s microsomal drug-metabolizing enzymes discovery. Pheochromocytoma. Carboxylmethyl transferase. Melatonin.

Ideal mentor. Infectious exhilaration in discovery. Research was genuine fun. Students came out of lab with same attitude.

Patents

Publication:1/1
Publication No:US 6630507 B1
Title:Cannabinoids as antioxidants and neuroprotectants
Publication Type:United States Utility Patent
Publication Date:Oct 7, 2003
Filing Date:Apr 21, 1999
Inventors:Hampson Aidan J, Axelrod Julius, Grimaldi Maurizio
Assignee:The United States Of America As Represented By The Department Of Health And Human Services
Abstract:Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.
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Axelrod
Photo: NIH

Name: Julius Axelrod
Birth: 30 May 1912, New York, NY, USA
Death: 29 December 2004, Rockville, MD, USA
Institution: National Institutes of Health, Bethesda, MD, USA
Award: "for their discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation"
Subject: neurophysiology
Portion of Cash: 1/3
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Thesis: ‘The Fate of Phenylisopropylamines.’