Howard M. Temin Ph.D.

The Nobel Prize in Physiology or Medicine 1975
Nobel Co-recipients David Baltimore, Renato Dulbecco
National Medal of Science - Biological Sciences 1992

Virologist. Interaction between tumor viruses and genetic material of cell. DNA provirus and RNA-directed DNA synthesis. Reverse Transcriptase. Intellectually courageous. Civic minded.

How fortunate to live in a country at a time and in a social class that has enabled us to realize our potential. Not been possible for many.

Patents

Publication:	1/6
Publication No:	US 5554524 A
Title:	More complex type retroviruses having mixed type LTR, and uses thereof
Publication Type:	United States Utility Patent
Publication Date:	Sep 10, 1996
Filing Date:	Jun 22, 1994
Inventors:	Temin Howard M, Boris-Lawrie Kathleen A
Assignee:	Wisconsin Alumni Research Foundation
Abstract:	Chimeric retroviral vectors were constructed containing the long terminal repeats (LTRs) from a simple retrovirus (e.g. spleen necrosis virus (SNV); murine leukemia virus (MLV)) devoid of the integration site (att) and more complex retroviral (e.g. bovine leukemia virus (BLV); human immunodeficiency virus (HIV)) cis-acting regulatory sequences (e.g. att; primer binding site (PBS); encapsidation site (E), and polypurine tract (ppt)) and coding regions. Cells transfected with these constructs produce replication competent retrovirus particles. These retroviral particles provide a source of viral antigens that can be employed in both diagnostic assays and as immunogens for the production of high-titer specific antisera.
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Publication:	2/6
Publication No:	US 5124263 A
Title:	Recombination resistant retroviral helper cell and products produced thereby
Publication Type:	United States Utility Patent
Publication Date:	Jun 23, 1992
Filing Date:	Jan 12, 1989
Inventors:	Temin Howard M, Dougherty Joseph P
Assignee:	Wisconsin Alumni Research Foundation
Abstract:	An improved helper cell for growing up stocks of replication incompetent retrovirus vectors is disclosed. The helper cell resists recombination events due to the fact that natural promoters and poly(A) sequences in the helper sequences have been replaced with foreign promoters and poly(A) sequences bearing little or no homology to the vectors. Plasmids containing these modified sequences can still create a helper cell with resulting expression of the needed helper proteins, yet there is much less risk of recombination events in the helper cell. Also disclosed are vectors produced by such helper cells, target cells infected by such vectors, and helper cells which convert vectors so that they can be used with hosts from different species.
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Publication:	3/6
Publication No:	US 4980289 A
Title:	Promoter deficient retroviral vector
Publication Type:	United States Utility Patent
Publication Date:	Dec 25, 1990
Filing Date:	Apr 27, 1987
Inventors:	Temin Howard M, Dougherty Joseph P
Assignee:	Wisconsin Alumni Research Foundation
Abstract:	A recombinant retrovirus vector is disclosed. It is of the type having a normally replication incompetent retrovirus gene sequence with a foreign eukaryotic gene to be expressed. The retrovirus gene sequence is designed so as to be promoter deficient in the right side LTR. The vector can produce progeny virus from helper cells, which progeny can infect a eukaryotic host cell, form a provirus, and express the eukaryotic gene in the host cell. However, the provirus will then be defective in the retrovirus promoter, such that retrovirus RNA is not expressed from the provirus.
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Publication:	4/6
Publication No:	US 4650764 A
Title:	Helper cell
Publication Type:	United States Utility Patent
Publication Date:	Mar 17, 1987
Filing Date:	Mar 26, 1984
Inventors:	Temin Howard M, Watanabe Shinichi
Assignee:	Wisconsin Alumni Research Foundation
Abstract:	A helper cell for providing retrovirus protein which is required by a normally replication incompetent recombinant retrovirus gene sequence in order to replicate is disclosed. In one embodiment there is a eukaryotic host cell, a first retrovirus gene sequence in the cell which has a helper portion coding for aretrovirus protein and which is capable of expressing the retrovirus protein, and adefective portion which renders the gene sequence replication imcompetent. In this embodiment, there is also a second retrovirus gene sequence in the cell having a defective retrovirus port.
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Publication:	5/6
Publication No:	JPH 06261764 A
Title:	Mixed LTR containing super complex retrovirus and method for use thereof
Publication Type:	Japanese Patent
Publication Date:	Sep 20, 1994
Filing Date:	Feb 17, 1994
Inventors:	Temin Howard M, Boris-Lawrie Kathleen A
Assignee:	Wisconsin Alumni Research Foundation
Abstract:	PURPOSE: To provide a method for producing Gag, Pol and Env antigen of mutation type of a more complex type retrovirus without producing another pathogenic complex retrovirus protein and used for developing a safe and effective vaccine to diseases caused by the more complex type retrovirus. CONSTITUTION: This DNA contains long terminal repeats(LTRs) from a simple retrovirus and a DNA encoding a specific more complex type retrovirus protein, and the DNA sequence encodes MC type att, pbs, E and ppt. The retrovirus has an RNA sequence of the long terminal repeats from the simple retrovirus and the RNA sequence encoding the specific more complex type retrovirus protein, and the RNA sequence encodes the MC type att, pbs, E and ppt. The method for producing the retrovirus protein comprises introducing the retrovirus into a living mammalian host and allowing the virus in the host to produce the retrovirus protein. The method for producing an antibody comprises infecting a host tissue with the retrovirus, allowing the host tissue to replicate the virus to produce at least one kind of more complex type retrovirus protein, and allowing the antibody to produce the more complex retrovirus protein.
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Publication:	6/6
Publication No:	EP 0611822 A2
Title:	More complex type retroviruses having mixed type LTR, and uses thereof
Publication Type:	European Patent
Publication Date:	Aug 24, 1994
Filing Date:	Feb 17, 1994
Inventors:	Temin Howard M, Boris-Lawrie Kathleen A
Assignee:	Wisconsin Alumni Research Foundation
Abstract:	A recombinant retrovirus comprising an RNA sequence having simpler (S) Type retroviral long termini ; a more complex (MC) Type att, pbs, E and ppt RNA sequence ; and an RNA sequence encoding an MC Type retroviral protein selected from human immunodeficiency virus proteins, human spumaretrovirus proteins, human T-lymphotropic virus proteins and bovine leukemia virus proteins. The recombinant retrovirus is useful as a vaccine against MC Type retroviruses.
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