Robert J. Lefkowitz MD

Nobel Prize in Chemistry 2012
National Medal of Science - Biological Sciences 2007 USA
Nobel co-recipient Brian K. Kobilka

Physician- Cardiologist, Scientist. G-protein-coupled receptors; approximately half of all medicines used today use this kind of receptor.

"Strong family history of coronary artery disease ... at age 50 I had quadruple bypass surgery [1994]. I minimize my risk factors with daily physical exercise, a vegetarian diet and appropriate medications".

Vita

Professional Experience
Military Service
Honors and Awards
Membershipts
Editorial Boards
Pharmaceutical and Biotechnology Boards
Offices Held
Named and Honorary Lectures

Professional Experience:

7-66/6-67 Intern, Department of Medicine
Columbia-Presbyterian Medical Center, New York

7-67/6-68 Assistant Resident, Department of Medicine
Columbia-Presbyterian Medical Center, New York

7-68/6-70 Clinical & Research Associate
National Institute of Arthritis & Metabolic Diseases

National Institutes of Health, Bethesda, Maryland

7-70/6-71 Senior Resident, Department of Medicine
Massachusetts General Hospital, Boston, Massachusetts

7-71/6-73 Clinical and Research Fellow, Department of Cardiology
Massachusetts General Hospital, Boston, Massachusetts

7-71/6-73 Teaching Fellow, Department of Medicine
Harvard Medical School, Boston, Massachusetts

7-73/6-77 Associate Professor of Medicine
Duke University Medical Center, Durham, N.C.

7-73/6-85 Assistant Professor of Biochemistry
Duke University Medical Center, Durham, N.C.

7-77/6-82 Professor of Medicine
Duke University Medical Center, Durham, N.C.

7-76 Investigator, Howard Hughes Medical Institute
Duke University Medical Center, Durham, N.C.

7-82 James B. Duke Professor of Medicine
Duke University Medical Center, Durham, N.C.

7-85 Professor of Biochemistry
Duke University Medical Center, Durham, N.C.

7-03 Professor of Immunology
Duke University Medical Center, Durham, NC

Military Service:

1968-1970 United States Public Health Service (NIH)

Honors and Awards:

1962 Phi Beta Kappa
1964 Roche Prize for Excellence in Medical Studies
1965 Alpha Omega Alpha
1966 Janeway Prize
1973-1976 Established Investigator of the American Heart Association
1978 Young Scientist Award of the Passano Foundation
1978 John J. Abel Award in Pharmacology of the American Society for Pharmacology and Experimental Therapeutics
1979 Young Investigator Award, American College of Clinical Pharmacology
1979 George W. Thorn Award for Scientific Excellence of the Howard Hughes Medical Institute
1982 Ernst Oppenheimer Memorial Award of the Endocrine Society
1982 James B. Duke Professor of Medicine, Duke University Medical Center
1982 Gordon Wilson Award, American Clinical and Climatological Assn.
1983 Lita Annenberg Hazen Award for Excellence in Clinical Research
1985 Award for Outstanding Research of the International Society for Heart Research
1986 Goodman and Gilman Award of the American Society for Pharmacology and Experimental Therapeutics
1986 H.B. van Dyke Award for Excellence in Medical Research from the College of Physicians & Surgeons of Columbia University
1986 Steven C. Beering Award for Outstanding Achievement in Biomedical Science of the Indiana University School of Medicine
1987 North Carolina Award for Science
1988 National Academy of Sciences
1988 American Academy of Arts and Sciences
1988 Gairdner Foundation International Award
1990 Novo Nordisk Biotechnology Award
1990 Association of American Medical Colleges Biomedical Research Award
1990 American Heart Association Basic Research Prize with Alfred G. Gilman
1990 Honorary Member Japanese Biochemical Society
1991 City of Medicine Award with Alfred Gilman and Phillip Leder - Durham, North Carolina
1992 Columbia University College of Physicians and Surgeons Alumnus Award for Distinguished Achievements in Medicine
1992 Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research
1992 Giovanni Lorenzini Prize for Basic Biomedical Research
1993 Joseph Mather Smith Prize, Columbia University College of Physicians and Surgeons
1994 Institute of Medicine, National Academy of Sciences
1995 The Endocrine Society Gerald D. Aurbach Lecture Award
1996 Miami 1996 Bio/Technology Winter Symposia Feodor Lynen Award
1996 Ciba Award for Hypertension Research
1997 Glorney-Raisbeck Award in Cardiology The New York Academy of Medicine
2000 NOVARTIS/DREW Award in Biomedical Research
2000 F.E. Shideman-Sterling Award University of Minnesota
2001 The Walter B. Cannon Memorial Award, American Physiological Society
2001 The Louis and Artur Lucian Award for Research in Circulatory Disease McGill University
2001 Fred Conrad Koch Award The Endocrine Society
2001 Jessie Stevenson Kovalenko Medal The National Academy of Sciences
2001 2001 Peter Harris Distinguished Scientist Award International Society for Heart Research
2001 The Francis Gilman Blake Award Association of American Physicians
2002 Appointed Fellowship International Academy of Cardiovascular Sciences
2002 Pasarow Cardiovascular Research Award The Robert J. and Claire Pasarow Foundation
2003 Medal of Merit International Academy of Cardiovascular Sciences
2003 IPSEN Endocrinology Prize Fondation IPSEN, Paris, France
2003 Institut de France Fondation Lefoulon-Delalande Grand Prix for Science
2003 Founding Distinguished Scientist Award American Heart Association
2004 1st American Society of Biological Chemistry and Molecular Biology Herbert Tabor Lecture Award
2004 Distinguished Faculty Award Duke University Medical Center
2004 Doctor of Science, honoris causa Medical University of South Carolina
2004 Doctor of Science, honoris causa Mt. Sinai School of Medicine of New York University
2006 Eugene Braunwald Academic Mentorship Award American Heart Association
2007 Albany Medical Center Prize in Medicine & Biomedical Research
2007 The Shaw Prize in Life Science and Medicine
2007 Distinguished Lecture Award: Basic Science, Heart Failure Society of America
2007 National Medal of Science [presented Sept. 29, 2008 by President George W. Bush]
2008 Doctor of Science, honoris causa Albany Medical College of New York
2009 Research Achievement Award, American Heart Association
2009 Steven's Triennial Prize, Columbia University College of Physicians & Surgeons
2010 BBVA Foundation Frontiers of Knowledge Award
2011 SBS Society for Biomolecular Sciences Achievement Award
2011 Norman Weiner Award - American Society for Pharmacology and Experimental Therapeutics
2011 Kober Medal - Association of American Physicians
2012 Nobel Prize in Chemistry
2012 Honorary Fellowship of the British Pharmacological Society
2013 Honorary Fellowship,Royal Society of Chemistry Honorary
2014 Fellow, American Association for Cancer Research
2014 Fellow, American Association for the Advancement of Science
2014 John Jay Award - Columbia College
2014 Bull City Hall of Fame Award- Durham Chamber of Commerce

Memberships:

American Federation for Clinical Research
American Society of Biological Chemists
American Society for Clinical Investigation
American Heart Association, Councils on Basic Science, Clinical Cardiology and Hypertension
American Board of Internal Medicine - Diplomate
American Society for Pharmacology and Experimental Therapeutics
Endocrine Society
Association of American Physicians
National Academy of Sciences
American Academy of Arts and Sciences - Class II - Section 5
Institute of Medicine, National Academy of Sciences
The American Physiological Society
Senior Fellow of the American Asthma Foundation

Editorial Boards:

Molecular Pharmacology 1978-1998
Journal of Cardiovascular Pharmacology 1978-1983
Membrane Biochemistry 1978-1998
Life Sciences 1978-
Archives of Biochemistry and Biophysics 1979-1982
Journal of Receptor Research 1979-
Journal of Clinical Investigation 1979-1984, 1990-
Journal of Biological Chemistry 1982-1987
Journal of Hypertension 1982-1985
Biochemistry 1986-2000
FASEB Journal 1990-1992
Circulation Research 1993-1999
Chemistry & Biology 1993-1998
Proceeding of the Association of American Physicians 1995-
Molecular Biology of the Cell 1996-
Circulation 2000-
Physiological Genomics 1999 -
Molecular Interventions 2000 -

Pharmaceutical and Biotechnology Boards

Abbott 1982 - 1986 Consultant
Smith, Kline & French 1982 - 1988 Scientific Advisory Board
Genentech 1987 - present Scientific Advisory Board
Affymax 1988 - 1992 Founding Member - Scientific Advisory Board
Ariad 1991 - 1999 Founding Member - Scientific Advisory Board
Norak 2000 - 2004 Founding Scientist (one of four)
Lexicon 2001 - Board of Directors
Five Prime Therapeutics 2002-present Scientific Advisory Board
Trevena 2008- Scientific Co-Founder

Offices Held:

American Federation for Clinical Research - National Council - 1978-1983 Secretary/Treasurer - 1980-1983

American Society for Clinical Investigation - Councillor - 1982-1985 President-Elect - 1986-1987 President - 1987-1988

Association of American Physicians - Treasurer -1989-1994

Councillor - 1994-1999 Vice President - 1999 - 2000 President - 2000-2001

USA National Academy of Sciences Chairman - Section 42 (Medical Physiology and Metabolism) - 1995-1998 Secretary - Class IV (Medical Sciences) - 1998-2001 Councillor - 2004-2007

Named and Honorary Lectures

"Smith, Kline and French Distinguished Lecturer"
University of Michigan Medical School
Ann Arbor, Michigan
October 25, 1978

"State-of-the-Art Lecturer"
1978 Annual Meeting of the Midwest Section
of the American Federation for Clinical Research
Chicago, Illinois
November 2, 1978

"New York University Honors Program Lecturer"
New York University Medical Center School of Medicine
New York, New York
December 18, 1978

"Distinguished Lecturer in Pharmacology and Medicine"
University of Arizona Health Sciences Center
Tucson, Arizona
April 19, 1980

"Wendell Griffith Lecturer for 1980"
Department of Biochemistry
St. Louis University Medical Center School of Medicine
St. Louis, Missouri
April 22, 1980

"Pfizer Lecturer"
Medical University of South Carolina
Charleston, South Carolina
October 7, 1980

"Smith, Kline and French Research Lectureship"
Smith, Kline and French Laboratories
Philadelphia, Pennsylvania
April 8, 1981

"4th Michael J. Bent Memorial Lecturer"
Meharry Medical College
Nashville, Tennessee
October 14, 1981

"Distinguished Lecturer"
1982 Annual Meeting of the Southern Section
of the American Federation for Clinical Research
New Orleans, Louisiana
January 14, 1982

"Pfizer Lecturer"
Stanford University School of Medicine
Stanford, California
March 24, 1982
"Class of 1947 Lecturer"
The University of Wisconsin Medical School
Madison, Wisconsin
October 14, 1982

"Gordon Wilson Lecture and Award"
American Clinical and Climatological Association
Phoenix, Arizona
October 25, 1982

"Fourteenth Annual Louis F. Bishop Lectureship"
32nd Annual Scientific Session of the
American College of Cardiology
New Orleans, Louisiana
March 23, 1983

"State of the Art Lecturer"
American Society of Nephrology
Washington, D.C.
December 5, 1983

"Pfizer Lecturer"
The University of Iowa
Iowa City, Iowa
March 8, 1984

"Emil Smith Lecturer"
University of California, Los Angeles
Los Angeles, California
March 9, 1984

"George Thorn Visiting Professor"
Brigham and Women's Hospital
Boston, Massachusetts
April 13, 1984
"23rd Paul K. Smith Memorial Lecturer"
The George Washington University
Washington, D.C.
May 14, 1984

"Pfizer Lecturer"
University of Texas Health Science Center at Dallas
Dallas, Texas
September 13, 1984

"William N. Creasy Memorial Lecturer"
The University of Texas Medical School
Houston, Texas
January 17, 1985

"James Law Distinguished Lecturer"
Cornell University
Ithaca, New York
February 7, 1985

"6th Annual Leslie L. Bennett Lecturer"
University of California, San Francisco
San Francisco, California
May 24, 1985

"Twelfth Annual Henry Turner Lecturer"
The University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
October 16, 1985

"Sixth Annual Oliver Cope Lecturer"
Massachusetts General Hospital
Boston, Massachusetts
February 5, 1986
"1986 H.B. van Dyke Lecturer"
College of Physicians & Surgeons of Columbia University
New York, New York
April 7, 1986

"Sterling Drug Visiting Professor of Pharmacology"
The University of Michigan Medical School
Ann Arbor, Michigan
May 12, 1986

"Arthur C. Corcoran Memorial Lecture"
Council for High Blood Pressure Research
American Heart Association
Cleveland, Ohio
October 9, 1986

"George Drummond Lectureship"
Alberta Heritage Foundation for Medical Research
Edmonton, Alberta
November 6, 1986

"Lewis A. Conner Memorial Lecture"
American Heart Association
Anaheim, California
November 16, 1987

"John P. Peters Memorial Lecture"
Yale University
New Haven, Connecticut
December 2, 1987

"Pfizer Lecturer"
Albert Einstein College of Medicine
Bronx, New York
December 14, 1987

"Sixty-Ninth Mellon Lecture"
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
March 15, 1988

"The Edwin G. Krebs Lecture in Molecular Pharmacology"
University of Washington
Seattle, Washington
April 6, 1988

"Sterling Drug-Maurice L. Tainter"
Visiting Professorship
Stanford University School of Medicine
Stanford, California
April 7, 1988

"Abraham White Memorial Lecture"
Syntex Research
Palo Alto, California
August 15, 1988

"The Seventh Annual Jeanette Piperno Memorial Lecture"
Temple University
Philadelphia, Pennsylvania
September 27, 1988

"Twelfth Annual Irvine H. Page Lecture"
The Cleveland Clinic Foundation
Cleveland, Ohio
April 3, 1989

"Lawson Wilkins Pediatric Endocrine Society Lecturer"
Washington, D.C.
May 5, 1989

"The Theodore G. Klumpp, Sterling Drug Lecture"
Harvard Medical School
Boston, Massachusetts
September 15, 1989

"Dr. Aaron I. Grollman Memorial Lecture
University of Maryland
Baltimore, Maryland
November 30, 1989

"The Twentieth Annual Schueler Distinguished Lecture in Pharmacology"
Tulane University
New Orleans, Louisiana
March 22, 1990

"The Harvey Society Lecture"
The Rockefeller University
New York, New York
November 15, 1990

"Choh Hao Li Memorial Lecture"
University of California at Berkley
Berkley, California
April 2, 1991

"National Institutes of Health Lecture"
Warren Grant Magnuson Clinical Center
National Institutes of Health
Bethesda, Maryland
June 13, 1991

"Ulf von Euler Lecture in Physiology"
Karolinska Institute
Stockholm, Sweden
February 10, 1992

"J.H. Quastel Lecture"
University of Montreal
Montreal, Quebec, Canada
April 1-2, 1992

"Jewish Hospital Board of Directors
Lecture of Distinction in Research"
Jewish Hospital
Washington University Medical Center
St. Louis Missouri
April 12, 1993

Evans Research Day Lecturer
Boston University School of Medicine
Boston, Massachusetts
November 2, 1993

Leonard T. Skeggs, Jr.
Case Western Reserve University
Cleveland, Ohio
January 24, 1994

Jack Cooper Lecture
Yale University
New Haven, Connecticut
October 3, 1994

Fourth Annual Avery Stellman Lecture
University of North Carolina, Chapel Hill
Chapel Hill, North Carolina
May 15, 1995

1995 Gerald D. Aurbach Lecture
The Endocrine Society
Washington, D.C.
June 16, 1995

"1996 Gladstone Distinguished Lecture"
The J. David Gladstone Institutes
San Francisco, California
January 26, 1996

"St. Geme Lecture"
University of Colorado School of Medicine
Denver, Colorado
January 29, 1996

"Feodor Lynen Lecture"
The 1996 Miami Bio/Technology Winter Symposia
Ft. Lauderdale, Florida
February 11, 1996

"Solomon A. Berson Distinguished Lectureship"
of the Endocrinology & Metabolism Section
The American Physiological Society
Washington, DC
April 16, 1996

"Twelfth Annual Ray A. and Robert L. Kroc Lectureship"
Joslin Diabetes Center
Boston, Massachusetts
September 26, 1996

"Medical School Lecture"
The University of Texas-Houston
Houston, Texas
October 8, 1997

"The Ralph R. Landes Lecture"
University of North Carolina - Chapel Hill
Chapel Hill, North Carolina
January 22, 1998

"Hans Hecht Lecture"
The University of Chicago
Chicago, Illinois
September 1, 1998

"The Tenth Annual Sterling Lecture"
Tufts University
Boston, MA
October 7, 1998

Dean's Hour Lecture
University of Arkansas College of Medicine
Little Rock, Arkansas
March 10, 1999

Twelfth Annual Lee E. Farr Lecture
Yale University
New Haven, Connecticut
May 11, 1999

Bulfinch Visiting Professor
Massachusetts General Hospital
Boston, Massachusetts
June 9-11, 1999

2nd Annual J.G. Reves Lecture
Duke University Medical Center
Durham, North Carolina
July 21, 1999

Fouad A. Bayshour Distinguished Physiologist Lectureship
The University of Texas SW Medical Center
Dallas, Texas
October 4, 1999

"Pfizer Lecture"
Whitehead Institute
Cambridge, MA
November 16, 1999

"Menek Goldstein Memorial Lecture"
New York University
New York, NY
December 2, 1999

"Harold Feinberg Lecture"
The University of Illinois
Chicago, Illinois
March 24, 2000

"Neil C. Moran Lecture"
Emory University
Atlanta, Georgia
April 4, 2000

"Louis V. Avioli Lecture"
Washington University School of Medicine
St. Louis, MO
April 17, 2000

"Alexander M. Cruickshank Lecture"
Gordon Research Conferences
Meriden, NH
June 15, 2000

F.E. Shideman - Sterling Annual Lecture
University of Minnesota
Minneapolis, MN
September 25, 2000

The 2000 Robert M. Berne Lecture
University of Virginia
Charlottesville, VA
October 16, 2000

4th Annual Connie Lerea Lecture
New York Medical College, Valhalla, NY
November 3, 2000

The Walter B. Cannon Memorial Award Lecture
American Physiological Society
Orlando, FL
March 31, 2001

7th Ray A. and Robert L. Kroc Lecture
University of Massachusetts Medical School
Worcester, MA
May 11, 2001

10th Annual Efraim Racker Lecture
Cornell University
Ithaca, NY
November 1, 2001

29th Annual Carl Vernon Moore Memorial Lecture
Washington University
St. Louis, Missouri
November 16, 2001

1st Annual Eva Neer Memorial Lecture
Brigham and Women's Hospital
Boston, Massachusetts
March 21, 2002

26th Annual Carl F. Schmidt Honorary Lecture
University of Pennsylvania
Philadelphia, PA
April 8, 2002

NIH Director's Wednesday Afternoon Lecture
The Florence Mahoney Lecture
Bethesda, MD
June 19, 2002

The Paul D. Lamson Memorial Lecture 2002
Vanderbilt University
Nashville, TN
October 22, 2002

The 217th Lilly Lecture
Eli Lilly and Company
Indianapolis, IN
September 24, 2003

2003 George Boxer Memorial Lecture
UMD New Jersey Robert Wood Johnson Medical School
Piscataway, New Jersey
October 20, 2003

2003 Thomas Smith Memorial Lecture
Council on Basic Cardiovascular Sciences, American Heart Association
Scientific Sessions 2003
Orlando, FL
November 11, 2003

32nd Annual Verna and Marrs McLean Lecture
Baylor College of Medicine
Houston, Texas
February 5, 2004

2004 Sterling Visiting Professor
Albany Medical College
Albany, New York
April 7, 2004

Leonard Leight Lecture
University of Louisville
Louisville, Kentucky
November 17, 2004

Kober Lecture
ASCI/AAP Joint Meeting
Chicago, Illinois
April 30, 2006

2006 Ada Doisy Lecture in Biochemistry
University of Illinois
Urbana, Illinois
May 4, 2006

Distinguished Visiting Mentor Lecture
University of Iowa
Iowa City, Iowa
September 13, 2006

9th Annual Greenfield Family Lecture Series
Case Western Reserve University School of Medicine
Cleveland, Ohio
September 21, 2006

Gullemin Nobel Lecture
Salk Institute for Biological Studies
LaJolla, California
October 26, 2006

Tinsley Harrison Visiting Professor Lecture
Vanderbilt University School of Medicine
Nashville, TN
March 29, 2007

Distinguished Lecture Award: Basic Science
Heart Failure Society of America
Washington, D.C.
September 16, 2007

Clyde and Helen Wu Distinguished Lecture Series
Columbia University Medical Center
New York, New York
December 10, 2007

Dr. Martin Rodbell Lecture Series
NIEHS, NIH
Research Triangle Park, NC
May 5, 2008

Calabresi Lecturer
Yale University School of Medicine
June 11-12, 2008

2nd Annual Hugh Arthur Prichard Memorial Lecture
University of Maryland School of Medicine
March 6, 2009

2010 Jack M. Buchanan Medal
Dept. of Biology
MIT
Cambridge, MA
September 28, 2010

2010 Annual Theodore Kopanyi Lecture
Georgetown University
Washington, DC
November 4, 2010

2011 John Daly Lecture
NIH
Washington, DC
April 12, 2011

2011 Norman Weiner Lecture
ASPET Meeting
Washington, DC
April 13, 2011

2013 Sir James Black Honorary Lecture
ASPET Meeting
Boston, MA
April 24, 2013

2013 Wylie Vale Memorial Lecture
Salk Institute
La Jolla, CA
June 18, 2013

2013 Frances Feinberg Lecture
Northwestern University
Chicago, Ill
September 30, 2013

2012 Pincoffs Lecture in Medicine
Baltimore Maryland
November 12, 2013

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