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Publications

Robert J. Lefkowitz MD

Nobel Prize in Chemistry 2012
National Medal of Science - Biological Sciences 2007 USA

Nobel co-recipient Brian K. Kobilka

Physician- Cardiologist, Scientist. G-protein-coupled receptors; approximately half of all medicines used today use this kind of receptor.

"Strong family history of coronary artery disease ... at age 50 I had quadruple bypass surgery [1994]. I minimize my risk factors with daily physical exercise, a vegetarian diet and appropriate medications".

Publications

Journal Articles in NCBI/PubMed

883 Journal Articles:

Articles:

  1. Lefkowitz, R.J., Roth, J., Pricer, W. and Pastan, I. ACTH receptors in the adrenal: Specific binding of ACTH-125I and relation to adenyl cyclase. Proc. Natl. Acad. Sci. 65, 745-752, 1970. PMCID: 282969
  2. Lefkowitz, R.J. Specific binding of ACTH-125I by adrenal cyclase preparations. Proc. Fogarty Inter'l. Center Colloquim on the Biological Role of Adenyl Cyclase and Cyclic AMP, 1969.
  3. Lefkowitz, R.J., Roth J., Pricer, W. and Pastan, I. Radioreceptor assay of adrenocorticotropic hormone: New approach to assay of polypeptide hormones in plasma. Science 170: 633-635, 1970.PMID:4319388
  4. Lefkowitz, R.J., Roth J. and Pastan, I. Effects of calcium on ACTH stimulation of the adrenal: Separation of hormone binding from adenyl cyclase activity. Nature 228: 864-866, 1970. PMID: 4320054
  5. Lefkowitz, R.J., Roth J. and Pastan, I. ACTH-receptor interaction in the adrenal: A model for the first step in the action of hormones which stimulate adenyl cyclase. Ann. of N.Y. Acad. Sci. 185: 195-209, 1971. PMID:4330491
  6. Lefkowitz, R.J., Roth, J. and Pastan, I. Radioreceptor assay of ACTH in Methods in Investigative and Diagnostic Endocrinology, (S.A. Berson and R.S. Yalow, eds.). North Holland Publishing Co., Amsterdam, 1972.
  7. Lefkowitz, R.J. and Haber, E. A fraction of the ventricular myocardium that has the specificity of the cardiac beta?adrenergic receptor. Proc. Natl. Acad. Sci. 68: 1773-1777, 1971. PMID:389290
  8. Roth, J., Pastan, I., Lefkowitz, R.J., Pricer, W., Freychet, P. and Nevil D. ACTH receptors in the adrenal and insulin receptors in liver in "Structure Activity Relationship of Protein and Polypeptide Hormones," (M. Margolis and F.C. Greenwood, eds.). Excerpta Medica, Amsterdam, p. 228, 1971.
  9. Lefkowitz, R.J. Characterization and purification of the cardiac beta-adrenergic receptor in The Role of Membranes in Metabolic Regulation, (M. Mehlman, ed.). Academic Press, pp. 261-285, 1972.
  10. Lefkowitz, R.J., Haber, E. and O'Hara, D. Identification of the cardiac beta-adrenergic receptor protein: Solubilization and purification by affinity chromatography. Proc. Natl. Acad. Sci. 69: 2828-2832, 1972. PMID: 389654
  11. Lefkowitz, R.J. and Levey, G.S. Norepinephrine: Dissociation of beta-receptor binding from adenylate cyclase activation in solubilized myocardium. Life Sci. 11: 821-828, 1972. PMID:4628614
  12. Lefkowitz, R.J., Sharp, G. and Haber, E. Specific binding of beta-adrenergic catecholamines to a subcellular fraction from cardiac muscle. J. Biol. Chem. 248: 342-349, 1973. PMID:41444255
  13. Lefkowitz, R.J. and Haber, E. Physiological receptors as physicochemical entities. Circ. Res. 32, Suppl. 1: 46-52, 1973. PMID:4351359
  14. Lefkowitz, R.J. Isolated hormone receptors: Physiological and clinical implications. New Engl. J. Med. 288: 1061-1066, 1973. PMID:4144513
  15. Lefkowitz, R.J. Isolated beta-adrenergic binding sites: Potential assay vehicle for measurement of catecholamines. Pharm. Revs. 25: 259-268, 1973.PMID:4150174
  16. Lefkowitz, R.J., O'Hara, D. and Warshaw, J. Binding of catecholamines to receptors in cultured myocardial cells. Nature, New Biology 244: 79-80, 1973.PMID:4516145
  17. Haber, E. and Lefkowitz, R.J. Isotopic displacement assays: The relative merits of antibodies and isolated physiological receptors in Diagnostic Nuclear Cardiology. C.V. Mosby Co., St. Louis, pp. 343-347, 1974.
  18. Lefkowitz, R.J. Approaches to the measurement of catecholamines in plasma present and future in Diagnostic Nuclear Cardiology. C.V. Mosby Co., St. Louis, pp. 366-370, 1974.
  19. Lefkowitz, R.J. Toward isolation of beta-adrenergic binding protein, in Frontiers in Catecholamine Research, (E. Usdin and S. Snyder, eds.). Pergamon Press, pp. 361-368, 1973.
  20. O'Hara, D. and Lefkowitz, R.J. Agarose-norepinephrine derivatives for purification of adrenergic receptors and binding proteins in Methods of Enzymology Affinity Techniques, (S.P. Colowick and N.O. Kaplan, eds.). Academic Press, pp. 695-700, 1974.
  21. Butcher, R.W., Crofford, O.B., Gammeltoff, S., Gliemann, J., Gavin, J.R., Goldfine, I., Kahn, R., Rodbell, M., Roth, Jr., Jarrett, L., Larner, J., Lefkowitz, R.J., Levine, R. and Marinetti, G.V. Insulin activity: The solid matrix. Science 182: 396-397, 1973. PMID:4356902
  22. Lefkowitz, R.J. Molecular pharmacology of beta-adrenergic receptors. Biochem. Pharmacol. 23: 2069-2076, 1974. PMID:4153299
  23. Lefkowitz, R.J., O'Hara, D. and Warshaw, J.B. Surface interaction of [3H]norepinephrine with cultured embryo myocardial cells. Biochem. Biophys. Acta 332: 317-328, 1974.
  24. Lefkowitz, R.J. Selectivity in beta-adrenergic responses: Clinical implications. Circulation 49: 783-786, 1974.PMID:4151328
  25. Vatner, D. and Lefkowitz, R.J. [3H]Propranolol binding site in myocardial membranes: Non-identity with beta-adrenergic receptors. Mol. Pharmacol. 10: 450-456, 1974.PMID:4847937
  26. Lefkowitz, R.J. Catecholamine stimulated myocardial adenylate cyclase: Effects of phospholipase digestion and the role of membrane lipids. J. Mol. and Cell. Cardiol. 7: 27-37, 1975. PMID:1121031
  27. Caron, M.G. and Lefkowitz, R.J. Temperature immutability of adenylate cyclase-coupled beta-adrenergic receptors. Nature 249: 258-260, 1974. PMID:4151464
  28. Lefkowitz, R.J. Catecholamine stimulation of myocardial adenylate cyclase: Effects of nucleotides. J. Mol. and Cell. Cardiol. 7: 237-248, 1975. PMID:1127710
  29. Lefkowitz, R.J. Stimulation of catecholamine sensitive adenylate cyclase by 5'guanylyl imidodiphosphate. J. Biol. Chem. 249: 6119-6124, 1974. PMID:4425095
  30. Lefkowitz, R.J. [3H]Norepinephrine binding: Unrelated to catechol-o-methyl transferase. Biochem. Biophys. Res. Commun. 58: 1110-1118, 1974.PMID:4365564
  31. O'Keefe, D., Lefkowitz, R.J., Grantham, N.R., Beierholm, E.A. and Daggett, W.M. Effects of cardiac denervation and failure on canine myocardial norepinephrine binding sites. Cardiovasc. Res., Vol. IX, No. 2, pp. 219-223, 1975.PMID:45648
  32. Lefkowitz, R.J. [3H]GTP binding sites in solubilized myocardium: Relation to adenylate cyclase. J. Biol. Chem. 250: 1006-1011, 1975.
  33. Lefkowitz, R.J. Heterogeneity of adenylate cyclase-coupled beta-adrenergic receptors. Biochem. Pharmacol. 24: 583-590, 1975.PMID:235928
  34. Lefkowitz, R.J., Mukherjee, C., Coverstone, M. and Caron, M.G. Stereospecific [3H] (-)alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. Biochem. Biophys. Res. Commun. 60: 703-709, 1974. PMID:4370935
  35. Limbird, L.E. and Lefkowitz, R.J. Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. Biochem. Biophys. Acta, Enzymology 377: 186-196, 1975. PMID:235292
  36. Lefkowitz, R.J. Catecholamine sensitive adenylate cyclase: Biochemical model of beta-adrenergic receptors. Proceedings of 12th International Conference of International Medicine, 1975.
  37. Lefkowitz, R.J. Biochemistry of beta-adrenergic receptor and adenylate cyclase. Proceedings of the 9th Meeting of the Federation of European Biochemistry Society, 1975.
  38. Caron, M.G. and Lefkowitz, R.J. Beta-adrenergic receptors: Basic studies and clinical implications. Proceedings of the 1st International Asthma Conference in New Directions in Asthma (M.Stein, ed.). American College of Chest Physicians, Park Ridge, Ill. pp. 85-101, 1975.
  39. Lefkowitz, R.J. Clinical pharmacology of beta-adrenergic blocking drugs. Medical Challenge 9: 72-76, 1977.
  40. Aprille, J.R., Lefkowitz, R.J. and Warshaw, J.B. [3H]Norepinephrine binding and lipolysis by isolated fat cells. Biochem. Biophys. Acta 373: 502-513, 1974. PMID:4433592
  41. Lefkowitz, R.J. [3H](-)Alprenolol: New tool for the study of beta-adrenergic receptors in Methods in Receptor Research (M. Blecher, ed.). Marcel Dekker, Inc., New York.
  42. Mukherjee, C., Caron, M.G., Coverstone, M. and Lefkowitz, R.J. Identification of beta-adrenergic receptors in frog erythrocyte membranes with [3H](-)alprenolol. J. Biol. Chem. 250: 4869-4875, 1975. PMID:238972
  43. Lefkowitz, R.J. and Caron, M.G. Characteristics of 5'guanylyl- imidodiphosphate activated adenylate cyclase. J. Biol. Chem. 250: 4418-4423,1975. PMID:166994
  44. Lefkowitz, R.J. Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. Biochem. Pharmacol. 24: 1651, 1975.PMID:11
  45. Lefkowitz, R.J., Caron, M.G., Limbird, L., Mukherjee, C. and Williams, L.T. Membrane bound hormone receptors in Membrane Bound Enzymes (A. Martinosi, ed.). Plenum Press, New York.
  46. Alexander, R.W., Williams, L.T. and Lefkowitz, R.J. Identification of cardiac beta-adrenergic receptors by [3H](-)alprenolol binding. Proc. Natl. Acad. Sci. USA 72: 1564-1568, 1975.PMID:1055427
  47. Mukherjee, C., Caron, M.G. and Lefkowitz, R.J. Catecholamine induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptors. Proc. Natl. Acad. Sci. USA , 72:1945-1949, 1975.PMID:432665
  48. Lefkowitz, R.J. Identification of beta-adrenergic receptors in Isolation of Hormone Receptors (G. Levey, ed.). Marcell Dekker, New York, 1975.
  49. Limbird, L.E., DeMeyts, P. and Lefkowitz, R.J. Beta-adrenergic receptors: Evidence for negative cooperativity. Biochem. Biophys. Res. Commun. 64: 1160-1168, 1975. PMID:1137592
  50. Mickey, J.V., Tate, R. and Lefkowitz, R.J. Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (-)isoproterenol in vitro. J. Biol. Chem. 250: 5727-5729, 1975.PMID:167023
  51. Lefkowitz, R.J., Caron, M.G. and Mukherjee, C. Identification and regulation of beta-adrenergic receptors in Proceedings of the 9th Miles International Symposium on Cell Surface Receptors, Raven Press, New York, 1975.
  52. Mukherjee, C., Caron, M.G., Mullikin, D. and Lefkowitz, R.J. Structure activity relationship of beta-adrenergic receptors: Determination by direct binding studies. Mol. Pharmacol. 12: 16-31, 1976.PMID:3725
  53. Lefkowitz, R.J. and Limbird, L.E. The beta-adrenergic receptor and adenylate cyclase. Biochimica et Biophysica Acta 457: 1-39, 1976.PMID:769837
  54. Lefkowitz, R.J., Caron, M.G. and Mukherjee, C. Beta-adrenergic receptors: structure activity relations determined by direct binding studies in Receptors in Pharmacology (J. Smythies and R. Bradley, eds.). Marcel Dekker, Inc., New York, Vol. 11, pp. 97-121, 1978.
  55. Limbird, L.E. and Lefkowitz, R.J. Adenylate cyclase-coupled beta-adrenergic receptors: Role of membrane lipids and other factors in receptor binding and enzyme stimulation by catecholamines. Mol. Pharmacol. 12: 559-567, 1976.PMID:958206
  56. Williams, L.T., Snyderman, R. and Lefkowitz, R.J. Identification of beta-adrenergic receptors in human leukocytes with (-) [3H]alprenolol. J. Clin. Invest. 57: 149-155, 1976.PMID:436634
  57. Zatz, M., Kebabian, J.W., Romero, J.A., Lefkowitz, R.J. and Axelrod, J. Pineal beta-adrenergic receptor: Correlation of binding of 3H-(1)-alprenolol with stimulation of adenylate cyclase. J. Pharmacol. Exp. Therap. 196: 714-722, 1976.PMID:4608
  58. Alexander, R.W., Davis, J.N. and Lefkowitz, R.J. Direct identification of beta-adrenergic receptors in rat brain. Nature 258: 437, 1975.PMID:620
  59. Lefkowitz, R.J., Mukherjee, C., Caron, M.G., Limbird, L.E., Alexander, R.W., Williams, L.T., Mickey, J.V., Tate, R. Regulation of adenylate cyclase-coupled beta-adrenergic receptors. Recent Progress in Hormone Research 32: 597-632, 1976. PMID:785560
  60. Limbird, L.E. and Lefkowitz, R.J. Biochemical and molecular characteristics of beta-adrenergic receptor binding sites in Proceedings of the Nato Advanced Study Institute on Surface Membrane Receptors, NATO ASI, Series, Vol. 11, pp. 387-404, Plenum Press, New York, 1976.
  61. Williams, L.T., Jarett, L. and Lefkowitz, R.J. Adipocyte beta-adrenergic receptors: Identification and subcellular localization by (-)[3H]alprenolol binding. J. Biol. Chem. 251: 3096-3104, 1976. PMID:942608
  62. Caron, M.G. and Lefkowitz, R.J. Solubilization and characterization of the beta-adrenergic receptor of frog erythrocytes. J. Biol. Chem. 251: 2374-2384, 1976.PMID:1191347
  63. Caron, M.G. and Lefkowitz, R.J. Solubilization of the beta-adrenergic receptor. Biochem. Biophys. Res. Commun. 68: 315-322, 1976. PMID:1082747
  64. Lefkowitz, R.J. The beta-adrenergic receptor, a mini review. Life Sci. 18: 461-472, 1976.PMID:1191347
  65. Lefkowitz, R.J. and Limbird, L.E. Biochemical techniques for the study of drug action. Progress in Cardiovascular Diseases, Vol. 18, pp. 309-321, 1976.PMID:737
  66. Mickey, J.V., Tate, R., Mullikin, D. and Lefkowitz, R.J. Characterization of catecholamine tolerance in vitro: Correlation between adenylate cyclase sensitivity and beta-adrenergic receptor binding. Mol. Pharmacol. 12: 409-419, 1976. PMID:934056
  67. Davis, J.N., Miller, R.D. and Lefkowitz, R.J. A possible role for neurotransmitter receptors in stroke. Proc. of the Tenth Princeton Conference of Cerebrovascular Disease, 1976.
  68. Mukherjee, C. and Lefkowitz, R.J. Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: Resensitization by 5'guanylylimidodiphosphate and other purine nucleotides. Proc. Natl. Acad. Sci. USA 73: 1494-1498, 1976.PMID:430323
  69. Mukherjee, C., Caron, M.G. and Lefkowitz, R.J. Regulation of beta-adrenergic receptors by beta-adrenergic agonists in vivo. Endocrinology 99: 347-357, 1976.PMID:954636
  70. Limbird, L. and Lefkowitz, R.J. Negative cooperativity among beta-adrenergic receptors of frog erythrocytes. J. Biol. Chem. 251: 5007-5014, 1976.PMID:956174
  71. Williams, L.T. and Lefkowitz, R.J. Identification of alpha-adrenergic receptors by [H3]dihydroergocryptine binding. Science 192: 791-793, 1976. PMID:4894
  72. Rudolph, S.A. and Lefkowitz, R.J. Receptors, cyclic nucleotides and transport, in Handbook of Transport (D. Tosteson, ed.), Springer-Verlag.
  73. Lefkowitz, R.J., Mullikin, D. and Caron, M.G. Regulation of beta-adrenergic receptors by 5'guanylylimidodiphosphate and other purine nucleotides. J. Biol. Chem. 251: 4688-4692,1976.PMID:947904
  74. Lefkowitz, R.J. Identification and regulation of beta-adrenergic receptors in Hormone Receptors, (D. Klachko, L. Forte and J. Franz, eds.). Plenum Press, New York, Vol. 96, pp. 137-160, 1978.
  75. Rauckman, E.J., Rosen, G.M. and Lefkowitz, R.J. Pharmacological activity of nitroxide analogues of dichlorisoproterenol and propranolol. J. Med. Chem. 19: 1254-1256, 1976.PMID:11346
  76. Davis, J.N. and Lefkowitz, R.J. Beta-adrenergic receptor binding synaptic localization in rat brain. Brain Research 113: 214-220, 1976.PMID:953730
  77. Caron, M.G. and Lefkowitz, R.J. Biological activity of agarose-immobilized catecholamines. Biochem. Biophys. Acta 444: 472-486, 1976.PMID:9146
  78. Lefkowitz, R.J. Beta-adrenergic receptors: Recognition and regulation. New Engl. J. Med. 295: 323-328, 1976.PMID:6910
  79. Williams, L.T., Mullikin, D. and Lefkowitz, R.J. Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. J. Biol. Chem. 251: 6915-6923, 1976. PMID:825511
  80. Lefkowitz, R.J. Regulation of beta-adrenergic receptors by beta-adrenergic agonists, in Hormone Receptors, Vol. II (B. O'Malley and L. Birnbaumer, eds.), Academic Press, New York.
  81. Lefkowitz, R.J., Mukherjee, C., Caron, M.G., Mickey, J.V. and Tate, R. Biochemical mechanisms for regulation of beta-adrenergic receptors by beta-adrenergic agonists, in Proceedings of the Vth Interncrine Congressational Endo, 1976.
  82. Mukherjee, C. and Lefkowitz, R.J. Regulation of beta-adrenergic receptors in isolated frog erythrocyte plasma membranes. Mol. Pharmacol. 13: 291-303, 1977.PMID:16207
  83. Mukherjee, C. and Lefkowitz, R.J. Direct radioligand binding studies of beta-adrenergic receptors in intact frog erythrocytes. Life Sciences 19:1897, 1976. PMID:187891
  84. Lefkowitz, R.J. Desensitization of beta-adrenergic receptors by beta-adrenergic agonists, in Proceedings of the 10th CINP Congress (Collegium Internationale Neuro-Psychopharmacologicum), Pergamon Press, Ltd., 1976.
  85. Lefkowitz, R.J. Smoking, catecholamines and the heart (signed editorial). New Engl. J. Med. 295: 615-616, 1976.PMID:950975
  86. Lefkowitz, R.J. Radioligand binding studies of adrenergic receptors. Wenner-Gren Center International Symposium Series. in: Central Adrenaline Neurons (Ed. K. Ruxe, et al., Pergamon Press, Oxford & New York, pp. 291-301, 1976.
  87. Limbird, L.E. and Lefkowitz, R.J. Resolution of beta-adrenergic receptors and adenylate cyclase by gel exclusion chromatography. J. Biol. Chem. 252: 799-802, 1977. PMID:833154
  88. Williams, L.T. and Lefkowitz, R.J. Molecular pharmacology of alpha-adrenergic receptors: Use of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations. Mol. Pharmacol. 13: 304-313, 1977.PMID:192992
  89. Randall, M.H., Altman, L.J. and Lefkowitz, R.J. Structure and biological activity of (-) [3H]dihydroalprenolol: A radioligand for studies of beta-adrenergic receptors. J. Med. Chem. 20:1090, 1977. PMID:197238
  90. Williams, L.T., Gore, T. and Lefkowitz, R.J. Ectopic beta-adrenergic receptor binding sites: Possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. J. Clin. Invest. 59: 319, 1977. PMID:13086
  91. Lefkowitz, R.J. and Williams, L.T. Catecholamine binding to the beta-adrenergic receptor. Proc. Natl. Acad. Sci. USA 74: 515-519, 1977.PMID:15249
  92. Davis, J.N., Strittmatter, W.J., Hoyler, E. and Lefkowitz, R.J. [3H]Dihydroergocryptine binding in rat brain. Brain Research 132: 327-336,1977.PMID:196714
  93. Williams, L.T., Pike, M., Snyderman, R. and Lefkowitz, R.J. Specific receptors for chemotactic peptides on human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA 74: 1204-1208, 1977.PMID:265563
  94. Lefkowitz, R.J. Biochemical characteristics of alpha- and beta-adrenergic receptors and their relevance to the clinician. Cardiovasc. Med. 1977.
  95. Lefkowitz, R.J. Identification and regulation of adrenergic receptors. Proceedings of the American Society of American Society of Neuropsychopharmacology Meeting, 1977.
  96. Lefkowitz, R.J. Modulation of norepinephrine action at alpha and beta adrenergic receptors in hypertension. Report of the National Hypertension Task Force, 1977.
  97. Williams, L.T., Lefkowitz, R.J., Hathaway, D.R., Watannabe, A.M. and Besch, H.R. Thyroid hormone regulation of beta-adrenergic receptor number. J. Biol. Chem. 252: 2787-2790, 1977.PMID:15999
  98. Strittmatter, W.J., Davis, J.N. and Lefkowitz, R.J. Alpha-adrenergic receptors in rat parotid cells: I. Correlations of [3H]dihydroergocryptine binding and catecholamine stimulated potassium efflux. J. Biol Chem. 252: 5472-5477, 1977.PMID:195950
  99. Strittmatter, W.J., Davis, J.N. and Lefkowitz, R.J. Alpha-adrenergic receptors in rat parotid cells: II. Desensitization of receptor binding sites and potassium release. J. Biol. Chem. 252: 5478-5482, 1977.PMID:195951
  100. Lefkowitz, R.J. Identification and regulation of alpha- and beta-adrenergic receptors. Fed. Proc., 37: 123-129, 1978.PMID:203489
  101. Lefkowitz, R.J. and Hamp, M. Comparison of agonist and antagonist radioligand binding to beta-adrenergic receptors. Nature 268: 453, 1977. PMID:19707
  102. Williams, L.T. and Lefkowitz, R.J. Regulation of rabbit myometrial alpha-adrenergic receptors by estrogen and progesterone. J. Clin. Invest. 60: 815-818, 1977.PMID:197125
  103. Lefkowitz, R.J., Mullikin D., Wood C., Gore, T. and Mukherjee, C. Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides. J. Biol. Chem. 252: 5295-5303, 1977.PMID:195945
  104. Williams, L.T. and Lefkowitz, R.J. Slowly reversible binding of a beta-adrenergic agonist to a nucleotide sensitive state of the beta-adrenergic receptor. J. Biol. Chem. 252: 7207-7213, 1977.PMID:198405
  105. Lefkowitz, R.J. Molecular properties and regulation of alpha- and beta-adrenergic receptors. Proceedings of P & S Symposium on Neuronal Informations Transfer, pp. 59-71, Academic Press, New York, 1978.
  106. Lefkowitz, R.J. and Williams, L. Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors. Advances in Cyclic Nucleotide Research, Vol. 9, (W.J. George and L.J. Ignarro, eds.), Raven Press, New York, 9:1-17, 1978.PMID:208372
  107. Pike, L.J. and Lefkowitz, R.J. Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta-adrenergic receptors. Mol. Pharmacol. 14: 370-375, 1978.PMID:25377
  108. Glaubiger, G. and Lefkowitz, R.J. Elevated beta-adrenergic receptor number after chronic propranolol treatment. Biochem. Biophs. Res. Commun. 78: 720-725, 1977.PMID:199185
  109. Lefkowitz, R.J. Molecular and regulatory properties of beta-adrenergic receptors and their clinical implications. Excerpta Medica Symposium on "Beta-adrenergic Blockade: A New Era in Cardiovascular Medicine," 1977.
  110. Newman, K., Williams, L.T., Bishopric, N. and Lefkowitz, R.J. Identification of platelet alpha-adrenergic receptors by [3H]dihydroergocryptine binding. J. Clin. Invest. 61: 395-402, 1978.PMID:23392
  111. Tsai, Bie Shung and Lefkowitz, R.J. [3H]Dihydroergocryptine binding to alpha-adrenergic receptors in canine aortic membranes. J. Pharm. Exp. Therap. 204: 606-614, 1978.PMID:24730
  112. Lefkowitz, R.J. Recent advances in the study of drug receptors. Yearbook of Drug Therapy, 1978.
  113. Caron, M.G., Beaubieu, M., Raymond, V., Drouin, J., Gagne, B., Lefkowitz, R.J. and Labrie, F. Dopaminergic receptors in the anterior pituitary gland: Identification by [3H]dihydroergocryptine binding. J. Biol. Chem. 253: 2244-2253, 1978.PMID:416027
  114. Lefkowitz, R.J., Mullikin, D. and Williams, L.T. A desensitized state of the beta-adrenergic receptor not associated with high affinity agonist occupancy. Mol. Pharmacol. 14: 376-380, 1978. PMID:25378
  115. Limbird, L. and Lefkowitz, R.J. Agonist-induced increase in apparent beta-adrenergic receptor size. Proc. Natl. Acad. Sci. USA 75: 228-232, 1978. PMID:24213
  116. Williams, L.T., Mullikin, D. and Lefkowitz, R.J. Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors. J. Biol. Chem. 253: 2984-2989,1978. PMID:25276
  117. Tsai, B. Shung and Lefkowitz, R.J. Agonist specific effects of monovalent and divalent cations on adenylate cyclase coupled alpha-adrenergic receptors in rabbit platelets. Mol. Pharmacol. 14: 540, 1978. PMID:210368
  118. Pike, L.J. and Lefkowitz, R.J. Multiple effects of N,N' dicyclohexyl carbodiimide on the beta-adrenergic receptor-adenylate cyclase system in frog erythrocytes. J. Cyclic Nucleotide Res. 4: 27-34, 1978. PMID:205559
  119. Wessels, M.R., Mullikin, D. and Lefkowitz, R.J. Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. J. Biol. Chem. 253: 3371-3373, 1978. PMID:25886
  120. Williams, R.S. and Lefkowitz, R.J. Alpha-adrenergic receptors in rat myocardium: Identification by binding of [3H]dihydroergocryptine. Circ. Res. 43: 721-727, 1978. PMID:213201
  121. Glaubiger, G, Tsai, B.S., Lefkowitz, R.J., Johnson, E.M. and Weiss, B. Chronic guanethidine treatment increases cardiac beta-adrenergic receptors. Nature 273: 240-242,1978. PMID:205804
  122. Lefkowitz, R.J., Limbird, L.E., Williams, L.T. and Wessels, M. Beta-adrenergic receptors: Regulatory role of agonists. Keystone. J. of Supramol. Struct. 8: 501-510, 1978. PMID:31515
  123. Clarke, W. and Lefkowitz, R.J. Hepatic alpha-adrenergic receptors: Identification and subcellular localization with [3H]dihydroergocryptine. J. Biol. Chem. 253: 5975-5979,1978. PMID:210164
  124. Caron, M., Williams, L.T. and Lefkowitz, R.J. Labelling of peripheral adrenoceptors. Proceedings of the Symposium on Adrenoceptors, Pergamon Press, 1978.
  125. Williams, L.T. and Lefkowitz, R.J. Methodological approach to radioligand binding studies of adrenergic receptors. Proceedings of the Symposium on Adrenoceptors, Pergamon Press, 1978.
  126. Lefkowitz, R.J., Williams, L.T., Pike, L.J. and Wessels, M. Receptor binding studies of beta-adrenergic receptors: New insights into activation and desensitization of adenylate cyclase. Proceedings of the 7th International Pharmacology Symposium, Pergamon Press, 1978.
  127. Williams, L.T. and Lefkowitz, R.J. Pharmacology of the sympathetic nervous systems in "Beta-Blockers and Their Role in Hypertension." Med. Ed. Press, New Jersey, 1978.
  128. Caron, M.G., Srinivasan, Y., Pitha, J. and Lefkowitz, R.J. The beta-adrenergic receptor of frog erythrocyte: Purifications by biospecific affinity chromatography. Proceedings of the IIIrd International Catecholamine Symposium, 547-549,1978.
  129. Wood, C.L., Arnett, C.D., Clarke, W.R., Tsai, B.S. and Lefkowitz, R.J. Subclassification of alpha-adrenergic receptors by direct binding studies. Biochem. Pharmacol. 28: 1277-1282,1979. PMID:36095
  130. Williams, R.S., Guthrow, E. and Lefkowitz, R.J. Beta-adrenergic receptors of human lymphocytes are unaltered by hyperthroidism. J. Clin. Endo. Metab. 48: 503-505,1979. PMID:218998
  131. Limbird, L.E., Hickey, A. and Lefkowitz, R.J. Unique uncoupling of the frog erythrocyte adenylate cyclase by manganese. J. Biol. Chem. 254: 2677-2683,1979. PMID:429310
  132. Caron, M.G., Srinivasan, Y., Pitha, J., Kiolek, K. and Lefkowitz, R.J. Affinity chromatography of the beta-adrenergic receptors. J. Biol. Chem. 254: 2923-2927,1979. PMID:218957
  133. Tsai, B.S. and Lefkowitz, R.J. Agonist-specific effects of guanine nucleotides on platelet alpha-adrenergic receptors. Mol. Pharmacol. 16: 61-68, 1979. PMID:39249
  134. Williams, R.S. and Lefkowitz, R.J. Thyroid hormone regulation of alpha-adrenergic receptors: Studies in rat myocardium. J. Cardiovasc. Pharm. 1: 181-189, 1979. PMID:94388
  135. Hancock, A., De Lean, A. and Lefkowitz, R.J. Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: Application of a computerized model fitting technique. Mol. Pharmacol. 16: 1-9, 1979. PMID:39239
  136. Hoffman, B., Schocken, D., Wood, C., Tsai, B.S., De Lean, A. and Lefkowitz, R.J. Alpha-adrenergic receptor subtypes: Quantitative assessment by ligand binding. Life Sci. 24: 1739-1746,1979. PMID:222980
  137. Wood C., Caron, M.G. and Lefkowitz, R.J. Separation of alpha- and beta-adrenergic receptors by affinity chromatography. Biochem. Biophys. Res. Commun. 88: 1-8, 1979. PMID:222278
  138. Wessels, M., Mullikin, D. and Lefkowitz, R.J. Selective alteration of high affinity agonist binding: A mechanism of beta-adrenergic receptor desensitization. Mol. Pharmacol. 16: 10-20, 1979. PMID:39240
  139. Caron, M.G., Srinivasan, Y., Snyderman, R. and Lefkowitz, R.J. Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. Proc. Natl. Acad. Sci. USA 76: 2263,1979. PMID:36615
  140. Limbird, L.E., De Lean, A., Pike, L.J., Hickey, A. and Lefkowitz, R.J. Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes: Application of new methods for the analysis of receptor-effector coupling. Biochem. Biophys. Acta 586: 298-314, 979. PMID:224939
  141. Tsai, B.S. and Lefkowitz, R.J. Multiple effects of guanine nucleotides on human platelet adenylate cyclase. Biochem. Biophys. Acta 587: 28-41, 1979. PMID:486544
  142. Pike, L.J. and Lefkowitz, R.J. Beta-adrenergic receptors determine affinity but not intrinsic activity of drugs for stimulation of adenylate cyclase. Nature 280: 502-504,1979. PMID:37448
  143. Limbird, L.E., Hickey, A.R. and Lefkowitz, R.J. The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. J. Cyclic Nucleotide Res. 5: 251,1979. PMID:573291
  144. Bishopric, N.H., Cohen, H. and Lefkowitz, R.J. Beta-adrenergic receptors in lymphocyte subpopulations. J. All. Clin. Immun. 65: 29-33,1980. PMID:6243144
  145. Caron, M.G., Srinivasan, Y., and Lefkowitz, R.J. Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations. Proceedings of the 1st International Colloquium on Receptors, Raven Press , New York, 1979.
  146. Lefkowitz, R.J. Direct radioligand binding studies of adrenergic receptors: Biochemical, physiological and clinical implications. Annal Intern. Med. 91: 450-558, 1979.
  147. Caron, M.G., Limbird, L.E., and Lefkowitz, R.J. The beta-adrenergic receptor of the frog erythrocyte. Mol. Cell. Biochem. 28: 45-67,1979. PMID:231201
  148. Stadel, J. and Lefkowitz, R.J. Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors. Mol. Pharmacol. 16: 709-718, 1979. PMID:231192
  149. Hoffman, B.B. and Lefkowitz, R.J. Radioligand binding studies of adrenergic receptors: New insights into molecular and physiological regulation. Annu. Rev. Pharmacol. Toxicol. 20: 581-608, 1980. PMID:6247962
  150. Lefkowitz, R.J. and Hoffman, B.B. Adrenergic receptors. Adv. Cyclic Nucleotide Res., Vol. 12 (P. Hamet and H. Sands, eds.). Raven Press, New York, 12: 37-47,1978. PMID:6250368
  151. Stadel, J., De Lean, A. and Lefkowitz, R.J. A high affinity agonist-beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. J. Biol. Chem. 255: 1436-1441, 1980. PMID:6243637
  152. Mukherjee, A., Wong, T.M., Buja, L.M., Lefkowitz, R.J. and Willerson, J.T. Beta-adrenergic and muscarinic cholinergic receptors in canine myocardium: Effects of ischemia. J. Clin. Invest. 64: 1423-1428, 1979. PMCID:PMC371291
  153. Voeikov, V.L. and Lefkowitz, R.J. Effects of local anesthetic on guanyl nucleotide modulation of the catecholamine sensitive adenylate cyclase systems and on beta-adrenergic receptors. Biochem. Biophys. Acta 629: 266, 1980. PMID:6248119
  154. Hoffman, B.B. and Lefkowitz, R.J. An assay for alpha-adrenergic receptor subtypes using [3H]-dihydroergocryptine. Biochem. Pharmacol. 29: 452-454, 1980. PMID:6244840
  155. Kent, R.S., De Lean, A. and Lefkowitz, R.J. Quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modelling of ligand binding data. Mol. Pharmacol. 17: 14-23, 1980. PMID:6104284
  156. De Lean, A. and Lefkowitz, R.J. A comment on [3H]dihydroergocryptine binding in uterine membranes. Nature 283: 109-110, 1980. PMID:6243175
  157. Davies, A. and Lefkowitz, R.J. Regulation of adrenergic receptors in Recent Advances in Clinical Pharmacology, (D. Shand, ed.). Churchill Livingstone Press, 1979.
  158. McConnaughey, M.M., Jones, L.R., Watanabe, A.M., Besch, H.R., Jr., Williams, L.T. and Lefkowitz, R.J. Thyroxine and propylthiouracil effects on alpha- and beta-adrenergic receptor number, ATPase activities and sialic acid content of rat cardiac membrane vesicles. J. Cardiovasc. Pharm. 1:609-624, 1979. PMID:94627
  159. Hoffman, B.B., Mullikin-Kilpatrick, D. and Lefkowitz, R.J. Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes. J. Cyclic Nucleotide Res. 5: 355-366,1979. PMID:230209
  160. Limbird, L.E., Gill, M. and Lefkowitz, R.J. Agonist promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein. Proc. Natl. Acad. Sci. USA 77: 775-779, 980. PMID:6244585
  161. Limbird, L.E., Gill, M., Stadel, J.M., Hickey, A.R. and Lefkowitz, R.J. Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. J. Biol. Chem. 255: 1854-1861, 1980. PMID:6243651
  162. Lefkowitz, R.J., Wessels, M. and Stadel, J. Hormones, receptors and cyclic AMP: Their role in target cell refractoriness in Current Topics in Cellular Regulation, (B. Horecker and E. Stadtman, eds.), 17: 205-230, 1980. PMID:6254729
  163. Lefkowitz, R.J. Alpha- and beta-adrenergic receptors in Biochemical Regulation of Blood Pressure, (R. Soffer, ed.). Wiley and Sons, New York, pp. 283-299, 1982.
  164. Hoffman, B.B. and Lefkowitz, R.J. [3H]WB4101: Caution about its role as an alpha-adrenergic subtype selective radioligand. Biochem. Pharmacol. 29: 1537-1541, 1980.PMID:6249320
  165. Lefkowitz, R.J. Technical points for using (-)[3H]dihydroalprenolol in the study of beta-adrenergic receptors in Receptor Site Analysis, Technical Bulletin of New England Nuclear Co., 1979.
  166. Hoffman, B.B. and Lefkowitz, R.J. Radioligand binding studies of peripheral alpha-adrenergic receptor subtypes in Proceedings of the American College of Neuropsychopharmacology Meeting, (E. Usdin, ed.), 1979.
  167. Schocken, D., Caron, M.G. and Lefkowitz, R.J. The human placenta--A rich source of beta-adrenergic receptors: Characterization of the receptors in particulate and solubilized preparations. J. Clin. Endo. Metab. 50: 1082-1088, 1980. PMID:6103009
  168. Pitha, J., Zjawiony, J., Lefkowitz, R.J. and Caron, M.G. Macromolecular beta-adrenergic Antagonist discriminating between receptor and antibody. Proc. Natl. Acad. Sci. USA 77: 2219-2223, 1980. PMID:6154947
  169. Williams, R.S. and Lefkowitz, R.J. The effects of thyroid hormones on adrenergic receptors in Molecular Basis of Thyroid Hormone Action, (A. Samuels and J. Oppenheimer, eds.). Academic Press, New York, 1980.
  170. Stadel, J. and Lefkowitz, R.J. Molecular mechanisms of desensitization of the beta-adrenergic receptor coupled adenylate cyclase. Proc. of the Western Pharmacology Society 23: 469-475, 1980. PMID:5250160
  171. Hoffman, B.B. and Lefkowitz, R.J. Heterogeneity of radioligand binding to alpha-adrenergic receptors: Analysis of guanine nucleotide regulation in relation to receptor subtypes. J. Biol. Chem. 255: 4645-4652, 1980. PMID:6246079
  172. Lefkowitz, R.J. Recent developments in adrenergic receptor research. Annual Reports in Medicinal Chemistry 15: 217, 1980.
  173. Pike, L.J. and Lefkowitz, R.J. Activation and desensitization of beta-adrenergic receptor coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes. J. Biol. Chem. 255: 6860-6867, 1980. PMID:6104667
  174. Lefkowitz, R.J. Modifications of adenylate cyclase activity by alpha-and beta-adrenergic receptors: Insights from radioligand binding studies. Proceedings of the Conference on Neurotransmitter Receptors, (E. Usdin, ed.). Pergamon Press, New York, 1980.
  175. De Lean, A., Stadel, J.M. and Lefkowitz, R.J. A ternary complex model explains the agonist-specific binding properties of the adenylate-cyclase coupled beta-adrenergic receptor. J. Biol. Chem. 255: 7108-7117, 1980. PMID:6248546
  176. Davies, A.O. and Lefkowitz, R.J. Corticosteroid-induced differential regulation of beta-adrenergic receptors on lymphocytes and polymorphonuclear leukocytes. J. Clin. Endo. Metab. 51: 599, 1980. PMID:6251106
  177. Hoffman, B.B., Michel, T., Mullikin-Kilpatrick, D., Lefkowitz, R.J., Tolbert, M.E., Gilman, H. and Fain, J. Agonist versus antagonist binding to alpha-adrenergic receptors. Proc. Natl. Acad. Sci. USA 77: 4569-4573, 1980. PMID:6107908
  178. Briggs, M.M. and Lefkowitz, R.J. Parallel modulation of catecholamine activation of adenylate cyclase and formation of high affinity agonist receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid. Biochemistry 19: 4461-4465, 1980. PMID:6250586
  179. Pike, L.J. and Lefkowitz, R.J. Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. Biochem. Biophys. Acta. 632: 354-365, 1980. PMID:6251915
  180. Lefkowitz, R.J. and Hoffman, B.B. New directions in adrenergic receptor research. Part I - Trends in Pharmacological Sciences, 1: 314-317, 1980.
  181. Lefkowitz, R.J. and Hoffman, B.B. New directions in adrenergic receptor research. Part II - Trends in Pharmacological Sciences, 1: 369-372, 1980.
  182. Stadel, J., De Lean, A. and Lefkowitz, R.J. Molecular mechanisms of coupling in hormone-receptor-adenylate cyclase systems. Advances in Enzymology 53: 1-43, 1982. PMID:6277164
  183. Hoffman, B.B. and Lefkowitz, R.J. Alpha-adrenergic receptor subtypes. N. Engl. J. Med. 302: 1390-1396, 1980. PMID:6246426
  184. Lefkowitz, R.J. Pharmacological principles related to the autonomic nervous system in Cecil Textbook of Medicine, 16th Edition, (James B. Wyngaarden and Lloyd H. Smith, Jr., eds.), 1981.
  185. Lefkowitz, R.J. Mechanisms for regulation of beta-adrenergic receptor function in desensitization. Proceedings of the World Conference on Clinical Pharmacology and Therapeutics. Macmillan Journals, Ltd., pp. 145-153, 1980.
  186. Garcia-Sainz, J.A., Hoffman, B.B., Li, S.Y., Lefkowitz, R.J. and Fain, J. Role of alpha1-adrenoceptors in the turnover of phosphatidylinositol and of alpha2-adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. Life Sci. 27: 953-962, 1980. PMID:6107811
  187. Lefkowitz, R.J., De Lean, A., Hoffman, B.B., Stadel, J.M., Kent, R., Michel, T. and Limbird, L.E. Molecular pharmacology of adenylate cyclase coupled alpha- and beta-adrenergic receptors. Advances in Cyclic Nucleotide Research 14: 145-161, 1981. PMID:6269377
  188. Michel, T., Hoffman, B.B. and Lefkowitz, R.J. Differential regulation of the alpha2-adrenergic receptor by Na+ and guanine nucleotides. Nature 288: 709-711, 1980. PMID:6256638
  189. Pike, L.J. and Lefkowitz, R.J. Correlation of beta-adrenergic receptor stimulated [3H]GDP release and adenylate cyclase activation: Differences between frog and turkey erythrocyte membranes. J. Biol. Chem. 256: 2207-2212, 1981. PMID:6257708
  190. Pitha, J., Zjawiony, J.Z., Nasrin, N., Lefkowitz, R.J. and Caron, M.G. Potent beta-adrenergic antagonist possessing chemically reactive group. Life Sci. 27: 1791-1798, 1980. PMID:6110155
  191. Lefkowitz, R.J. The sympathetic nervous system, catecholamine receptors and hypertension. Frontiers in Hypertension Research (John H. Laragh, Fritz R. Buhler and Donald W. Seldin, eds.), Springer Verlag, pp. 312-315, 1981.
  192. Caron, M.G., Shorr, R.G.L. and Lefkowitz, R.J. Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. Adv. Cyclic Nucleotide Res. 14: 127-134, 1981. PMID:6269375
  193. Hoffman, B.B., Dukes, D. and Lefkowitz, R.J. Alpha-adrenergic receptor subtypes in liver membranes: Delineation with subtype selective radioligands. Life Sci. 28: 265-272, 1981. PMID:6261059
  194. Burns, T.W., Langley, P.E., Terry, B.E., Bylund, D.B., Hoffman, B.B., Tharp, M.D., Lefkowitz, R.J., Garcia-Sainz, J.A. and Fain, J.N. Pharmacological characterization of adrenergic receptors in human adipocytes. J. Clin. Invest. 67: 467-475, 1981. PMCID:PMC370588
  195. Burgisser, E., Lefkowitz, R.J. and De Lean, A. Anomalous equilibrium binding properties of high affinity racemic radioligands. Mol. Pharmacol. 19: 205-216, 1981. PMID:6262614
  196. Davies, A., De Lean, A. and Lefkowitz, R.J. Myocardial beta-adrenergic receptors from adrenalectomized rats: Impaired formation of high affinity agonist receptor complexes. Endocrinology 108: 720-722, 1981. PMID:6256161
  197. Tharp, M., Hoffman, B.B. and Lefkowitz, R.J. Alpha-adrenergic receptors in human adipocyte membranes: Identification by [3H]yohimbine binding. J. Clin. Endo. Metab. 52: 709-714, 1981. PMID:6110673
  198. Williams, R.S., Dukes, D.F. and Lefkowitz, R.J. Subtype specificity of alpha-adrenergic receptors in rat heart. J. Cardiovasc. Pharmacol. 3: 522-531, 1981. PMID:6168833
  199. Burgisser, E., De Lean, A. and Lefkowitz, R.J. Alternative explanation for the apparent "two step" binding kinetics of high affinity racemic radioligands. Mol. Pharmacol. 19: 509-512, 1981. PMID:6267448
  200. Davies, A.O. and Lefkowitz, R.J. Regulation of adrenergic receptors in Receptor Regulation, (R.J. Lefkowitz, ed.). Churchill Livingstone, London, Series B, Vol. 13, pp. 83-121, 1981.
  201. Lefkowitz, R.J. Biochemical mechanisms of hormone receptor-effector coupling. Minisymposium presented at the 72nd Annual Meeting of the American Society of Biological Chemists, pp. 48-49, 1981.
  202. Michel, T., Hoffman, B. and Lefkowitz, R.J. Regulation of adenylate cyclase by adrenergic receptors in Biochemical Actions of Hormones, (G. Litwack, ed.). Academic Press, New York, pp. 43-68, 1982.
  203. Lavin, T.N., Hoffman, B.B. and Lefkowitz, R.J. Determination of subtype selectivity of alpha-adrenergic antagonists: Comparison of selective and non-selective radioligands. Mol. Pharmacol. 20: 28-34, 1981. PMID:6117003
  204. Shorr, R., Lefkowitz, R.J. and Caron, M. Purification of the beta-adrenergic receptor: Identification of the hormone binding subunit. J. Biol. Chem. 256: 5820-5826, 1981. PMID:6263890
  205. Stiles, G.L. and Lefkowitz, R.J. Thyroid hormone modulation of agonist-beta-adrenergic receptor interactions in the rat heart. Life Sci. 28: 2529-2536, 1981. PMID:6114379
  206. Hoffman, B.B. and Lefkowitz, R.J. Adrenergic receptors in the heart. Annu. Rev. Physiol. 44: 475-484, 1982. PMID:6280590
  207. Hoffman, B.B., Yim, S., Tsai, B.S. and Lefkowitz, R.J. Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. Biochem. Biophys. Res. Commun. 100: 724, 1981. PMID:6268073
  208. Davies, A.O. and Lefkowitz, R.J. Agonist promoted high affinity state of the beta-adrenergic receptors in human neutrophils: Modulation by corticosteroids. J. Clin. Endo. Metab. 53: 703-708, 1981. PMID:6116722
  209. Michel, T., Hoffman, B.B., Lefkowitz, R.J. and Caron, M.G. Different sedimentation properties of agonist and antagonist-labelled alpha2 adrenergic receptors. Biochem. Biophys. Res. Commun., 100: 1131-1136, 1981. PMID:6268079
  210. Stadel, J., Mullikin, D., Dukes, D. and Lefkowitz, R.J. Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. J. Cyclic Nucleotide Res. 7: 37-47, 1981. PMID:6265513
  211. Stiles, G.L. and Lefkowitz, R.J. Identification and characterization of beta-adrenergic receptors in myocardium under normal and pathologic conditions in Catecholamines and the Heart, (W. Delius, E. Gerlach, H. Grobecker and W. Kubler, eds.). Springer-Verlag, 1981, pp. 61-71.
  212. Hoffman, B.B. and Lefkowitz, R.J. Agonist interactions with alpha adrenergic receptors. J. Cardiovasc. Pharmacol. 4: 514-518, 1982. PMID:6175829
  213. Stadel, J.M., Shorr, R.G.L., Limbird, L.E. and Lefkowitz, R.J. Evidence that a beta-adrenergic receptor associated guanine nucleotide regulatory protein conveys GTP-cS dependent adenylate cyclase activity. J. Biol. Chem. 256: 8718-8723, 1981. PMID:6267049
  214. Hoffman, B.B., Lavin, T.N., Lefkowitz, R.J. and Ruffolo, R.R., Jr. Alpha-adrenergic receptor subtypes in rabbit uterus: Mediation of myometrial contraction and regulation by estrogens. J. Pharmacol. Exp. Ther. 219: 290-295, 1981. PMID:6270302
  215. Stiles, G.L., Stadel, J.M., De Lean, A. and Lefkowitz, R.J. Hypothyroidism modulates beta-adrenergic receptor-adenylate cyclase interactions in rat reticulocytes. J. Clin. Invest. 68: 1450-1455, 1981. PMCID:PMC370947
  216. De Lean, A., Hancock, A. and Lefkowitz, R.J. Validation and statistical analysis of a computer modelling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol. Pharmacol. 21: 5-16, 1982. PMID:6982395
  217. Lavin, T., Heald, S., Jeffs, P., Shorr, R., Lefkowitz, R.J. and Caron, M.G. Photoaffinity labelling of the beta-adrenergic receptor. J. Biol. Chem. 256: 11944-11950, 1981. PMID:6271767
  218. Pitha, J., Zjawiony, J., Lefkowitz, R.J. and Caron, M.G. Polymeric drugs by direct copolymerization: Polymer of beta-adrenergic antagonist alprenolol and its binding to receptors and antibodies. Makromol. Chem. 182: 1945-1950, 1981.
  219. Garcia-Sainz, J.A., Litosch, I., Hoffman, B.B., Lefkowitz, R.J. and Fain, J.N. Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes. Biochem. Biophys. Acta 678: 334-341, 1981. PMID:6274417
  220. Franki, J.E., Jakoi, L., Davies, A.O., Lefkowitz, R.J., Snyderman, R. and Lazarus, G.S. Polymorphonuclear leukocyte function in psoriasis: Chemotaxis, chemokinesis, beta-adrenergic receptors and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. J. Invest. Dermatol. 81: 254-257, 1983. PMID:6309987
  221. Stiles, G. and Lefkowitz, R.J. Characterization of alpha- and beta-adrenergic receptors by biochemical methods in Alpha- and Beta-Adrenoceptors and the Cardiovascular System, (R.P. Ahlquist and W. Kobinger, eds.). Excerpta Medica, 1981.
  222. Hoffman, B.B., Michel, T. and Lefkowitz, R.J. Interactions of agonists with platelet alpha2 adrenergic receptors. Endocrinology 110: 926-932, 1982. PMID:6120077
  223. Burgisser, E., De Lean, A. and Lefkowitz, R.J. Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptors by guanine nucleotides. Proc. Natl. Acad. Sci. USA 79: 1732-1736, 1982. PMID:6979043
  224. Briggs, M. and Lefkowitz, R.J. The beta-adrenergic receptor and adenylate cyclase: Model system for the study of transmembrane signalling in Cellular Regulation of Secretion and Release, (M. Conn, ed.). Academic Press, New York, pp. 23-49, 1982.
  225. Lefkowitz, R.J. Receptor heterogeneity: Subtypes vs. ligand-induced alterations in Membrane Transport and Neuroreceptors (D. Oxender, A. Blume, I. Diamond and C.F. Fox, eds.). Alan R. Liss, Inc., New York, pp. 431-432, 1981.
  226. Lefkowitz, R.J., Caron, M.G., Michel, T. and Stadel, J.M. Mechanisms of hormone receptor-effector coupling: The beta-adrenergic receptor and adenylate cyclase. Fed. Proc. 41: 2664-2670, 1982.PMID:6125416
  227. Caron, M.G., Lavin, T., Shorr, R.G. and Lefkowitz, R.J. Purification and photoaffinity labelling of the beta-adrenergic receptor of frog erythrocytes. Metabolism 31: 658-663, 1982. PMID:6283304
  228. Stadel, J. and Lefkowitz, R.J. The beta-adrenergic receptor: Ligand binding studies illuminate the mechanism of receptor-adenylate cyclase coupling in Current Topics in Membranes and Transport, (R. Martin and A. Kleinzeller, eds.). Academic Press, New York, Vol. 18, pp. 45-66, 1983.
  229. Lefkowitz, R.J. Clinical physiology of adrenergic receptor regulation. Amer. J. Physiol. 243: E43-E47, 1982. PMID:6124130
  230. Shorr, R.G.L., Heald, S.L., Jeffs, P.W., Lavin, T.N., Strohsacker, M.W., Lefkowitz, R.J. and Caron, M.G. The beta-adrenergic receptor: Rapid purification and covalent labelling by photoaffinity crosslinking. Proc. Natl. Acad. Sci. USA 79: 2778-2782, 1982. PMID:6283543
  231. Stiles, G.L. and Lefkowitz, R.J. Hormone-sensitive adenylate cyclase: Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition. J. Biol. Chem. 257: 6287-6291, 1982. PMID:6281265
  232. Stadel, J. and Lefkowitz, R.J. Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. J. Cyclic Nucleotide Res. 7: 363-374, 1981. PMID:6125532
  233. Wikberg, J. and Lefkowitz, R.J. Adrenergic receptors in the heart: Pre- and postsynaptic mechanisms in nervous control of cardiovascular function. Oxford University Press, 1982.
  234. Stiles, G.L. and Lefkowitz, R.J. A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using the turkey erythrocyte membrane as the acceptor. Arch. Biochem. Biophys.. 217: 368-375, 1982. PMID:6127058
  235. Koo, C., Lefkowitz, R.J. and Snyderman, R. The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states. Biochem. Biophys. Res. Commun. 106: 442-449, 1982. PMID:6285921
  236. Stiles, G.L. and Lefkowitz, R.J. Human platelet adenylate cyclase: Delineation of distinct stimulatory and inhibitory guanine nucleotide regulatory pathways. Transactions of the Association of American Physicians Volume XCV, pp. 244-252, 1982. PMID:6299299
  237. Stiles, G.L., Hoffman, B.B., Hubbard, M., Caron, M.G. and Lefkowitz, R.J. Guanine nucleotides and alpha1 adrenergic receptors in the heart. Biochem. Pharmacol. 32: 69-71, 1983. PMID:6299299
  238. Stadel, J.M., Nambi, P., Lavin, T.N., Heald, S.L., Caron, M.G. and Lefkowitz, R.J. Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase: Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labelling. J. Biol. Chem. 257: 9242-9245, 1982. PMID:6125504
  239. Shorr, R.G.L., Strohsacker, M.W., Lavin, T.N., Lefkowitz, R.J. and Caron, M.G. The beta1-adrenergic receptor of the turkey erythrocyte: Molecular heterogeneity revealed by purification and photoaffinity labelling. J. Biol. Chem. 257: 12341-12350, 1982. PMID:6288717
  240. Lavin, T.N., Nambi, P., Heald, S.L., Jeffs, P.W., Lefkowitz, R.J. and Caron, M.G. [125I]Para-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor: Characterization of the ligand and photoaffinity labelling of beta1 and beta2 adrenergic receptors. J. Biol. Chem. 257: 12332-12340, 1982. PMID:6288716
  241. Heinsimer, J.A. and Lefkowitz, R.J. Adrenergic receptors: Biochemistry, Regulation, molecular mechanisms and clinical implications. J. Lab. Clin. Med. 100: 641-658, 1983. PMID:6127370
  242. Vale, R.D., De Lean, A., Lefkowitz, R.J. and Stadel, J.M. Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A: Evidence for discrete classes of insulin binding sites. Mol. Pharmacol. 22: 619-626, 1982. PMID:6759916
  243. Michel, T. and Lefkowitz, R.J. Hormonal inhibition of adenylate cyclase: Alpha2 adrenergic receptors promote release of [3H]Gpp(NH)p from platelet membranes. J. Biol. Chem. 257: 13557-13563, 1982. PMID:6292195
  244. Wikberg, J. and Lefkowitz, R.J. Alpha2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: Direct demonstration by radioligand binding. Life Sci. 31: 2899-2905, 1982. PMID:6298533
  245. Lefkowitz, R.J., Stadel, J.M. and Caron, M.G. Adenylate cyclase-coupled beta-adrenergic receptors: Structure and mechanisms of activation and desensitization. Annu. Rev. Biochem. 52: 159-186, 1983. PMID:6137187
  246. Regan, J., Barden, N., Lefkowitz, R.J., Caron, M.G., DeMarinis, R.M., Krog, A.J., Holden, K.G., Matthews, W.D. and Hieble, J.P. Affinity chromatography of human platelet alpha2-adrenergic receptors. Proc. Natl. Acad. Sci. USA 79: 7223-7227,1982. PMID:6130523
  247. Stadel, J.M., Strulovici, B., Nambi, P., Lavin, T.N., Briggs, M.M., Caron, M.G. and Lefkowitz, R.J. Desensitization of the beta adrenergic receptor of frog erythrocytes: Recovery and characterization of the down regulated receptors in sequestered vesicles. J. Biol. Chem. 258: 3032-3038, 1983. PMID:6298219
  248. Benovic, J.L., Stiles, G.L., Lefkowitz, R.J. and Caron, M.G. Photoaffinity labelling of mammalian beta-adrenergic receptors: Metal-dependent proteolysis explains apparent heterogeneity. Biochem. Biophys. Res. Commun. 110: 504-511, 1983. PMID:6301455
  249. Heald, S.L., Jeffs, P.W., Lavin, T.N, Nambi, P., Lefkowitz, R.J. and Caron, M.G. Synthesis of [125I]-labelled (~)-15-[4'-azidobenzyl]-carazolol: A potent beta-adrenergic photoaffinity probe. J. Med. Chem. 26: 832-838, 1983. PMID:6304313
  250. Davies, A.O. and Lefkowitz, R.J. In vitro desensitization of beta-adrenergic receptors in human neutrophils: Attenuation by corticosteroids. J. Clin. Invest. 71: 565-571, 1983. PMCID:PMC436904
  251. Strader, C.D., Pickel, V.M., Joh, T.H., Strohsacker, M.W., Shorr, R.G.L., Lefkowitz, R.J. and Caron, M.G. Antibodies to the beta-adrenergic receptor: Attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. Proc. Natl. Acad. Sci. USA 80: 1840-1844, 1983. PMID:6300875
  252. Lefkowitz, R.J. Adrenergic receptors: Regulation at the biochemical, physiological and clinical levels. Transactions of the American Clinical and Climatological Association 94: 75-90, 1983. PMID:6137097
  253. Stadel, J.M., Nambi, P., Shorr, R.G.L., Sawyer, D.F., Caron, M.G. and Lefkowitz, R.J. Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta adrenergic receptor. Proc. Natl. Acad. Sci. USA 80: 3173-3177, 1983. PMID:6304694
  254. Strulovici, B., Stadel, J.M. and Lefkowitz, R.J. Functional integrity of desensitized beta-adrenergic receptors: Internalized receptors reconstitute catecholamine stimulated adenylate cyclase activity. J. Biol. Chem. 258: 6410-6414, 1983. PMID:6304039
  255. Briggs, M.M., Stadel, J.M., Iyengar, R. and Lefkowitz, R.J. Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. Arch. Biochem. Biophys. 224: 142-151, 1983. PMID:6307146
  256. Kao, K.-J., Tsai, B.-S., McKee, P.A., Lefkowitz, R.J. and Pizzo, S.V. Inhibitory effect of ristocetin and factor VIII/Von Willebrand factor protein on human platelet adenylate cyclase activity. Thromb. Res., 30: 301-308,1983. PMID:6408756
  257. Burgisser, E. and Lefkowitz, R.J. ??adrenergic receptors. Brain Receptor Methodologies Part A - General Methods and Concepts. Amines and Acetylcholine (P.J. Marangos, I. Campbell and R.M. Cohen, eds.), Academic Press, Orlando, Florida, pp. 229-253, 1984.
  258. Stiles, G.L., Strasser, R.H., Lavin, T.N., Jones, L.R., Caron, M.G. and Lefkowitz, R.J. The cardiac beta-adrenergic receptor: Structural similarities of beta1 and beta2 receptor subtypes demonstrated by photoaffinity labelling. J. Biol. Chem. 258: 8443-8449, 1983. PMID:6305985
  259. Koo, C., Lefkowitz, R.J. and Snyderman, R. Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. J. Clin. Invest., 72:748-753, 1983. PMCID:PMC1129239
  260. Davies, A.O. and Lefkowitz, R.J. Regulation of beta-adrenergic receptors by steroid hormones. Annu. Rev. Physiol. 46: 119-130, 1984. PMID:6324653
  261. Wikberg, J.E.S., Lefkowitz, R.J. and Caron, M.G. Solubilization of rat liver alpha1 adrenergic receptors: Agonist specific alteration in receptor binding affinity. Biochem. Pharmacol. 32: 3171-3178, 1983. PMID:6139112
  262. Cerione, R.A., Strulovici, B., Benovic, J.L., Strader, C.D., Caron, M.G. and Lefkowitz, R.J. Reconstitution of ??adrenergic receptors into lipid vesicles: Affinity chromatography purified receptors convey catecholamine responsiveness to a heterologous adenylate cyclase system. Proc. Natl. Acad. Sci. USA 80: 4899-4903, 1983. PMID:6308659
  263. Stiles, G.L., Taylor, S. and Lefkowitz, R.J. Human cardiac beta-adrenergic receptors: Subtype heterogeneity delineated by direct radioligand binding. Life Sci. 33: 467-473, 1983. PMID:6135968
  264. Stiles, G.L., Caron, M.G. and Lefkowitz, R.J. The beta-adrenergic receptor: Biochemical mechanisms of physiological regulation. Physiol. Rev. 64: 661-743, 1984. PMID:6143332
  265. Stadel, J.M., Nambi, P., Shorr, R.G.L., Sawyer, D.F., Caron, M.G. and Lefkowitz, R.J. Phosphorylation of the ??adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Transactions of the Association of American Physicians Volume XCVI, pp. 137-145, 1983. PMID:6093309
  266. Shorr, R.G.L., Lefkowitz, R.J. and Caron, M.G. The beta-adrenergic receptor: Elucidation of its molecular structure. The Enzymes of Biological Membranes, (A.N. Martionsi, ed.), Plenum Press, New York, pp. 399-422, 1984.
  267. Stiles, G.L., Strasser, R.H., Caron, M.G. and Lefkowitz, R.J. Mammalian beta-adrenergic receptors: Structural differences in beta1 and beta2 subtypes revealed by peptide map. J. Biol. Chem. 258: 10689-10694, 1983. PMID:6309811
  268. Stiles, G.L. and Lefkowitz, R.J. Cardiac beta-adrenergic receptors. Annu. Rev. Med., Vol. 35, pp. 149-164, 1984. PMID:6144285
  269. De Lean, A., Rouleau, D. and Lefkowitz, R.J. Activation of adenylate cyclase by beta-adrenergic receptors: Investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. Life Sci. 33: 943-954, 1983. PMID:6310288
  270. Caron, M.G., Regan, J.W., Dickinson, K.E.J., Leeb-Lundberg, L.M.F., Benovic, J.L., Wikberg, J.E.S., Heald, S.L., DeMarinis, R.M., DeBernardis, J.F. and Lefkowitz, R.J. Molecular characterization of adrenergic receptors by affinity chromatography and photoaffinity labeling in Neurology and Neurobiology, Catecholamines Part A: Basic and Peripheral Mechanisms (E. Usdin, A. Carlsson, A. Dahlstrom and J. Engel, eds.). Alan R. Liss, Inc., New York, pp. 283-291, 1984.
  271. Lefkowitz, R.J., Stadel, J.M., Cerione, R.A., Strulovici, B. and Caron, M.G. Structure and function of ??adrenergic receptors: Regulation at the molecular level. Adv. Cyclic Nucleotide Res. 17: 19-28, 1984. PMID:6145320
  272. Stiles, G.L., Caron, M.G. and Lefkowitz, R.J. The ??adrenergic receptor: Structure, function and regulation in Mechanisms of Drug Action. Academic Press, New York, pp. 37-48, 1983.
  273. Lefkowitz, R.J. and Michel, T. Plasma membrane receptors. J. Clin. Invest. 72: 1185-1189, 1983. PMCID:PMC370401
  274. Caron, M.G., Leeb-Lundberg, L.M.F., Strader, C.D., Dickinson, K.E.J., Pickel, V.M., Joh, T. and Lefkowitz, R.J. Biochemical characterization of adrenergic receptors: Photoaffinity labeling and immunocytochemical localization in the brain. Monoamine Innervation of Cerebral Cortex (H.E. Jasper, L. Descarries and T.A. Reader, eds.). Alan R. Liss, Inc., New York, pp. 135-151, 1984.
  275. Caron, M.G., Leeb-Lundberg, L.M.F., Strader, C.D., Dickinson, K.E.J., Pickel, V.M., Joh, T. and Lefkowitz, R.J. Molecular biology of adrenergic receptors in the rat and frog central nervous system. Hypertension 6: II-22 - II-27, 1984. PMID:6321475
  276. Leeb-Lundberg, L.M.F., Dickinson, K.E.J., Heald, S.L., Wikberg, J.E.S., DeBernardis, J.F., Winn, M., Arendsen, D.L., Lefkowitz, R.J. and Caron, M.G. Covalent labeling of the cerebral cortex a1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe. Biochem. Biophys. Res. Commun. 115: 946-951, 1983. PMID:6313003
  277. Cerione, R.A., Strulovici, B., Benovic, J.L., Lefkowitz, R.J. and Caron, M.G. The pure ??drenergic receptor: A single polypeptide confers catecholamine responsiveness to an adenylate cyclase system. Nature 306: 562-566, 1983. PMID:6316161
  278. Shorr, R.G.L., Kempner, E.S., Strohsacker, M.W., Nambi, P., Lefkowitz, R.J. and Caron, M.G. Determination of the molecular size of frog and turkey erythrocyte beta adrenergic receptors by radiation inactivation. Biochemistry 23: 747-753, 1984.
  279. Heinsimer, J.A. and Lefkowitz, R.J. The beta-adrenergic receptor in heart failure. Hospital Practice 18: 103-125, 1983. PMID:6138306
  280. Lefkowitz, R.J., Nambi, P., Stadel, J.M., Cerione, R., Strulovici, B. and Caron, M.G. Beta-adrenergic receptors: Physiological regulation studied at the molecular level. Catecholamines as Hormone Regulators, (N. Ben-Jonathan, J.M. Bahr and R.I. Weiner, eds.), Raven Press, New York, Vol. 18, pp. 65-75, 1985.
  281. Leeb-Lundberg, L.M.F., Dickinson, K.E.J., Heald, S.L., Wikberg, J.E.S., Hagen, P.-O., DeBernardis, J.F., Winn, M., Arendsen, D.L., Lefkowitz, R.J. and Caron, M.G. Photoaffinity labeling of mammalian a1-adrenergic receptors: Identification of the ligand binding subunit with a high affinity radioiodinated probe. J. Biol. Chem. 259: 2579-2587, 1984. PMID:6321475
  282. Lefkowitz, R.J. Not necessarily about receptors. Clin. Res. 31: 543-549, 1983.
  283. Strulovici, B. and Lefkowitz, R.J. Activation, desensitization and recycling of frog erythrocyte ??adrenergic receptors: Differential perturbation by in situ trypinsization. J. Biol. Chem. 259: 4389-4391, 1984. PMID:6323469
  284. Nambi, P., Sibley, D.R., Stadel, J.M., Michel, T., Peters, J.R. and Lefkowitz, R.J. Cell free desensitization of catecholamine-sensitive adenylate cyclase: Agonist and cAMP promoted alterations in turkey erythrocyte beta-adrenergic receptors. J. Biol. Chem. 259: 4629-4633, 1984. PMID:6323481
  285. Willingham, M.C., Strader, C.D., Lefkowitz, R.J. and Pastan, I. Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. Exp. Cell Res. 151: 573-577, 1984. PMID:6142826
  286. Sibley, D.R., Peters, J.R., Nambi, P., Caron, M.G. and Lefkowitz, R.J. Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: Degradation of the Mr = 49,000 protein explains apparent heterogeneity. Biochem. Biophys. Res. Commun. 119: 458-464, 1984. PMID:6324763
  287. Heinsimer, J.A., Davies, A.O., Downs, R.W., Levine, M.A., Spiegel, A.M., Drezner, M.K., De Lean, A., Wreggett, K.A., Caron, M.G. and Lefkowitz, R.J. Impaired formation of ??adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. J. Clin. Invest. 73: 1335-1343, 1984. PMCID:PMC425155
  288. Shorr, R.G.L., Strohsacker, M.W., Rebar, R., Lefkowitz, R.J., Caron, M.G. and Crooke, S.T. Membrane bound hormone receptor purification and characterization by HPLC in Progress in HPLC: Gel Permeation of Proteins and Peptides, (H. Arvez, S. Arvez and Y. Kato, eds.). VNU Science Press, Utrecht, Holland, 1984.
  289. Strulovici, B. and Lefkowitz, R.J. Adenylate cyclase coupled ??adrenergic receptors: Biochemical Mechanisms of Desensitization in Mechanisms of Receptor Regulation, (G. Poste and S.T. Crooke, es.). Plenum Publishing Corp., New York, N.Y., pp. 279-294, 1985.
  290. Stiles, G.L., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Mammalian ??adrenergic receptors: Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains. J. Biol. Chem. 259: 8655-8663, 1984. PMID:6330118
  291. Regan, J.W., DeMarinis, R.M., Caron, M.G. and Lefkowitz, R.J. Identification of the subunit binding site of ???adrenergic receptors using [3H]phenoxybenzamine. J. Biol. Chem. 259: 7864-7869, 1984. PMID:6330087
  292. Stiles, G.L. and Lefkowitz, R.J. Thyroid hormones and the ??adrenergic receptor-adenylate cyclase system. Thyroid Today VII: 1-6, 1984.
  293. Caron, M.G., Cerione, R.A., Benovic, J.L., Strulovici, B., Staniszewski, C., Lefkowitz, R.J., Codina-Salada, J. and Birnbaumer, L. Biochemical characterization of the adrenergic receptors: Affinity labeling, purification and reconstitution studies. Adv. Cyclic Nucleotide Res. 19: 1-12, 1985. PMID:2988293
  294. Lefkowitz, R.J., Caron, M.G. and Stiles, G.L. Mechanisms of membrane receptor regulation: Biochemical, physiological and clinical insights derived from studies of the adrenergic receptors. N. Engl. J. Med. 310: 1570-1577, 1984. PMID:6145093
  295. Sibley, D.R., Peters, J.R., Nambi, P., Caron, M.G. and Lefkowitz, R.J. Desensitization of turkey erythrocyte adenylate cyclase: Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. J. Biol. Chem. 259: 9742-9749, 1984. PMID:6086645
  296. Dickinson, K.E.J., Leeb-Lundberg, L.M.F., Heald, S.L., Wikberg, J.E.S., DeBernardis, J.F., Caron, M.G. and Lefkowitz, R.J. Photoaffinity crosslinking of a radioiodinated probe 125I-A55453 into a1-adrenergic receptors. Mol. Pharmacol. 26: 187-195, 1984. PMID:6090880
  297. Nambi, P., Sibley, D.R., Caron, M.G. and Lefkowitz, R.J. Photoaffinity labeling of ??adrenergic receptors in mammalian tissues. Biochem. Pharmacol. 33: 3813-3822, 1984. PMID:6095862
  298. Benovic, J.L., Shorr, R.G.L., Caron, M.G. and Lefkowitz, R.J. The mammalian ?2-adrenergic receptor: Purification and characterization. Biochemistry 23: 4510-4518, 1984. PMID:6093858
  299. Cerione, R.A., Codina, J., Benovic, J.L., Lefkowitz, R.J., Birnbaumer, L. and Caron, M.G. The mammalian ?2-adrenergic receptor: Reconstitution of functional interactions between the pure receptor and the pure stimulatory nucleotide binding protein (Ns) of the adenylate cyclase system. Biochemistry 23: 4519-4525, 1984. PMID:6149763
  300. Garcia-Sainz, J.A., Boyer, J.L., Michel, T., Sawyer, D., Stiles, G.L., Dohlman, H. and Lefkowitz, R.J. Effect of pertussis toxin on alpha2-adrenoceptors: Decreased formation of the high affinity state for agonists. FEBS Lett. 172: 95-98, 1984. PMID:6329826
  301. Strulovici, B., Cerione, R.A., Kilpatrick, B.F., Caron, M.G. and Lefkowitz, R.J. Direct demonstration of impaired functionality of a purified desensitized ??adrenergic receptor in a reconstituted system. Science 225: 837-840, 1984. PMID:6089331
  302. Sibley, D.R., Nambi, P., Peters, J.R. and Lefkowitz. R.J. Phorbol diesters promote ??adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. Biochem. Biophys. Res. Commun. 121: 973-979, 1984. PMID:6331437
  303. Cerione, R.A., Sibley, D.R., Codina, J., Benovic, J.L., Winslow, J., Neer, E.J., Birnbaumer, L., Caron, M.G. and Lefkowitz, R.J. Reconstitution of a hormone-sensitive adenylate cyclase system: The pure ??adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. J. Biol. Chem. 259: 9979-9982, 1984. PMID:6088509
  304. Strasser, R.H., Stiles, G.L. and Lefkowitz, R.J. Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. Endocrinology 115: 1392-1400, 1984. PMID:6090100
  305. Stiles, G.L., Caron, M.G. and Lefkowitz, R.J. The characterization of mammalian ?1- and ?2-adrenergic receptors. Proceedings of the Satellite Symposium "The Pharmacology of Adrenoceptors" of the 9th International Congress of Pharmacology, Manchester, England, August 6-8, 1985.
  306. Caron, M.G., Cerione, R.A., Leeb-Lundberg, L.M.F., Benovic, J.L., Regan, J.W., Dickinson, K.E.J., Heald, S.L. and Lefkowitz, R.J. Biochemical characterization of the adrenergic receptors: Purification, affinity labelling and reconstitution studies. Proceedings of the 7th International Congress of Endocrinology, Quebec, Canada, July 1-7, 1985.
  307. Lefkowitz, R.J., Cerione, R.A., Benovic, J.L., Strulovici, B., Stiles, G.L., Codina, J., Birnbaumer, L. and Caron, M.G. Purification, characterization and reconstitution of the adenylate cyclase-coupled ??adrenergic receptor. IUPHAR 9th International Congress of Pharmacology, Proceedings, (W. Paton, J. Mitchell and P. Turner, eds.), Vol. 1, pp. 293-297, 1985.
  308. Dickinson, K.E.J. and Lefkowitz, R.J. Adrenergic receptors in Encyclopedia of Neuroscience (G. Adelman, ed.), Birkhauser Boston, Inc., Cambridge, Mass., Vol.I, 14-16, 1987.
  309. Strader, C.D., Sibley, D.R. and Lefkowitz, R.J. Association of sequestered beta-adrenergic receptors with the plasma membrane: A novel mechanism for receptor down regulation. Life. Sci. 35: 1601-1610, 1984. PMID:6090842
  310. DeMarinis, R.M., Krog, A.J., Shah, D.H., Lafferty, J., Holden, K.G., Hieble, J.P., Matthews, W.D., Regan, J.W., Lefkowitz, R.J. and Caron, M.G. Development of affinity ligands for purification of alpha2 adrenoceptors from human platelet membranes. J. Med. Chem. 27: 918-921, 1984. PMID:6330361
  311. Birnbaumer, L., Codina, J., Mattera, R., Hildebrandt, J.D., Sunyer, T., Rojas, F.J., Cerione, R.A., Caron, M.G., Lefkowitz, R.J. and Iyengar, R. The structural basis for the reciprocal regulation of hormone receptors and adenylyl cyclases with special emphasis on the mode of action of glucagon. Hormonal Control of Gluconeogenesis, (Edited by Naomi Kraus-Friedmann), CRC Press, Inc., Boca Raton, Florida, Vol. II, 1986.
  312. Stiles, G.L., Strasser, R.H., Kilpatrick, B.F., Taylor, S.R. and Lefkowitz, R.J. Endogenous proteinases modulate the function of the ??adrenergic receptor-adenylate cyclase system. Biochim. Biophys. Acta, 802: 390-398, 1985. PMID:6095918
  313. Peters, J.R., Nambi, P., Sibley, D.R. and Lefkowitz, R.J. Enhanced adenylate cyclase activity of turkey erythrocytes following treatment with ??adrenergic receptor antagonists. Eur. J. Pharmacol. 107: 43-52, 1985. PMID:6151904
  314. Birnbaumer, L., Codina, J., Mattera, R., Cerione, R.A., Hildebrandt, J.D., Sunyer, T., Rojas, F.J., Caron, M.G., Lefkowitz, R.J. and Iyengar, R. Regulation of hormone receptors and adenylyl cyclase by guanine nucleotide binding N protein. Recent Progress in Hormone Research (R.O. Greep, ed.), Vol 41, pp. 41-99, Academic Press, Orlando, Florida, 1986. PMID:2996090
  315. Cerione, R.A., Staniszewski, C., Benovic, J.L., Lefkowitz, R.J., Caron, M.G., Gierschik, P., Somers R., Spiegel, A.M., Codina, J. and Birnbaumer, L. Specificity of the functional interactions of the ??adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J. Biol. Chem. 260: 1493-1500, 1985. PMID:2981858
  316. Heinsimer, J.A. and Lefkowitz, R.J. The impact of aging on adrenergic receptor function: Clinical and biochemical aspects. J. Am. Geriatr. Soc. 33: 184-188, 1985.
  317. Birnbaumer, L., Codina, J., Sunyer, T., Hildebrandt, J.D., Cerione, R.A., Lefkowitz, R.J. and Caron, M.G. Dual coupling mechanisms in the regulation of cAMP formation. Proceedings of the Princess Liliane Symposium on "The Role of Receptors in Biology and Medicine," Brussels, Belgium, Oct. 29-30, pp. 193-211, 1985.
  318. Birnbaumer, L., Codina, J., Sunyer, T., Rosenthal, W. and Hildebrandt, J.D., Cerione, R.A., Caron, M.G., Lefkowitz, R.J., Sekura, R.D. Structural and functional properties of Ns and Ni, the regulatory components of adenylyl cyclases. In Pertussis Toxin, (Sekura, R.D., Moss, J. and Vaughn, M., eds.), Academic Press, New York, pp. 77-104, 1985.
  319. Cerione, R.A., Benovic, J.L., Codina, J., Staniszewski, C., Sibley, D.R., Winslow, J., Gierschik, P., Somers, R., Strulovici, B., Spiegel, A.M., Neer, E.J., Birnbaumer, L., Lefkowitz, R.J. and Caron, M.G. Reconstitution of the ??adrenergic-coupled adenylate cyclase system into phospholipid vesicles. Symposia Medica Hoechst, Vol. 19, "Adrenergic Receptors: Molecular Properties and Therapeutic Implications," (R.J. Lefkowitz and E. Lindenlaub, eds.), Schattauer Verlag, Stuttgart, West Germany, pp. 300-326, 1985.
  320. Caron, M.G., Benovic, J.L., Stiles, G.L., Leeb-Lundberg, L.M.F., Dickinson, K.E.J., Regan, J.W., Heald, S.L., Nambi, P., Strulovici, B., Cerione, R.A. and Lefkowitz, R.J. Biochemical properties of the adrenergic receptors delineated by purification and photoaffinity labeling. Symposia Medica Hoechst, Vol. 19, "Adrenergic Receptors: Molecular Properties and Therapeutic Implications," (R.J. Lefkowitz and E. Lindenlaub, eds.), Schattauer Verlag, Stuttgart, West Germany, pp. 7-27, 1985.
  321. Nambi, P., Stadel, J.M., Sibley, D.R., Strulovici, B., Caron, M.G. and Lefkowitz, R.J. Mechanisms of ??adrenergic receptor desensitization. Symposia Medica Hoechst, Vol. 19, "Adrenergic Receptors: Molecular Properties and Therapeutic Implications," (R.J. Lefkowitz and E. Lindenlaub, eds.), Schattauer Verlag, Stuttgart, West Germany, pp. 437-451, 1985.
  322. Nambi, P., Peters, J.R., Sibley, D.R. and Lefkowitz, R.J. Desensitization of the turkey erythrocyte ??adrenergic receptor in a cell-free system: Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. J. Biol. Chem. 260: 2165-2171, 1985. PMID:2982811
  323. Sibley, D.R., Strasser, R.H., Caron, M.G. and Lefkowitz, R.J. Homologous desensitization of adenylate cyclase is associated with phosphorylation of the ??adrenergic receptor. J. Biol. Chem. 260: 3883-3886, 1985. PMID:2858484
  324. Stadel, J.M. and Lefkowitz, R.J. Dual regulation of adenylate cyclase by stimulatory and inhibitory pathways. Endocrinology, Second Edition, (L.J. DeGroot, ed.), Grune & Stratton, New York, Vol. 1:75-93, 1989.
  325. Benovic, J.L., Pike, L.J., Cerione, R.A., Staniszewski, C., Yoshimasa, T., Codina, J., Birnbaumer, L., Caron, M.G. and Lefkowitz, R.J. Phosphorylation of the mammalian ??adrenergic receptor by cyclic AMP-dependent protein kinase: Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. J. Biol. Chem. 260: 7094-7101, 1985. PMID:2987243
  326. Strasser, R.H. and Lefkowitz, R.J. Homologous desensitization of ??adrenergic receptor coupled adenylate cyclase: Resensitization by polyethylene glycol treatment. J. Biol. Chem. 260: 4561-4564, 1985. PMID:2985555
  327. Dickinson, K.E.J., Heald, S.L., Jeffs, P.W., Lefkowitz, R.J. and Caron, M.G. Covalent labeling of the ??adrenergic ligand binding site with para(bromacetamidyl)benzylcarazolol: A highly potent ??adrenergic affinity label. Mol. Pharmacol. 27: 499-506, 1985. PMID:2985948
  328. Benovic, J.L. and Lefkowitz, R.J. Regulation of receptor function. The Enzymes, (P.D. Boyer and E.G. Krebs, eds.), Vol. 18, 319-333, 1987.
  329. Sibley, D.R. and Lefkowitz, R.J. Molecular mechanisms of receptor desensitization using the ??adrenergic receptor-coupled adenylate cyclase system as a model. Nature 317: 124-129, 1985. PMID:2993919
  330. Regan, J.W., DeMarinis, R.M. and Lefkowitz, R.J. Arylazide photoaffinity probe for ???adrenoceptors. Biochem. Pharmacol. 34: 3667-3672, 1985. PMID:2864929
  331. Nambi, P., Sibley, D.R. and Lefkowitz, R.J. Sensitization of frog erythrocyte adenylate cyclase system by tumor promoting phorbol diesters. Can. J. Physiol. Pharmacol. 63: 983-986, 1985. PMID:3878225
  332. Leeb-Lundberg, L.M.F., Cotecchia, S., Lomasney, J.W., DeBernardis, J.F., Lefkowitz, R.J. and Caron, M.G. Phorbol esters promote a1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. Proc. Natl. Acad. Sci. USA 82: 5651-5655, 1985. PMIKD:2994039
  333. Lefkowitz, R.J., Cerione, R.A., Codina, J., Birnbaumer, L. and Caron, M.G. Reconstitution of the ??adrenergic receptor. J. Membr. Biol. 87:1-12, 1985. PMID:2865370
  334. Lefkowitz, R.J. and Caron, M.G. Adrenergic receptors: Molecular mechanisms of clinically relevant regulation. Clin. Res. 33: 395-406, 1985. PMID:2994939
  335. Cerione, R.A., Codina, J., Kilpatrick, B.F., Staniszewski, C., Gierschik, P., Somers, R.L., Spiegel, A.M., Birnbaumer, L., Caron, M.G. and Lefkowitz, R.J. Transducin and the inhibitory nucleotide regulatory protein (Ni) inhibit the Ns (stimulatory nucleotide regulatory protein)-mediated stimulation of adenylate cyclase in phospholipid vesicle systems. Biochemistry 24: 4499-4503, 1985. PMID:3933556
  336. Cerione, R.A., Benovic, J.L., Codina, J., Birnbaumer, L., Lefkowitz, R.J. and Caron, M.G. The ??adrenergic receptor-coupled adenylate cyclase: Reconstitution of the functional interactions of the various purified components. In: The Receptors (P.M. Conn, ed.), Vol. IV, Academic Press, Orlando, Florida, pp. 1-36, 1985.
  337. Strasser, R.H., Cerione, R.A., Codina, J., Caron, M.G. and Lefkowitz, R.J. Homologous desensitization of the ??adrenergic receptor: Functional integrity of the desensitized receptor from mammalian lung. Mol. Pharmacol. 28: 237-245, 1985.PMID:2993846
  338. Caron, M.G., Benovic, J.L., Leeb-Lundberg, L.M.F., Cerione, R.A., Regan, J.W., Cotecchia, S., Lomasney, J., Nakata, H., Sibley, D.R., Strasser, R.H., Strulovici, B. and Lefkowitz, R.J. Biochemical pharmacology of the adrenergic receptors: Regulation of responsiveness by phosphorylation of the receptors. In: New Tests for New Drugs, Wichtig Editore, Milano, Italy, 3: 3-22, 1986.
  339. Cerione, R.A., Staniszewski, C., Caron, M.G., Lefkowitz, R.J., Codina, J. and Birnbaumer, L. A role for Ni in the hormonal stimulation of adenylate cyclase. Nature 318: 293-295, 1985. PMID:2999605
  340. Sibley, D.R., Jeffs, R.A., Daniel, K., Nambi, P. and Lefkowitz, R.J. Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. Arch. Biochem. Biophys. 277:373-381, 1986. PMID:3484932
  341. Cotecchia, S., Leeb-Lundberg, L.M.F., Hagen, P.-O., Lefkowitz, R.J. and Caron, M.G. Phorbol ester effects on a1 adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells. Life Sci. 37: 2389-2398, 1985. PMID:3001461
  342. Benovic, J.L., Strasser, R.H., Caron, M.G. and Lefkowitz, R.J. ??Adrenergic receptor kinase: Identification of a novel protein kinase which phosphorylates the agonist-occupied form of the receptor. Proc. Natl. Acad. Sci. USA. 83: 2797-2801, 1986. PMID:2871555
  343. Strasser, R.H., Sibley, D.R. and Lefkowitz, R.J. A novel catecholamine activated cAMP independent pathway for ??adrenergic receptor phosphorylation in wild type and mutant S49 lymphoma cells: Mechanism of homologous desensitization of adenylate cyclase. Biochemistry 25: 1371-1377, 1986. PMID:3008828
  344. Regan, J.W., Nakata, H., DeMarinis, R.M., Caron, M.G. and Lefkowitz, R.J. Purification and characterization of the human platelet ???adrenergic receptor. J. Biol. Chem. 261: 3894-3900, 1986. PMID:3005306
  345. Cerione, R.A., Regan, J.W., Nakata, H., Codina, J., Benovic, J.L., Gierschik, P., Somers, R.L., Spiegel, A.M., Birnbaumer, L., Lefkowitz, R.J. and Caron, M.G. Functional reconstitution of the ???adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J. Biol. Chem. 261: 3901-3909, 1986. PMID:3005307
  346. Lefkowitz, R.J. and Caron, M.G. Regulation of adrenergic receptor function by phosphorylation. Curr. Top. Cell. Regul. (B. Horecker and E. Stadtman, eds.), Academic Press, Orlando, Florida, 209-231, 1986.
  347. Lomasney, J.W., Leeb-Lundberg, L.M.F., Cotecchia, S., Regan, J.W., DeBernardis, J.F., Caron, M.G. and Lefkowitz, R.J. Mammalian ?1-adrenergic receptor: Purification and characterization of the native receptor ligand binding subunit. J. Biol. Chem. 261: 7710-7716, 1986. PMID:3011796
  348. Cerione, R.A., Staniszewski, C., Gierschik, P., Codina, J., Somers, R.L., Birnbaumer, L., Spiegel, A.M., Caron, M.G. and Lefkowitz, R.J. Mechanism of guanine nucleotide regulatory protein mediated inhibition of adenylate cyclase: Studies with isolated subunits of transducin in a reconstituted system. J. Biol. Chem. 261: 9514-9520, 1986. PMID:3013893
  349. Lefkowitz, R.J. and Caron, M.G. Regulation of adrenergic receptor function by phosphorylation. J. Mol. Cell. Cardiol. 18: 885-895, 1986. PMID:3023644
  350. Sibley, D.R., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Molecular mechanisms of ??adrenergic receptor desensitization. In: "Molecular Mechanisms of Neuronal Responsivity," Advances in Experimental Medicine and Biology, Y.H. Ehrlich (ed.), Plenum, New York, 221, 253-273, 1987.
  351. Dickinson, J.E.J., Leeb-Lundberg, L.M.G., Strasser, R.H., Caron, M.G. and Lefkowitz, R.J. Identification of the subunit structure of rat pineal adrenergic receptors by photoaffinity labeling. J. Neurochem. 46:1153-1160, 1986. PMID:3005506
  352. Dixon, R.A.F., Kobilka, B.K., Strader, D.J., Benovic, J.L., Dohlman, H.G., Frielle, T., Bolanowski, M.A., Bennett, C.D., Rands, E., Diehl, R.E., Mumford, R.A., Slater, E.E., Sigal, I.S., Caron, M.G., Lefkowitz, R.J. and Strader, C.D. Cloning of the gene and cDNA for mammalian ??adrenergic receptor and homology with rhodopsin. Nature 321: 75-79, 1986. PMID:3010132
  353. Nakata, H., Regan, J.W. and Lefkowitz, R.J. Chemical modification of ?2-adrenoceptors: Possible role for tyrosine in the ligand binding site of. Biochem. Pharmacol. 35:4089-4094. 1986. PMID:3022750
  354. Regan, J.W., Raymond, J.R., Lefkowitz, R.J. and DeMarinis, R.M. Photoaffinity labeling of human platelet and rabbit kidney ?2-adrenoceptors with [3H]SKF 102229. Biochem. Biophys. Res. Commun. 137: 606-613, 1986. PMID:3015124
  355. Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. Light dependent phosphorylation of rhodopsin by the ??adrenergic receptor kinase. Nature 321: 869-872, 1986. PMID:3014340
  356. Strasser, R.H., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. ??agonist and prostaglandin E1-induced translocation of the ??adrenergic receptor kinase: Evidence that the kinase may act on multiple adenylate cyclase coupled receptors. Proc. Natl. Acad. Sci. USA 83: 6362-6366, 1986. PMID:3018728
  357. Lefkowitz, R.J., Benovic, J.L., Kobilka, B. and Caron, M.G. Receptors and rhodopsin: Shedding new light on an old subject. Trends in Pharmacological Sciences 7: 444-448, 1986.
  358. Caron, M.G., Benovic, J.L., Leeb-Lundberg, L.M.F., Cerione R.A., Regan, J.W., Lomasney, J.W., Cotecchia, S., Nakata H., Sibley, D.R., Strasser, R.H. and Lefkowitz, R.J. Biochemical characterization of the adrenergic receptors: Regulation of responsiveness by phosphorylation of the receptors. (Taniguchi Symposia on Brain Sciences No. 9, Japan Scientific Societies. In: Molecular Genetics in Developmental Neurobiology (Y. Tsukada, ed.), pp. 27-43, 1986.
  359. Sibley, D.R., Strasser, R.H., Benovic, J.L., Daniel, K. and Lefkowitz, R.J. Phosphorylation/ Dephosphorylation of the ??adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proc. Natl. Acad. Sci. USA 83: 9408-9412, 1986. PMID:3025843
  360. Kobilka, B.K., Dixon, R.A.F., Frielle, T., Dohlman, H.G., Bolanowski, M.A., Sigal, I.S., Yang-Feng, T.L., Francke, U., Caron, M.G. and Lefkowitz, R.J. cDNA for the human??2-adrenergic receptor: A protein with multiple membrane spanning domains and a chromosomal location shared with the PDGF receptor gene. Proc. Natl. Acad. Sci. USA 84:46-50, 1987. PMID:3025863
  361. Dohlman, H.G., Caron, M.G. and Lefkowitz, R.J. Structure and function of the ?2-adrenergic receptor-homology with rhodopsin. Kidney Int. 32: S-2-S-7, 1987.
  362. Lefkowitz, R.J., Benovic, J.L. and Caron, M.G. Molecular and regulatory properties of adrenergic receptors. Recent Prog. Horm. Res. 43: 469-497, 1986.PMID:2819998
  363. Stadel, J.M. and Lefkowitz, R.J. ??Adrenergic receptors: Identification and characterization by radioligand binding studies. The ??Adrenergic Receptors, (John P. Perkins, ed.), Humana Press, Inc., Clifton, N.J., 1986.
  364. Cerione, R.A., Gierschik, P., Staniszewski, C., Benovic, J.L., Codina, J., Somers, R., Birnbaumer, L., Spiegel, A.M., Lefkowitz, R.J. and Caron, M.G. Functional differences in the bc complexes of transducin and the inhibitory ÅÚguanine nucleotide regulatory protein, Biochemistry 26: 1485-1491, 1987. PMID:3032251
  365. Leeb-Lundberg, L.M.F., Cotecchia, S., DeBlasi, A., Caron, M.G. and Lefkowitz, R.J. Regulation of adrenergic receptor function by phosphorylation: Agonist-promoted desensitization and phosphorylation of a1- adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. J. Biol. Chem. 262: 3098-3105, 1987. PMID:3029100
  366. Bouvier, M., Leeb-Lundberg, L.M., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Regulation of adrenergic receptor function by phosphorylation: Effects of agonist occupancy on phosphorylation of ?1- and ?2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. J. Biol. Chem. 262:3106-3113, 1987. PMID:3029101
  367. Lefkowitz, R.J. and Caron, M.G. Adrenergic receptors. Adv. Second Messenger Phosphoprotein Res., 21, 1-10, 1988. PMID:2843210
  368. Birnbaumer, L., Codina, J., Sunyer, T., Hildebrandt, J.D., Sekura, R.D., Cerione, R.A., Lefkowitz, R.J., and Caron, M.G. Dual coupling mechanisms in the regulation of cAMP formation. In: The Role of Receptors in Biology and Medicine (A.M. Gotto, Jr. and B.W. O'Malley, eds.), Raven Press, New York, pp. 193-211, 1986.
  369. Sibley, D.R., Nambi, P., and Lefkowitz, R.J. Molecular mechanisms of hormone receptor desensitization. In Molecular Mechanisms of Transmembrane Signalling, Molecular Aspects of Cellular Regulation (eds.) P. Cohen, M. Houslay, Vol. 3, pp. 359-374, 1985.
  370. Nambi, P., Stadel, J.M. Sibley, D.R., Strulovici, B., Caron, M.G., and Lefkowitz, R.J. Cell-free desensitization of the ??adrenergic receptor: Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. Annals of the New York Academy of Sciences 463: 122-124, 1986.
  371. Kobilka, B.K., Frielle, T., Dohlman, H.G., Bolanowski, M.A., Dixon, R.A.F., P. Keller, Caron, M.G., and Lefkowitz, R.J. Delineation of the intronless nature of the human and hamster ?2-adrenergic receptor genes and their putative promoter regions. J. Biol. Chem. 262: 7321-7327, 1987. PMID:3034889
  372. Dohlman, H.G., Caron, M.G., and Lefkowitz, R.J. A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry 26: 2657-2664, 1987. PMID:3038163
  373. Sibley, D.R., Benovic, J.L., Caron, M.G., and Lefkowitz, R.J. Regulation of transmembrane signaling by receptor phosphorylation. Cell, 48: 913-922, 1987. PMID:3030559
  374. Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J., and Caron, M.G. Purification and characterization of the ??adrenergic receptor kinase. J. Biol. Chem. 262, 9026-9032, 1987. PMID:3036840
  375. Sibley, D.R. and Lefkowitz, R.J. ??Adrenergic receptor-coupled adenylate cyclase: Biochemical mechanisms of regulation. Mol. Neurobiol. 1: 121-154, 1987. PMID:2855789
  376. Yoshimasa, T., Sibley, D.R., Bouvier, M., Lefkowitz, R.J., and Caron, M.G. "Cross Talk" between second messenger generating systems: Phorbol esters induce phosphorylation of the catalytic unit of adenylate cyclase and enhancement of its activity. Nature 327: 67-70, 1987. PMID:3033513
  377. Mayor, F., Jr., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Somatostatin induces translocation of the ??adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. J. Biol. Chem. 262: 6468-6471, 1987. PMID:2883186
  378. Dohlman, H.G., Bouvier, M., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. The multiple membrane spanning topography of the ?2-adrenergic receptor: Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. J. Biol. Chem. 262: 14282-14288, 1987. PMID:2821000
  379. Strasser, R.H., Benovic, J.L., Lefkowitz, R.J. and Caron, M.G. The ??adrenergic receptor kinase: Role in homologous desensitization in S49 lymphoma cells. Adv. Exp. Med. Biol. 231:503-517, 1987. PMID:2843012
  380. Bolanowski, M.A., Kobilka, B.K., Dixon, R.A.F., Caron, M.G., and Lefkowitz, R.J. Structure of the mammalian ?2-adrenergic receptor. Proceedings of the 3rd International Symposium on "The Molecular Basis of the Actions of Drugs and Toxic Substances" San Francisco, Ca., (Eds. N. Castagnoli, T.P. Singer, C.C. Wang), 197-210, 1988.
  381. Frielle, T., Collins, S., Daniel, K.W., Caron, M.G., Lefkowitz, R.J. and Kobilka, B.K. Cloning of the cDNA for the human ?1 adrenergic receptor. Proc. Natl. Acad. Sci. USA 84: 7920-7924, 1987. PMID:2825170
  382. Kobilka, B.K., Frielle, T., Collins, S., Yang-Feng, T., Kobilka, T.S., Francke, U., Lefkowitz, R.J. and Marc G. Caron. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329: 75-79, 1987. PMID:3041227
  383. Frielle, T., Kobilka, B.K., Dohlman, H., Caron, M.G. and Lefkowitz, R.J. The ??adrenergic receptor and other receptors coupled to guanine nucleotide regulatory proteins. Federation Proceedings of APS Symposium, 1987 FASEB Meeting "Molecular Biology in Physiology", Raven Press, New York, 79-91, 1987.
  384. Kobilka, B.K., MacGregor, C., Daniel, K., Kobilka, T.S., Caron, M.G. and Lefkowitz, R.J. Functional activity and regulation of human ???adrenergic receptors expressed in Xenopus ocytes. J. Biol. Chem. 262:15796-15802, 1987. PMID:2824467
  385. Benovic, J.L., Kuhn, H., Weyand, I., Codina, J., Caron, M.G. and Lefkowitz, R.J. Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48K protein) Proc. Natl. Acad. Sci. USA 84:8879-8882, 1987. PMID:2827157
  386. Kobilka, B.K., Matsui, H., Kobilka, T.S., Yang-Feng, T.L., Francke, U., Caron, M.G., Lefkowitz, R.J. and J.W. Regan. Cloning, sequencing, and expression of the gene coding for the human platelet ???adrenergic receptor. Science 238:650-656, 1987. PMID:2823383
  387. Benovic, J.L., Regan, J.W., Matsui, H., Mayor, Jr., F., Cotecchia, S., Leeb-Lundberg, L.M.F., Caron, M.G. and Lefkowitz, R.J. Agonist-dependent phosphorylation of the ???adrenergic receptor by the ??adrenergic receptor kinase. J. Biol. Chem. 262:17251-17253, 1987. PMID:2826414
  388. Bouvier, M., Hnatowich, M., Collins, S., Kobilka, B.K., DeBlasi, A., Lefkowitz, R.J. and Caron, M.G. Expression of a human cDNA encoding the ??adrenergic receptor in Chinese hamster fibroblasts (CHW): Functionality and regulation of the expressed receptors. Mol. Pharmacol. 33:133-139, 1988. PMID:2828911
  389. Lefkowitz, R.J., Kobilka, B.K., Benovic, J.L. and Caron, M.G. Adrenergic receptors: New insights into structure, function and regulation. Proceedings of the 1988 Miami Bio/Technology Winter Symposium, "Advances in Gene Technology: Protein Engineering and Production", Miami, FL, Vol. 8:100-101, 1988.
  390. Sibley, D.R., Daniel, K., Strader, C.D. and Lefkowitz, R.J. Phosphorylation of the ?-adrenergic receptor in intact cells: Relationship to heterologous and homologous mechanisms of adenylate cyclase. Arch. Biochem. Biophys. 258:24-32, 1987. PMID:2444163
  391. Benovic, J.L., Staniszewski, C., Mayor, F., Jr., Caron, M.G. and Lefkowitz, R.J. ?-adrenergic receptor kinase: Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. J. Biol. Chem. 263:3893-3897, 1988. PMID:2831211
  392. Lefkowitz, R.J. and Caron, M.G. The adrenergic receptors: Models for the study of receptors coupled to guanine nucleotide regulatory proteins. J. Biol. Chem. 263:4993-4996, 1988. PMID:3128532
  393. Sibley, D.R. and Lefkowitz, R.J. Biochemical mechanisms of ??adrenergic regulation. ISI Atlas of Science: Pharmacology 2:66-70, 1988.
  394. Dohlman, H.G., Caron, M.G., Strader, C.D., Amlaiky, N. and Lefkowitz, R.J. Identification and sequence of a binding site peptide of the ?2-adrenergic receptor. Biochemistry 27:1813-1817, 1988. PMID:2837273
  395. Sibley, D.R., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Phosphorylation of cell surface receptors: A mechanism for regulating signal transduction pathways. Endocr. Rev. 9:38-56, 1988. PMID:2836188
  396. Caron, M.G., Kobilka, B.K., Frielle, T., Benovic, J.L., Regan, J.W., Collins, S., MacGregor, C. and Lefkowitz, R.J. Adrenergic receptors: Molecular and regulatory properties revealed by cloning of their genes. In: Recent Advances in Receptor Chemistry. Proceedings of the 6th Camerino-Noordwijkerhout Symposium, Camerino, Italy (Ed. C. Melchiore and M. Giannella) p. 63-76, 1988.
  397. O'Dowd, B.F., Lefkowitz, R.J., Caron, M.G. Structure of the adrenergic and related receptors. Annu. Rev. Neurosci. 12: 67-83, 1988.
  398. Benovic, J.L., Bouvier, M., Caron, M.G. and Lefkowitz, R.J. Regulation of adenylyl cyclase-coupled??-adrenergic receptors. Annu. Rev. Cell Biol. 4: 405-428, 1988. PMID:2848553
  399. Yang, S-D., Fong, Y-L. Benovic, J.L., Sibley, D.R., Caron, M.G.and Lefkowitz, R.J. Dephosphorylation of the ?2-adrenergic receptor and rhodopsin by latent phosphatase 2. J. Biol.Chem. 263:8856-8858, 1988. PMID:2837466
  400. Kobilka, B.K., Kobilka, T.S., Daniel, K., Regan, J.W., Caron, M.G. and Lefkowitz, R.J. Chimeric ?2-?2-adrenergic receptors: Delineation of domains involved in effector coupling and ligand binding specificity. Science 240:1310-1316, 1988. PMID:2836950
  401. Bouvier, M., Hausdorff, W.P, De Blasi, A., O'Dowd, B.F., Kobilka, B.K., Caron, M.G. and Lefkowitz, R.J. Removal of phosphorylation sites from the ?2-adrenergic receptor delays onset of agonist promoted desensitization. Nature 333:370-372, 1988. PMID:2836733
  402. Collins, S., Quarmby, V.E., Beckman, W.C., French, F.S., Lefkowitz, R.J. and Caron, M.G. Regulation of the ?2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone. FEBS Lett. 233 (1), 173-176, 1988. PMID:2838324
  403. Collins, S., Bolanowski, M.A., Caron, M.G. and Lefkowitz, R.J. Genetic regulation of ?-adrenergic receptors. Annu. Rev. Physiol. 51:203-215, 1989. PMID:2540696
  404. Regan, J.W., Kobilka, T.S., Yang-Feng, T.L., Caron, M.G. and Lefkowitz, R.J. Cloning and expression of a human kidney cDNA for a novel ?2-adrenergic receptor. Proc. Natl. Acad. Sci., USA 85:6301-6305, 1988. PMID:2842764
  405. Collins, S., Caron, M.G. and Lefkowitz, R.J. ??Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J. Biol. Chem. 263:9067-9070, 1988. PMID:2837475
  406. Cotecchia, S., Schwinn, D.A., Randall, R.R., Lefkowitz, R.J., Caron, M.G. and Kobilka, B.K. Molecular cloning and expression of the cDNA for the hamster alpha1-adrenergic receptor. Proc. Natl. Acad. Sci. USA 85:7159-7163, 1988. PMID:2845398
  407. O'Dowd, B.F., Hnatowich, M., Regan, J.W., Leader, W.M., Caron, M.G. and Lefkowitz, R.J. Site-directed mutagenesis of the cytoplasmic domains of the human ?2-adrenergic receptor: Localization of regions involved in G protein-receptor coupling. J. Biol. Chem. 263:15985-15992, 1988. PMID:2846532
  408. Lefkowitz, R.J. The Spirit of Science. J. Clin. Invest. 82:375-378, 1988. PMCID:PMC303524
  409. Fargin, A., Raymond, R.J., Lohse, M.J., Kobilka, B.K., Caron, M.G. and Lefkowitz, R.J. The genomic clone G-21 encodes the serotonin (5-HT1A) receptor. Nature, 335:358-360, 1988. PMID:3138543
  410. Lefkowitz, R.J., Kobilka, B.K., Benovic, J.L., Bouvier, M, Cotecchia, S., Hausdorff, W.P., Dohlman, H.G., Caron, M.G. Molecular biology of adrenergic receptors. Cold Spring Harbor Symposia on Quantitative Biology, Volume LIII, 507-514, 1988.
  411. Caron, M.G., Bouvier, M., Hausdorff, W.P., Benovic, J.L., Kobilka, B.K., Cotecchia, S., Regan, J.W., and Lefkowitz, R.J. The adrenergic receptors: Control of hormone responsiveness by phosphorylation. International Conference of Second Messenger Systems in Cellular Control, Prospective for New Drugs. London, England, 1988.
  412. Frielle, T., Daniel, K.W., Caron, M.G. and Lefkowitz, R.J. Structural basis of ?-adrenergic receptor subtype specificity studied with chimeric ?1/?2-adrenergic receptors. Proc. Natl. Acad. Sci. USA, 85:9494-9498, 1988. PMID:2849109
  413. Leeb-Lundberg, L.M.F., Cotecchia, S., Lefkowitz, R.J. and Caron, M.G. Desensitization and phosphorylation of a1-adrenoceptors coupled to inositol phospholipid metabolism. In: Progress in Catecholamine Research, Alan R. Liss, Inc., pp 375-385, 1988.
  414. Cotecchia, S., Schwinn, D.A., Lefkowitz, R.J. and Caron, M.G. The ?1-adrenergic receptor as a paradigm of receptors coupled to guanine nucleotide binding proteins. Proceedings of the XVIth C.I.N.P. Congress, Munich, Germany, 1988.
  415. Benovic, J.L., Stone, W.C., Caron, M.G. and Lefkowitz, R.J. Inhibition of the ?-adrenergic receptor kinase by polyanions. J. Biol. Chem. 264:6707-6710, 1989. PMID:2468660
  416. Matsui, H., Lefkowitz, R.J., Caron, M.G. and Regan, J.W. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet ?2-adrenergic receptor. Biochemistry 28:4125-4130, 1989. PMID:2546589
  417. O'Dowd, B.F., Hnatowich, M., Caron, M.G., Lefkowitz, R.J. and Bouvier, M. Palmitoylation of the human ?2-adrenergic receptor: Mutation of CYS341 in the carboxyl tail leads to an uncoupled, non-palmitoylated form of the receptor. J. Biol. Chem. 264:7564-7569, 1989. PMID:2540197
  418. Lohse, M.J., Lefkowitz, R.J., Caron, M.G. and Benovic, J.L. Inhibition of ?-adrenergic receptor kinase prevents homologous desensitization of??2-adrenergic receptors. Proc. Natl. Acad. Sci. USA, 86:3011-3015, 1989. PMID:2541428
  419. Palacios, J.M., O'Dowd, B.F., Cotecchia, S., Hnatowich, M.G. Caron and R.J. Lefkowitz. Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. Life Sciences 44:2057-2065, 1989. PMID:2545987
  420. Benovic, J.L., Staniszewski, C., Cerione, R.A., Codina, J., Lefkowitz, R.J. and Caron, M.G. The mammalian ?-adrenergic receptor: Structural and functional characterization of the carbohydrate moiety. J. Recept. Res. 7:257-281, 1989. PMID:2887651
  421. Caron, M.G., Kobilka, B.K., Frielle, T., Bolanowski, M.A., Benovic, J.L. and Lefkowitz, R.J. Cloning of the cDNA and genes for the hamster and human ?2-adrenergic receptors. J. Recept. Res. 8:7-21, 1988. PMID:2838630
  422. Frielle, T., Kobilka, B.K., Lefkowitz, R.J. and Caron, M.G. Human ?1- and ?2-adrenergic receptors: Structurally and functionally related receptors derived from distinct genes. Trends Neuro Sci. (Pers. Ed.), 11, 321-324, 1988.
  423. Kwatra, M.M., Benovic, J.L., Caron, M.G., Lefkowitz, R.J. and Hosey, M.M. Phosphorylation of chick heart muscarinic cholinergic receptors by the ?-adrenergic receptor kinase. Biochemistry, 28:4543-4547, 1989. PMID:2765501
  424. Collins, C., Bouvier, M., Bolanowski, M.A., Caron, M.G. and Lefkowitz, R.J. Cyclic AMP stimulates transcription of the ?2-adrenergic receptor gene in response to short term agonist exposure. Proc. Natl. Acad. Sci. USA, 86:4853-4857, 1989. PMID:2472635
  425. Lefkowitz, R.J., Kobilka, B.K. and Caron, M.G. The new biology of drug receptors. Biochem. Pharmacol. 38:2941-2948, 1989. PMID:2551299
  426. Raymond, J.R., Fargin, A., Lohse, M.J., Regan, J.W., Senogles, S.E., Lefkowitz, R.J. and M.G. Caron. Identification of the ligand binding subunit of the human 5-HT1A receptor with [125I]-N3-NAPS, a high affinity radioiodinated photoaffinity probe. Mol. Pharmacol. 36:15-21, 1989. PMID:2526292
  427. Raymond, J.R., Hnatowich, M., Caron, M.G. and Lefkowitz, R.J. Structure-function relationships of G protein-coupled receptors. ADP-ribosylating Toxins and G Proteins: Insights into Signal Transduction, eds. J. Moss and M. Vaughan, 163-188, 1990.
  428. Hausdorff, W.P., Bouvier, M., O'Dowd, B.F., Irons, G.P., Caron, M.G. and Lefkowitz, R.J. Phosphorylation sites on two domains of the??2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J. Biol. Chem. 264:12657-12665, 1989. PMID:2545714
  429. O'Dowd, B.F., Hnatowich, M., Caron, M.G. and Lefkowitz, R.J. The family of adrenergic and structurally related G protein-coupled receptors. In: Receptor Sub-Units and Complexes, Eds. E.A. Barnard, A.S.V. Burgen and G.C.K. Roberts, Cambridge Press, in press, 1989.
  430. Fargin, A., Raymond, J.R., Regan, J.W., Cotecchia, S., Lefkowitz, R.J. and Caron, M.G. Effector coupling mechanisms of the cloned 5-HT1A receptor. J. Biol. Chem. 264:14848-14852, 1989. PMID:2549039
  431. Bouvier, M., Collins, S., O'Dowd, B.F., Campbell, P.T., DeBlasi, A., Kobilka, B.K., MacGregor, C., Irons, G.P., Caron, M.G. and Lefkowitz, R.J. Two distinct pathways for cAMP mediated down regulation of the ?2-adrenergic receptor: Phosphorylation of the receptor and regulation of its mRNA level. J. Biol. Chem. 264:16786-16792, 1989. PMID:2476447
  432. Liggett, S.B., Bouvier, M., Hausdorff, W.P., O'Dowd, B., Caron, M.G. and Lefkowitz, R.J. Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant ?2-adrenergic receptors lacking phosphorylation sites. Mol. Pharmacol. 36:641-646, 1989. PMID:2554115
  433. Raymond, J.R., Fargin, A., Middleton, J.P., Graff, J.M., Haupt, D. M., Caron, M.G., Lefkowitz, R.J and Dennis, V.W. The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. J. Biol. Chem. 264:21943-21950, 1989. PMID:2557347
  434. Caron, M.G., Hnatowich, M., Dohlman, H., Bouvier, M., Benovic, J., O'Dowd, B.F., Kobilka, B.K., Hausdorff, W.P. and Lefkowitz, R.J. Structure and function of adrenergic receptors: Models for understanding G-protein-coupled receptors. G Proteins, Eds., R. Iyengar/L. Birnbaumer. Academic Press, Orlando, FL, 295-315, 1990.
  435. Benovic, J.L., Onorato, J., Lohse, M.J., Dohlman, H.G., Staniszewski, C., Caron, M.G. and Lefkowitz, R.J. Synthetic peptides of the hamster ?2-adrenoceptor as substrates and inhibitors of the??-adrenoceptor kinase. Br. J. Clin. Pharmac. 30:3S-12S, 1990. PMID:2176526
  436. Hoffman, B.B. and Lefkowitz, R.J., Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eighth Edition, Chapter 11, pp. 221-243. Adrenergic Receptor Antagonists, (Ed. A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor) Macmillan Publishing Co., New York, 1990.
  437. Hoffman, B.B. and Lefkowitz, R.J. Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eighth Edition, Chapter 10, PP. 187-220. Catecholamines and sympathomimetic Drugs, (Eds. A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor) Macmillan Publishing Co., New York, 1990.
  438. Lefkowitz, R.J., Hoffman, B.B. and Taylor, P. Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eighth Edition, Chapter 5, pp. 84-121. Neurohumoral Transmission: The Autonomic and Somatic Motor Nervous Systems, (Eds. A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor) Macmillan Publishing Co., New York, 1990.
  439. Benovic, J.L., DeBlasi, A., Stone, W.C., Caron, M.G. and Lefkowitz, R.J. ?-Adrenergic receptor kinase: Primary structure delineates a multigene family. Science 246:235-240, 1989. PMID:2552582
  440. Frielle, T., Caron, M.G. and Lefkowitz, R.J. The mammalian ?-adrenergic receptors. In: Oxford Surveys on Eukaryotic Genes N. MacLean, editor, Oxford University Press, Oxford, Vol. 6:53-66, England, 1989.
  441. Lorenz, W., Lomasney, J.W., Collins, S., Regan, J.W., Caron, M.G. and Lefkowitz, R.J. Expression of three alpha-2 adrenergic receptor subtypes in rat tissues: Implications for alpha-2 receptor classification. Mol. Pharmacol. 38:599-603, 1990. PMID:2172770
  442. Cotecchia, S., Kobilka, B.K., Daniel, K.W., Nolan, R.D., Lapetina, E.Y., Caron, M.G., Lefkowitz, R.J. and Regan, J.W. Multiple second messenger pathways of ?-adrenergic receptor subtypes expressed in eukaryotic cells. J. Biol. Chem. 265:63-69, 1990. PMID:2152928
  443. Hausdorff, W.P., Hnatowich, M., O'Dowd, B.F., Caron, M.G. and Lefkowitz, R.J. A mutation of the ?2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. J. Biol. Chem.:265:1388-1393, 1990. PMID:2153131
  444. Lefkowitz, R.J. and Caron, M.G. The Adrenergic Receptors. In: Advances in Second Messenger and Phosphoprotein Research: In: The Biology and Medicine of Signal Transduction. (Eds. Yasumatoma Nishizuka et al., Raven Press, N.Y. Volume 24: 1-8, 1990.
  445. Lefkowitz, R.J. and Caron, M.G. The Adrenergic Receptors. Proceedings of The Robert A. Welch Foundation Conferences on Chemical Research, XXXIII, 183-199, 1989.
  446. Dohlman, H.G., Caron, M.G., DeBlasi, A., Frielle, T., and Lefkowitz, R.J. A role of extracellular disulfide bonded cysteines in the ligand binding function of the ?2-adrenergic receptor. Biochemistry 29:2335-2342, 1990. PMID:2159799
  447. Lohse, M.J., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Multiple pathways of rapid ?2-adrenergic receptor desensitization: Delineation with specific inhibitors. J. Biol. Chem. 265:3202-3209, 1990. PMID:2154473
  448. Yang-Feng, T.L., Xue, F., Zhong, W., Cotecchia, S., Frielle, T., Caron, M.G., Lefkowitz, R.J. and Francke, U. Chromosomal organization of adrenergic receptor genes. Proc. Natl. Acad. Sci. USA, 87:1516-1520, 1990. PMID:2154750
  449. Liggett, S.B., Bouvier, M., O'Dowd, B.F., Caron, M.G., Lefkowitz, R.J. and DeBlasi, A. Substitution of an extracellular cysteine in the ?2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. Biochem. and Biophys. Res. Commun. 165:257-263, 1989. PMID:2556136
  450. Perkins, J.P., Hausdorff, W.P. and Lefkowitz, R.J. Mechanisms of ligand-induced desensitization of the ?-adrenergic receptor. In The Beta-Adrenergic Receptors, (ed. J.P. Perkins), Humana Press, Clifton, NJ, pp 125-180, 1990.
  451. Caron, M.G., Kobilka, B.K., Bouvier, M., Hausdorff, W.P., Benovic, J.L., Lohse, M., Cotecchia, S., Regan, J.W., Fargin, A., Raymond and Lefkowitz, R.J. Catecholamine receptors: Structure, function and regulation. In: Molecular Mechanisms of Hormone Action (eds. U. Guhring, E. Helmreich and G. Schultz), Springer-Verlag, 195-200,1989.
  452. Raymond, R.J., Hnatowich, M., Lefkowitz, R.J. and Caron, M.G. Adrenergic Receptors. Hypertension 15:119-131, 1990. PMID:2105909
  453. Cotecchia, S., Exum, S., Caron, M.G. and Lefkowitz, R.J. Regions of the ?1-adrenergic receptor implicated in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. Proc. Natl. Acad. Sci. USA 87:2896-2900, 1990. PMID:2158097
  454. Schwinn, D.A., Lomasney, J.W., Lorenz, W., Szklut, Fremeau, R.T., Jr., Yang-Feng, T.L., Caron, M.G., Lefkowitz, R.J. and Cotecchia, S. Molecular cloning and expression of the cDNA for a novel ?1-adrenergic receptor subtype. J. Biol. Chem. 265:8183-8187, 1990. PMID:1970822
  455. Fargin, A., Raymond, R.J., Lefkowitz, R.J. and Caron, M.G. Biochemical characterization of the cloned human 5-HT1A receptor expressed in mammalian cells. In: Serotonin: From Cell Biology to Pharmacology and Therapeutics, R. Paoletti et al. (eds.), Kluwer Academic Publishers, 19-24, 1990.
  456. Dohlman, H.G., Caron, M.G. and Lefkowitz, R.J. Structural and functional studies of the ?-adrenergic receptor. Neuropeptides and Their Receptors, Alfred Benzon Symposium, T.W. Schwartz, L.M. Hilsted, and J.F. Rehfeld (eds.), Munksgaard, Copenhagen, 29:269-281, 1990.
  457. Benovic, J.L., Onorato, J.J., Caron, M.G. and Lefkowitz, R.J.Regulation of G Protein-coupled receptors by agonist-dependent phosphorylation. In: G Proteins and Signal Transduction, (eds. N.M. Nathanson and T.K. Harden, The Rockefeller University Press, New York: 87-103, 1990.
  458. Valiquette, M., Bonin, H., M. Hnatowich, M.G. Caron, Lefkowitz, R.J. and Bouvier, M. Involvement of tyrosine residues, located in the carboxyl tail of the human ?2-adrenergic receptor in agonist-induced down-regulation of the receptor. Proc. Natl. Acad. Sci. USA 87:5089-5103, 1990. PMID:2164220
  459. Seuwen, K., Magnaldo, I., Kobilka, B.K., Caron, M.G., Regan, J.W., Lefkowitz, R.J. and Pouyssegur, J. ?2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human ?2-adrenergic receptor gene. Cell Regulation 1:445-451, 1990. PMID:1981685
  460. Lomasney, J.W., Lorenz, W., Allen, L.F., King, K., Regan, J.W., Yang-Feng, T.L., Caron, M.G. and Lefkowitz, R.J. Expansion of the Alpha2-adrenergic receptor family: Cloning and Characterization of a human Alpha2-adrenergic receptor subtype, the gene for which is located on chromosome 2. Proc. Natl. Acad. Sci. USA 87:5094-5098, 1990. PMID:2188401
  461. Lefkowitz, R.J., Hausdorff, W.P., and Caron, M.G. Role of phosphorylation in desensitization of the ?-adrenoceptor. Trends in Pharmacol. Sci. 11:190-194, 1990.
  462. Collins, S., Bouvier, M., Lohse, M.J., Benovic, J.L., Caron, M.G. and Lefkowitz, R.J. Glycoprotein receptors and cell triggering. Biochemical Society Transactions 18:541-544, 1990. PMID:2177406
  463. Lohse, M.J., Benovic, J.L., Codina, J., Caron, M.G. and Lefkowitz, R.J. ?Arrestin: A protein that regulates ?-adrenergic receptor function. Science 248:1547-1550, 1990. PMID:2163110
  464. Schwinn, D.A., Caron, M.G. and Lefkowitz, R.J. The ?-adrenergic receptor as a model for molecular structure-function relationships in G protein-coupled receptors. In: The Heart and Cardiovascular System, (Eds. H.M. Fozzard, E. Haber, R. Jennings, A. Katz. and H. Morgan), Raven Press, New York, pp. 1657-1684, 1990.
  465. Hausdorff, W.P., Caron, M.G. and Lefkowitz, R.J. Turning off the signal: Desensitization of ?-adrenergic receptor function. FASEB J.4:2881-2889, 1990. PMID:2165947
  466. Caron, M.G. and Lefkowitz, R.J. The ?-adrenergic receptors: Structure-function relationships. In The Beta Adrenergic Receptors, (ed. J.P. Perkins), Humana Press, Clifton, NJ, pp. 41-72, 1991.
  467. King, K., Dohlman, H.G., Thorner, J., Caron, M.G. and Lefkowitz, R.J. Control of mating signal transduction by a mammalian ?2-adrenergic receptor and Gs ?-subunit. Science 250:121-123, 1990. PMID:2171146
  468. Collins, S., Altsdhmied, J., Herbsman, O., Caron, M.G., Mellon, P.L. and Lefkowitz, R.J. A cAMP response element in the ?2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. J. Biol. Chem. 265:19330-19335, 1990. PMID:2172252
  469. O'Dowd B.F., Collins S., Bouvier M, Caron, M.G. and Lefkowitz R.J. (1990): Structural, functional and genetic aspects of receptors coupled to G proteins. In: Molecular Biology of Receptors Which Couple to G-proteins, ed. M. Brann, Cambridge: Birkhauser Boston, Inc., pp. 31-61, 1992.
  470. Liggett, S.B., Ostrowski, J., Chesnut, L.C., Caron, M.G. and Lefkowitz, R.J. Role of the ?-adrenergic receptor kinase in desensitization of the ?2-adrenergic receptor. In: Transactions of the Association of American Physicians, Vol. CIV:40-47, 1991. PMID:1668989
  471. Hausdorff, W.P., Lohse, M.J., Bouvier, M., Liggett, S.B., Caron, M.G. and Lefkowitz, R.J. Two kinases mediate agonist-dependent phosphorylation and desensitization of the ?2-adrenergic receptor. In: Hormone Perception and Signal Transduction in Animals and Plants. No. XLIV, Eds. J. Roberts, C.Kirk and M. Venis, The Company of Biologists Limited, Cambridge, UK, 225-240, 1990.
  472. Collins, S., Caron, M.G. and Lefkowitz, R.J. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu. Rev. Physiol.53:497-508, 1991. PMID:2042970
  473. Raymond, J.R., Albers, F.J., Middleton, J.P., Lefkowitz, R.J., Caron, M.G., Obeid, L.M. and Dennis, V.W. 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphatidylinositol hydrolysis and phosphate uptake via distinct G protein pools. J. Biol. Chem. 266:372-379, 1991, PMID:1845968
  474. Campbell, P.T., Hnatowich, O'Dowd, B.F., Caron, M.G., Lefkowitz, R.J., and Hausdorff, W.P. Mutations of the human ?2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. Mol. Pharmacol. 39:192-198, 1991. PMID:1847493
  475. Schwinn, D.A., Cotecchia, S., Lorenz, W., Caron, M.G. and Lefkowitz, R.J. The ?1C-adrenergic receptor: A new member of the a1-adrenergic receptor family. Transactions of the Association of American Physicians, Vol. CIII:112-118, 1991.
  476. Liggett, S.B., Caron, M.G., Lefkowitz, R.J. and Hnatowich, M. Coupling of a mutated form of the human ?2-adrenergic receptor to Gi and Gs: Requirement for multiple cytoplasmic domains in the coupling process. J. Biol. Chem., 266:4816-4821, 1991. PMID:1848226
  477. Lomasney, J.W., Cotecchia, S., Lorenz, W., Leung, W-Y., Schwinn, D.A., Yang-Feng, T.L., Brownstein, Lefkowitz, R.J., and Caron, M.G. Molecular cloning and expression of the cDNA for the ?1A-adrenergic receptor. J. Biol. Chem., 266:6365-6369, 1991. PMID:1706716
  478. Onorato, J.J., Palczewski, K., Regan, J.W., Caron, M.G., Lefkowitz, R.J. and Benovic, J.L. The role of acidic amino acids in peptide substrates of the ?-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30:5118-5125, 1991. PMID:1645191
  479. Benovic, J.L., W.C. Stone, K. Huebner, C. Croce, M.G. Caron and R.J. Lefkowitz. cDNA cloning and chromosomal localization of the human ?-adrenergic receptor kinase. FEBS Lett. 283:122-126, 1991. PMID:2037065
  480. Roth, N., Campbell, P., Caron, M.G., Lefkowitz, R.J., Lohse, M.J. Comparative rates of desensitization of ?-adrenergic receptors by the ?-adrenergic receptor kinase and the cyclic AMP dependent protein kinase. Proc. Natl. Acad. Sci., USA, 88:6201-6204, 1991. PMID:1648731
  481. Kurose, H., Regan, J.W., Caton, M.G. and Lefkowitz, R.J. Functional interactions of recombinant ?2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry 30:3335-3341, 1991. PMID:1849000
  482. O'Dowd, B.F., Hnatowich and Lefkowitz, R.J. Adrenergic and related G protein-coupled receptors, structure and function. Encyclopedia of Human Biology, vol. 1:81-92, 1991.
  483. Hausdorff, W.P., Campbell, P.T., Ostrowski, J., Yu, S.S., Caron, M.G. and Lefkowitz, R.J. A small region of the ?-adrenergic receptor is selectively involved in its rapid regulation. Proc. Natl. Acad. Sci. USA, 88:2979-2983, 1991. PMID:1849641
  484. Oakey, R.J., Caron, M.G., Lefkowitz, R.J., and Seldin, M.F. Genomic organization of adrenergic and serotonin receptors in the mouse: Linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics 10:338-344, 1991. PMID:1676978
  485. Lefkowitz, R.J. Thrombin receptor: Variation on a theme. Nature 351:353-355, 1991. PMID:1851963
  486. Benovic, J.L., Onorato, J.J., Arriza, J.L., Stone, W.C., Lohse, M., Jenkins, N., Gilbert, D.J., Copeland, N.G., Caron, M.G. and Lefkowitz, R.J. Cloning, expression and chromosomal localization of ?-adrenergic receptor kinase 2: A new member of the receptor kinase family. J. Biol. Chem. 266:14939-14946, 1991. PMID:1869533
  487. Dohlman, H.G., Thorner, J., Caron, M.G. and Lefkowitz, R.J. Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60:653-688, 1991.PMID:1652922
  488. Lorenz, W., Inglese, J., Palczewski, K., Onorato, J.J., Caron, M.G. and Lefkowitz, R.J. The receptor kinase family: Primary structure of rhodopsin kinase reveals similarities to the ?-adrenergic receptor kinase. Proc. Natl. Acad. Sci. USA. 88: 8715-8719, 1991.PMID:1656454
  489. Collins, S., Caron, M.G. and Lefkowitz, R.J. From ligand binding to gene expression: New insights into the regulation of G protein-coupled receptors. Trends in Biochem. Sci., 17:37-39, 1992. PMID:1316650
  490. Ostrowski, J., Kjelsberg, M.A., Caron, M.G. and Lefkowitz, R.J. Mutagenesis of the ?2-adrenergic receptor: how structure elucidates function. Annu. Rev. Pharmacol. and Toxicol. 32:167-183,1992.PMID:1318669
  491. Schwinn, D.A., Page, S.O., Middleton, J.P., Lorenz, W., Liggett, S.B., Yamamoto, K., Lapetina, E.Y., Caron, M.G., Lefkowitz, R.J. and Cotecchia, S. The ?1C-adrenergic receptor: Characterization of signal transduction pathways and mammalian tissue heterogeneity. Molec. Pharmacol. 40:619-626, 1991.PMID:1658600
  492. Fargin, A., Yamamoto, K., Cotecchia, S., Goldsmith, P.K., Spiegel, A.M., Lapetina, E.G., Caron, M.G. and Lefkowitz, R.J. Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. Cellular Signalling, 3:547-557, 1991. PMID:1786205
  493. Allen, L.F., Lefkowitz, R.J., Caron, M.G. and Cotecchia, S. G-protein-coupled receptors as proto-oncogenes: Constitutively activating mutation of the ?1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc. Natl. Acad. Sci, USA, 88:11354-11358, 1991. PMID:1662393
  494. Cotecchia, S., Ostrowski, J., Kjelsberg, M.A., Caron, M.G. and Lefkowitz, R.J. Discrete amino acid sequences of the alpha1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. J. Biol. Chem., 268:1633-1639, 1992. PMID:1680130
  495. Liggett, S.B., Ostrowski, J., Chesnut, L., Kurose, H., Raymond, J.R., Caron, M.G. and Lefkowitz, R.J. Sites in the third intracellular loop of the ?2-adrenergic receptor confer short term agonist promoted desensitization: Evidence for a receptor kinase mediated mechanism. J. Biol. Chem. 267:4740-4746, 1992. PMID:1311318
  496. Inglese, J., Glickman, J.F., Lorenz, W., Caron, M.G. and Lefkowitz, R.J. Isoprenylation of a protein kinase: Requirement of farnesylation/?-carboxyl methylation for full enzymatic activity of rhodopsin kinase. J. Biol. Chem. 267:1422-1425, 1992. PMID:1730692
  497. Kjelsberg, M.A., Cotecchia, S., Ostrowski, J., Caron, M.G. and Lefkowitz, R.J. Constitutive activation of the ?1B-adrenergic receptor by all amino acid substitutions at a single site. J. Biol. Chem. 267:1430-1433, 1992.PMID:1346134
  498. Roth, N.S., Lefkowitz, R.J. and Caron, M.G. Structure and function of the adrenergic receptor family. Cellular and Molecular Mechanisms in Hypertension. Ed. R.H. Cox, Plenum Press, New York, pp. 223-238, 1991.
  499. Collins, S., Lohse, M.J., O'Dowd, B., Caron, M.G., and Lefkowitz, R.J. Structure and regulation of G protein-coupled receptors: The ?2-adrenergice receptor as a model. In: Vitamins and Hormones. Eds. G.D. Aurbach and D.B. McCormick, Academic Press, Inc., San Diego, CA., vol. 46:1-32, 1991.PMID:1660639
  500. Lomasney, J.W., Cotecchia, S., Lefkowitz, R.J., and Caron, M.G. Molecular biology of ?-adrenergic receptors: Implications for receptor classification and for structure-function relationships. Biochim et Biophys Acta. 1095:127-139, 1991. PMID:1657194
  501. Hausdorff, W.P., Sung, J., Caron, M.G. and Lefkowitz, R.J. Recent molecular analyses of ?-adrenergic receptor phosphorylation, sequestration and down regulation. Asia Pacific J. of Pharmacol. 7:149-158, 1992.
  502. Collins, S., Altschmied, J., Mellon, P.L., Caron, M.G. and Lefkowitz, R.J. Multiple pathways regulate adrenergic receptor responsiveness. In: Neurotransmitter Regulation of Gene Transcription, Fidia Research Foundation symposium Series. Thieme Medical Publishers, Washington, D.C. (Editors: Erminio Costa and Tong H. Joh), Vol. 7:183-191, 1991.
  503. Pitcher, J., Lohse, M.J., Codina, J., Caron, M.G. and Lefkowitz, R.J. Desensitization of the isolated ?2-adrenergic receptor by ?AR-kinase, cAMP dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry, 31:3193-3197, 1992. PMID:1348186
  504. Lohse, M.J., Andexinger, S., Pitcher, J., Trukawinski, S., Codina, J., Faure, J-P., Caron, M.G. and Lefkowitz, R.J. Receptor-specific desensitization with purified proteins: Stoichiometry, kinase-dependence and receptor specificity of ?-arrestin and arrestin in the ?2-adrenergic receptor and rhodopsin systems. J. Biol. Chem., 267:8558-8564, 1992. PMID:1349018
  505. Luttrell, D.K., Hausdorff, W.P., Moyers, J.E., Gilmer, T.M., Parsons, S.J., Caron, M.G. and Lefkowitz, R.J. Overexpression of PP60c-src is associated with altered regulation of adenylylcyclase. Cellular Signalling, 4:531-541, 1992. PMID:1384635
  506. Hausdorff, W.P., Pitcher, J.A., Luttrell, D.K., Linder, M.E., Kurose, H., Parsons, S.J., Caron, M.G. and Lefkowitz R.J. Tyrosine phosphorylation of G protein a subunits by pp60c-src. Proc. Natl. Acad. Sci., USA, 89:5720-5724, 1992.PMID:1378615
  507. Arriza, J.W., Dawson, T.M., Simerly, R.B., Martin, L.J., Caron, M.G., Snyder, S.H., and Lefkowitz, R.J. The G protein-coupled receptor kinases ?ARK1 and ?ARK2 are widely distributed at synapses in rat brain. J. Neurosci., 12:4045-4055, 1992.PMID:1403099
  508. Bylund, D.B., Blaxall, H.S., Iversen, L.J., Caron, M.G., Lefkowitz, R.J., and Lomasney J.L. Pharmacological characteristics of alpha-2 adrenergic receptors: Comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol. Pharmacol., 42:1-5, 1992.PMID:1353247
  509. Caron, M.G. and Lefkowitz, R.J. Catecholamine Receptors: Structure, function and regulation. In: Recent Progress in Hormone Research, 48:276-290, 1993.
  510. Pitcher, J.A., Inglese, J., Higgins, J.B., Arriza, J.L., Casey, P. J., Kim, C.K., Benovic, J.L., Kwatra, M.M., Caron, M.G. and Lefkowitz, R.J. Role of ?? Subunits of G proteins in targeting the ?-adrenergic receptor kinase to membrane-bound receptors. Science, 257:1264-1267, 1992. PMID:8463335
  511. Inglese, J., Koch, W.J., Caron, M.G. and Lefkowitz, R.J. The role of isoprenylation in the regulation of signal transduction via the G protein-coupled receptor kinases. Nature, 359:147-150, 1992.PMID:1522899
  512. Attramadal, H., Arriza, J.L., Aoki, C., Dawson, T.M., Codina, J., Kwatra, M.M., Snyder, S.H., Caron, M.G. and Lefkowitz, R.J. ?Arrestin2 - a novel member of the arrestin/?arrestin gene family. J. Biol. Chem., 267:17882-17890, 1992.PMID:151224
  513. Lefkowitz, R.J., Inglese, J., Koch, W.J., Pitcher J., Attramadal and Caron, M.G. G protein coupled receptors: Regulatory role of receptor kinases and arrestin proteins. In: Cold Spring Harbor Symposia on Quantitative Biology: The Cell Surface (vol. 57), Cold Spring Harbor Laboratory, N.Y., pp. 127-133, 1992.
  514. Lefkowitz, R.J., Cotecchia, S., Kjelsberg, M.A., Pitcher, J., Koch, W.J., Inglese J. and Caron, M.G. Adrenergic Receptors: Recent insights into their mechanism of activation and desensitization. In: Advances in Second Messenger and Phosphoprotein Research, Vol. 28. Raven Press, New York, N.Y. pp.1-9, 1993.
  515. Lefkowitz, R.J. G proteins: The subunit story thickens. Nature 358:372, 1992. PMID:1322498
  516. Inglese, J., Koch, W.J., Pitcher, J., Caron, M.G. and Lefkowitz, R.J. Regulation of G protein-coupled receptors: The receptor kinase family. In: BioJapan '92 Symposium Proceedings. Yokohama, Japan, pp 85-93, 1992.
  517. Yu, S.S., Lefkowitz, R.J. and Hausdorff, W.P. ?-adrenergic receptor sequestration: A mechanism of receptor resensitization. J. Biol. Chem., 268:337-341, 1993. PMID:8380158
  518. Schleicher, S., Boekhoff, I., Arriza, J., Lefkowitz, R.J. and Breer, H. A ??adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. Proc. Natl. Acad. Sci., USA, 90:1420-1424, 1993. PMID:8381966
  519. Liggett, S.B. and Lefkowitz, R.J. Adrenergic receptor-coupled adenylyl cyclase systems. Regulation of receptor function by phosphorylation, sequestration and down regulation. Regulation of Cellular Signal Transduction Pathways by Desensitization and Amplification. (Eds. David Sibley and Miles Houslay.) John Wiley & Sons, Ltd., Sussex, England. Vol. 3:71-95, 1994.
  520. Pippig, S., Andexinger, S., Daniel, K., Puzicha, M., Caron, M.G., Lefkowitz, R.J., and Lohse, M.J. Overexpression of ?-arrestin and ?-adrenergic receptor kinase augment desensitization of ?-adrenergic receptors. J. Biol. Chem., 268:3201-3208, 1993. PMID:8381421
  521. Dawson, T.M., Arriza, J.L., Jaworsky, D.E., Borisy, F.F., Attramadal, H., Lefkowitz, R.J. and Ronnett, G.V. ?-adrenergic receptor kinase-2 and ?-Arrestin-2 as mediators of odorant-induced desensitization. Science, 259:825-829, 1993. PMID:8381559
  522. Samama, P., Cotecchia, S., Costa, T. and Lefkowitz, R.J. A mutation-induced activated state of the ?2-adrenergic receptor-extending the ternary complex model. J. Biol. Chem., 268:4625-4636, 1993. PMID:8095262
  523. Lefkowitz, R.J. and Caron, M.G. The role of receptor kinases and arrestin-like proteins in G protein-linked receptor desensitization. In: Handbook of Experimental Pharmacology, Vol. "GTPases in Biology" I and II (eds. B. Dickey and L. Birnbaumer), in press, 1992.
  524. Kurose, H., Arriza, J.L. and Lefkowitz, R.J. Characterization of??2-adrenergic receptor subtype-specific antibodies. Mol. Pharmacol., 43:444-450, 1993. PMID:8095696
  525. Luttrell, L.M., Ostrowski, J., Cotecchia, S., Kendall, H. and Lefkowitz, R.J. Antagonism of catecholamine receptor signalling by expression of cytoplasmic domains of the receptors. Science, 259:1453-1457, 1993.PMID:8383880
  526. Collins, S., Ostrowski, J. and Lefkowitz, R.J. Cloning and sequence analysis of the human ?1-adrenergic receptor 5'-flanking promoter region. Biochim., Biophys. Acta., 1172:171-174, 1993. PMID:8382527
  527. Liggett, S.B., Freedman, N.J., Schwinn, D.A. and Lefkowitz, R.J. Structural basis for receptor subtype specific regulation revealed by a chimeric ?3/?2-adrenergic receptor. Proc. Natl. Acad. Sci, USA, 90:3665-3669, 1993. PMID:8386380
  528. Koch, W.J., Inglese, J., Stone, W.C. and Lefkowitz, R.J. The binding site for the??? subunits of heterotrimeric G proteins on the ??adrenergic receptor kinase. J. Biol. Chem., 268:8256-8260, 1993. PMID:8463335
  529. Blitzer, R.D., Omri, G., DeVivo, M., Carty, D.J., Premont, R.T., Codina, J., Birnbaumer, L., Cotecchia, S., Caron, M.G., Lefkowitz, R.J., Landau, E.M. and Iyengar, R. Coupling of the expressed ?1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes: The role of Go. J. Biol. Chem., 268:7532-7537, 1993. PMID:8385110
  530. Kwatra, M.M., Schwinn, D.A., Schreuers, J., Blank, J.L., Kim, C.M., Benovic, J.L., Krause, J.E., Caron, M.G., and Lefkowitz, R.J. The substance P receptor which couples to Gq/G11 is a substrate of ?ARK1 and 2. J. Biol. Chem., 268:9161-9164, 1993. PMID:7683643
  531. Price, D.T., Schwinn, D.A., Lomasney, J.W., Allen, L.F., Caron, M.G. and Lefkowitz, R.J. Identification, quantification, and localization of mRNA for three distinct alpha1 adrenergic receptor subtypes in human prostate. J. Urol., 150:546-551, 1993. PMID:7686987
  532. Ren, Q., Kurose, H., Lefkowitz, R.J. and Cotecchia, S. Constitutively active mutants of the ???adrenergic receptor. J. Biol. Chem., 268:16483-16487, 1993.PMID:8393865
  533. Lomasney, J.W., Allen, L.F. and Lefkowitz, R.J. Cloning and regulation of catecholamine receptor genes. In: Molecular Endocrinology: Basic Concepts and Clinical Correlations. Bruce Winetraub, ed., Raven Press, New York, NY., pp. 115-128, 1994.
  534. Inglese, J., Premont, R.T., Koch, W.J., Pitcher, J. and Lefkowitz, R.J. ?-adrenergic receptor kinase. In: The Protein Kinase Facts Book. D.G. Hardie, editor. Academic Press Limited, London, 98-101, 1995.
  535. Inglese, J., Premont, R.T., Koch, W.J., Pitcher, J. and Lefkowitz, R.J. Rhodopsin kinase. In: The Protein Kinase Facts Book. D.G. Hardie, editor Academic Press Limited, London, 102-104, 1995.
  536. Scheinin, M., Lomasney, J.W., Hayden-Hixson, Schambra, U.M., Caron, M.G., Lefkowitz, R.J. and Fremeau, R.T., Jr. Distribution of ?2-adrenergic receptor subtype gene expression. Mol. Brain Res., 21:133-149, 1994. PMID:8164514
  537. Lefkowitz, R.J. G protein-coupled receptor kinases. Cell, 74:409-412, 1993. PMID:8394218
  538. Lefkowitz, R.J. Cotecchia, S., Samama, P. and Costa, T. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. TIPS, 14:303-307, 1993.PMID:8249148
  539. Lefkowitz, R.J. and Premont, R.T. Diseased G-protein coupled receptors. J. Clin. Invest., 92:2089, 1993. PMCID:PMC288383
  540. Inglese, J., Freedman, N.J., Koch, W. and Lefkowitz, R.J. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem., 268:23735-23738, 1993. PMID:8226899
  541. Ishii, K., Chen, J., Ishii, M., Koch, W.J., Freedman, N.J., Lefkowitz, R.J. and Coughlin, S.R. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. J. Biol. Chem., 269:1125-1130, 1994. PMID:8288570
  542. Boekhoff, I., Inglese, J., Schleicher, S., Koch, W.J., Lefkowitz, R.J. and Breer, H. Olfactory desensitization requires membrane targeting of receptor kinase mediated by bg-subunits of heterotrimeric G. proteins. J. Biol. Chem., 269:37-40, 1994. PMID:8276821
  543. Lefkowitz, R.J. G protein-coupled receptors: Turned on to ill effect. Nature, 365:603-604, 1993. PMID:8413622
  544. Price, D.T., Lefkowitz, R.J., Caron, M.G., Berkowitz, D. and Schwinn, D.A. Localization of mRNA for three distinct ??-adrenergic receptor subtypes in human tissues: Implications for human??-adrenergic physiology. Mol. Pharmacol., 45:171-175, 1994.PMID:8114668
  545. Barak, L.S., Tiberi, M., Freedman, N.J., Kwatra, M.M., Lefkowitz, R.J. and Caron, M.G. A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated ?2 adrenergic receptor sequestration. J. Biol. Chem., 269:2790-2795, 1993. PMID:7507928
  546. Koch, W.J., Hawes, B.E., Inglese, J., Luttrell, L.M. and Lefkowitz, R.J. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G??-mediated signaling. J. Biol. Chem., 269:6193-6197, 1994. PMID:8119963
  547. Samama, P., Pei, G., Costa, T., Cotecchia, S. and Lefkowitz, R.J. Negative antagonists promote an inactive conformation of the ?2-adrenergic receptor. Mol. Pharmacol., 45:390-394, 1994. PMID:7908404
  548. Premont, R.T., Koch, W.J., Inglese and Lefkowitz, R.J. Identification, purification and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem., 269:6832-6841, 1994.PMID:8120045
  549. Lefkowitz, R.J. Receptors coupled to guanine nucleotide regulatory proteins. In From Bench to Bedside, Sterling Winthrop Symposium Commemorative Book, pps. 45-61, 1994.
  550. Pei, G., Samama, P., Lohse, M., Wang, M., Codina, J. and Lefkowitz, R.J. A constitutively active mutant ?2-adrenergic receptor is constitutively desensitized and phosphorylated. Proc. Natl. Acad. Sci., USA., 91:2699-2702, 1994. PMID:7908440
  551. Pei, G., Tiberi, M., Caron, M.G. and Lefkowitz, R.J. Novel approach to the study of G protein-couple receptor kinases: An in vitro purified membrane assay reveals differential receptor specificity and regulation by G??? Proc. Natl. Acad. Sci., USA, 91:3633-3636, 1994. PMID:8170959
  552. Inglese, J., Luttrell, L.M., Iniguez-Lluhi, J., Touhara, K., Koch, W.J. and Lefkowitz, R.J. Functionally active targeting domain of the ?-adrenergic receptor kinase: An inhibitor of the G??-mediated stimulation of type II adenylyl cyclase. Proc. Natl. Acad. Sci,, USA, 91:3637-3641, 1994.PMID:8170960
  553. Touhara, K., Inglese, J., Pitcher, J., Shaw, G. and Lefkowitz, R.J. Binding of G protein ??-subunits to pleckstrin homology domains. J. Biol. Chem., 269:10217-10220, 1994.PMID:8144601
  554. Kurose, H. and Lefkowitz, R.J. Differential desensitization and phosphorylation of three cloned and transfected ?2-adrenergic receptor subtypes. J. Biol. Chem., 269:10093-10099, 1994. PMID:7908287
  555. Milano, C.A., Allen, L.F., Rockman, H.A., Dolber, P.C., McMinn, T.R., Chien, K.R., Johnson, T.D., Bond, R.A. and Lefkowitz, R.J. Markedly enhanced myocardial function in transgenic mice with cardiac overexpression of the human beta2-adrenergic receptor. Science, 264:582-586, 1994. PMID:8160017
  556. Hawes, B.E., Luttrell, L.M., Exum S.T. and Lefkowitz, R.J. Inhibition of G protein-coupled receptor signalling by expression of cytoplasmic domains of the receptor. J. Biol. Chem., 269:15776-15787, 1994.PMID:8195232
  557. Milano, C.A., Allen, L.F., Dolber, P.C. and Lefkowitz, R.J. Overexpression of a constitutively active ?1-adrenergic receptor in transgenic mice induces cardia hypertrophy. Surgical Forum, American college of Surgeons., 45:304-306, 1994.
  558. Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iniguez-Lluhi, J.A. Lefkowitz, R.J., Bourne, H.R., Jan, Y.N. and Jan, L.Y. Activation of the cloned muscarinic potassium channel by G protein ?? subunits. Nature, 370:143-146, 1994. PMID:8022483
  559. Milano, C.A., Dolber, P.C., Rockman, H.A., Bond, R.A., Venable, M.E., Allen, L.F. and Lefkowitz, R.J. Myocardial expression of a constitutively active alpha 1B-adreneric receptor in transgenic mice induces cardiac hypertrophy. Proc. Natl. Acad. Sci., USA, , 91:10109-10133, 1994. PMID:7937846
  560. Kwatra, M.M., Lefkowitz, R.J. and Caron, M.G. Partially purified and reconstituted G protein-coupled receptors as substrates of specific receptor kinases. In: Methods: A Companion to Methods in Enzymology, Reconstitution of Membrane Transport Proteins (ed. M.Montal), San Diego: Academic Press, Vol. 6(1) 11-17, 1994.
  561. Koch, W.J., Hawes, B.E., Allen, L.F. and Lefkowitz, R.J. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G?? activation of p21ras. Proc. Natl. Acad. Sci., USA, 91:12706-12710, 1994. PMID:7809106
  562. Milano, C.A., Allen, L.F., Dolber, P.C., Johnson, T.D., Rockman, H.A., Bond, R.A. and Lefkowitz, R.J. Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J. Thorac. and Cardiovasc. Surg., 109:236-241, 1995. PMID:7853876
  563. Stoffel, R.H., Randall, R.R., Premont, R.T., Lefkowitz, R.J. and Inglese, J. Palmitoylation of G protein-coupled receptor kinase, GRK6: Lipid modification diversity in the GRK family. J. Biol. Chem., 269:27791-27794, 1994. PMID:7961702
  564. Hawes, B.E., Touhara, K., Kurose, H., Lefkowitz, R.J. and Inglese, J. Determination of the G??-binding domain of phosducin: A regulatable modulator of G??-signaling. J. Biol. Chem., 269:29825-29830, 994. PMID:7961975
  565. Premont, R.T., Inglese, J. and Lefkowitz, R.J. Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J., 9:176-182, 1995. PMID:7781920
  566. Walensky, L.D., Roskams, A.J., Lefkowitz, R.J., Snyder, S.H. and Ronnett, G.V. Odorant receptors and desensitization proteins colocalize in mammalian sperm. Mol. Med., 1:130-141, 1995. PMID:8529092
  567. Inglese J., Koch, W.J., Touhara, K., and Lefkowitz, R.J. G?? interaction: factoring in pleckstrin homology domains and Ras-MAP kinase signaling pathways, TIBS, 20:151-156, 1995.PMID:7770915
  568. Lefkowitz, R.J. Rodbell and Gilman win 1994 Nobel prize for physiology and medicine. TIPS, 15:442-444, 1994. PMID:7886813
  569. Lefkowitz, R.J. G Proteins in medicine. N. Engl. J. Med., 332:186-187, 1995. PMID: 7800014
  570. Nair, L.A., Inglese, J., Stoffel, R., Koch, W.J., Lefkowitz, R.J., Kwatra and Grant, A.O. Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G??. Circ. Res., 76:832-838,
  571. 1995.PMID:7729000
  572. Koch, W.J., Rockman, H.A., Samama, P., Hamilton, R.A., Bond, R.A., Milano, C.A. and Lefkowitz, R.J. Cardiac function in transgenic mice overexpressing the ?-adrenergic receptor kinase or a ?ARK inhibitor. Science 268:1350-1353, 1995. PMID:7761854
  573. Chen, J., DeVivo, M., Dingus, J., Harry, A., Li, J., Sui, J., Carty, D.J., Blank, J.L., Exton, J., Stoffel, R.H., Inglese, J., Lefkowitz, R.J., Logothetis, D.E., Hildebrandt, J.D., and Iyengar, R. A region of adenylyl cyclase 2 critical for regulation by G protein ?? subunits. Science 268:1166-1169, 1995. PMID:7761832
  574. Bond, R.A., Leff, P., Johnson, T.D., Milano, C.A., Rockman, H.A., McMinn, T.F., Apparsundaram, S., Hyek, M.F., Kenakin, T.P., Allen, L.F. and Lefkowitz, R.J. Physiologic effects of inverse agonists in transgenic mice with myocardial overexpression of the ?2-adrenoceptor. Nature 374:272-726, 1995. PMID:7885448
  575. Pitcher, J.A., Touhara, K., Payne, E.S. and Lefkowitz, R. J. Pleckstrin homology domain-mediated membrane association and activation of the ?-adrenergic receptor kinase requires coordination with G??-subunits and lipid. J. Biol. Chem. 270:11707-11710, 1995.PMID:7744811
  576. Luttrell, L.M., Hawes, B.E., Touhara, K., van Biesen, T., Koch, W.J. and Lefkowitz, R.J. Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. J. Biol. Chem., 270:12984-12989, 1995. PMID:7768889
  577. Hawes, B.E., van Biesen, T., Koch, W.J., Luttrell, L.M., Lefkowitz, R.J. Distinct pathways of Gi and Gq-mediated mitogen activated protein kinase activation. J. Biol. Chem., 270:17148-17153, 1995. PMID:7615510
  578. Pitcher, J.A., Payne, E.S., Csortos, C., DePaoli-Roach, A.A. and Lefkowitz, R.J. The G protein-coupled receptor phosphatase: A protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc. Natl. Acad. Sci., USA, 92:8343-8347, 1995. PMID:7667292
  579. Luttrell, L.M., van Biesen, T., Hawes, B.E., Koch, W.J., Touhara, K. And Lefkowitz, R.J. G???subunits mediate MAP kinase activation by the tyrosine kinase IGF1 receptor. J. Biol. Chem., 270:16495-16498, 1995. PMID:7622449
  580. Pei, G., Kieffer, B.L., Lefkowitz, R.J. and Freedman, N.J. Agonist-dependent phosphorylation of the mouse ?-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase C. Mol. Pharmacol., 48:173-177, 1995. PMID:7651349
  581. Touhara, K., Koch, W.J., Hawes, B.E., and Lefkowitz, R,.J. Mutational analysis of the pleckstrin homology domain of the ?-adrenergic receptor kinase: Differential effects of G?? and phosphatidylinositol 4,5-biphosphate binding. J. Biol. Chem., 270:17000-17005, 1995. PMID:7622521
  582. Freedman, N.J., Liggett, S.B., Drachman, D., E., Pei, G., Caron, M. G. And Lefkowitz, R.J. Phosphorylation and desensitization of the human ?1-adrenergic receptor: Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J. Biol. Chem., 270:17953-17961, 1995. PMID:7629102
  583. Pitcher, J.A., Krueger, K.M., Touhara, K. And Lefkowitz, R.J. Recent insights into the mechanisms of agonist-specific G protein-coupled receptor desensitization and resensitization. Proceedings of the Alfred Benzon Symposium 39, Copenhagen. Editors: Thue W. Schwartz, et al., 91-106, 1996.
  584. Kingsmore, S.F., Peppel, K., Suh, D., Caron, M.G., Lefkowitz, R.J. and Seldin, M.F. Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. Mamm. Genome. 6(4):306-7, 1995. PMID:7613043
  585. Kwatra, M.M., Schreurs, J., Schwinn, D.A., Innis, M.A., Caron, M.G. and Lefkowitz, R.J. Immunaffinity purification of epitope-tagged human ?2-adrenergic receptor to homogeneity. Protein Expression and Purification, 6:717-721, 1995. PMID:8746622
  586. Touhara, K., Hawes, B.E., van Biesen, T. and Lefkowitz, R.J. G?? subunits stimulate Shc phosphorylation. Proc. Natl. Acad. Sci., USA, 92:9284-9287, 1995. PMID:7568118
  587. Hieble, J.P., Bylund, D.B., Clarke, D.E., Eikenburg, D.C., Langer, S.Z., Lefkowitz, R.J., Minneman, K.P. and Ruffolo, R.R., Jr. International Union of Pharmacology X. Recommendation for nomenclature of ?1-adrenoceptors: Consensus update. Pharmacol. Rev. 47:267-270, 1995. PMID:7568329
  588. Chen, C.K., Inglese, J., Lefkowitz, R.J. and Hurley, J.B. Ca2+dependent interaction of recoverin with rhodopsin kinase. J. Biol. Chem., 270:18060-18066, 1995. PMID:7629115M
  589. Van Biesen, T., Hawes, B.E., Luttrell, D.K., Krueger, K.M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L.M. and Lefkowitz, R.J. Receptor-tyrosine-kinase- and G??-mediated MAP kinase activation by a common signaling pathway. Nature 376:781-784, 1995.PMID:7651538
  590. Desensitization of G protein-coupled receptors. Freedman, N.J. and Lefkowitz, R.J. In: 1995 Recent Progress in Hormone Research Proceedings, 51:319-353, 1996. PMID:8701085
  591. Luttrell, L.M., van Biesen, T., Hawes,,, B.E., Koch, W.J., Krueger, K.M., Touhara, K. and Lefkowitz, R.J. G protein-coupled receptors and their regulation: Activation of the MAP kinase signaling pathway by G protein-coupled receptors. In: Advances in Second Messenger and Phosphorprotein Research, (Eds. Drs. Jackie Corbin and Sharron Francis), Raven Press, New York, New York, 31:263-277, 1997.
  592. Koch, W.J., Milano, C.A. and Lefkowitz, R.J. Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. Circ. Res., 78:511-516, 1996. PMID:8635207
  593. van Biesen, T., Hawes, B.E., Raymond, J.R., Luttrell, L.M., Koch, W.J. and Lefkowitz, R.J. Go-protein ?-subunits activate mitogen-activated protein kinase via a novel PKC-dependent mechanism. J. Biol. Chem., 271:1266-1269, 1996. PMID:8576109
  594. Diversé-Pierluissi, M., Inglese, J., Stoffel, R.H., Lefkowitz, R.J. and Dunlap, K. G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced calcium channel inhibition. Neuron, 16:579-585, 1996. PMID:8785055
  595. Premont, R.T., Macrae, A.D., Stoffell, R.H., Chung, N., Pitcher, J., Ambrose, C., Inglese, J., MacDonald, M.E. and Lefkowitz, R.J., Characterization of the G protein-coupled receptor kinase GRK4. J. Biol. Chem., 271:6403-6410, 1996. PMID:8626439
  596. Hoffman, B.B. and Lefkowitz, R.J. Goodman and Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, Chapter 6, pp. 105-139. The autonomic and somatic motor nervous systems, (Eds. J.G. Hardman and L.E. Limbird, P.B. Molinoff, R.W. Ruddon, and A.G. Gilman) Macmillan Publishing Co., New York, 1996.
  597. Hoffman, B.B. and Lefkowitz, R.J. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists. Goodman and Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, Chapter 10, pp. 199-248, (Eds. J.G. Hardman and L.E. Limbird, P.B. Molinoff, R.W. Ruddon, and A.G. Gilman) Macmillan Publishing Co., New York, 1996.
  598. Rockman, H.A., Hamilton, R.A., Jones, L.R., Milano, C.A., Mao, L. and Lefkowitz, R.J. Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the ?2-adrenergic receptor is associated with reduced phospholamban protein. J. Clin. Invest., 97:1618-1623, 1996. PMCID:PMC507225
  599. Tiberi, M., Nash, S.R., Bertrand, L., Lefkowitz, R.J. and Caron, M.G. Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. J. Biol. Chem. 271:3771-3778, 1996. PMID:8631993
  600. Lefkowitz, R.J. G protein-coupled receptors and receptor kinases: From molecular biology to potential therapeutic applications. Nature Biotechnology. 14:283-286, 1996. PMID:9630887
  601. Opperman, M., Freedman, N.J., Alexander, R.W. and Lefkowitz, R.J. Phosphorylation of the type-1A antiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J. Biol. Chem., 271:13266-13272, 1996.PMID:8662816
  602. Fredericks, Z.L., Pitcher, J.A. and Lefkowitz, R.J. Identification of the G Protein-coupled receptor kinase phosphorylation sites in the Human ?2-adrenergic receptor. J. Biol. Chem., 271:13796-13803, 1996. PMID:8662852
  603. Ménard, L., Ferguson, S.G., Barak, L.S., Bertrand, L., Premont, R.T., Colapietro, A-M., Lefkowitz, R.J. and Caron, M.G. Members of the G protein-coupled receptor kinase family that phosphorylate the ?2-adrenergic receptor facilitate sequestration. Biochemistry 35:4155-4160, 1996. PMID:8672451
  604. Oppermann, M., Diversé-Pierluissi, M., Drazner, M.H., Dyer, S.L., Freedman, N.J., Peppel, K.C. and Lefkowitz, R.J. Monoclonal antibodies reveal receptor specificity among G protein-coupled receptor kinases. Proc. Natl. Acad. Sci., USA, 93:7649-7654, 1996. PMID:8755530
  605. Hawes, B.E., Luttrell, L.M., van Biesen, T. and Lefkowitz, R.J. Phosphatidylinositol 3-kinase is an early intermediate in the G??-mediated mitogen activated protein kinase signaling pathway. J. Biol. Chem., 271:12133-12136, 1996. PMID:8647803
  606. Pitcher, J.A., Fredericks, Z.L., Stone, W.C., Premont, R.T., Stoffel, R.H., Koch, W.J. and Lefkowitz, R.J. Phosphatidylinositol-4,5-biphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity; location, structure and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J. Biol. Chem., 271:24907-24913, 1996. PMID:8798768
  607. Macrae, A.D., Premont, R.T., Jaber, M., Peterson, A.S. and Lefkowitz, R.J. Cloning, characterization and chromosomal localization of Rec1.3, a member of the G protein-coupled receptor family highly expressed in brain. Molec. Brain Res., 42:245-254, 1996. PMID:9013780
  608. Luttrell, L.M., Hawes, B.E., van Biesen, T., Luttrell, D.K., Lansing, T.J. and Lefkowitz, R.J. Role of c-Src tyrosine kinase in G protein-coupled receptor- and G ?? subunit-mediated activation of mitogen activated protein kinases. J. Biol. Chem., 271:19443-19450, 1996. PMID:8702633
  609. Rockman, H.A., Choy, D-J., Rahman, N.U., Akhter, S.A., Lefkowitz, R.J. and Koch, W.J. Receptor specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc. Natl. Acad. Sci., USA, 93:9954-9959, 1996. PMID:8790438
  610. Bond, R.A. and Lefkowitz, R.J. The third beta is not the charm. J. Clin. Invest., 98:241, 1996.PMID:8755628
  611. Jaber, M., Koch, W.J., Rockman, H.A., Smith, B., Bond, R.A., Sulik, K., Lefkowitz, R.J., Caron, M.G. and Giros, B. Essential role of ?-adrenergic receptor kinase 1 in cardiac development and function. Proc. Natl. Acad. Sci., USA, 93:12974-12979, 1996.PMID:8917529
  612. Rockman, H.A., Koch, W.J., and Lefkowitz, R.J. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am. J. Physiol. 272(Heart Circ. Physiol. 41): H1553-H1559, 1997. PMID:9139936
  613. Krueger, K.M., Daaka, Y., Pitcher, J.A. and Lefkowitz, R.J. The role of sequestration in G protein-coupled receptor resensitization: Regulation of ?2-adrenergic receptor dephosphorylation by vesicular acidification. J. Biol. Chem., 272:5-8, 1997. PMID:8995214
  614. Samama, P., Bond, R.A., Rockman, H.A., Milano, C.A. and Lefkowitz, R.J. Ligand-induced overexpression of a constitutively active ?2-adrenergic adrenoceptor: Pharmacological creation of a phenotype in transgenic mice. Proc. Natl. Acad. Sci., USA, 94:137-141, 1997. PMID:8990174
  615. Rockman, H.A., Koch, W.J., Milano, C.A. and Lefkowitz, R.J. Myocardial ?-adrenergic receptor signaling in vivo: Insights from transgenic mice. J. Molec. Med. 74:489-495, 1996. PMID:8892053
  616. Zhang, J., Ferguson, S.S.G., Barak, L.S., Jaber, M., Giros, B., Lefkowitz, R.J. and Caron, M.G. Molecular mechanisms of G protein-coupled receptor signaling: Role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. Receptors and Channels, 5:193-199, 1997. PMID:9606723
  617. Boekoff, I., Touhara, K., Danner, S., Inglese, J., Lohse, M.J., Breer, H. and Lefkowitz, R.J. Phosducin: Potential role in modulation of olfactory signaling. J. Biol. Chem., 272:4606-4613, 1997. PMID:9020189
  618. Luttrell, L.M., Della Rocca, G.J., van Biesen, T., Luttrell, D.K. and Lefkowitz, R.J. G?? subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor: A scaffold for G protein-coupled receptor-mediated Ras activation. J. Biol. Chem., 272:4637-4644, 1997. PMID:9020193
  619. van Biesen, T., Luttrell, L.M., Hawes, B.E. and Lefkowitz, R.J. Mitogenic signaling via G protein-coupled receptors. Endocr. Rev., 17:698-714, 1996. PMID:8969974
  620. Garnovskaya, M.S., van Biesen, T., Hawes, B., Ramos, S.C., Lefkowitz, R.J., and Raymond, R.J. Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein ??-subunit-initiated pathway. Biochemistry 35:13716-13722, 1996. PMID:8901512
  621. Daaka, Y., Pitcher, J.A., Richardson, M., Stoffel, R.H., Robishaw, J.E. and Lefkowitz, R.J. Receptor and G?? isoform-specific interactions with G protein-coupled receptor kinases. Proc. Natl. Acad. Sci., USA, 94:2180-2185, 1997. PMID:9122168
  622. Drazner, M.H., Peppel, K.C., Dyer, S., Grant, A.O., Koch, W.J. and Lefkowitz, R.J. Potentiation of ?-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. J. Clin. Invest., 99:288-296, 1997. PMID:9005997
  623. Drazner, M.H., Koch, W.J. and Lefkowitz, R.J. Potentiation of ?-adrenergic signaling by gene transfer. Proc. Assoc. Amer. Phys., 109:220-227, 1997. PMID:9154638
  624. Sizmann, D., Kuusinen, H., Keranen, S., Lomasney, J., Caron, M.G., Lefkowitz, R.J. and Keinanem, K. Production of adrenergic receptors in yeast. Receptors and Channels 4:197-203, 1997. PMID:9014242
  625. Stoffel, III, R.H., Pitcher, J.A. and Lefkowitz, R.J. Targeting G protein-coupled receptor kinases to their receptor substrates. J. Membr. Biol. 157:1-8, 1997. PMID:9141353
  626. Menard, L., Ferguson, S.S.G., Zhang, J., Lin, F-T., Lefkowitz, R.J., Caron, M.D., Barak, L.S. Synergistic regulation of ?2-adrenergic receptor sequestration: Intracellular complement of ?ARK and ?arrestin determine kinetics of internalization. Mol. Pharmacol., 51:800-808, 1997. PMID:9145918
  627. Bittner, H.B., Chen, E.P., Milano, C.A., Lefkowitz, R.J. and Van Tright, P. Functional analysis of myocardial performance in murine hearts overexpressing the ?2-adrenergic receptor. J. Mol. Cell Cardiol., 29:961-967, 1997. PMID:9152857
  628. Korzick, D.H., Xiao, R-P., Ziman, B.D., Koch, W.J., Lefkowitz, and Lakatta, E.G. Transgenic manipulation of ?-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. Am. J. Physiol. 272:H590-H596, 1997. PMID:9038983
  629. Freedman, N.J., Ament, A.S., Oppermann, M., Stoffel, R.H., Exum, S.T. and Lefkowitz, R.J. Phosphorylation and desensitization of human endothelin A and B receptors: Evidence for G protein-coupled receptor specificity. J. Biol. Chem., 272:17734-17743, 1997. PMID:9211925
  630. Della Rocca, G.J., van Biesen, T., Daaka, Y., Luttrell, D.K., Luttrell, L.M. and Lefkowitz, R.J. Ras-dependent MAP kinase activation by G protein-coupled receptors: Convergence of Gi- and Gq -mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J. Biol. Chem., 272:19125-19132, 1997. PMID:9235901
  631. Luttrell, L.M., van Biesen, T., Hawes, B.E., Della Rocca, G.J., Luttrell, D.K. and Lefkowitz, R.J. Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. Advances in Pharmacology 42:466-470, 1997. Academic Press, San Diego, CA, David Goldstein, Editor.PMID:9327940
  632. Lefkowitz, R.J., Pitcher, J., Krueger, K., and Daaka, Y. Mechanisms of ?-adrenergic receptor desensitization and resensitization. Advances in Pharmacology 42:416-419, 1997. Academic Press, Dan Diego, CA, David Goldstein, Editor. PMID:9327928
  633. Koch, W.J., Lefkowitz, R.J., Milano, C.A., Akhter, S.A. and Rockman, H.A. Myocardial overexpression of adrenergic receptors and receptor kinases. Advances in Pharmacology 42:502-506, 1997. Academic Press, San Diego, CA, David Goldstein, Editor. PMID:9327950
  634. Akhter, S.A., Milano, C.A., Shotwell, K.F., M-C. Cho, Rockman, H.A., Lefkowitz, R.J. and Koch, W.J. Transgenic mice with cardiac overexpression of ?1B-adrenergic receptors; in vivo ?1-mediated regulation of ?-adrenergic signaling. J. Biol. Chem., 272:21253-21259, 1997.PMID:9261135
  635. Peppel, K., Boekoff, I., McDonald, P., Breer, H., Caron, M.G. and Lefkowitz, R.J. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J. Biol. Chem., 272:25425-25428, 1997. PMID:9325250
  636. Daaka, Y., Luttrell, L. and Lefkowitz, R.J. Switching of the coupling of the ?2-adrenergic receptor to different G proteins by protein kinase A.. Nature, 390:88-91, 1997. PMID:9363896
  637. Akhter, S.A., Skaer, C., Kypson, A.P., McDonald, P.H., Peppel, K.C., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Restoration of ?-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl. Acad. Sci., USA, 94:12100-12105, 1997. PMID:9342369
  638. Lin, F-T., Krueger, K.M., Kendall, H.E., Daaka, Y., Fredericks, Z.L., Pitcher, J.A. and Lefkowitz, R.J. Clathrin-mediated endocytosis of the ?-adrenergic receptor is regulated by phosphorylation/ dephosphorylation of ?-arrestin1. J. Biol. Chem., 272:31051-31057, 1997. PMID:9388255
  639. Luttrell, L.M., Daaka, Y., Della Rocca, G.J. and Lefkowitz, R.J. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts: Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. J. Biol. Chem., 272:31648-31656, 1997. PMID:9395506
  640. Macrae, A.D. and Lefkowitz, R.J. The function and regulation of the G protein-coupled receptor kinases. In: Hormones and Signaling, O'Mally, B.W., Ed., Academic Press, San Diego, CA. vol. 1:65-88, 1997.
  641. Daaka, Y., Luttrell, L.M., Ahn, S., Della Rocca, G.J., Ferguson, S.S.G., Caron, M.G. and Lefkowitz, R.J. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J. Biol. Chem., 273:685-688, 1998. PMID:9422717
  642. Ledent, C., Denef, J-F., Cotecchia, S., Lefkowitz, R.J., Dumont, J., Vassart, G. and Parmentier, M. Costimulation of adenylyl cyclase and phospholipase C by a mutant ?1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. Endocrinology 138:369-378, 1997. PMID:8977426
  643. Ishizaka, N., Alexander, R.W., Laursen, J.B., Kai, H., Fukuit, T., Oppermann, M., Lefkowitz, R.J., Lyons, P.R. and Griendling, K.K. G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. J. Biol. Chem. 272:32482-32488, 1997. PMID:9405459
  644. Hall, R.A., Premont, R.T., Chow, C-W., Blitzer, J.T., Pitcher, J.A., Claing, A., Stoffel, R.H., Barak, L.S., Shenolikar, S., Weinman, E.J., Grinstein, S. and Lefkowitz, R.J. The ?2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature, 392:626-630, 1998. PMID:9560162
  645. Della Rocca, G.J., Lefkowitz, R.J. and Koch, W.J. Methods of sequestering ?? in the intact cell. In: G Proteins: Techniques of Analysis, Ed. David R. Manning, CRC Press LLC, Boca Raton, FL, pp: 247-267, 1999.
  646. Ford, C.E., Skiba, N.P., Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rosal, R., Weng, G., Yang, C-S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J., and Hamm, H.E. Molecular basis for interactions of G protein ?? subunits with effectors. Science, 280:1271-1274, 1998. PMID:9596582
  647. Pitcher, J.A., Hall, R.A., Daaka, Y., Zhang, J., Ferguson, S.S.G., Hester, S., Miller, S., Caron, M.G., Lefkowitz, R.J. and Blarak, L.S. The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. J. Biol. Chem., 273:12316-12324, 1998. PMID:9575184
  648. Akhter, S.A., Luttrell, L.M., Rockman, H.A., Lefkowitz, R.J. and Koch, W.J. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science, 280:574-577, 1998. PMID:9554846
  649. Davies, M.G., Huynh, T.T.T., Fulton, G.J., Lefkowitz, R.J., Svendsen, E., Hagen, P-O. and Koch, W.J. G-protein signaling and vein graft intimal hyperplasia. Reduction of intimal hyperplasia in vein grafts by a G?? inhibitor suggests a major role of G-protein signaling in lesion development. Arterioscler. Thromb. Vasc. Biol., 18(8):1275-1280, 1998.
  650. Lefkowitz, R.J. G protein-coupled receptors. New roles for receptor kinases and ?-arrestins in receptor signaling and desensitization J. Biol. Chem., 273:18677-18680, 1998. PMID:9668034
  651. Koch, W.J. and Lefkowitz, R.J. Contemporary Endocrinology G-Proteins and Disease, Chapter 6, pp. 271-283. Altering adrenergic signaling and cardiac function in transgenic mice, (Ed. Allen M. Spiegel) Humana Press, Totowa, N.J., 1998.
  652. Rockman, H.A., Chien, K.R., Choi, D-J., Iaccarino, G., Hunter, J.J., Ross, R., Jr., Lefkowitz, R.J. and Koch, W.J. Expression of a ?-adrenergic receptor kinase1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc. Natl. Acad. Sci., USA, 95:7000-7005, 1998. PMID:9618528
  653. Kypson, A.P., Peppel, K., Akhter, S.A., Lily, R.E., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Ex vivo adenoviral-mediated gene transfer to the transplanted adult rat heart. J. Thorac. And Cardiovascular Surg. 115:623-630, 1998. PMID:9535450
  654. Rockman, H.A., Choi, D-J., Akhter, S.A., Jaber, M., Giros, B., Lefkowitz, R.J., Caron, M.G. and Koch, W.J. Control of myocardial contractile function by the level of ?-adrenergic receptor kinase1 in gene targeted mice. J. Biol. Chem., 273:18180-18184, 1998. PMID:9660778
  655. Snow, B.E., Hall, R.A., Krumins, A., Brothers, G.M., Bouchard, D., Brothers, C.A., Mangion, J., Chung, S., Gilman, A.G., Lefkowitz, R.J. and Siderovski, D.P. Characterization of RGS12: GTPase activating specificity of the RGS domain and binding specificity of an alternatively spliced PDZ domain. J. Biol. Chem., 273:17749-17755, 1998. PMID:9651375
  656. Hall, R.A., Ostegaard, L.S., Premont, R.T., Blitzer, J.T., Rahman, N., Welsh, M.J. and Lefkowitz, R.J. A carboxyl-terminal motif found in the ?2-adrenergic receptor, P2Y1 receptor and CFTR determines binding to the NHERF family of PDZ proteins. Proc. Natl. Acad. Sci., 95:8496-8501, 1998. PMID:9671706
  657. Freeman, J.L.R., De La Cruz, E.M., Pollard, T.D., Lefkowitz, R.J., and Pitcher J.A. Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. J. Biol. Chem., 273:20653-20657, 1998. PMID:9685424
  658. Gaballa, M.A., Peppel, K., Lefkowitz, R.J., Aguirre, M., Dolber, P.C., Pennock, G.D., Koch, W.J., and Goldman, S. Enhanced vasorelaxation by overexpression of ?2-adrenergic receptors in large arteries. J. Molec. Cell Cardiol. 30:1037-1045, 1998. PMID:9618244
  659. Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., and Koch, W.J. Reciprocal invivo regulation of myocardial G protein-coupled receptor kinase expression by ?-adrenergic receptor stimulation and blockade. Circulation, 98:1783-1789, 1998. PMID:9788834
  660. Stoffel, R.H., Inglese, J., Macrae, A.D., Lefkowitz, R.J., and Premont, R.T. Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase GRK6. Biochemistry, 37:16053-16059, 1998. PMID:9819198
  661. Pitcher, J.A., Freedman, N.J., and Lefkowitz, R.J. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67:653-692, 1998. PMID:9759500
  662. Xiao, R-P., Avdonin, P., Zhou, Y-Y., Cheng, H., Akhter, S.A., Eschenhagen, T., Lefkowitz, R.J., Koch, W.J. and Lakatta E.G. Coupling of ?2-adrenergic receptor to GI proteins and its physiological relevance in murine cardiac myocytes. Circ. Res., 84:43-52, 1999. PMID:9915773
  663. Iaccarino, G., Dolber, P.C., Lefkowitz, R.J., and Koch, W.J. ?ARK1 levels in catecholamine-induced myocardial hypertrophy: Regulation by ? but not ?1 adrenergic stimulation. Hypertension, 33(partII) 396-401, 1999. PMID:9931136
  664. Premont, R.T., Claing, A., Vitale, N., Freeman, J.L.R., Pitcher, J.A., Patton, W.A., Moss, J., Vaughan, M. and Lefkowitz, R.J. ?2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ARF GAP. Proc. Natl. Acad. Sci., USA, 95:14082-14087, 1998. PMID:9826657
  665. Luttrell, L.M., Ferguson, S.S.G., Daaka, Y., Miller, W.E., Maudsley, S., Della Rocca, G.J., Lin, F-T., Kawakatsu, H., Owada, K., Luttrell, D.K., Caron, M.G. and Lefkowitz, R.J. ?-arrestin-dependent formation of ?2-adrenergic receptor/Src kinase complexes and mitogenic signaling. Science, 283:655-661, 1999. PMID:9924018
  666. Lin, F-T., Daaka, Y. and Lefkowitz, R.J. ?-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J. Biol. Chem. 273:31640-31643, 1998. PMID:9822622
  667. Ahn, S., Maudsley, S., Luttrell, L.M., Lefkowitz, R.J., and Daaka, Y. Src-mediated tyrosine phosphorylation of dynamin is required for ?-adrenergic receptor internalization and MAPK signaling. J. Biol. Chem., 274:1185-1188, 1999. PMID:9880482
  668. Della Rocca, G.J., Mukhin, Y.V., Garnovskaya, M.N., Daaka, Y., Clark, B., Luttrell, L.M., Lefkowitz, R.J. and Raymond, J.R. Serotonin 5-HT1A receptor-mediated MAP kinase activation requires calcium/calmodulin-dependent receptor endocytosis. J. Biol. Chem., 274:4749-4753, 1999. PMID:9988712
  669. Iaccarino, G., Lefkowitz, R.J., and Koch, W.J. Myocardial G protein coupled receptor kinases: Implications for heart failure therapy. Proc. Am. Assoc. Phys., 111:399-405, 1999.
  670. McDonald, P.H., Cote, H.L., Lin, F-T., Premont, R.T., Pitcher, J.A. and Lefkowitz, R.J. Identification of NSF as a ?-arrestin1 binding protein; implications for ?2-AR regulation. J. Biol. Chem., 274:10677-10680, 1999. PMID:10196135
  671. Kypson, A.P., Hendrickson, S.C., Akhter, S.A., Wilson, K., McDonald, P.H., Lilly, R.E., Dolber, P.C., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Adenovirus-mediated gene transfer of the ?2-adrenergic receptor to donor hearts enhances cardiac function. Gene Therapy, 6:1298-1304, 1999. PMID:10455439
  672. Luttrell, L.M., Daaka, Y. and Lefkowitz, R.J. Regulation of tyrosine kinase cascades by G-protein coupled receptors. Current Opinion in Cell Biology, 11:177-183, 1999. PMID:10209148
  673. Iaccarino, G., Smithwick, L.A., Lefkowitz, R.J. and Koch, W.J. Targeting G?? signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis. Proc. Natl. Acad. Sci., USA, 96:3945-3950, 1999. PMID:10097143
  674. An, R., Heath, B.M., Higgins, J.P., Koch, W.J., Lefkowitz, R.J. and Kass, R.S. β2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. J. Physiol. (Lond) 516:19-30, 1999. PMID:10066919
  675. Akhter, S.A., Eckhart, A.D., Rockman, H.A., Shotwell, K., Lefkowitz, R.J. and Koch, W.J. In vivo inhibition of elevated myocardial ?-adrenergic receptor kinase activity in hybrid transgenic mice restores normal ?-adrenergic signaling and function. Circulation, 100:648-653, 1999. PMID:10441103
  676. Della Rocca, G.J., Maudsley, S., Daaka, Y., Lefkowitz, R.J. and Luttrell, L.M. Pleiotropic coupling of G protein-coupled receptors to the MAP kinase cascade: Role of focal adhesions and receptor tyrosine kinase. J. Biol. Chem., 274:13978-13794, 1999. PMID:10318809
  677. Walker, J.K.L., Peppel, K., Lefkowitz, R.J., Caron, M.G. and Fisher, J.T. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. Am. J. Physiol. 276:1214-1221, 1999. PMID:10198406
  678. Lin, F-T., Miller, W.E., Luttrell, L.M. and Lefkowitz, R.J. Feedback regulation of ?-arrestin1 function by extracellular signal-regulated kinases. J. Biol. Chem., 274:15971-15974, 1999. PMID:10347142
  679. Koch, W.J., Lefkowitz, R.J. and Rockman, H.A. Functional consequences of altering myocardial adrenergic receptor signaling. Annu. Rev. Physiol., 62:237-260, 2000. PMID:10845091
  680. Maurice, J.P., Hata, J.A., Shah, A.S., White, D.C., McDonald, P.H., Dolber, P.C., Wilson, K.H., Lefkowitz, R.J., Glower, D.D. and Koch, W.J. Enhancement of cardiac function following adenoviral-mediated invivo intracoronary ?2-adrenergic receptor gene delivery. J. Clin. Invest., 104:21-29, 1999. PMID:PMC408402
  681. Hall, R.A., Spurney, R.F., Premont, R.T., Rahman, N., Blitzer, J.T., Pitcher, J.A. and Lefkowitz, R.J. G protein-coupled receptor kinase 6A phosphorylates the Na+/H+ exchanger regulatory factor (NHERF) via a PDZ domain-mediated interaction. J. Biol. Chem., 274:24328-24334, 1999. PMID:10446210
  682. Hall, R.A., Premont, R.T. and Lefkowitz, R.J. Heptahelical receptor signaling: Beyond the G protein paradigm. J. Cell Biol, 145:927-932, 1999. PMID:10352011
  683. Premont, R.T., Macrae, A.D., Aparicio, A.A.J.R., Kendall, H.E., Welch, J.E. and Lefkowitz, R.J. The GRK4 subfamily of G protein-coupled receptor kinases: Alternative splicing, gene organization and sequence conservation. J. Biol. Chem., 274:29381-29389, 1999. PMID:10506199
  684. Pitcher, J.A. and Lefkowitz, R.J. The G protein-coupled receptor phosphatase. Regulation of G protein-coupled receptor function and expression. Ed. Jeffrey L. Benovic, Wiley-Liss, Inc., NY, NY, 179-195, 1999.
  685. Pitcher, J.A., Tesmer, J.J.G., Freeman, J.L.R., Capel, W.D., Stone, W.C. and Lefkowitz, R.J. Feedback inhibition of GRK2 activity by extracellular signal-regulated kinases. J. Biol. Chem., 274:34531-34534, 1999. PMID:10574913
  686. Tang, Y., Hu, L.A., Miller, W.E., Ringstad, N., Hall, R.A., Pitcher, J.A., DeCamilli, P and Lefkowitz, R.J. Indentification of the endophelins (SH3p4/p3/p13) as novel binding partners for the ?1-adrenergic receptor. Proc. Natl. Acad. Sci., USA, 96:12559-12564, 1999. PMID:10535961
  687. Gainetdinov, R.R., Bohn, L.M., Walker, J.K.L., Leporte, S.A., Macrae, A.D., Caron, M.G., Lefkowitz, R.J. and Premont, R.T. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron, 24:1029-1036, 1999. PMID:10624964
  688. Cross, H.R., Steenbergen, C., Lefkowitz, R.J., Koch, W.J. and Murphy E. Overexpression of the cardiac ?2-adrenergic receptor and expression of a ?ARK1 inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. Circ. Res., 85:1077-1084, 1999. PMID:10571539
  689. Eckhart, A.D., Duncan, S.J., Penn, R.B., Benovic, J.L., Lefkowitz, R.J. and Koch, R.J. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases. Circ. Res., 86:43-50, 2000. PMID:10625304
  690. Lefkowitz, R.J., Rockman, H.A. and Koch, W.J. Catecholamines, cardiac "?" adrenergic receptors and heart failure. Circulation, 101:1634-1637, 2000. PMID:10758041
  691. Bohn, L.M., Lefkowitz, R.J. Gainetdinov, R.R., Peppel, K., Caron, M.D. and Lin, F-T. Enhanced morphine analgesia in mice lacking ?arrestin-2. Science, 286:2495-2498, 1999. PMID:10617462
  692. Claing, A., Perry, S.J., Achiriloaie, M., Walker, J.K.L., Albanesi, J.P., Lefkowitz, R.J., Premont, R. T. Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proc. Natl. Acad. Sci., USA, 97:1119-1124, 2000. PMID:10655494
  693. Pierce, K.L., Maudsley, S., Daaka, Y., Luttrell, L.M. and Lefkowitz, R.J. Role of endocytosis in the activation of the ERK cascade by sequestering and non-sequestering G protein-coupled receptors. Proc. Natl. Acad. Sci., USA, 97:1489-1494, 2000. PMID:10677489
  694. Maudsley, S., Pierce, K.L., Zamah, A.M., Miller, W.E., Ahn, S., Daaka, Y., Lefkowitz, R.J. and Luttrell, L.M. The ?2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor. J. Biol. Chem., 275:9572-9580, 2000.
  695. Miller, W.E., Maudsley, S., Ahn, S., Khan, K.D., Luttrell, L.M. and Lefkowitz, R.J. ?-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC: Role of ?-arrestin1 dependent targeting of c-SRC in receptor endocytosis. J. Biol. Chem., 275:11312-11319, 2000. PMID:10753943
  696. Shah, A.S. Lilly E., Kypson, A.P., Tai, O., Hatta, J.A., Pippen, A., Silvestry, S.C., Lefkowitz, R.J., Glower, D. and Koch, W.J. Intracoronary adenovirus-mediated delivery and overexpression of the 101:408-414, 2000.?2-adrenergic receptor in the heart. Prospects for molecular ventricular assistance. Circulation 101:408-414, 2000. PMID:10653833
  697. White, D.C., Hata, J.A., Shah, A.S., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Preservation of myocardial ?-adrenergic receptor signaling delays the development of heart failure following myocardial infarction. Proc. Natl. Acad. Sci., USA, 97:5428-5433, 2000. PMID:10779554
  698. Fraser, I.D.C., Cong, M., Kim, J., Rollins, E.N., Daaka, Y., Lefkowitz, R.J. and Scott, J.D. Assembly of an A kinase-anchoring protein-?2-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr. Biol., 10:409-412, 2000. PMID:10753752
  699. Premont, R.T., Claing, A., Vitale, N., Perry, S.J. and Lefkowitz. R.J. The GIT family of ARF GTPase-activating proteins: Functional diversity of GIT2 through alternative splicing. J. Biol. Chem., 275:22373-22380, 2000. PMID:10896954
  700. Vitale, N., Patton, W.A., Moss, J., Vaughan, N., Lefkowitz, R.J. and Premont, R.T. GIT proteins, a novel family of phosphatidylinositol, 3,4,5-triphosphate-stimulated GTPase-activating proteins for ARF6. J. Biol. Chem., 275:13901-13906, 2000. PMID:10788515
  701. Zhang, S.J., Cheng, H., Zhou, Y.Y., Wang, D.J., Zhu, W., Ziman, B., Spurgeion, H., Lefkowitz, R.J., Lakatta, E.G., Koch, W.J., and Xiao, R.P. Inhibition of spontaneous ?2-adrenergic activation rescues ?1-adrenergic contractile response in cardiomyocytes overexpressing ?2-adrenoceptor. J. Biol. Chem., 275:21773-21779, 2000. PMID:10787424
  702. Freeman, J.L.R., Pitcher, J.A., Li, X., Bennett, V. and Lefkowitz, R.J. ?-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. FEBS Letters 473:280-284, 2000. PMID:10818226
  703. Lefkowitz, R.J. The superfamily of heptahelical receptors. Nature Cell Biology 2:E132-E136, 2000.
  704. Maudsley, S., Zamah, A.M., Rahman, N., Blitzer, J.T., Luttrell, L.M., Lefkowitz, R.J. and Hall, R.A. PDGF receptor association with the Na+/H+ exchanger regulatory factor (NHERF) potentiates receptor activity. Molec. and Cellular Biol., 20/22;8352-8363, 2000. PMID:11046132
  705. Hu, L.A., Tang, Y., Miller, W.E., Cong, M., Lefkowitz, R.J. and Hall. R.A. ?1-adrenergic receptor association with PSD-95: Inhibition of receptor internalization and facilitation of ?1-adrenergic receptor interaction with NMDA receptors. J. Biol. Chem. 275:38659-38666, 2000. PMID:10995758
  706. McDonald, P.H., Chow, C-W., Miller, W.E., Laporte, S.A., Field, M.E., Lin, F-T., Davis, R.J., and Lefkowitz, R.J. ?arrestin2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science, 290:1574-1577, 2000. PMID:11090355
  707. Cao, W., Luttrell, L.M., Medvedev, A.V., Pierce, K.L., Daniel, K.W., Dixon, T.M., Lefkowitz, R.J., and Collins, S. Direct binding of activated c-Src to the ?3-adrenergic receptor is required for MAP kinase activation. J. Biol. Chem., 275:38131-38134, 2000. PMID:11013230
  708. Shah, A.S., White, D.C., Emani, S., Kypson, A.P., Lilly, E., Wilson, K., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. In vivo ventricular gene delivery of a ?-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 103:1311-1316, 2001. PMID:11238278
  709. Bohn, L.M., Gainetdinov, R.R., Lin, F-T., Lefkowitz, R.J., and Caron, M.G. Mu opioid receptor desensitization by ?Arrestin2 determines morphine tolerance but not dependence. Nature 408:720-723, 2000. PMID:11130073
  710. Gainetdinov, R.R., Premont, R.T., Caron, M.G., and Lefkowitz, R.J. Receptor specificity of G-protein-coupled receptor kinases. TIPS 21:366-367, 2000. PMID:11050311
  711. Miller, W.E. and Lefkowitz, R.J. Expanding roles for ?-arrestins as scaffolds/adapters in GPCR signaling and trafficking. Current Opinion in Cell Biology 13:139-146, 2001. PMID:11248546
  712. Pierce, K.L., Luttrell, L.M., and Lefkowitz, R.J. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539, 2001.PMID:11313899
  713. Lefkowitz, R.J., and Willerson, J.T. Opportunities in cardiovascular research. JAMA 285:581-586, 2001. PMID:11176863
  714. Zhu, W-Z, Zheng, M., Koch, W.J., Lefkowitz, R.J., Kobilka, B.K., and Xiao, R-P. Dual modulation of cell survival and cell death by ?2-adrenergic signaling in adult mouse cardiac myocytes. Proc. Natl. Acad. Sci., USA, 98:1607-1612, 2001. PMID:11171998
  715. Luttrell, L.M., Roudabush, F.L., Choy, E.W., Miller, W.E., Field, M.E., Pierce, K.L., and Lefkowitz, R.J. Activation and targeting of extracellular signal-regulated kinases by ?arrestin scaffolds. Proc. Natl. Acad. Sci., USA, 98:2449-2454, 2001. PMID:11226259
  716. Kohout, T.A., Lin, F-T., Perry, S.J., Conner, D.A., and Lefkowitz, R.J. ?Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci., USA, 98:1601-1606, 2001. PMID:11171997
  717. Cong, M., Perry, S.J., Lin, F-T., Fraser, I.D., Hu, L.A., Chen, W., Pitcher, J.A., Scott, J.D., and Lefkowitz, R.J. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J. Biol. Chem., 276:15192-15199, 2001. PMID:11278469
  718. Miller, W.E. and Lefkowitz, R.J. Arrestins as signaling molecules involved in apoptotic pathways: A real eye opener. Science's STKE: http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/69/ pe1?ijkey=EzYNE9b31SJcI&keytype=ref&siteid=sigtrans, 2001.
  719. Pierce, K.L., Tohgo, A., Ahn, S, Field, M.E., Luttrell, L.M., and Lefkowitz, R.J. Epidermal growth factor receptor dependent ERK activation by G protein-coupled receptors: A co-culture system for identifying intermediates upstream and downstream of HB-EGF shedding. J. Biol. Chem. 276:23155-23160, 2001. PMID:11290747
  720. Harding, V. B., Jones, L. R., Lefkowitz, R.J., Koch, W.J., and Rockman, H.A. Cardiac ?ARK1 inhibition prolongs survival and augments ? blocker therapy in a mouse model of severe heart failure. Proc. Natl. Acad. Sci. USA, 98:5809-5814, 2001. PMID:11331748
  721. Freeman, K., Lerman, I., Kranias, E.G., Bohlmeyer, T., Bristow, M.R., Lefkowitz, R.J., Iaccarino, G., Koch, W.J. and Leinwand, L.A. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J. Clin. Invest. 107:967-974, 2001. PMCID:PMC199560
  722. Iaccarino, G., Keys, J.R., Rapacciuolo, A., Shotwell, K.F., Lefkowitz, R.J., Rockman, H.A., and Koch, W.J. Regulation of the myocardial ?ARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing ?1B-adrenergic receptors. J. Am. Coll. Cardiol., 38:534-540, 2001. PMID:11499749
  723. Miller, W.E., McDonald, P.H., Cai, S.F., Field, M.E., Davis, R.J., and Lefkowitz, R.J. Identification of a motif in the carboxy terminus of ?-arrestin2 responsible for activation of JNK3. J. Biol. Chem., 276:27770-27780, 2001. PMID:11356842
  724. Lefkowitz, R.J. 2001: An AAP Odyssey, Association of American Physicians Presidential Address. J. Clin. Invest. , 108:S9-S13, 2001. PMID:11669075
  725. Pierce, K.L. and Lefkowitz, R.J. Classical and New Roles of ?-Arrestins in the Regulation of G-Protein-Coupled Receptors. Nature Reviews: Neuroscience, 2:727-733, 2001. PMID:11584310
  726. Claing, A., Chen, W., Miller, W.E., Vitale, N., Moss, J., Premont, R.T., Lefkowitz, R.J. ?Arrestin-Mediated ARF6 Activation and ?2-Adrenergic Receptor Endocytosis. J. Biol. Chem., 276:42509-42513, 2001. PMID:11533043
  727. Kohout, T.A., Takaoka, H., McDonald, P.H., Perry, S.J., Mao, L., Lefkowitz, R.J., Rockman, H.A. Augmentation of Cardiac Contractility Mediated by the Human?3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice. Circulation, 104:2485-2491, 2001. PMID:11705829
  728. Imamura, T., Huang, J., Dalle, S., Usui, I., Ugi, S., Lefkowitz, R.J., Olefsky, J.M. ?-arrestin- mediated Recruitment of the Src Family Kinase Yes Mediates Endothelin-1-stimulated Glucose Transport. J. Biol. Chem., 276:43663-43667, 2001. PMID:11546805
  729. McDonald, P.H., Lefkowitz, R.J. ?Arrestins: New roles in regulating heptahelical receptors' functions. Cellular Signalling, 13:683-689, 2001. PMID:11602178
  730. Shenoy, S.K., McDonald, P.H., Kohout, T.A., Lefkowitz, R.J. Regulation of Receptor Fate by Ubiquitination of Activated ?2-Adrenergic Receptor and ?-Arrestin. Science, 294:1307-1313, 2001. PMID:11588219
  731. Cong, M., Perry, S.J., Hu, L.A., Hanson, P.I., Claing, A., Lefkowitz, R.J. Binding of the beta 2 adrenergic receptor to N-ethylmaleimide sensitive factor regulates receptor recycling. J. Biol. Chem., 276:45145-45152, 2001. PMID:11577089
  732. Claing, A., Laporte, S.A., Caron, M.G., Lefkowitz, R.J. Endocytosis of G Protein-Coupled Receptors: Roles of G protein-coupled receptor kinases and ?arrestin proteins. Progress in Neurobiology, 66:61-79, 2002. PMID:11900882
  733. Paing, M.M., Stutts, A.B., Kohout, T.A., Lefkowitz, R.J., Trejo, J. ?-Arrestins Regulate Protease- activated Receptor-1 Desensitization but not Internalization or Down-regulation. J. Biol. Chem. 277:1292-1300, 2002. PMID:11694535
  734. Hu, L.A., Chen, W., Premont, R.T., Cong, M., Lefkowitz, R.J. G protein-coupled receptor kinase 5 regulates ?1-adrenergic receptor association with PSD-95. J. Biol.Chem. 277:1607-1613, 2002. PMID:11700307
  735. Chen, Wei, Hu, L.A., Semenov, M.V., Yanagawa, S., Kikuchi, A., Lefkowitz, R.J., Miller, W.E. ?arrestin1 Modulates LEF Transcriptional Activity Through Interaction with Phosphorylated Dishevelled Proteins. Proc. Natl. Acad. Sci. USA 98:14889-14894, 2001. PMID:11742073
  736. Rockman, H.A., Koch, W.J., Lefkowitz, R.J. Seven Membrane Spanning Receptors and Heart Function. Nature 415:206-212, 2002. PMID:11805844
  737. Luttrell, L.M., and Lefkowitz, R.J. The role of ?-arrestins in the termination and transduction of G- protein-coupled receptor signals. Journal of Cell Science 115: 455-465, 2002. PMID:11861753
  738. Perry, S.J. and Lefkowitz, R.J. Arresting developments in heptahelical receptor signaling and regulation. Trends in Cell Biology 12:130-138, 2002.PMID:11859025
  739. Tohgo, A., Pierce, K.L., Choy, E.W., Lefkowitz, R.J. and Luttrell, L.M. ?-arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK mediated transcription following angiotensin AT1a receptor stimulation. J. Biol. Chem., 277:9429-9436, 2002.PMID:11777902
  740. Fong, A.M., Premont, R.T., Richardson, R.M., Yen-Rei, A.Y., Lefkowitz, R.J. and Patel, D.D. Defective Lymphocyte Chemotaxis in ?-Arrestin2- And GRK6-Deficient Mice. Proc. Natl. Acad. Sci. USA 99: 7478-7483, 2002. PMID:12032308
  741. Ahn, S., Kim, J., Lucaveche, C.L., Reedy, M.C., Luttrell, L.M., Lefkowitz, R.J. and Daaka, Y. Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor. J. Biol. Chem. 277:26642-26651, 2002. PMID:12011079
  742. Eckhart, A., Fentzke, R.C., Lepore, J., Lang, R., Lin, H., Lefkowitz, R.J., Koch, W.J. and Leiden, J.M. Inhibition of ?ARK1 Restores Impaired Biochemical ?-Adrenergic Receptor Responsiveness but does not Rescue CREDA133 Induced Cardiomyopathy, J. Mol. Cell Cardiol., 34, 669-677, 2002. PMID:12054854
  743. Zamah, A.M., Delahunty, M., Luttrell, L.M., Lefkowitz, R.J. PKA-Mediated Phosphorylation of the ?2-Adrenergic Receptor Regulates its Coupling to Gs and Gi: Demonstration in a Reconstituted System. J. Biol. Chem. 277:31249-31256, 2002. PMID:12063255
  744. Lin, F.T., Chen, W., Shenoy, S., Cong, M., Exum, S.T. and Lefkowitz, R.J. Phosphorylation of ?- Arrestin2 Regulates Its Function in Internalization of ?2-Adrenergic Receptors. Biochemistry 41: 10692-10699, 2002. PMID:12186555
  745. Lefkowitz, R.J., Pierce, K.L. and Luttrell, L.M. Dancing with Differeint Partners: PKA Phosphorylation of Seven Membrane Spanning Receptors Regulates Their G Protein Coupling Specificity , Molecular Pharmacology 62:971-974, 2002. PMID:12391258
  746. Pierce, K.L., Premont, R.T. and Lefkowitz, R.J. Seven Transmembrane Spanning Receptors, Nature Rev. Molec. Cell. Biol. 3:639-650, 2002. PMID:12209124
  747. Perry, S.J., Baillie, G.S., Kohout, T.A., McPhee, I., Magiera, M.M., Ang, K.L., Miller, W.E., McLean, A.J., Conti, M., Houslay, M.D. and Lefkowitz, R.J. Targeting of cyclic AMP degradation to ?2- adrenergic receptors by ?-arrestins. Science 298:834-836, 2002. PMID:12399592
  748. Freeman, J.L.R., Gonzalo, P., Pitcher, J.A., Claing, A., Lavergne, J-P, Rebous, J-P and Lefkowitz, R.J. ?2-Adrenergic Receptor Stimulated, G protein Coupled Receptor Kinase 2 mediated, phosphorylation of Ribosomal Protein P2, Biochemistry 41:12850-12857, 2002.PMID:12379128
  749. Hall, R.A. and Lefkowitz, R.J. Regulation of G protein-Coupled Receptor Signaling by Scaffold Proteins, Circ. Res., 91:672-680, 2002. PMID :12386143
  750. Bohn, Laura M., Lefkowitz, Robert J., Caron, Marc G. Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in ?arrestin-2 Knockout Mice, J. Neurosci., 22(23):10494-10500, 2002. PMID:12451149
  751. Kohout, T.A. and Lefkowitz, R.J. Regulation of G protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization. Molecular Pharmacology, 63:9-18, 2003.PMID:12488531
  752. Hanyaloglu, A.C., Seeber, R.M., Kohout, T.A., Lefkowitz, R.J. and Eidne, Karin A. Homo and heter-oligomerization of thyrotropin releasing hormone (TRH) receptor subtypes: Differential regulation of ?-arrestins 1 and 2, J. Biol. Chem., 277:50422-50430, 2002. PMID:12393857
  753. Tohgo, A., Choy, E.W., Gesty-Palmer, D., Pierce, K.L., Laporte, S., Oakley, R.H., Caron, M.G., Lefkowitz, R.J. and Luttrell, L.M. The Stability of the G Protein-Coupled Receptor-?-arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation, J. Biol. Chem., 278:6258-6267, 2003. PMID:12473660
  754. Baillie, G.S., Sood, A. McPhee, I., Gall, I., Perry, S.J., Lefkowitz, R.J. and Houslay, M.D. ?-arrestin mediated PDE4 phosphodiesterase recruitment regulates ?-adrenoceptor switching from Gs to Gi, Proc. Natl. Acad. Sci. USA, 100:940-945, 2003.PMID:12552097
  755. Ahn, S., Nelson, C.D., Garrison, F.R., Miller, W.E. and Lefkowitz, R.J. Desensitization, Internalization and Signaling Functions of ?-arrestins Demonstrated by RNA Interference, Proc. Natl. Acad. Sci. USA, 100:1740-1744, 2003. PMID:12582207
  756. Shenoy, S.K. and Lefkowitz, R.J. Trafficking patterns of ?-arrestin and G-Protein-Coupled Receptors determined by the kinetics of ?-arrestin deubiquitination, J. Biol. Chem., 278:14498- 14506, 2003. PMID:12574160
  757. Lefkowitz, R.J. A Magnificent Time with the "Magnificent Seven" Transmembrane Spanning Receptors, Circ. Res. 92(4):342-344, 2003. PMID:12623870
  758. Lodowski, D.T., Pitcher, J.A., Capel. W.D., Lefkowitz, R.J. and Tesmer, J.J.G. Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and G??, Science, 300:1256- 1262, 2003.
  759. Miller, W.E., Houtz, D.A., Nelson, C.D., Kolattukudy, P.E. and Lefkowitz, R.J. GRK Phosphorylation and ?arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR, J. Biol. Chem. 278(24):21663-21671, 2003. PMID:12668664
  760. Hu, L.A., Chen, W., Whalen, E., Premont, R. and Lefkowitz, R.J. GIPC interacts with the ?1- adrenergic receptor and regulates ?1-adrenergic receptor mediated ERK activation, J. Biol. Chem., 278(28):26295-26301, 2003. PMID:12724327
  761. Lodowski, D.T., Barnhill, J.F., Pitcher, J.A., Capel, W.D., Lefkowitz, R.J. and Tesmer, J.J.G. Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and G?1?2. Acta Crystallogr D Biol Crystallogr, D59:936-939, 2003.
  762. Gainetdinov, R.R., Bohn, L.M., Sotnikova, T.D., Cyr, M., Laakso, A., Macrae, A.D., Torres, G.E., Kim, K-M., Lefkowitz, R.J., Caron, M.G. and Premont, R.T. Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice. Neuron, 38:291-303, 2003.
  763. Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L.A., Miller, W.E., Caron, M.G., Barak, LS., Nusse, R. and Lefkowitz, R.J. Dishevelled2 Recruits ?arrestin2 to mediate Wnt5A-Stimulated Endocytosis of Frizzled. Science, 301:1391-1394, 2003.
  764. Walker, J.K.L., Fong, A.M., Lawson, B.L., Savov, J.D., Patel, D.D., Schwartz, D.A. and Lefkowitz, R.J. ?-arrestin-2 regulates the development of allergic asthma. J. Clin. Invest., 112:566-574, 2003.PMCID:PMC171386
  765. Rapacciuolo, A., Suvarna, S., Barki-Harrington, L., Luttrell, L.M., Cong, M., Lefkowitz, R.J. and Rockman, H.A. PKA and GRK phosphorylation mediate ?-1 adrenergic receptor endocytosis through different pathways. J. Biol. Chem., 278:35403-35411, 2003. PMCID:12821660
  766. Wei, H., Ahn, S., Shenoy, S.K., Karnik, S.S., Hunyady, L., Luttrell, L.M. and Lefkowitz, R.J. Independent ?-Arrestin2 and G protein mediated pathways for angiotensin II activation of ERK1/2. Proc. Natl. Acad. Sci. USA, 100:10782-10787, 2003.
  767. Chen, W., Kirkbride, K.C., How, T., Nelson, C.D., Mo, J., Frederick, J.P., Wang, X-F., Lefkowitz, R.J. and Blobe, G.C. ?-Arrestin2 mediates endocytosis of type III TGF-? receptor and down regulation of its signaling. Science, 301:1394-1397, 2003.
  768. Vines, C.M., Revankar, C.M., Maestas, D.C., LaRusch, L.L., Cimino, D.F., Kohout, T.A., Lefkowitz, R.J. and Prossnitz, E.R. N-formyl Peptide Receptors Internalize but do not recycle in the Absence of Arrestins. J. Biol. Chem., 278:41581-41584, 2003. PMCID:12947104
  769. Shenoy, S.K. and Lefkowitz, R.J. Multifaceted roles of ?-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem. J., 375:503-515, 2003.
  770. Martin, N.P., Lefkowitz, R.J. and Shenoy, S.K. Regulation of V2 Vasopressin Receptor Degradation by Agonist Promoted Ubiquitination. J. Biol. Chem., 278:45954-45959, 2003. PMID:12960162
  771. Terman, G.W., Jin, W, Cheong Y-P, Lowe, J, Caron, M.G., Lefkowitz, R.J. and Chavkin, C. G- Protein Receptor Kinase 3 (GRK3) Influences Opioid Analgesic Tolerance but not Opioid Withdrawal. Br. J. Pharmacol., 141:55-64, 2004
  772. Walker, J.K.L., Gainetdinov, R.R., Feldman, D.S., Fawn, P.K., Caron, M.G., Lefkowitz, R.J., Premont, R.T. and Fisher, J.T. G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation, Am. J. Physiol. Lun Cell Mol. Physiol, 286:L312-319, 2004.
  773. Kavelaars, A., Vroon, A., Raatgever, R., Fong, A.M., Premont, R., Patel, D.D., Lefkowitz, R.J. and Heijnen, C.J. Increased acute inflammation, leukotriene B4-induced chemotaxis and signaling in mice deficient for G Protein-Coupled Receptor Kinase 6 J. Immunol., 171: 6128-6134, 2003.
  774. Povsic, T.J., Kohout, T.A. and Lefkowitz, R.J. ?-Arrestin1 mediates IGF-1 stimulated activation of PI-3-K and anti-apoptosis. J. Biol. Chem., 278:51334-51339, 2003. PMID:14534298
  775. McLaughlin, J.P., Myers, L.C., Zarek, P.E., Caron, M.G., Lefkowitz, R.J., Czyzyk, T.A., Pintar, J.E. and Chavkin, C. Prolonged ?-opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J. Biol. Chem., 279:1810-1818, 2004. PMID:14597630
  776. Bohn, L.M., Gainetdinov, R.R., Sotnikova, T.D., Medvedev, I.O., Lefkowitz, R.J., Dykstra, L.S. and Caron, M.G. Enhanced Rewarding Properties of Morphine, but not Cocaine, in ?-arrestin-2 Knock- out Mice. J. Neurosci., 23:10265-10273, 2003.
  777. Ahn, S., Wei, H., Garrison, T.R. and Lefkowitz, R.J. Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by ?-Arrestins 1 and 2. J. Biol. Chem., 279:7807-7811, 2004. PMID:14711824
  778. Gainetdinov, R.R., Premont, R.T., Bohn, L.M., Lefkowitz, R.J. and Caron, M.G. Desensitization of G Protein-Coupled Receptors and Neuronal Functions, Annu. Rev. Neurosci. 27:107-44, 2004.
  779. Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R. and Hart, A.C. G Protein-coupled receptor kinase function is essential for Chemosensation in C. elegans. Neuron 42: 581-593, 2004.
  780. Freedman, N.J. and Lefkowitz, R.J. Anti-?1-adrenergic receptor antibodies and heart failure: causation, not just correlation. J. Clin. Invest. 113: 1379-1382, 2004. PMID:15146232
  781. Galliera, E., Jala, V.R., Trent, J.O., Bonecchi, R., Signorelli, P., Lefkowitz, R.J., Mantovani, A., Locati, M., Haribabu, B. ?-Arrestin dependent constitutive internalization of the human chemokine decoy receptor D6. J. Biol. Chem. 279: 25590-25597, 2004. PMID:15084596
  782. Lefkowitz, R.J. Forward to "G Protein Coupled Receptor-Protein Interactions". (S. R.George and B.F. O'Dowd, Eds). John Wiley & Sons, page ix, 2005.
  783. Martin, N.P., Whalen, E.J., Zamah, M.A., Pierce, K.L. and Lefkowitz, R.J. PKA mediated phosphorylation of the ?1-adrenergic receptor promotes Gs/Gi switching. Cellular Signalling 16: 1397-1403, 2004
  784. Witherow, D.S., Garrison, T.R., Miller, W.E. and Lefkowitz, R.J. ?-arrestin inhibits NF?B activity via its interaction with the NF?B inhibitor I?B?. Proc. Natl. Acad. Sci. USA 101: 8603-8607, 2004.
  785. Tachibana, H., Prasad, S.V.N., Lefkowitz, R.J., Koch, W.J. and Rockman, H.A. Level of ?ARK1 inhibition determines the degree of cardiac dysfunction following chronic pressure overload induced heart failure. Circulation 111: 591-597, 2005.
  786. Xu, M., Petraschka, M., McLaughlin, J.P., Westenbroek, R.E., Caron, M.G., Lefkowitz, R.J., Czyzyk, T.A., Pintar, J.E., Terman, G.W. and Chavkin, C. Neuropathic pain activates the endogenous ? opioid system in mouse spinal cord and induces opioid receptor tolerance. Journal of Neuroscience 24, 4576-4584, 2004.
  787. Lefkowitz, R.J. and Whalen, E.J. ?-arrestins: traffic cops of cell signaling. Current Opinion in Cell Biology 16, 1-7, 2004.
  788. Wang, Q., Zhao, J., Brady, A.E., Feng, J., Allen, P.B., Lefkowitz, R.J., Greengard, P. and Limbird, L.E. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science 304:1940-1944, 2004.
  789. Bond, R.A. and Lefkowitz, R.J. "GPCRs as Drug Targets - Analysis of Activation and Constitutive Activity". Historical Background. Seifert, Wieland (Eds.) (Series: Methods and Principles in Medicinal Chemistry. Series editors: R. Mannhold, H. Kubinyi, G. Folkers), Wiley-VCH publishers, Volume 24, pages 3-10, 2005.
  790. Bohn, L.M., Dykstra, L.A., Lefkowitz, R.J., Caron, M.G. and Barak, L.S. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol. Pharmacol. 66: 106-112, 2004. PMID:15213301
  791. Ahn, S., Shenoy, S.K. Wei, H. and Lefkowitz, R.J. Differential kinetic and spatial patterns of ?-arrestin2 and G protein-mediated ERK activated by the angiotensin II receptor. J. Biol. Chem. 279: 35518-35525, 2004. PMID:15205453
  792. Dinudom, A., Fotia, A.B., Lefkowitz, R.J., Young, J.A., Kumar, S, and Cook, D.I. The Kinase Grk2 regulates Nedd4/Nedd4-dependent control of epithelial Na+ channels. Proc. Natl. Acad. Sci. 101: 11886-11890, 2004.
  793. Usui, I., Imamura, T., Huang, J., Satoh, H., Shenoy, S.K., Lefkowitz, R.J., Hupfeld, C.J. and Olefsky, J.M. ?-Arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate-1. Mol. Cell Biol. 24: 8929-8937, 2004.
  794. Lefkowitz, R.J. Historical review: A brief history and personal retrospective of seven-transmembrane receptors. Trends in Pharmacological Sciences 25/8: 413-422, 2004. PMID:15276710
  795. Wei, H., Ahn, S., Barnes, W.G. and Lefkowitz, R.J. Stable interaction between ?-arrestin 2 and AT1A receptor is required for ?-arrestin 2 mediated activation of extracellular signal-regulated kinase 1 and 2. J, Biol. Chem. 279: 48255-48261, 2004. PMID:15355986
  796. Ge, L., Shenoy, S.K., Lefkowitz, R.J., DeFea, K.A. Constitutive protease-activated receptor-2 mediated migration of MDA MB-231 breast cancer cells requires both ?-arrestin-1 and 2. J. Biol. Chem. 279: 55419-55424, 2004. PMID:15489220
  797. Xiao, K., Shenoy, S.K., Nobles, K., and Lefkowitz, R.J. Activation Dependent Conformational Changes in β-arrestin2. J. Biol. Chem.279: 55744-55753, 2004. PMID:15501822
  798. Shenoy, S.K. and Lefkowitz, R.J. Resonating to the music of Ubiquitination. News and Views. In Nature Methods 1:191-193, 2004.
  799. Chen, W., Ren, X, Nelson, C.D., Barak, L.S., Chen, J.K., Beachy, PA., de Sauvage, F., and Lefkowitz, R.J. Activity-Dependent Internalization of Smoothened Mediated by β-arrestin 2 and GRK2, Science, 306:2257-2260, 2004.
  800. Kim, J., Ahn, S., Ren, X-R., Whalen, E., Reiter, E., Wei, H. and Lefkowitz, R.J. Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II Receptor signaling. Proc. Natl. Acad. Sci. USA 102: 1442-1447, 2005.
  801. Ren, X-R., Reiter, E., Ahn, S., Kim, J., Chen, W. and Lefkowitz, R.J. Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor. Proc. Natl. Acad. Sci. USA 102: 1448-1453, 2005.
  802. Hunton, D.L., Barnes, W.G., Kim, J., Ren, X-R, Violin, J.D., Reiter E., Milligan, G., Patel, D. and Lefkowitz, R.J. β-Arrestin 2 dependent AT1A receptor mediated pathway of chemotaxis uncoupled from G protein Signaling. Mol. Pharmacol. 67: 1229-1236, 2005. PMID:15635042
  803. Barnes, W.G., Reiter, E., Violin, J.D., Ren, X-R., Milligan, G. and Lefkowitz, R.J. β-Arrestin1 and G?q/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem., 280:8041-8050, 2005. PMID:15611106
  804. Milasta, S., Evans, N.A., Ormiston, L, Wilson, S., Lefkowitz, R.J., and Milligan, G. The affinity of interactions between the orexin-1 receptor and β-arrestin-2 determines the kinetics of ERK MAP kinase regulation and is defined by a single C-terminal cluster of hydroxyl amino acids. Biochem. J. 387:573-584, 2005.
  805. Lefkowitz, R.J. and Shenoy, S.K. Transduction of Receptor Signals by β-arrestins. Science 308: 512-517, 2005.
  806. Shenoy, S.K. and Lefkowitz, R.J. Receptor-specific ubiquitination of β-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J. Biol. Chem. 280: 15315-15324, 2005.PMID:15699045
  807. Girnita, L., Shenoy, S.K., Schat, B., Vasilcanu, R., Girnita, A, Lefkowitz, R.J. and Larsson, O. β-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem. 280: 24412-24419, 2005.PMID:15878855
  808. Beaulieu, J-M., Sotnikova, T.D., Marion, S., Lefkowitz, R.J., Gainetdinov, R.R. and Caron, M.G. An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-273, 2005.
  809. Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function. J Mol Neurosci. 26(2-3):293-4, 2005
  810. Shenoy, S.K. and Lefkowitz, R.J. Seven-Transmembrane Receptor Signaling Through β-Arrestin. Science', STKE: www.stke.org/cgi/content/full/sigtrans;205/308/cm10.
  811. Shenoy, S.K. and Lefkowitz, R.J. Receptor regulation: β-arrestin moves up a notch. Nature Cell Biology 7: 1159-1161, 2005.
  812. Rajagopal, K., Lefkowitz, R.J. and Rockman, H.A. When 7 transmembrane receptors are not G protein-coupled receptors. J. Clin. Invest. 115: 2971-2974, 2005.PMCID:PMC1265881
  813. Shenoy, S.K., Drake, M.T., Nelson, C.D., Houtz, D.A., Xiao, K., Madabushi, S., Reiter, E., Premont, R.T., Lichtarge, O. and Lefkowitz, R.J. β-arrestin-dependent G Protein-independent ERK 1/2 Activation by the β2-adrenergic receptor. J.Biol. Chem. 281:1261-1273,2006. PMID:16280323
  814. Gesty-Palmer, G., Chen, M., Reiter, E., Ahn, S, Nelson C.D., Loomis, C.R., Spurney, R.F, Luttrell, L.M., and Lefkowitz, R.J. Distinct β-arrestin and G protein dependent pathways for parathyroid hormone receptor-stimulated ERK 1/2 activation. J. Biol. Chem. 281:10856-10864, 2006.PMID:16492667
  815. Reiter, E. and Lefkowitz, R.J. GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends in Endocrinology and Metabolism 17: 159-165, 2006.
  816. Violin, J.D., Ren, X-R and Lefkowitz, R.J. GRK specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J. Biol. Chem. 281: 20577-20588, 2006. PMID:16687412
  817. Meloni, A.R., Fralish, G.B., Kelly, P., Salahpour, A., Chen, J.K., Wechsler-Reya, R.J., Lefkowitz, R.J., Caron, M.G. Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2. Molecular and Cellular Biology 26: 7550-7560, 2006.
  818. Drake, M.T., Shenoy, S.K. and Lefkowitz, R.J. Trafficking of G Protein - Coupled Receptors. Circ. Res. 99:570-582, 2006. PMID:16973913
  819. Lefkowitz, R.J., Rajagopal, K. and Whalen, E.J. New Roles for β-Arrestins in Cell Signaling: Not Just for Seven Transmembrane Receptors. Molecular Cell, 24:643-652, 2006.
  820. Rajagopal, K., Whalen, E.J., Violin, J.D., Stiber, J.A., Rosenberg, P.B., Premont, R.T., Coffman, T.M., Rockman, H.W., and Lefkowitz, R.J. β-arrestin2-Mediated Inotropic Effects of the Angiotensin II Type 1A Receptor in Isolated Cardiac Myocytes. Proc. Natl. Acad. Sci. 103:16284-16289, 2006.
  821. Violin, J.D., DeWire, S.M., Barnes, W.G., and Lefkowitz, R.J. GRK and β-arrestin Mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics. J. Biol. Chem. 281:36411-36419, 2006. PMID:17008309
  822. Lefkowitz, R.J. Seven Transmembrane Receptors - A Brief Personal Retrospective. Biochemica et Biophysica Acta 1768: 748-755, 2007. PMID:17173855
  823. Nelson, C.D., Perry, S.J., Regier, D.S., Prescott, S.M., Topham, M.K. and Lefkowitz, R.J. Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by β-arrestins. Science 315: 663-666, 2006.
  824. Girnita, L., Shenoy S.K., Sehat, B., Vasilcanu, R., Vasilcanu, D., Girnita, A., Lefkowitz, R.J., and Larsson, O. β-arrestin and Mdm2 mediated IGF-1 receptor stimulated ERK activation and cell cycle progression. J. Biol. Chem. 282:11329-11338, 2007. PMID:17303558
  825. Violin, J.D. and Lefkowitz, R.J. β-Arrestin-Biased Ligands at Seven-Transmembrane Receptors. Trends in Pharmacological Sciences 28:416-422, 2007. PMID:17644195
  826. Whalen, E.J., Foster, MW, Matsumoto, A, Ozawa, K, Violin, J.D., Que, L.G., Benhar, M., Keys, J.R., Koch, W.J., Daaka, Y., Lefkowitz, R.J., and Stamler, J.S. Regulation of β-adrenergic receptor Signaling by S-nitrosylation of G Protein-Coupled Receptor Kinase 2. Cell 129:511-522, 2007.
  827. DeWire, S.M., Ahn, S., Lefkowitz, R.J., and Shenoy, S.K. β-arrestins and Cell Signaling. Annu Rev. Physiology 69:483-510, 2007.
  828. Lefkowitz, R.J. Seven transmembrane receptors: something old, something new. Acta Physiologica 190:9-19, 2007.
  829. Nobles, K.N., Ziqiang G., Kunhong, X, Oas T.G., and Lefkowitz, R.J. The Active Conformation of β-arrestin1: Direct Evidence for the Phosphate Sensor in the N-domain and Conformational Differences in the Active States of beta;-arrestins1 and 2. J. Biol. Chem. 282:21370-21381, 2007. PMID:17513300
  830. Xiao, K., McClatchy, D.B., Shukla, A.K., Zhao, Y., Chen, M., Shenoy, S.K., Yate, J.R., and Lefkowitz, R.J. Functional Specialization of 7beta;-arrestin Interactions Revealed by Proteomic Analysis. Proc. Natl. Acad. Sci., USA, 104:12011-12016, 2007.
  831. Noma, T., Lemaire, A., Prasad, S.V.N., Barki-Harrington, L., Tilley, D.G., Chen, J., Corvoisier P., Violin, J.D., Wei, H., Lefkowitz, R.J. and Rockman, H.A. β-Arrestin mediated β1-adrenergic receptor transactivation of the epidermal growth factor receptor confers cardioprotection. J. Clin. Invest. 117:2445-2458, 2007. PMCID:PMC1952636
  832. Shenoy, S.K., Barak, L.S., Xiao, K. Ahn, S., Luttrell, L.M., and Lefkowitz, R.J. Ubiquitination of β-arrestin links 7-transmembrane receptor endocytosis and ERK activation. J. Biol. Chem. 282: 29549-29562, 2007. PMID:17666399
  833. Wisler, J.W, DeWire, S.M, Whalen, E.J, Violin, J.D, Drake, M.T, Ahn, S., Shenoy, S.K, and Lefkowitz, R.J. A novel mechanism of beta blocker action: carvedilol stimulates β-arrestin signaling. Proc. Natl. Acad. Sci., 104:16657-16662, 2007.
  834. Beaulieu, J-M., Marion, S., Rodriguiz, R.M., Medvedev, I.O., Sotnikova, T.D., Ghisi, V., Wetsel, W.C., Lefkowitz, R.J., Gainetdinov, R.R. and Caron, M.G. A ?-arrestin 2 signaling complex mediates lithium action in vivo. Cell 132: 125-136, 2008.
  835. Violin, J.D., DiPilato, L.M., Yildirim, N., Elston, T.C., Zhang, J. and Lefkowitz, R.J. ?2-Adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real-time cAMP dynamics. J. Biol. Chem. 283: 2949-2961, 2008. PMID:18045878
  836. Lefkowitz, R.J. The Annual ASCI Meeting: Does Nostalgia Have a Future? J. Clin. Invest. 118: 1231-1233, 2008. PMCID:PMC2276792
  837. Drake, M.T., Violin, J.D., Whalen, E.J., Wisler, J.W., Shenoy, S.K. and Lefkowitz, R.J. ?-Arrestin-Biased Agonism at the ?2-Adrenergic Receptor. J. Biol. Chem. 283:5669-5676, 2008.PMID:18086673
  838. Lefkowitz, R.J., Sun, J-P, Shukla, A.K. A Crystal Clear View of the ?2-Adrenergic Receptor. Nature Biotechnology 26: 189-191, 2008.
  839. DeWire, S.M., Kim, J., Whalen, E.J., Ahn, S., Chen, M. and Lefkowitz, R.J. ?-Arrestin-mediated Signaling Regulates Protein Synthesis. J. Biol. Chem. 283: 10611-10620, 2008.PMID:2447657
  840. Shukla, A.K., Violin, J.D., Whalen, E.J., Gesty-Palmer, D., Shenoy, S.K. and Lefkowitz, R.J. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proc. Natl. Acad. Sci. USA, 105: 9988-9995, 2008. PMCID:PMC2481318
  841. Kovacs, J.J., Whalen, E.J., Liu, R., Xiao, K., Kim, J., Chen, M., Wang, J., Chen, W. and Lefkowitz, R.J. Beta-arrestin mediated localization of smoothened to the primary cilium. Science 320: 1777-1781, 2008. PMCID:PMC2587210
  842. Ozawa, K., Hess, D.T., Lefkowitz, R.J., and Stamler, J.S. S-nitrosylation of b-arrestin regulates b-adrenergic receptor trafficking. Molecular Cell 31: 395-405, 2008. PMID:18519945
  843. Kim, J., Zhang, L., Peppel, K., Wu, J-H, Zidar, D.A., Brian, L., DeWire, S.M., Lefkowitz, R.J., and Freedman, N.J. β-arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration. Circulation Research 103: 70-79, 2008.PMID:PMC2760159
  844. Barak, L.S., Salapour, A., Zhang, X., Masri, B., Sotnikova, T.D., Ramsey, A.J., Violin, J.D., Lefkowitz, R.J., Caron, M.G., and Gainetdinov, R.R. Pharmacological characterization of membrane-expressed human trace amine associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer (BRET) cAMP biosensor. Mol., Pharm. 74: 585-594, 2008.PMID:18524885
  845. Nelson, C.D., Kovacs, J.J., Nobles, K.N., Whalen, E.J. and Lefkowitz, R.J. ?-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase I? promotes agonist-stimulated sequestration of the ?-2-adrenergic receptor. J. Biol. Chem. 283: 21093-21101, 2008. PMCID:PMC2475702
  846. Shukla, A.K., Sun, J.P. and Lefkowitz, R.J. Cystallizing thinking about the beta2-adrenergic receptor. Mol. Pharmacol. 73: 1333-1338, 2008. PMID:18239031
  847. Tarrant, T.K., Rampersad, R.R., Esserman, D., Rothlein, L.R., Liu, P., Premont, R.T., Lefkowitz, R.J., Lee, D.M. and Patel, D.D. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clinical Immunology 129: 115-122, 2008.PMCID:PMC2637521
  848. Ahn, S., Kim, J., Hara, M.R., Ren, X-R. and Lefkowitz, R.J. ?-Arrestin-2 Mediates Anti-Apoptotic Signaling Through Regulation of BAD Phosphorylation. J. Biol. Chem. 284: 8855-8865, 2009.PMCID:PMC2659243
  849. Shenoy, S.K., Modi, A.S., Shukla, A., Xiao, K., Berthouze, M., Ahn, S., Wilkinson, K.D., Miller, W.E. and Lefkowitz, R.J. ?-Arrestin-dependent signaling and trafficking of 7TMRs is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc. Natl. Acad. Sci. USA 106: 6650-6655, 2009. PMCID:PMC2667797
  850. Walters, R.W., Shukla, A.K., Kovacs, J.J., Violin, J.D., DeWire, S.M., Lam, C.M., Chen, J.R., Muehlbauer, M.J., Whalen, E.J. and Lefkowitz, R.J. ?-arresin1 Mediates nicotinic acid induced flushing, but not its antilipolytic effect. J. Clin. Invest. 119: 1312-1321, 2009.PMCID:PMC2673863
  851. Kim, J., Ahn, S., Rajapopal, K. And Lefkowitz, R.J. Independent ?-Arrestin2 and Gq/PKC? Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the EGFR. J. Biol. Chem. 284: 11953-11962, 2009. PMCID:PMC2673264
  852. Zidar, D.A., Violin, J.D., Whalen, E.J. and Lefkowitz, R.J. Selective Engagement of G protein-coupled Receptor Kinase (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. USA 106: 9649-9654, 2009.PMCID:PMC2689814
  853. Gesty-Palmer, D., Flannery, P., Yuan, L., Corsino, L., Spurney, R., Lefkowitz, R.J. and Luttrell, L.M. A ?-Arrestin Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation. Science Translational Medicine 1: 1-9, 2009. PMCID: PMC2852200
  854. Xie, L., Xiao, K., Whalen, E.J., Forrester, M.T., Gygi, S.P., Lefkowitz, R.J. and Stamler, J.S. Oxygen-regulated ?2-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation. Science Signaling 78: 1-10, 2009. PMCID:PMC2788937.
  855. Chen, M., Philipp, M., Wang, J., Premont, R.T., Garrison, T.R., Caron, M.G., Lefkowitz, R.J. and Chen, W. G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway. J. Biol. Chem. 284: 35040-35048, 2009. PMCID:PMC2787365
  856. Kovacs, J.J., Hara, M.R., Davenport, C.L., Kim, J. and Lefkowitz, R.J. Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways. Developmental Cell 17: 443-458, 2009. PMCID:PMC3221601
  857. Rajagopal, S., Kim, J., Ahn, S., Craig, S., Lam, C.M., Gerard, N.P., Gerard, C. and Lefkowitz, R.J. ??arrestin-but not G-protein-mediated signaling by the "Decoy" Receptor CXCR7. Proc. Natl. Acad. Sci. USA, 107: 628-32, 2010. PMCID: PMC2818968
  858. Rajagopal, S., Rajagopal, K., Lefkowitz, R.J. Teaching Old receptors new tricks: biasing seven-transmembrane receptors. Nature Reviews Drug Discovery 9, 1-12, 2010. PMCID: PMC2902265
  859. Shukla, A.K., Kim, J., Ahn, S., Xiao, K., Shenoy, S.K., Liedtke, W., and Lefkowitz, R.J. Arresting a TRP Channel - β-Arrestin1 Mediates Ubiquitination and Functional Downregulationof TRPV4. J. Biol. Chem. 285: 30115-30125, 2010. PMCID: PMC2943294
  860. Xiao, K., Sun, J., Kim, J., Rajagopal, S., Zhai, B., Villen, J., Haas, W., Kovacs, J.J., Shukla, A.K., Hara, M.R., Hernandez, M., Lachmann, A., Zhao, S., Lin, Y., Cheng, Y., Mizuno, K., Ma'ayan, A., Gygi, S.P. and Lefkowitz, R.J. Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci., 107, 15299-15304, 2010. PMCID: PMC2930550
  861. Kenakin, T., Agnati, L.F., Caron, M., Fredholm, B., Guidoli, D., Kobilka, B., Lefkowitz, R.J., Woods, A., Fuxe, K. G protein-coupled receptors: finding the words to describe mononers, oligomers, and their molecular mechanisms and defining their meaning. Recep. Signal Transduct. Res. 30: 284-286, 2010. PMID:20858022
  862. Whalen, E., Rajagopal, S. and Lefkowitz, R.J. The Therapeutic Potential of β-Arrestin and G protein-biased Agonists. Trends in Molecular Medicine, Vol. 17, 126-139, 2011. PMID:21183406
  863. Lovgren, A.K., Kovacs, J.J., Xie, T., Potts, E.N., Li, Y., Foster, W.M., Liang, J., Meltzler, E.B., Jiang, D., Lefkowitz, R.J. and Noble, P.W. β-Arrestin DeficiencyProtects Against Pulmonary fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix. Science Translational Medicine, Vol. 3, 1-10, 2011. PMCID: PMC3094726
  864. Lefkowitz, R.J. Forward to "G protein-coupled receptors: From structure to function". (Jesus Giraldo and Jean-Philippe Pin, Eds). The Royal Society of Chemistry, 2011.
  865. Shenoy, S.K. and Lefkowitz, R.J. β-Arrestin-mediated receptor trafficking and signal transduction. Trends in Pharmacological Sciences 32: 521-533, 2011. PMCID:PMC3159699
  866. Rajagopal, S., Ahn, S., Rominger, D.H., Gowen-McDonald, W., Lam, C.M., DeWire, S.M., Violin, J.D. and Lefkowitz, R.J. Quantifying Ligand Bias at Seven-Transmembrane Receptors. Mol. Pharmacol. 80: 367-377, 2011. PMCID: PMC3164332
  867. Rockman, H.A. and Lefkowitz, R.J. Introduction to the Series on Novel Aspects of Cardiovascular G-Protein-Coupled Receptor Signaling. Circ. Res. 109: 202-204, 2011. PMCID:PMC3298859
  868. Kahsai, A.W., Xiao, K., Rajagopal, S., Ahn, S., Shukla, A.K., Sun, J., Oas, T.G. and Lefkowitz, R.J. Multiple Ligand-Specific Conformations of the *beta;2-Adrenergic Receptor. Nature Chemical Biology, 7: 692-700, 2011. PMCID:PMC3404607
  869. Nobles, K., Xiao, K., Ahn, S., Shukla, A.K., Lam, C.M., Rajagopal, S., Strachan, R.T., Huang, T-Y., Bressler, E.A., Hara, M.R., Shenoy, S.K., Gygi, S.P. and Lefkowitz, R.J. Distinct G Protein-Coupled Receptor Kinase Phosphorylation Sites on the β-Adrenergic Receptor: A Bar Code for Differential Encoding of β-Arrestin Functions. Science Signaling 4: 1-10, 2011. PMCID: PMC3415961
  870. Shukla, A.K., Xiao, K., and Lefkowitz, R.J. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends in Biochemical Sciences 36: 457-469, 2011. PMCID:PMC3168679
  871. Reiter, E., Ahn, S., Shukla, A.K. and Lefkowitz, R.J. Molecular mechanisms of β-arrestin-biased agonism at seven transmembrane receptors. Ann. Review of Pharmacology and Toxicology 52: 179-197, 2011. PMID:21942629
  872. Hara, M.R., Kovacs, J.J., Whalen, E.J., Rajagopal, S., Strachan, R.T., Grant, W., Towers, A.J., Williams, B., Lam, C.M., Xiao, K., Shenoy, S.K., Gregory, S.G., Ahn, S., Duckett, D.R. and Lefkowitz, R.J. Stress Response Pathway Regulates DNA Damage Through &betal2-Adrenoreceptors and β-Arrestin-1. Nature 477: 349-353, 2011. PMID: 21857681 [PubMed - in process]
  873. Heitzler, D., Durand, G., Gallay, N., Rizk, A., Ahn, S, Kim, J., Violin, J.D., Dupuy, L., Gauthier, C., Piketty, V., Crepieux, P., Poupon, A., Clement, F., Fages, F., Lefkowitz, R.J. and Reiter, E. Competing G protein-coupled receptor kinases balance G protein and beta-arrestin signaling. Mol. Syst. Biol,, 8, 1-17, 2012.PMCID:PMC3397412
  874. Fereshteh, M., Ito, T., Kovacs, J., Zhao, C., Kwon, H.Y., Tornini, V., Konuma, T., Chen, M., Lefkowitz, R.J. and Reya T. Beta-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences 109, 12532-12537, 2012.PMCID:PMC3411976
  875. Hara, M.R., Sachs, B.D., Caron, M.G. and Lefkowitz, R.J. Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle, 12, 219-224, 2013. PMC3575451.
  876. Weiss, D.R., Ahn, S.K., Sassano, M.F., Kleist, A., Zhu, X., Strachan, R., Roth, B.L., Lefkowitz, R.J. and Shoichet, B.K. Conformation guides molecular efficacy in docking screens of activated beta2-adrenergic G protein coupled receptor. ACS Chemical Biology 8, 1018-1026, 2013.
  877. Shukla, A.K., Manglik, A., Kruse, A.C., Xiao, K., Reis, R.I., Tseng, Wei-Chou, Staus, D., Hilger, D., Uysal, S., Huang, L.Y., Paduch, M., Shukla, P.T., Koide, A., Kide, S., Weis, W.I., Kossiakoff, A.A., Kobilka, B.K. and Lefkowitz, R.J. Structure of active beta-arrestin 1 bound to a G protein-coupled receptor phosphopeptide. Nature 497, 137-142, 2013.
  878. Lefkowitz, R.J. Arrestins Come of Age: A Personal Historical Perspective. Progress in Molecular Biology and Translational Science 118, 3-18, 2013.
  879. Aristotelous, T., Ahn, S., Shukla, A.K., Gawron, S., Sassano, M.F., Kahsai, A.W., Wingler, L.M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K.D., Roth, B.., Gilbert, I.H., Hopkins, A.L., Lefkowitz, R.J. and Navratilova, I. Discovery of β-2-Adrenergic Receptor Ligands Using Biosensor Frament Screening of Tagged Wild-Type Receptor. ACS Medicinal Chemistry Letters 4, 1005-1010, 2013.
  880. Simard, E., Kovacs, J.J., Miller, W.E., Kim, J., Grandbois, M. and Lefkowitz, R.J. ?-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. PLOS ONE, in press, 2013.
  881. Wisler, J.W., Xiao, K., Thomsen, A.R.B. and Lefkowitz, R.J. Recent developments in biased agonism. Current Opinion in Cell Biolog 27:18-24, 2013
  882. Strachan, R.T., Sun, J-P, Rominger, D.H., Violin, J.D., Ahn, S., Thomsen, A.R., Xu, X., Kleist, A., Costa, T. and Lefkowitz, R.J. Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism at a G Protein-Coupled Receptor (GPCR). Journal of Biol. Chem., in press, 2014.
  883. Staus, D. P., Wingler, L.M., Strachan, R.T., Rasmussen, S.G.F., Pardon, E., Ahn, S., Steyaert, J., Kobilka, B.K. and Lefkowitz, R.J. Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies. Molecular Pharmacology 85: 472-481, 2014.
  884. Shukla. A.K., Westfield, G.H., Xiao, K., Reis, R.I., Huang, L-Y., Tripathi-Shukla, P., Qian, J., Li, Sheng, Blanc, A., Oleskie, A.N., Dosey, A.M., Su, M., Liang, C-R., Gu, L-L., Shan, J-M., Chen, X., Hanna, R., Choi, M., Yao, X.J., Klink, B.U., Kahsai, A.W. Sidhu, S.S., Koide, S., Penczek, P.A., Kossiakoff, A.A., Woods, V.L., Kobilka, B.K., Skiniotis, G. and Lefkowitz, R.J. Visualization of Arrestin Recruitment by a G Protein-Coupled Receptor. Nature, in press, 2014.

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Robert Lefkowitz
Photo: Bengt Nyman, Painting Tim Tompkins - PaintHistory.com

Name: Robert J. Lefkowitz
Birth: 15 April, 1943, New York, USA
Institution: Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA
Award: "for studies of G-protein-coupled receptors"
Subject: Biochemistry
Portion of cash: 1/2
National Medal of Science- Biological Sciences 2007 USA
Nobel Lecture at Uppsala University
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