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Herbert C Brown Ph.D.
The Nobel Prize in Chemistry 1979
The President's National Medel of Sciences - Physical Sciences, 1969
Nobel co-recipient Georg Wittig
Organic Chemist. Development of use of boron into important reagents in organic synthesis. School, advanced several times, graduating at 12; refused further advancement, avoiding being sister's classmate.
Graduating, Depression years, future wife Sarah gave him gift, Stock's 'Hydrides of Boron and Silicon' because cheapest chemistry book! Led to Nobel Prize!
Patents
| Publication: | 1/102 |
| Publication No: | WO 8704438 A1 |
| Title: | Novel optically active alkali metal mono- and diorganylborohydrides and boranes and process for preparing and using same |
| Publication Type: | Application |
| Publication Date: | Jul 30, 1987 |
| Filing Date: | Jan 21, 1987 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich Boranes Inc |
| Abstract: | Treatment of boronic esters of very high optical purity with alkali metal aluminum hydride and treatment of borinic esters of very high optical purity with alkali metal monoalkoxyaluminohydride provides novel, quantitative synthesis of novel alkali metal monoorganyl- and diorganylborohydrides containing boron directly attached to the asymmetric center or centers of essentially 100% optical purity. These optically active mono- and diorganylborohydrides provide new, useful optically active reducing agents and convenient sources for optically active mono- and diorganylboranes. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 2/102 |
| Publication No: | US 6248885 B1 |
| Title: | Borane-trialkylamine hydroboration agents |
| Publication Type: | Grant |
| Publication Date: | Jun 19, 2001 |
| Filing Date: | Apr 7, 1998 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | Borane-trialkylamines of the formula H3B.NRR1R2 wherein R is a tertiary alkyl group having 4 to 8 carbon atoms, and R1 and R2 are the same or different straight or branched chain alkyl from 1 to 4 carbon atoms are provided. The compounds are new hydroboration agents. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 3/102 |
| Publication No: | US 6204405 B1 |
| Title: | Borane-trialkylamine hydroboration agents |
| Publication Type: | Grant |
| Publication Date: | Mar 20, 2001 |
| Filing Date: | Dec 22, 1999 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | New, economical and convenient procedures for the preparation of catecholborane in high chemically pure form using tri-O-phenylene bis borate readily prepared from the reaction of catechol with boric acid, and diborane or borane-Lewis base complexes. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 4/102 |
| Publication No: | US 6008414 A |
| Title: | Dioxane-monochloroborane and dioxane-dichloroborane |
| Publication Type: | Grant |
| Publication Date: | Dec 28, 1999 |
| Filing Date: | Feb 16, 1999 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | Highly reactive hydroborating agents dioxane-monochloroborane and dioxane-dichloroborane are provided. Also provided by this invention are methods for producing dioxane-monochloroborane, dioxane-dichloroborane and methods for hydroborating olefins with these reagents. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 5/102 |
| Publication No: | US 5567849 A |
| Title: | Borane-sulfide hydroboration agents |
| Publication Type: | Grant |
| Publication Date: | Oct 22, 1996 |
| Filing Date: | May 9, 1995 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A borane-sulfide represented by the formula BH3.SR1 R2 wherein B is boron, H is hydrogen, R1 and R2 each are straight or branched chain alkyl or alkoxy with at least one R being a branched chain when both R1 and R2 are alkyl, and S is sulfur. The compounds are hydroboration agents |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 6/102 |
| Publication No: | US 5543569 A |
| Title: | Borane-N,N-dialkylaniline hydroboration agents |
| Publication Type: | Grant |
| Publication Date: | Aug 6, 1996 |
| Filing Date: | May 9, 1995 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | Borane-N,N-dialkylanilines represented by the formula H3 B. C6 H5 NRR' wherein N is nitrogen, R is isobutyl or isopropyl and R' is straight or branched chain lower alkyl. The compounds are useful as hydroboration agents and for generating diborane. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 7/102 |
| Publication No: | US 5504240 A |
| Title: | Borane-hydroxydialkylsulfide borates |
| Publication Type: | Grant |
| Publication Date: | Apr 2, 1996 |
| Filing Date: | May 9, 1995 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | Novel borane adducts of hydroxydialkylsulfide borate esters represented by formula ##STR1## wherein R is straight or branched chain alkyl or alkoxy having from 2 to 5 carbon atoms and n is 1 to 3 inclusive. The compound are new hydroboration agents. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 8/102 |
| Publication No: | US 5481038 A |
| Title: | Borane-N,N-diisopropylalkylamine hydroboration agents |
| Publication Type: | Grant |
| Publication Date: | Jan 2, 1996 |
| Filing Date: | May 9, 1995 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | Borane-N,N-diisopropylalkylamines as represented by the formula: H3 B.NPrzi 2 R wherein Pri is isopropyl, R is branched-chain alkyl or cycloalkyl having 3 to 6 carbon atoms and B is boron are provided. The compounds are new hydroboration agents. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 9/102 |
| Publication No: | US 5380940 A |
| Title: | Bis(bicyclo(2.2.2)octyl)haloboranes |
| Publication Type: | Grant |
| Publication Date: | Jan 10, 1995 |
| Filing Date: | Jun 26, 1992 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A novel class of enolboration reagents represented by the formula R2 BX/R'3 N wherein each R is the same or different alkyl or cycloalkyl, B is boron, X is halo, R' is lower alkyl and / indicates that R2 BX is preferably employed in the presence of R'3 N are disclosed. Methods of enolborating a wide variety of organic carbonyl compounds are also provided. Further, new bis(bicyclo[2.2.2.]octyl)haloboranes are efficacious for enolboration. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 10/102 |
| Publication No: | US 5276195 A |
| Title: | Process for producing dimethylorganoboranes |
| Publication Type: | Grant |
| Publication Date: | Jan 4, 1994 |
| Filing Date: | Jul 14, 1993 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A process for preparing a dimethylorganoborane represented by the formula R*BMe2 wherein R* is a chiral organyl group attached to the boron, B is boron and Me is methyl comprising treating a chiral boronic ester R*B(OR')2 with amethyl magnesium salt or trimethylaluminum wherein R* is the same chiral organyl group and R' is alkyl. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 11/102 |
| Publication No: | US 5220072 A |
| Title: | Process of synthesizing chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes |
| Publication Type: | Grant |
| Publication Date: | Jun 15, 1993 |
| Filing Date: | Mar 23, 1992 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A chemically and optically pure B-halodiiso-2-ethylapopinocampheylborane of essentially 100% ee represented by the formula: ##STR1## wherein B is borane and X is halo and a process for preparing. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 12/102 |
| Publication No: | US 5214209 A |
| Title: | Method of producing primary amines in high yields and novel intermediates therefor |
| Publication Type: | Grant |
| Publication Date: | May 25, 1993 |
| Filing Date: | Mar 26, 1990 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral organo group,attached to boron, B is boron and Me is methyl. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 13/102 |
| Publication No: | US 5210310 A |
| Title: | Optically active dimethylorganoboranes |
| Publication Type: | Grant |
| Publication Date: | May 11, 1993 |
| Filing Date: | Mar 26, 1990 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral organo group, attached to boron, B is boron and Me is methyl. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 14/102 |
| Publication No: | US 5202502 A |
| Title: | Process for producing optically active alcohols |
| Publication Type: | Grant |
| Publication Date: | Apr 13, 1993 |
| Filing Date: | Mar 23, 1992 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A chemically and optically pure B-halodiiso-2- ethylapopinocampheylborane of essentially 100% ee represented by the formula: ##STR1## wherein B is borane and X is halo, and a process of using such for the production of optically active alcohols. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 15/102 |
| Publication No: | US 5175378 A |
| Title: | Synthesis of optically pure forms of ipsdienol |
| Publication Type: | Grant |
| Publication Date: | Dec 29, 1992 |
| Filing Date: | Mar 16, 1992 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | An improved process for preparing either optically pure enantiomer of the bark beetle pheromones ipsenol and ipsdienol is provided. The process is also applicable to the condensation of aldehydes of widely varying properties to the corresponding chiral alcohol. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 16/102 |
| Publication No: | US 5175371 A |
| Title: | Synthesis of optically pure forms of ipsenol |
| Publication Type: | Grant |
| Publication Date: | Dec 29, 1992 |
| Filing Date: | Mar 16, 1992 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | An improved process for preparing either optically pure enantiomer of the bark beetle pheromones ipsenol and ipsdienol is provided. The process is also applicable to the condensation of aldehydes of widely varying properties to the corresponding chiral alcohol. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 17/102 |
| Publication No: | US 5159116 A |
| Title: | Chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes |
| Publication Type: | Grant |
| Publication Date: | Oct 27, 1992 |
| Filing Date: | Jul 15, 1991 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A chemically and optically pure B-halodiiso-2-ethylapopinocampheylborane of essentially 100% ee represented by ##STR1## wherein B is borane and X is halo. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 18/102 |
| Publication No: | US 5103063 A |
| Title: | Intermediates useful for the chiral isoprenylation of aldehydes |
| Publication Type: | Grant |
| Publication Date: | Apr 7, 1992 |
| Filing Date: | Aug 3, 1990 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | An improved process for preparing either optically pure enantiomer of the bark beetle pheromones ipsenol and ipsdienol is provided. The process is also applicable to the condensation of aldehydes of widely varying properties to the corresponding chiral alcohol. This invention also concerns novel intermediates R'2 B(2'-isoprenyl) wherein R' is isopinocampheyl, 2-isocaranyl and 4-isocaranyl. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 19/102 |
| Publication No: | US 5087700 A |
| Title: | Method of producing primary amines in high yields |
| Publication Type: | Grant |
| Publication Date: | Feb 11, 1992 |
| Filing Date: | Mar 26, 1990 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMez2 or R*BMe2 wherein R is an organo group, R* is a chiral organo group, attached to boron, B is boron and Me is methyl. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 20/102 |
| Publication No: | US 5068432 A |
| Title: | Process for producing optically pure 2-phenoxyphenylalkylamines |
| Publication Type: | Grant |
| Publication Date: | Nov 26, 1991 |
| Filing Date: | Feb 1, 1991 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 21/102 |
| Publication No: | US 5043479 A |
| Title: | Chemically and optically pure diisopinocampheylhaloboranes |
| Publication Type: | Grant |
| Publication Date: | Aug 27, 1991 |
| Filing Date: | Sep 1, 1989 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | Novel chemically pure diisopinocampheylhaloboranes of essentially 100% ee, represented by the formula Ipc2 BX wherein Ipc is isopinocampheyl and X is halo. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 22/102 |
| Publication No: | US 4978794 A |
| Title: | Novel β-(2-alkenyl)bis(2-isocaranyl)boranes |
| Publication Type: | Grant |
| Publication Date: | Dec 18, 1990 |
| Filing Date: | Mar 26, 1990 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | 2-Alkenylbis(2-isocaranyl)boranes represented by the formula: ##STR1## wherein R is 2-alkenyl. The compounds undergo asymmetric 2-alkenylboration with a variety of aldehydes and afford the corresponding alcohols in 94-99% ee. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 23/102 |
| Publication No: | US 4950791 A |
| Title: | Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein |
| Publication Type: | Grant |
| Publication Date: | Aug 21, 1990 |
| Filing Date: | Jun 12, 1989 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 24/102 |
| Publication No: | US 4918246 A |
| Title: | Process for preparing optically active haloalcohols |
| Publication Type: | Grant |
| Publication Date: | Apr 17, 1990 |
| Filing Date: | Jun 12, 1989 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 25/102 |
| Publication No: | US 4918242 A |
| Title: | Novel optically 1,3-phenoxypropylhalides |
| Publication Type: | Grant |
| Publication Date: | Apr 17, 1990 |
| Filing Date: | Jun 12, 1989 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A process for producing the optically pure (+)- or (-)-isomer of a phenyl- or substituted-phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 26/102 |
| Publication No: | US 4918229 A |
| Title: | Method of producing primary amines in high yields and novel intermediates therefor |
| Publication Type: | Grant |
| Publication Date: | Apr 17, 1990 |
| Filing Date: | Jul 29, 1988 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMBe2 wherein R is an organo group, R* is a chiral organo group attached to boron, B is boron and Me is methyl. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 27/102 |
| Publication No: | US 4918207 A |
| Title: | Novel optically active halo-substituted tetrahydrofurans |
| Publication Type: | Grant |
| Publication Date: | Apr 17, 1990 |
| Filing Date: | Jun 12, 1989 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Sigma-Aldrich Co. |
| Abstract: | A process for producing the optically pure (+)- or (-) isomer of a pheynl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 28/102 |
| Publication No: | US 4895996 A |
| Title: | Synthesis of alkenes from enamines via hydroboration |
| Publication Type: | Grant |
| Publication Date: | Jan 23, 1990 |
| Filing Date: | Oct 17, 1988 |
| Inventors: | Christian T. Goralski, Bakthan Singaram, Herbert C. Brown |
| Assignee: | Purdue Research Foundation, The Dow Chemical Company |
| Abstract: | Alkenes are prepared by the hydroboration of enamines followed by an elimination reaction to form the alkene. This process has wide applicability and is useful for the stereospecific synthesis of [Z] isomers. It is preferred to use 9-borabicyclo[3.3.1 nonane as the hydroborating agent and to use methanol to catalyze the elimination reaction. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 29/102 |
| Publication No: | US 4886924 A |
| Title: | Stereospecific synthesis of [E]-alkenes from enamines via hydroboration |
| Publication Type: | Grant |
| Publication Date: | Dec 12, 1989 |
| Filing Date: | Oct 17, 1988 |
| Inventors: | Christian T. Goralski, Bakthan Singaram, Herbert C. Brown |
| Assignee: | The Dow Chemical Company |
| Abstract: | A process for the stereospecific synthesis of [E] alkenes from enamines comprising the steps of hydroborating the enamine; esterifying the organoborane so formed and oxidizing the boronic ester in the presence of hydrogen peroxide and in the absence of added base under conditions sufficient to form the [E] alkene in high yield. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 30/102 |
| Publication No: | US 4870212 A |
| Title: | Process for synthesizing lithium mono- and diorganylborohydrides |
| Publication Type: | Grant |
| Publication Date: | Sep 26, 1989 |
| Filing Date: | Dec 17, 1987 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | Improved processes for liberating boronic, RB(OR')2, and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 31/102 |
| Publication No: | US 4870177 A |
| Title: | Process for synthesizing lithium mono- and diorganylborohydrides |
| Publication Type: | Grant |
| Publication Date: | Sep 26, 1989 |
| Filing Date: | Dec 17, 1987 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | Improved processes for liberating boronic, RB(OR')2, and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 32/102 |
| Publication No: | US 4868344 A |
| Title: | Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein |
| Publication Type: | Grant |
| Publication Date: | Sep 19, 1989 |
| Filing Date: | Mar 30, 1988 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resoltuion processes ad novel intermediates useful in the process including optically pure haloalcohols are provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 33/102 |
| Publication No: | US 4868337 A |
| Title: | Optically active borinic esters and ketones |
| Publication Type: | Grant |
| Publication Date: | Sep 19, 1989 |
| Filing Date: | Dec 17, 1987 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | A process for synthesizing an optically pure ketone comprising the steps of: treating an appropriate optically pure boronic ester with an organolithium compound at -78° C. to obtain the "ate" complex, separating the optically pure borinic ester from the complex and converting said borinic ester into an optically pure ketone represented by the formulae: R*COR1 and R*COC.tbd.CR1 wherein R* is a chiral organyl moiety and R1 is an achiral organyl moeity. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 34/102 |
| Publication No: | US 4866181 A |
| Title: | Process for producing optically active alcohols |
| Publication Type: | Grant |
| Publication Date: | Sep 12, 1989 |
| Filing Date: | Dec 17, 1987 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | A process for preparing optically active alcohols by reducing ketones using mono- or diisopinocampheylhaloboranes as reducing agents |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 35/102 |
| Publication No: | US 4855506 A |
| Title: | Process for lithium mono- and diorganylborohydrides |
| Publication Type: | Grant |
| Publication Date: | Aug 8, 1989 |
| Filing Date: | Dec 17, 1987 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | Improved processes for liberating boronic, RB(OR')2' and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 36/102 |
| Publication No: | US 4795821 A |
| Title: | Optically active borinic esters and ketones |
| Publication Type: | Grant |
| Publication Date: | Jan 3, 1989 |
| Filing Date: | Aug 29, 1986 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | A process for synthesizing an optically pure ketone comprising the steps of: treating an appropriate optically pure boronic ester with an organolithium compound at -78° C. to obtain the "ate" complex, separating the optically pure borinic ester from the complex and converting said borinic ester into an optically pure ketone represented by the formulae: R*COR1 and R*COC.tbd.CR1 wherein R* is a chiral organyl moeity and R1 is an achiral organyl moeity. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 37/102 |
| Publication No: | US 4772752 A |
| Title: | Mono- and diisopinocampheylhaloboranes as new chiral reducing agents |
| Publication Type: | Grant |
| Publication Date: | Sep 20, 1988 |
| Filing Date: | Aug 29, 1986 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | Novel mono- and diisopinocampheylhaloboranes, represented by the formulae IpcBX2 and Ipc2 BX wherein Ipc is isopinocampheyl and X is halo, as well as processes for making and using same. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 38/102 |
| Publication No: | US 4772751 A |
| Title: | Process for lithium mono- and diorganylborohydrides |
| Publication Type: | Grant |
| Publication Date: | Sep 20, 1988 |
| Filing Date: | Aug 29, 1986 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | Improved processes for liberating boronic, RB(OR')2, and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 39/102 |
| Publication No: | US 4713380 A |
| Title: | Production of optically pure organoboranes |
| Publication Type: | Grant |
| Publication Date: | Dec 15, 1987 |
| Filing Date: | Jan 16, 1985 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | A process for upgrading to essentially 100% enantiomeric excess the optical purity of an organoborane intermediate represented by the formulae: IcpBHR* or Icp2 BR* wherein Icp is isopinocampheyl and R* is a unsubstituted or substituted, acyclic or cyclic alkyl having from 4 to 30 carbon atoms, comprising the steps of hydroborating cis-alkene, a trans-alkene or a tertiary-alkene with monoisopinocampheylborane or diisopinocampheylborane, obtaining a solid organoborane and recrystallizing the solid organoborane to obtain an enantiomeric excess of essentially 100% ee of said organoborane. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 40/102 |
| Publication No: | US 4518798 A |
| Title: | Preparing esters and carboxylic acids from lower olefins |
| Publication Type: | Grant |
| Publication Date: | May 21, 1985 |
| Filing Date: | Sep 30, 1982 |
| Inventors: | George M. Kramer, Walter Weissman, Herbert C. Brown, Rowland Pettit |
| Assignee: | Exxon Research & Engineering Co. |
| Abstract: | Esters or carboxylic acids are prepared from olefins containing at least two carbon atoms by reacting the olefin with carbon monoxide in the presence of: (i) a first complex of a selected Lewis acid with the ester or carboxylic acid, whichever is the reaction product recovered; (ii) a second complex of the Lewis acid with an alcohol, if an ester is being prepared, or with water, if a carboxylic acid is being prepared; and (iii) a metal carbonyl compound containing a Group IB transition metal in the first oxidation state; and by recovering the reaction product(s). The preferred olefin is propylene, the preferred ester to be prepared is methylisobutyrate, the preferred metal is copper and the preferred Lewis acid is boron trifluoride. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 41/102 |
| Publication No: | US 4320027 A |
| Title: | Process for producing highly stabilized borane-tetrahydrofuran solutions |
| Publication Type: | Grant |
| Publication Date: | Mar 16, 1982 |
| Filing Date: | May 2, 1980 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | A process which comprises heating a stabilized solution of borane in tetrahydrofuran containing an organic sulfide and finely divided particles of sodium fluoroborate at an elevated temperature for a period of time sufficient to convert the sodium fluoroborate particles to a form which permits them to be readily removed from the solution such as by settling, filtration or centrifugation. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 42/102 |
| Publication No: | US 4298750 A |
| Title: | Borane-1,4-thioxane |
| Publication Type: | Grant |
| Publication Date: | Nov 3, 1981 |
| Filing Date: | Feb 19, 1980 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | The novel borane-1,4-thioxane is synthesized by adding the calculated quantity of diborane to 1,4-thioxane. It is a stable liquid at 25° C. The neat liquid is approximately 8.0 M in borane. The product, in spite of the additional oxygen atom in the ring, exhibits the desirable hydroborating and reducing action of borane-methyl sulfide. However, it possesses a major advantage over the latter in that the donor component, 1,4-thioxane, in contrast to methyl sulfide, is readily soluble in water and can be washed out of typical reaction mixtures. This greatly facilitates the synthetic applications of borane-1,4-thioxane over borane-methyl sulfide. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 43/102 |
| Publication No: | US 4082810 A |
| Title: | Bulky trialkylborohydrides |
| Publication Type: | Grant |
| Publication Date: | Apr 4, 1978 |
| Filing Date: | Oct 16, 1975 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | Borohydride hydrogenations using agents of the formula M[RR'R"BH] wherein M is a metal and R, R', and R" are each organic groups, at least one of them beinga secondary or tertiary alkyl group, are described herein. These compounds are active hydrogenating agents which are particularly useful because they permit steric control of the hydrogenation of carbonyl groups, they permit selective hydrogenation of functional groups or, where one of the R groups is optically active, they permit stereoselective hydrogenation. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 44/102 |
| Publication No: | US 3984479 A |
| Title: | Preparation of 9-BBN |
| Publication Type: | Grant |
| Publication Date: | Oct 5, 1976 |
| Filing Date: | Nov 8, 1973 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | 9-Borabicyclo (3.3.1) noname (9-BBN), a relatively stable solid dialkylborane, can be used to reduce a wide variety of reducible chemical compounds, including both organic and inorganic compounds. The stability of the reagent greatly reduces the operating difficulties encountered with other dialkylboranes having similar reduction properties, which are thermally and hydrolytically unstable. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 45/102 |
| Publication No: | US 3882037 A |
| Title: | Stabilized borane-tetrahydrofuran solutions |
| Publication Type: | Grant |
| Publication Date: | May 6, 1975 |
| Filing Date: | Feb 22, 1973 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Aldrich-Boranes, Inc. |
| Abstract: | The presence of an aliphatic, alicyclic, or cyclic sulfide stabilizes solutions of diborane in tetrahydrofuran, permitting the storage of such solutions for long periods of time at ambient temperatures. Such stabilized solutions can be prepared without handling diborane gas by treating a suspension of an ionic borohydride in tetrahydrofuran, containing an aliphatic, alicyclic, or cyclic sulfide, with boron trifluoride, followed by removal of the precipitated fluoroborate. Such solutions are excellent for hydroboration, and possess major advantages over borane-tetrahydrofuran solutions available previously in being highly stable. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 46/102 |
| Publication No: | US 3439046 A |
| Title: | Process for oxidation of hydrocarbylborane compounds to alcohols |
| Publication Type: | Grant |
| Publication Date: | Apr 15, 1969 |
| Filing Date: | Apr 18, 1967 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 47/102 |
| Publication No: | US 3358034 A |
| Title: | Selective hydroboration process |
| Publication Type: | Grant |
| Publication Date: | Dec 12, 1967 |
| Filing Date: | Mar 12, 1964 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 48/102 |
| Publication No: | US 3350454 A |
| Title: | Process of producing amines |
| Publication Type: | Grant |
| Publication Date: | Oct 31, 1967 |
| Filing Date: | Sep 27, 1963 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 49/102 |
| Publication No: | US 3345418 A |
| Title: | Catalytic process for preparing organoboron compounds from diborane |
| Publication Type: | Grant |
| Publication Date: | Oct 3, 1967 |
| Filing Date: | Aug 29, 1957 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 50/102 |
| Publication No: | US 3322686 A |
| Title: | Hydrogenation of chemical compounds and catalysts therefor |
| Publication Type: | Grant |
| Publication Date: | May 30, 1967 |
| Filing Date: | Feb 5, 1963 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown Charles A, Brown Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 51/102 |
| Publication No: | US 3277178 A |
| Title: | Preparation of aldehydes from acid halides |
| Publication Type: | Grant |
| Publication Date: | Oct 4, 1966 |
| Filing Date: | Feb 27, 1962 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 52/102 |
| Publication No: | US 3254129 A |
| Title: | Optically active organoboranes |
| Publication Type: | Grant |
| Publication Date: | May 31, 1966 |
| Filing Date: | Jan 17, 1961 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 53/102 |
| Publication No: | US 3180710 A |
| Title: | Gas generator |
| Publication Type: | Grant |
| Publication Date: | Apr 27, 1965 |
| Filing Date: | Feb 11, 1963 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown Charles A, Brown Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: |  |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 54/102 |
| Publication No: | US 3173967 A |
| Title: | Isomerization of internal olefins to terminal olefins |
| Publication Type: | Grant |
| Publication Date: | Mar 16, 1965 |
| Filing Date: | May 28, 1958 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 55/102 |
| Publication No: | US 3161686 A |
| Title: | Novel organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Dec 15, 1964 |
| Filing Date: | Mar 30, 1960 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 56/102 |
| Publication No: | US 3147272 A |
| Title: | Method of preparing partially reduced organic compounds |
| Publication Type: | Grant |
| Publication Date: | Sep 1, 1964 |
| Filing Date: | Aug 18, 1959 |
| Inventors: | Herbert C Brown, Richard F Mcfarlin, Rao Bookinkere C Subba |
| Assignee: | Herbert C Brown, Richard F Mcfarlin, Rao Bookinkere C Subba |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 57/102 |
| Publication No: | US 3134823 A |
| Title: | Process involving the reaction of group i-b metal compounds with an organoboron compound in the presence of a strong base |
| Publication Type: | Grant |
| Publication Date: | May 26, 1964 |
| Filing Date: | Dec 12, 1960 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 58/102 |
| Publication No: | US 3133961 A |
| Title: | Method of producing organoboron products |
| Publication Type: | Grant |
| Publication Date: | May 19, 1964 |
| Filing Date: | May 3, 1961 |
| Inventors: | Herbert C Brown, Rao Bookinkeve Channakes Subba, Paul A Tierney |
| Assignee: | Purdue Research Foundation |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 59/102 |
| Publication No: | US 3085112 A |
| Title: | Preparation of hydrocarbon boron compounds |
| Publication Type: | Grant |
| Publication Date: | Apr 9, 1963 |
| Filing Date: | Dec 22, 1960 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 60/102 |
| Publication No: | US 3078313 A |
| Title: | Selective hydroboration |
| Publication Type: | Grant |
| Publication Date: | Feb 19, 1963 |
| Filing Date: | Jun 15, 1961 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 61/102 |
| Publication No: | US 3078312 A |
| Title: | Isomerization of organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 19, 1963 |
| Filing Date: | Mar 30, 1960 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 62/102 |
| Publication No: | US 3078311 A |
| Title: | Catalytic process for preparing organoboron compounds from diborane |
| Publication Type: | Grant |
| Publication Date: | Feb 19, 1963 |
| Filing Date: | Jan 21, 1960 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 63/102 |
| Publication No: | US 3078310 A |
| Title: | Isomerization of primary, secondary or tertiary organoboron compounds into isomers threof |
| Publication Type: | Grant |
| Publication Date: | Feb 19, 1963 |
| Filing Date: | Dec 7, 1959 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 64/102 |
| Publication No: | US 3078309 A |
| Title: | Preparation of organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 19, 1963 |
| Filing Date: | Nov 6, 1959 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 65/102 |
| Publication No: | US 3078308 A |
| Title: | Process for the production of organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 19, 1963 |
| Filing Date: | Aug 31, 1959 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 66/102 |
| Publication No: | US 3026356 A |
| Title: | Process for the preparation of organo boron compounds |
| Publication Type: | Grant |
| Publication Date: | Mar 20, 1962 |
| Filing Date: | Apr 25, 1958 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 67/102 |
| Publication No: | US 3026329 A |
| Title: | Mono-and di-chloroborane etherates |
| Publication Type: | Grant |
| Publication Date: | Mar 20, 1962 |
| Filing Date: | Jul 11, 1957 |
| Inventors: | Herbert C Brown, Rao Bookinkeve Channakes Subba, Paul A Tierney |
| Assignee: | Purdue Research Foundation |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 68/102 |
| Publication No: | US 2993933 A |
| Title: | Simultaneous preparation of organoboron compounds and separation of internal olefinsfrom alpha-olefins |
| Publication Type: | Grant |
| Publication Date: | Jul 25, 1961 |
| Filing Date: | May 28, 1958 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 69/102 |
| Publication No: | US 2988513 A |
| Title: | Stabilized boron trichloride compositions |
| Publication Type: | Grant |
| Publication Date: | Jul 25, 1961 |
| Filing Date: | Apr 25, 1958 |
| Inventors: | Herbert C Brown, Paul A Tierney |
| Assignee: | Herbert C Brown, Paul A Tierney |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 70/102 |
| Publication No: | US 2964378 A |
| Title: | Low temperature preparation of alkali metal borohydrides from metal hydrides and alkyl borates in solution |
| Publication Type: | Grant |
| Publication Date: | Dec 13, 1960 |
| Filing Date: | Jun 3, 1955 |
| Inventors: | Herbert C Brown, Paul A Tierney |
| Assignee: | Herbert C Brown, Paul A Tierney |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 71/102 |
| Publication No: | US 2945886 A |
| Title: | Method for reducing chemical compounds by reacting with alkali metal borohydrides |
| Publication Type: | Grant |
| Publication Date: | Jul 19, 1960 |
| Filing Date: | Feb 20, 1957 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 72/102 |
| Publication No: | US 2925441 A |
| Title: | Method of preparing organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 16, 1960 |
| Filing Date: | Oct 30, 1958 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 73/102 |
| Publication No: | US 2925438 A |
| Title: | Method of converting unsaturated organic compounds to organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 16, 1960 |
| Filing Date: | Feb 1, 1957 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 74/102 |
| Publication No: | US 2925437 A |
| Title: | Method for converting unsaturated organic compounds to organoboron compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 16, 1960 |
| Filing Date: | Oct 30, 1956 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 75/102 |
| Publication No: | US 2874165 A |
| Title: | Reduction of carbonyl compounds with boron hydrides |
| Publication Type: | Grant |
| Publication Date: | Feb 17, 1959 |
| Filing Date: | Apr 25, 1955 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 76/102 |
| Publication No: | US 2856428 A |
| Title: | Method for hydrogenating organic compounds by reacting with alkali metal borohydrides |
| Publication Type: | Grant |
| Publication Date: | Oct 14, 1958 |
| Filing Date: | Jul 13, 1955 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 77/102 |
| Publication No: | US 2819328 A |
| Title: | Propylene polymerization with pf5 |
| Publication Type: | Grant |
| Publication Date: | Jan 7, 1958 |
| Filing Date: | Apr 8, 1954 |
| Inventors: | Brown Herbert C, Higley Willard S |
| Assignee: | Standard Oil Co |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 78/102 |
| Publication No: | US 2780626 A |
| Title: | 2, 6-alkylpyridines |
| Publication Type: | Grant |
| Publication Date: | Feb 5, 1957 |
| Filing Date: | Aug 13, 1953 |
| Inventors: | Kanner Bernard, Herbert C Brown |
| Assignee: | Research Corp. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 79/102 |
| Publication No: | US 2767230 A |
| Title: | Alkylation process |
| Publication Type: | Grant |
| Publication Date: | Oct 16, 1956 |
| Filing Date: | Mar 4, 1954 |
| Inventors: | Herbert C Brown, Willard S Higley |
| Assignee: | Standard Oil Corp. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 80/102 |
| Publication No: | US 2762824 A |
| Title: | Manufacture of silicon compounds |
| Publication Type: | Grant |
| Publication Date: | Sep 11, 1956 |
| Filing Date: | Jun 16, 1953 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Ethyl Corp. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 81/102 |
| Publication No: | US 2727929 A |
| Title: | Aromatization of chlorine compounds |
| Publication Type: | Grant |
| Publication Date: | Dec 20, 1955 |
| Filing Date: | Dec 5, 1951 |
| Inventors: | Herbert C Brown, David D Humphreys |
| Assignee: | Ethyl Corp. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 82/102 |
| Publication No: | US 2709704 A |
| Title: | Carbinol production |
| Publication Type: | Grant |
| Publication Date: | May 31, 1955 |
| Filing Date: | Apr 7, 1954 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Brown, Herbert C. |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 83/102 |
| Publication No: | US 2683721 A |
| Title: | Method of reducing and hydrogenating chemical compounds by reacting with alkali metal borohydrides |
| Publication Type: | Grant |
| Publication Date: | Jul 13, 1954 |
| Filing Date: | Jan 17, 1952 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Hermann I Schlesinger, Herbert C Brown |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 84/102 |
| Publication No: | US 2636886 A |
| Title: | Uranium complexes of heterocyclic diketones |
| Publication Type: | Grant |
| Publication Date: | Apr 28, 1953 |
| Filing Date: | Jan 5, 1946 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Atomic Energy Commission |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 85/102 |
| Publication No: | US 2614113 A |
| Title: | Uranium purification as complexes of esters of trifluoroacetoacetic acid |
| Publication Type: | Grant |
| Publication Date: | Oct 14, 1952 |
| Filing Date: | Jun 5, 1946 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 86/102 |
| Publication No: | US 2600370 A |
| Title: | Uranium borohydride and method of making the same |
| Publication Type: | Grant |
| Publication Date: | Jun 10, 1952 |
| Filing Date: | Feb 4, 1946 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: |  |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 87/102 |
| Publication No: | US 2599203 A |
| Title: | Preparation of aluminum borohydride |
| Publication Type: | Grant |
| Publication Date: | Jun 3, 1952 |
| Filing Date: | Mar 22, 1946 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Atomic Energy Commission |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 88/102 |
| Publication No: | US 2596047 A |
| Title: | Uranium-aroyl aldehyde complexes and method of making same |
| Publication Type: | Grant |
| Publication Date: | May 6, 1952 |
| Filing Date: | Oct 23, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Atomic Energy Commission |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 89/102 |
| Publication No: | US 2584112 A |
| Title: | Organic phosphines |
| Publication Type: | Grant |
| Publication Date: | Feb 5, 1952 |
| Filing Date: | Aug 30, 1950 |
| Inventors: | Brown Herbert C |
| Assignee: | Standard Oil Co |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 90/102 |
| Publication No: | US 2555512 A |
| Title: | Organic phosphines |
| Publication Type: | Grant |
| Publication Date: | Jun 5, 1951 |
| Filing Date: | Nov 13, 1946 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 91/102 |
| Publication No: | US 2548585 A |
| Title: | Alkylation of urea with olefins |
| Publication Type: | Grant |
| Publication Date: | Apr 10, 1951 |
| Filing Date: | Nov 12, 1948 |
| Inventors: | Brown, Herbert C. |
| Assignee: | Standard Oil Co |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 92/102 |
| Publication No: | US 2545633 A |
| Title: | Preparation of lithium borohydride |
| Publication Type: | Grant |
| Publication Date: | Mar 20, 1951 |
| Filing Date: | Oct 16, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 93/102 |
| Publication No: | US 2544472 A |
| Title: | Preparation of diborane |
| Publication Type: | Grant |
| Publication Date: | Mar 6, 1951 |
| Filing Date: | Feb 6, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 94/102 |
| Publication No: | US 2543511 A |
| Title: | Preparation of diborane |
| Publication Type: | Grant |
| Publication Date: | Feb 27, 1951 |
| Filing Date: | May 9, 1946 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 95/102 |
| Publication No: | US 2534533 A |
| Title: | Methods of preparing alkali metal borohydrides |
| Publication Type: | Grant |
| Publication Date: | Dec 19, 1950 |
| Filing Date: | Nov 5, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 96/102 |
| Publication No: | US 2494968 A |
| Title: | Alkoxy borohydrides and their method of preparation |
| Publication Type: | Grant |
| Publication Date: | Jan 17, 1950 |
| Filing Date: | Jul 17, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 97/102 |
| Publication No: | US 2461663 A |
| Title: | Preparation of alkali metal borohydrides |
| Publication Type: | Grant |
| Publication Date: | Feb 15, 1949 |
| Filing Date: | Jan 11, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 98/102 |
| Publication No: | US 2461662 A |
| Title: | Preparation of alkali metal compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 15, 1949 |
| Filing Date: | Jan 9, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 99/102 |
| Publication No: | US 2461661 A |
| Title: | Preparation of alkali metal compounds |
| Publication Type: | Grant |
| Publication Date: | Feb 15, 1949 |
| Filing Date: | Jan 9, 1945 |
| Inventors: | Brown Herbert C, Schlesinger Hermann I |
| Assignee: | Brown Herbert C, Schlesinger Hermann I |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 100/102 |
| Publication No: | US 2326229 A |
| Title: | Process of producing carboxylic acid chlorides |
| Publication Type: | Grant |
| Publication Date: | Aug 10, 1943 |
| Filing Date: | Dec 4, 1942 |
| Inventors: | Herbert C Brown, Morris S Kharasch |
| Assignee: | Du Pont |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 101/102 |
| Publication No: | US 2326228 A |
| Title: | Chemical process |
| Publication Type: | Grant |
| Publication Date: | Aug 10, 1943 |
| Filing Date: | Dec 4, 1942 |
| Inventors: | Herbert C Brown, Morris S Kharasch |
| Assignee: | Du Pont |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 102/102 |
| Publication No: | US 2302228 A |
| Title: | Method of chlorination with sulphuryl chloride and production of monochloro-trimethyl acetic acid |
| Publication Type: | Grant |
| Publication Date: | Nov 17, 1942 |
| Filing Date: | Apr 2, 1940 |
| Inventors: | Herbert C Brown, Morris S Kharasch |
| Assignee: | Du Pont |
| Abstract: | No, Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
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Photo Purdue University. Painting Tim Tompkins PaintHistory.com
Name: Herbert Charles Brown
Birth: 22 May 1912, London, United Kingdom
Death: 19 December 2004, Lafayette, IN, USA
Institution: Purdue University, West Lafayette, IN, USA
Award: "for their development of the use of boron- and phosphorus-containing compounds, respectively, into important reagents in organic synthesis"
Subject: Organic chemistry
Portion of cash: 1/2
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