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James P. Allison, Ph.D.
The Nobel Prize in Physiology or Medicine 2018
Nobel co-recipient Tasuku Honjo
Cancer Immunologist. Discovered cancer therapy by inhibition of negative immune regulation. Pioneer. Place breaks/check points on inhibitory immune cells to attack cancer cells -
curative. Interest: How T cells work. First Nobel Prize for cancer therapy. Family history of cancer. Modest.
"Motivation of scientists: to know what nobody else knows."
Patents
| Publication: | 1/3 |
| Publication No: | US 9447186 B2 |
| Title: | Antibodies to human B7x for treatment of metastatic cancer |
| Publication Type: | United States Utility Patent |
| Publication Date: | September 20, 2016 |
| Filing Date: | October 10, 2013 |
| Inventors: | Xingxing Zang, James P. Allison |
| Assignee: | Sloan Kettering Institute for Cancer Research, Albert Einstein College of Medicine, Com Affiliation Inc |
| Abstract: | Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 2/3 |
| Publication No: | US 7704701 B2 |
| Title: | Diagnosis of prostate cancer with SPAS-1 cancer antigen |
| Publication Type: | United States Utility Patent |
| Publication Date: | April 27, 2010 |
| Filing Date: | January 29, 2007 |
| Inventors: | James P. Allison, Marcella Fasso, Nilabh Shastri |
| Assignee: | University of California |
| Abstract: | Compounds and methods for inducing protective immunity against cancer are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more SPAS-1 proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and pharmaceutical compositions for immunization against cancer, or can be used for the diagnosis of cancer and the monitoring of cancer progression. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 3/3 |
| Publication No: | DK 1137436 T3 |
| Title: | Stimulation of T cells against self antigens using CTLA-4 blocking agents |
| Publication Type: | Danish Patent |
| Publication Date: | October 13, 2008 |
| Filing Date: | December 3, 1999 |
| Inventors: | James P Allison, Arthur A Hurwitz, Andrea Vanelsas |
| Assignee: | University of California |
| Abstract: | Stimulation of T cells to respond to self antigens is achieved through a blockade of CTLA-4 signaling. CTLA-4 blocking agents are combined with antigen preparations, either alone or with additional immune response stimulating agents, in costimulation strategies to break immune tolerance and stimulate an enhanced T-cell response against self antigens. This enhanced response is useful for the treatment of non-immunogenic and poorly-immunogenic tumors, as well as other medical conditions requiring selective tissue ablation. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
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Painting Tim Tompkins - PaintHistory.com
Name: James P. Allison
Birth: 7 August 1948, Alice, TX, USA
Institution: University of Texas MD Anderson Cancer Center, Houston, TX, USA , Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA
Award: "for their discovery of cancer therapy by inhibition of negative immune regulation."
Portion of Cash: 1/2
Education, Post Doc: Ph.D. Biological Sciences, University of Texas, Auston, TX, 1973
Postdoctorial Fellow, Molecular Immunoloty, Scripps Clinic & Research Foundationn, La Jolla, CA
B.S., Microbiology, University of Texas, Auston, TX, 1969,
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