Great • Alfred • Nobel • Gives • Aspiration!
Nobel & Laureates' Ideas & Thought Processes!
Know Thyself Video

Alfred Nobel Video

Nonprofit Organization


James P. Allison, Ph.D.

The Nobel Prize in Physiology or Medicine 2018
Nobel co-recipient Tasuku Honjo

Cancer Immunologist. Discovered cancer therapy by inhibition of negative immune regulation. Pioneer. Place breaks/check points on inhibitory immune cells to attack cancer cells - curative. Interest: How T cells work. First Nobel Prize for cancer therapy. Family history of cancer. Modest.

"Motivation of scientists: to know what nobody else knows."


Publication No:US 9447186 B2
Title:Antibodies to human B7x for treatment of metastatic cancer
Publication Type:United States Utility Patent
Publication Date:September 20, 2016
Filing Date:October 10, 2013
Inventors:Xingxing Zang, James P. Allison
Assignee:Sloan Kettering Institute for Cancer Research, Albert Einstein College of Medicine, Com Affiliation Inc
Abstract:Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.
Representative Figure:No Figure
DetailsGoogle Patents
USPTO Patent Database
Publication No:US 7704701 B2
Title:Diagnosis of prostate cancer with SPAS-1 cancer antigen
Publication Type:United States Utility Patent
Publication Date:April 27, 2010
Filing Date:January 29, 2007
Inventors:James P. Allison, Marcella Fasso, Nilabh Shastri
Assignee:University of California
Abstract:Compounds and methods for inducing protective immunity against cancer are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more SPAS-1 proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and pharmaceutical compositions for immunization against cancer, or can be used for the diagnosis of cancer and the monitoring of cancer progression.
Representative Figure:No Figure
DetailsGoogle Patents
USPTO Patent Database
Publication No:DK 1137436 T3
Title:Stimulation of T cells against self antigens using CTLA-4 blocking agents
Publication Type:Danish Patent
Publication Date:October 13, 2008
Filing Date:December 3, 1999
Inventors:James P Allison, Arthur A Hurwitz, Andrea Vanelsas
Assignee:University of California
Abstract:Stimulation of T cells to respond to self antigens is achieved through a blockade of CTLA-4 signaling. CTLA-4 blocking agents are combined with antigen preparations, either alone or with additional immune response stimulating agents, in costimulation strategies to break immune tolerance and stimulate an enhanced T-cell response against self antigens. This enhanced response is useful for the treatment of non-immunogenic and poorly-immunogenic tumors, as well as other medical conditions requiring selective tissue ablation.
Representative Figure:No Figure
DetailsGoogle Patents
USPTO Patent Database

Discover Your Abilities and Aspirations!

$10 $25 $50 $100 Other
Tax Exempt 501(c)3 Non-Profit Organization
Any Currency

“One comes to be of just such stuff as that on which the mind is set” - Maithri Upanishath, VI.34:3

“…the peace that is found in libraries and laboratories…” - Louis Pasteur
Contact Us E-Mail: info@GangaLib.org
Ganga library non-profit 501(c)(3) org. Contributions tax deductible. IRS Tax ID 46-2892728

Copyright © 2023 Ganga Library Inc.   All Rights reserved.;
Painting Tim Tompkins - PaintHistory.com

Name: James P. Allison
Birth: 7 August 1948, Alice, TX, USA
Institution: University of Texas MD Anderson Cancer Center, Houston, TX, USA , Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA
Award: "for their discovery of cancer therapy by inhibition of negative immune regulation."
Portion of Cash: 1/2
Education, Post Doc: Ph.D. Biological Sciences, University of Texas, Auston, TX, 1973
Postdoctorial Fellow, Molecular Immunoloty, Scripps Clinic & Research Foundationn, La Jolla, CA
B.S., Microbiology, University of Texas, Auston, TX, 1969, Thought Process