Evelyn Maisel Witkin Ph.D.

National Medal of Science - Biological Science 2002

Zoologist - Molecular Geneticist. E. coli. DNA mutagenesis and DNA repair. Interests: Science education in public schools; Connections between contemporary Victorians poet Robert Browning and Charles Darwin.

Essentially same grant from 1956 until retirement in 1991.

Publications

Witkin E Journal Articles, NCBI/PubMed

Author of 98 papers in refereed scientific journals, from 1946 through 2005. Representative sample:

1947 Witkin, EM Genetics of resistance to radiation in Escherichia coli. Genetics 32:221-248

1951 Witkin, EM Nuclear segregation and the delayed appearance of induced mutations in Escherichia coli. Cold Spring Harbor Symp. Quant. Biol. 16:357-372.

1953 Witkin, EM Effects of temperature on spontaneous and induced mutations in Escherichia coli. Proc. Natl. Acad. Sci. USA 39: 427-

1956 Witkin, EM Time, temperature and protein synthesis: a study of ultraviolet-induced mutation in bacteria. Cold Spring Harbor Symp. Quant. Biol. 21: 123-140.

1959 Witkin, EM Post irradiation metabolism and the timing of ultraviolet-induced mutations in Escherichia coli. Proc. 10th Intern. Cong. Genetics 1: 280-299.

1963 Witkin, EM, BA Scutella and GM Bennett, Photo reversibility of induced mutations in a non-photoreversible strain of Escherichia coli. Proc. Natl. Acad, Sci USA 46: 226- 241.

1966 Witkin, EM Radiation-induced mutations and their repair. Science 152: 1345-1353.

1967 Witkin, EM The radiation-sensitivity of Escherichia coli B: A hypothesis relating filament formation and prophage induction. Proc. Natl. Acad. Sci. USA 57:1275-1279.

1967 Witkin, EM Mutation-proof and mutation-prone modes of survival in derivatives of Escherichia coli B differing in sensitivity to ultraviolet light. Brookhaven Symp. Biol. 20: 17-55.

1969 Witkin, EM Ultraviolet-induced mutations and DNA repair. Annu. Rev. Microbiol. 23:487-518 and Annu. Rev. Genet. 53: 525-552

1969 Witkin, EM The mutability toward ultraviolet light of recombination-deficient strains of Escherichia coli. Mutat. Res. 8: 9-14.

1971 Witkin, EM Ultraviolet mutagenesis in strains of E. coli deficient in DNA polymerase. Nature 229:81-82.

1973 Witkin, EM Ultraviolet mutagenesis in bacteria: the inducible nature of error-prone repair. Anais da Acad. Brasileira da Ciencias 45, suppl. 185-191.

1974 Witkin, EM Thermal Enhancement of ultraviolet mutability in a tif-1 uvrA derivative of Escherichia coli: evidence that ultraviolet mutagenesis depends upon an inducible function. Proc. Nat. Acad. Sci. USA 71:1930-1934.

1976 Witkin, EM Ultraviolet mutagenesis and inducible DNA repair. Bacteriol. Rev. 40:869-907. (ISI Citation Classic, 1987)

1984 Witkin, EM The SOS response: implications for cancer. In Genes and Cancer, M. Bishop, ed. Alan R. Liss, Inc., New York

1987 Witkin, EM Roegner-Maniscalco, V, Sweasy, JB and McCall, JO. Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutants but not in recA+ strains of Escherichia coli. Proc. Natl. Acad. Sci. USA 84:6805-6809.

1989 Witkin, EM Ultraviolet mutagenesis and the SOS response in Escherichia coli: a personal perspective. 1 Environ. Mol. Mutagen. 14 (Suppl. 16): 30-34.

1989 Garvey, N, EM Witkin and DE Brash, Ultraviolet photoproducts at the ochre mutation site in the glnU gene of Escherichia coli: relevance to "mutation frequency decline." Mol. Gen. Genet. 219: 359-364.

1991 Witkin, EM RecA protein in the SOS response: milestones and mysteries. Biochimie 73:133-141.

1991 Selby, C, Witkin, EM and Sancar, A Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair. Proc.Natl. Acad. Sci. USA. 88:11574-11578.

1992 Witkin, EM and Roegner-Maniscalco, V. Overproduction of DnaE protein (a subunit of DNA polymerase III) restores viability in a conditionally inviable Escherichia coli strain deficient in DNA polymerase I. J. Bacteriol. 174:4166-4168.

1992 Kirschner, J., Lim, D., Witkin, E. M., Garvey, N. and Roegner-Maniscalco, V. An SOS-inducible defective retronphage (R86) in Escherichia coli strain B. Mol. Micxrobiol. 6:2815-2824.

1994 Witkin, EM Mutation Frequency Decline Revisited. Bioessays 16:437-444.

1997 Witkin, EM The Wonders of Darwin's World. Perspectives in Biology and Medicine 40:471-478.

2001 Witkin, EM H. J. Muller and the Nature of the Gene. Genetics 157:461-463.

2002 Witkin, EM. Chances and Choices: Cold Spring Harbor 1944-1955. Ann. Rev. Microbiol. 56:1-15.

2005 Witkin, EM. Remembering Rollin Hotchkiss (1911-2004). Genetics 170:1443-1447.

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