®
Virtual
Great • Alfred • Nobel • Gives • Aspiration!
Nobel & Laureates' Ideas & Thought Processes!
501(C)3
Nonprofit Organization
Satoshi Omura
- MORE LISTS
- Nobel Prize Statistics
- Thought Process
- Medal, Cash, Charity
- Video Films Audio List
- Buffet, Gates, French Advice
- Special Events ▼
- Events
- Symphony Orchestra Concert, Washington, DC
- Alfred Nobel's Birth Anniversary Celebration - Essay Contest, International
- Poster Presentation of Nobel Prize 'Winners' motivations, Washington, DC
- Library name Ganga
- Vision Mission
- YOUR ESSAY
English
Amharic
Azerbaijani
German Deutsch
ಕನ್ನಡ Kannada
Português Portuguese
русский Russian
Español Spanish
Satoshi Omura
The Nobel Prize in Physiology or Medicine 2015
Nobel co-recipient: William C. Campbell, Tu Youyou
Award: "for their discoveries concerning a novel therapy against infections caused by roundworm parasites."
Patents
| Publication: | 1/88 |
| Publication No: | US 10538521 B2 |
| Title: | Pyrimidine derivative having antimalarial activity |
| Publication Type: | United States Utility Patent |
| Publication Date: | January 21, 2020 |
| Filing Date: | October 25, 2017 |
| Inventors: | Hiroshi Tomoda, Tohru Nagamitsu, Satoshi Omura |
| Assignee: | Kitasato Institute, Carna Biosciences Inc |
| Abstract: | The present invention provides a novel 2,4,6-substituted pyrimidine derivative, which is a compound represented by formula (I) (in the formula, ring A is a 6-membered heteroaryl group having at least one N atom optionally substituted with R1, R2, and R3; Z is an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted heterocycloalkyl group, or an optionally substituted heteroaryl group; and R1, R2, and R3 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted heterocycloalkyloxy group, an optionally substituted phenoxy group, an optionally substituted amino group, a nitro group, and a hydroxy group) or a pharmaceutically acceptable salt thereof. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 2/88 |
| Publication No: | US 10202627 B2 |
| Title: | Method for producing trehangelin |
| Publication Type: | United States Utility Patent |
| Publication Date: | September 12, 2019 |
| Filing Date: | February 28, 2017 |
| Inventors: | Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Yuki Inahashi |
| Assignee: | Kitasato Institute, Nagase & Co., Ltd |
| Abstract: | An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 3/88 |
| Publication No: | EP 3162805 B1 |
| Title: | Novel pharmaceutical compound having a cholesterol acyltransferase isozyme 2 (acat2) -inhibiting activity |
| Publication Type: | European Patent |
| Publication Date: | August 7, 2019 |
| Filing Date: | June 18, 2015 |
| Inventors: | Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu |
| Assignee: | Kitasato Institute |
| Abstract: | This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2. This invention relates to the compound represented by Formula (1), a salt thereof, or a solvate thereof. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 4/88 |
| Publication No: | CA 2913098 C |
| Title: | Tylosin derivatives and method for preparation thereof |
| Publication Type: | Canadian Patent |
| Publication Date: | November 2, 2021 |
| Filing Date: | May 23, 2014 |
| Inventors: | Gerd Kleefeld, Robrecht Froyman, Carolin LUDWIG, Satoshi Omura, Toshiaki Sunazuka, Hirose TOMOYASU, Sugawara AKIHIRO, Shiomi KAZURO |
| Assignee: | Bayer Animal Health GmbH, Kitasato Institute |
| Abstract: | The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (Ila), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 5/88 |
| Publication No: | US 9737558 B2 |
| Title: | Peyer's patch activator |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 22, 2017 |
| Filing Date: | September 18, 2013 |
| Inventors: | Haruki Yamada, Hiroaki Kiyohara, Kazuhiko Otoguro, Aki Ishiyama, Masato Iwatsuki, Satoshi Omura, Masami Mizu, Toshikazu Kawai, Jun Kashimura, Kenji Koge |
| Assignee: | Kitasato Institute, Mitsui Sugar Co., Ltd |
| Abstract: | The present invention provides a Peyer's patch activator containing a polysaccharide obtained from sugar cane as an active ingredient, wherein the polysaccharide contains α-glucan as a main component and has a peak molecular weight within a range of 720,000 to 1,080,000, with a proportion of glucose in all component sugars being 80% or more, and proportions of nonreducing terminal glucose and α-1,6-linked glucose being 20 to 30% and 15 to 25%, respectively. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 6/88 |
| Publication No: | EP 2862872 B1 |
| Title: | Novel cyclic depsipeptide derivative and pest control agent comprising same |
| Publication Type: | European Patent |
| Publication Date: | September 19, 2018 |
| Filing Date: | June 13, 2013 |
| Inventors: | Masaaki Mitomi, Masayo Sakai, Ryo Horikoshi, Yasumichi Onozaki, Satoshi Nakamura, Satoshi Omura, Toshiaki Sunazuka, Tomoyasu Hirose, Kazuro Shiomi, Rokuro Masuma |
| Assignee: | Kitasato Institute, Meiji Seika Pharma Co. |
| Abstract: | An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 7/88 |
| Publication No: | US 8822501 B2 |
| Title: | Pest control agents |
| Publication Type: | United States Utility Patent |
| Publication Date: | September 2, 2014 |
| Filing Date: | September 2, 2014 |
| Inventors: | Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka |
| Assignee: | Kitasato Institute, Meiji Seika Pharma Co. Ltd |
| Abstract: | Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 8/88 |
| Publication No: | EP 2782922 B1 |
| Title: | Antibacterial tylosin derivatives and methods for their preparation |
| Publication Type: | European Patent |
| Publication Date: | December 20, 2017 |
| Filing Date: | November 21, 2012 |
| Inventors: | Omura SATOSHI, Sunazuka TOSHIAKI, Hirose TOMOYASU, Sugawara AKIHIRO, Shiomi KAZURO, Gerd Kleefeld, Robrecht Froyman, Julia Charlotte DÖRNER, Carolin LUDWIG |
| Assignee: | Bayer Intellectual Property GmbH, Kitasato Institute |
| Abstract: | The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (I); a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 9/88 |
| Publication No: | EP 2752416 B1 |
| Title: | Novel mangromicin compound and production method therefor |
| Publication Type: | European Patent |
| Publication Date: | March 9, 2016 |
| Filing Date: | August 31, 2012 |
| Inventors: | Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto |
| Assignee: | Kitasato Institute |
| Abstract: | [Problem] The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. [Solution] The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. K10-0216 strain that produces said compound. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 10/88 |
| Publication No: | EP 2554546 B1 |
| Title: | Pyripyropene derivatives having acat2 inhibiting activity and stable to metabolizing enzymes |
| Publication Type: | European Patent |
| Publication Date: | July 19, 2017 |
| Representative Figure: | No Figure |
| Family | |
| Filing Date: | March 25, 2011 |
| Inventors: | Hiroshi Tomoda, Tohru Nagamitsu, Daisuke Matsuda, Taichi Ohshiro, Masaki Ohtawa, Satoshi Omura |
| Assignee: | Kitasato Institute |
| Abstract: | A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R 1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula -O-CH(R 7 )-R 8 where R 7 is a lower alkoxy group and R 8 is an aryl group, and R 2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a -CH 2 -acyloxy group and R 3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R 4 and R 3 is a group other than acetoxy, or R 2 and R 3 taken together form a group of the formula -O-CH(R 5 )-O- where R 5 is an aryl group. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 11/88 |
| Publication No: | EP 2256210 B1 |
| Title: | Wickerol and process for production thereof |
| Publication Type: | European Patent |
| Publication Date: | July 6, 2013 |
| Filing Date: | March 12, 2009 |
| Inventors: | Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Hideaki Ui, Takayuki Nagai, Haruki Yamada |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 12/88 |
| Publication No: | US 8378125 B2 |
| Title: | Substance FKI-3864 and method for preparation thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | February 19, 2013 |
| Filing Date: | February 12, 2009 |
| Inventors: | Hiroshi Tomoda, Ryuji Uchida, Rokuro Masuma, Satoshi Omura |
| Assignee: | Kitasato Institute |
| Abstract: | This invention relates to substance FKI-3864 represented by the following formula [I] having an inhibitory activity on the synthesis of triacylglycerols and a method for preparing the same. The substance FKI-3864 can be prepared by a method comprising culturing a microorganism which belongs to the genus Penicillium and is capable of producing the substance FKI-3864, and particularly Penicillium pinophilum FKI-3864 (FERM BP-11093) so as to accumulate the substance FKI-3864 in the culture and collecting the substance FKI-3864 from the culture. The substance has an inhibitory activity on the synthesis of intracellular triacylglycerols and is useful for prevention or treatment of obesity. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 13/88 |
| Publication No: | US 8519128 B2 |
| Title: | Pyripyropene derivatives having an ACAT2-inhibiting activity |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 27, 2013 |
| Filing Date: | December 17, 2008 |
| Inventors: | Hiroshi Tomoda, Tohru Nagamitsu, Satoshi Omura |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention is a compound having the general formula (I), (II), or (III) or a pharmacologically acceptable salt, solvate, or hydrate thereof, and a pharmaceutical composition containing such a compound, or its pharmacologically acceptable ester, or other pharmacologically acceptable derivative thereof as an active ingredient. The compound has an excellent ACAT 2-inhibiting activity by a mechanism different from that of a statin drug and is useful as a therapeutic or prophylactic agent for obesity, adiposis, hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, and arteriosclerosis, as well as obesity-derived hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, arteriosclerosis, and hypertension. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 14/88 | |
| Publication No: | ES 2379928 T3 | |
| Title: | Pest Control Agent | |
| Publication Type: | Spanish Patent | |
| Publication Date: | May 7, 2012 | |
| Filing Date: | November 30, 2007 | |
| Inventors: | Kimihiko Goto, Ryo Horikoshi, Kazuhiko Oyama, Satoshi Omura, Toshiaki Sunazuka | |
| Assignee: | Meiji Seika Kaisha Ltd, Kitasato Institute | |
| Abstract: | A compound represented by formula (I) or a salt thereof acceptable from an agricultural or horticultural point of view: ** Formula ** in which the two Rs represent a hydrogen atom respectively or the two Rs can be combined together to represent an oxo group. | |
| Representative Figure: | No Figure | |
| Family | ||
| Details | Google Patents USPTO Patent Database |
| Publication: | 15/88 |
| Publication No: | EP 1950219 B1 |
| Title: | Novel dihydropseudoerythromycin derivatives |
| Publication Type: | European Patent |
| Publication Date: | June 22, 2011 |
| Filing Date: | October 13, 2006 |
| Inventors: | Satoshi Omura, Toshiaki Sunazuka, Kenichiro Nagai, Hideaki Shima, Haruko Yamabe |
| Assignee: | Kitasato Institute, Aphoenix, Inc. |
| Abstract: | Compounds represented by the general formula [I] (wherein each symbol is as defined in the description) or pharmacologically acceptable salts thereof; and pharmaceutical compositions containing the compounds or the salts as the active ingredient. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 16/88 | |
| Publication No: | EP 2111756 B1 | |
| Title: | Pest control agents | |
| Publication Type: | European Patent | |
| Publication Date: | August 2, 2017 | |
| Filing Date: | May 31, 2006 | |
| Inventors: | Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka | |
| Assignee: | BASF SE, Kitasato Institute, Meiji Seika Pharma Co., Ltd | |
| Abstract: | Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I)or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier. | |
| Representative Figure: | No Figure | |
| Family | ||
| Details | Google Patents USPTO Patent Database |
| Publication: | 17/88 |
| Publication No: | EP 2019147 B1 |
| Title: | Novel k04-0144 substances and process for production thereof |
| Publication Type: | European Patent |
| Publication Date: | May 4, 2011 |
| Filing Date: | May 16, 2006 |
| Inventors: | Hiroshi Tomoda, Yong-Pil Kim, Hideaki Hanaki, Atsuko Matsumoto, Yoko Takahashi, Satoshi Omura |
| Assignee: | Kitasato Institute |
| Abstract: | K04-0144 substances A, B and C which can be produced by culturing a microorganism exemplified by Streptomyces sp. strain K04-0144 (which is capable of producing K04-0144 substances) in a culture medium and then collecting the substances from the culture medium. The substances have a potent antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and are therefore useful as therapeutic agents for MRSA infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria. A novel K04-0144 substance D which is also collected from the culture medium can enhance the effect of a β-lactam antibiotic (which has been used as an antibacterial agent) by using it in combination with the β-lactam antibiotic, and is therefore useful as a therapeutic agent for methicillin-resistant Staphylococcus aureus (MRSA) infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 18/88 |
| Publication No: | US 7982057 B2 |
| Title: | Compound of stemphones and production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | July 19, 2011 |
| Filing Date: | March 15, 2006 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda |
| Assignee: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda |
| Abstract: | The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 19/88 |
| Publication No: | US 7794991 B2 |
| Title: | Stemphones and production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | September 14, 2010 |
| Filing Date: | October 3, 2005 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to novel stemphones having enhancing effect of β-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of β-lactam antibiotic used as an antibacterial agent by combining with β-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including β-lactam antibiotic resistance. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 20/88 |
| Publication No: | US 7371548 B2 |
| Title: | Avermectin aglycon synthase genes |
| Publication Type: | United States Utility Patent |
| Publication Date: | May 13, 2008 |
| Filing Date: | December 7, 2004 |
| Inventors: | Satoshi Omura, Haruo Ikeda |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the biosynthesis of a polyketide compound, or its mutants having avermectin aglycon synthase activity, particularly functional modules and submodules in the DNA sequence derived from Streptomyces avermitilis, a polypeptide or mutants thereof encoded by the DNA or the mutants, a vector containing the DNA or the mutants, a host cell transformed with the DNA, the mutants thereof, or the vector, and a method for producing avermectin. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 21/88 |
| Publication No: | US 7250402 B2 |
| Title: | Avermectin derivatives |
| Publication Type: | United States Utility Patent |
| Publication Date: | July 31, 2007 |
| Filing Date: | November 29, 2004 |
| Inventors: | Satoshi Omura, Kenichiro Nagai, Toshiaki Sunazuka |
| Assignee: | Kitasato Institute |
| Abstract: | A compound represented by the general formula (I) or a salt thereof: wherein represents -CH-CH-, -CH2-CH2- or the like, between R<1 >and the carbon atom at 4'-position represents a single bond or a double bond, between R<2 >and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when represents -CH-CH- or -CH2-CH2-, and between R<1 >and the carbon atom at 4'-position represents a double bond, R<1 >represents -C(R<11>)(R<12>) (wherein R<11 >represents a lower alkyl group or the like and R<12 >represents a hydrogen atom or the like) or the like, and R<2 >represents a hydroxyl group or the like, or R<2 >may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when represents -CH-CH- or -CH2-CH2-, and between R<1 >and the carbon atom at 4'-position represents a single bond, R<1 >represents -OCH(R<1a>)(R<1b>) (wherein R<1a >represents a lower alkyl or the like and R<1b >represents a hydrogen atom or the like) or the like, and R<2 >represents a hydroxyl group or the like. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 22/88 |
| Publication No: | AU 2003268635 B2 |
| Title: | FKI-1366 substances and process for producing the same |
| Publication Type: | Australian Patent |
| Publication Date: | March 15, 2007 |
| Filing Date: | August 29, 2003 |
| Inventors: | Masayoshi Arai, Rokuro Masuma, Satoshi Omura, Hiroshi Tomoda |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism belonging to Beauveria sp. and having ability to produce FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366 FERM BP-08459) is cultured in a medium, accumulating FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C in the culture liquid and isolating FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C from the cultured mass. Since the thus obtained FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C or composition thereof have activity to enhance azole antifungal agent, the substance has an action against various fungal infections such as deep-seated mycosis and other fungal infections in the low concentration within short term. Consequently, the substance is useful for reducing frequency of appearance of resistant microorganisms and overcoming resistance, and is expected as a medicament. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 23/88 |
| Publication No: | EP 1632569 B1 |
| Title: | Strain belonging to the genus streptomyces and being capable of producing nemadictin and process for producing nemadictin using the strain |
| Publication Type: | European Patent |
| Publication Date: | March 10, 2010 |
| Filing Date: | June 11, 2003 |
| Inventors: | Satoshi Omura, Haruo Ikeda, Yumiko Ogasawara |
| Assignee: | Kitasato Institute |
| Abstract: | In the present invention, a recombination of gene groups of nemadectin aglycon biosynthesis is performed for obtaining C-13 hydroxylnemadectin, to which sugar groups can be attached, and a production strain which produces C-13 hydroxylnemadectin is produced. Further, C-13 glycosylnemadectin producing strain is prepared by introducing aveBI-BVIII genes involving glycosidation of avermectin and biosynthesis of oleandrose. As described, C-13 hydroxylnemadectin and C-13 glycosidated nemadectin can be obtained effectively by using the producing strain prepared by means of the molecular genetic technology, and improvement in the biological activity thereof can be expected. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 24/88 |
| Publication No: | US 6747056 B2 |
| Title: | K99-5041 substance and production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | June 8, 2004 |
| Filing Date: | February 6, 2003 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Yoko Takahashi, Yutaka Ebizuka, Masaaki Shibuya |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention comprising culturing a microorganism which belongs to genus Streptomyces and has ability to produce K99-5041-C1x substance and/or K99-5041-C2x substance in a medium, accumulating K99-5041-C1x substance and/or K99-5041-C2x substance in the culture fluid, and isolating K99-5041-C1x substance and/or K99-5041-C2x substance form the cultured mass. Since the obtained K99-5041-C1x substance and/or K99-5041-C2x substance exhibit inhibitory activity against lanosterol synthase, these substances are expected to apply clinically for preventive and therapeutic agents caused by accumulation of cholesterol in humans and antifungal agents. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 25/88 |
| Publication No: | AU 2003203250 B2 |
| Title: | Novel substances K01-B0171 and process for producing the same |
| Publication Type: | Australian Patent |
| Publication Date: | May 11, 2006 |
| Filing Date: | January 17, 2003 |
| Inventors: | Masato Iwatsuki, Satoshi Omura, Yoko Takahashi, Hiroshi Tomoda |
| Assignee: | Kitasato Institute |
| Abstract: | he present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 26/88 |
| Publication No: | DK 1350510 T3 |
| Title: | Use of an agent for suppressing infection and proliferation of human immunodeficiency virus |
| Publication Type: | Danish Patent |
| Publication Date: | August 29, 2005 |
| Filing Date: | November 25, 2002 |
| Inventors: | Satoshi Omura, Kiyoko Akagawa, Toshiaki Sunazuka |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to the use of a macrolide derivative in the manufacture of a medicament for suppression of infection and/or proliferation of human immunodeficiency syndrome virus in a macrophage derived from a human monocyte. The invention also relates to the use of a macrolide derivative for in vitro suppression of infection and/or proliferation of human immunodeficiency syndrome virus in a macrophage derived from a human monocyte. In both cases preferably the macrophage is an M type macrophage derived from a human monocyte. The medicaments of the present invention are useful for treatment of patients with HIV-1 infection as low cost chemotherapeutic agents, and in addition, are clinically useful as supplement agents in HAART (highly active anti-retroviral therapy). |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 27/88 |
| Publication No: | AU 2002301970 B2 |
| Title: | WK-5344A substance and WK-5344B substance and production thereof |
| Publication Type: | Austrialian Patent |
| Publication Date: | February 10, 2005 |
| Filing Date: | November 13, 2002 |
| Inventors: | Satoshi Omura, Yoko Takahashi, Hiroshi Tomoda |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to novel substance having inhibitory action on cholesteryl ester transfer protein, WK-5344A substance and WK-5344B substance, and process for production thereof. A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 28/88 |
| Publication No: | DE 60230686 D1 |
| Title: | ANTHELMINTIC SUBSTANCE FKI-1033 AND METHOD FOR THE PRODUCTION THEREOF |
| Publication Type: | German Patent |
| Publication Date: | February 12, 2009 |
| Filing Date: | November 12, 2002 |
| Inventors: | Satoshi Omura, Kazuro Shiomi, Rokuro Masuma |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism capable producing a substance FKI−1033 represented by the following formula: is cultured in a medium to accumulate the FKI−1033 in the culture medium and then the FKI−1033 is collected from the culture medium. Because of having ryanodine antagonism, insecticidal activity and anti−parasitic worm activity, the thus obtained FKI−1033 is expected as being useful as a chemical having satisfactory efficaciousness, toxicity, etc. and being applicable to pesticides, veterinary medicines and medicines. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 29/88 |
| Publication No: | AU 2002344494 B2 |
| Title: | Novel substance FKI-1033 and process for producing the same |
| Publication Type: | Australian Patent |
| Publication Date: | February 12, 2009 |
| Filing Date: | JNovember 12, 2002 |
| Inventors: | Rokuro Masuma, Satoshi Omura, Kazuro Shiomi |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism capable producing a substance FKI−1033 represented by the following formula: is cultured in a medium to accumulate the FKI−1033 in the culture medium and then the FKI−1033 is collected from the culture medium. Because of having ryanodine antagonism, insecticidal activity and anti−parasitic worm activity, the thus obtained FKI−1033 is expected as being useful as a chemical having satisfactory efficaciousness, toxicity, etc. and being applicable to pesticides, veterinary medicines and medicines. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 30/88 |
| Publication No: | US 7521428 B2 |
| Title: | Macrolide derivatives having effect of potentiating antifungal activity |
| Publication Type: | United States Utility Patent |
| Publication Date: | April 21, 2009 |
| Filing Date: | October 29, 2002 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka, Masayoshi Arai, Tohru Nagamitsu |
| Assignee: | Kitasato Institute |
| Abstract: | Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of appearance of resistant microorganisms. One such substance is a compound represented by the formula [I]: wherein R1 is Ac, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is H, when R1 Bzl, R2 and R3 are Bzl, and R4 is Me; when R1 is Ac, R2 and R3 are Pr, and R4 is Me; when R1 is Ac, R2 and R3 are Hex, and R4 is Me; when R1 is Ac, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 and R3 are Pr, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is Me; when R1 is H, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 is H, R3 is Bzl, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is H, or when R1 is H, R2 and R3 are Hex, and R4 is Et. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 31/88 |
| Publication No: | US 7514455 B2 |
| Title: | Inhibitors against complex II of electron transport system |
| Publication Type: | United States Utility Patent |
| Publication Date: | April 7, 2009 |
| Filing Date: | June 10, 2002 |
| Inventors: | Satoshi Omura, Kazuro Shiomi, Hiroshi Tomoda, Rokuro Masuma, Kiyoshi Kita |
| Assignee: | Kitasato Institute |
| Abstract: | An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or its tautomer 2-pyridone derivative represented by the general formula [II] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or salt thereof as an active ingredient. The compound inhibits the complex II strongly with nM order activity. Consequently, 2-pyridinol derivative or its tautomer, 2-pyridone derivative, are useful as the complex II inhibitor. |
| Representative Figure: | |
  | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 32/88 |
| Publication No: | US 7630836 B2 |
| Title: | Polynucleotides |
| Publication Type: | United States Utility Patent |
| Publication Date: | December 8, 2009 |
| Filing Date: | May 29, 2002 |
| Inventors: | Satoshi Omura, Haruo Ikeda, Jun Ishikawa, Hiroshi Horikawa, Tadayoshi Shiba, Yoshiyuki Sakaki, Masahira Hattori |
| Assignee: | Kitasato Institute, National Institute Of Technology And Evaluation |
| Abstract: | Novel polynucleotides derived from microorganisms belonging to actinomycetes and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 33/88 |
| Publication No: | US 7192742 B2 |
| Title: | FO-6979 substances and process for producing the same |
| Publication Type: | United States Utility Patent |
| Publication Date: | March 20, 2007 |
| Filing Date: | March 19, 2002 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda |
| Assignee: | Kitasato Institute, Japan Society For The Promotion Of Science |
| Abstract: | (Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 substances in the liquid culture medium. Then the FO-6979-M0, -M1, -M2, -M3 and -M4 substances are collected from the culture medium. The substances thus obtained are less toxic, specifically inhibit acyl-Coenzyme A: cholesterol acyltransferase, and inhibit the formation of oil droplets in macrophages. Owing to these characteristics, the above substances are useful in preventing and treating human diseases caused by cholesterol accumulation. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 34/88 |
| Publication No: | US 6512099 B2 |
| Title: | Roselipin derivative |
| Publication Type: | United States Utility Patent |
| Publication Date: | January 28, 2003 |
| Filing Date: | March 13, 2002 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda |
| Assignee: | Kitasato Institute |
| Abstract: | Roselipin derivatives which are represented by the following formula:[wherein R1 represents a hydrogen atom, mannose or acetylated mannose, R2 represents a hydrogen atom or a methyl group, and R3 represents a methyl group or a sugar alcohol], excluding a compound in which R1 is mannose, R2 is a hydrogen atom and R3 is arabinitol (roselipin 1A or 1B) and a compound in which R1 is acetylated mannose, R2 is a hydrogen atom and R3 is arabinitol (roselipin 2A or 2B), and which are useful for preventing and treating a disease of a human which is caused by accumulation of triacylglycerol can be obtained. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 35/88 |
| Publication No: | US 7132447 B2 |
| Title: | Substance FKI-1083 and process for producing the same |
| Publication Type: | Canadian Patent |
| Publication Date: | November 7, 2006 |
| Filing Date: | December 11, 2001 |
| Inventors: | Satoshi Omura, Kazuro Shiomi, Rokuro Masuma |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isolating FKI-1083 substance from the cultured mass. The thus obtained FKI-1083 substance has growth inhibitory activities against microorganisms, nematodes and arthropods, and is useful as anthelmintic and insecticide. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 36/88 |
| Publication No: | CA 2418968 C |
| Title: | Avermectin derivatives |
| Publication Type: | Canadian Patent |
| Publication Date: | November 24, 2009 |
| Filing Date: | August 8, 2001 |
| Inventors: | Satoshi Omura, Kenichiro Nagai, Toshiaki Sunazuka |
| Assignee: | Kitasato Institute |
| Abstract: | Provided is a compound represented by the general formula (I) or a salt thereof: (see formula I) wherein, -X~Y- represents -CH=CH- and the like, ~ between R2 and the carbon atom at 5-position represents a single bond or a double bond, R1 represents a lower alkyl group, a formyl group, a carboxyl group, a lower alkoxycarbonyl group (wherein a lower alkyl moiety of said lower alkoxycarbonyl group may be substituted wit h a heterocyclic group) and the like, and R1a represents a hydrogen atom, provid ed when R1 represents a lower alkoxycarbonyl group and the like, R1a may further represents a lower alkoxycarbonyl group and the like, when ~ between R2 and the carbon at om at 5-position is a single bond, R2 represents a hydroxyl group and the like, an d when ~ between R2 and the carbon atom at the 5-position is a double bound, R2 combines with the carbon atom at 5-position to form a hydroxime group (-C(=NOH)) and the like, and R3 represents a hydroxyl group or a tri(lower alkyl)silyloxy group. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 37/88 |
| Publication No: | US 6902925 B2 |
| Title: | Selection media for beauveriolide I or beauveriolide III and process for selectively producing these substances |
| Publication Type: | United States Utility Patent |
| Publication Date: | June 7, 2005 |
| Filing Date: | April 10, 2001 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda |
| Assignee: | Kitasato Institute, Japan Society For The Promotion Of Science |
| Abstract: | The present invention is a process for selective production of beauveriolide I substance or beauveriolide III substance, in which a beauveriolide producing microorganism strain FO-6979 or mutant thereof is cultured in a medium for fungi added with specific amino acid in order to produce beauveriolide I substance or beauveriolide III substance selectively with high yield; beauveriolide I substance or beauveriolide III substance is accumulated selectively in the cultured mass; and beauveriolide I substance or beauveriolide III substance is collected selectively with high yield from said cultured mass. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 38/88 |
| Publication No: | US 6818422 B2 |
| Title: | Substances K97-0239 and process for producing the same |
| Publication Type: | United States Utility Patent |
| Publication Date: | November 16, 2004 |
| Filing Date: | April 3, 2001 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda |
| Assignee: | Kitasato Institute, Japan Society For The Promotion Of Science |
| Abstract: | A microorganism capable of producing substances K97-0239 comprising K97-0239A represented by the following formula [I]: and K97-0239B represented by the following formula [II]: is cultured in a medium and the substances K97-0239 thus accumulated in the medium are collected from the culture medium. The obtained substances have a low toxicity and specifically inhibit the foaming of macrophages. Owing to these characteristics, they are useful in preventing and treating human arteriosclerosis and diseases caused thereby. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 39/88 |
| Publication No: | DE 60127948 D1 |
| Title: | PROCESS FOR THE PREPARATION OF AVERMECTIN DERIVATIVES |
| Publication Type: | German Patent |
| Publication Date: | May 31, 2007 |
| Filing Date: | February 23, 2001 |
| Inventors: | Hirofumi Endo, Hiroyuki Yamaguchi, Yutaka Kanda, Shinichi Hashimoto, Satoshi Omura, Haruo Ikeda |
| Assignee: | Kitasato Institute |
| Abstract: | According to the present invention, 22,23-dihydroavermectin B1a, which is useful as a medicine, a veterinary drug, and a pesticide, can be directly fermented and produced. This can obviate the need for the complicated and difficult conventional processes for purifying avermectin B1a at an industrial level and for chemically modifying avermectin B1a and can significantly decrease cost and time required in the industrial production of 22,34-dihydroavermectin B1a. The production of the formulation containing only 22,23-dihydroavermectin B1a, which is highly effective as a medicine, is also realized. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 40/88 |
| Publication No: | AU 2001227080 B2 |
| Title: | Method of detecting substance inhibiting type III secretion mechanism of bacterium and the function of secretory protein thereof |
| Publication Type: | Australian Patent |
| Publication Date: | February 10, 2005 |
| Filing Date: | January 22, 2001 |
| Inventors: | Akio Abe, Satoshi Omura |
| Assignee: | Kitasato Institute |
| Abstract: | A method whereby a substance specifically inhibiting the type III secretion mechanism and the function of a type III secretory protein secreted therefrom can be detected in a large amount within a short period of time without depending on any animal infection experiments. This method of detecting a bacterial type III secretion mechanism inhibitor is characterized by mixing a bacterium having the type III secretion mechanism with an erythrocyte suspension, adding a type III secretion mechanism inhibitor thereto and detecting a change in the hemolytic activity caused thereby. This method makes it possible to treat a number of samples within a short period of time by numerically expressing a substance inhibiting the type III secretion mechanism of a bacterium or the function of a type III secretory protein with the use of the hemolytic activity of erythrocytes as an indication. Owing to this characteristic, this method is advantageous in, for example, developing drugs. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 41/88 |
| Publication No: | US 6586200 B2 |
| Title: | Method for detecting substances inhibiting the bacterial type III secretion mechanism and function of secretory proteins thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | July 1, 2003 |
| Filing Date: | January 22, 2001 |
| Inventors: | Satoshi Omura, Akio Abe |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to a method for detecting substances specifically inhibiting a type III secretion mechanism and functions of the type III secretory proteins, within short time and large amounts thereof, without depending upon animal infectious experiments. Namely it relates to the method for detection of a type III secretory mechanism inhibitor comprising mixing a bacterium having the type III secretory mechanism and an erythrocyte suspension, adding the type III secretory mechanism inhibitor thereto, and detecting changes in the thus formed hemolytic activity. The method for detecting substances can be treated large amount of samples within short time by exhibiting the substances inhibiting the type III secretion mechanism or the functions of the type III secretory proteins as numerical index of the hemolytic activity of erythrocytes. Consequently, the present invention is useful for development of drugs. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 42/88 |
| Publication No: | US 6835747 B1 |
| Title: | Ft-0554a substances and process for the preparation thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | December 28, 2004 |
| Filing Date: | August 22, 2000 |
| Inventors: | Satoshi Omura, Kazuro Shiomi, Tohru Nagamitsu, Toshiaki Sunazuka, Yuzuru Iwai |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to obtain novel FT-0554A substance useful for infectious disease of parasite, especially helminth and more particularly relates to the novel FT-0554A substance represented by the following formula [I] or the tautomer thereof represented by the formula [II] obtained by treating FT-0554 substance represented by the formula [III] under alkaline condition. |
| Representative Figure: | |
   | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 43/88 |
| Publication No: | US 6734292 B1 |
| Title: | Pseudoerythromycin derivatives |
| Publication Type: | United States Utility Patent |
| Publication Date: | May 11, 2004 |
| Filing Date: | August 17, 2000 |
| Inventors: | Satoshi Omura, Yuzuru Iwai, Toshiaki Sunazuka, Tohru Nagamitsu |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention is to obtain novel anti-inflammatory agents having decreased antibacterial activity and increased anti-inflammatory action, and is psedoerythromycin derivatives represented by the following general formula [I], wherein R1 and R2 are same or different and each represents H, alkyl, alkynyl, acyl or sulfonyl, in which these groups may optionally have substituents, and Me indicates methyl. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 44/88 |
| Publication No: | US 6790968 B1 |
| Title: | Substance FKI-0076 and process for producing the same |
| Publication Type: | United States Utility Patent |
| Publication Date: | September 14, 2004 |
| Filing Date: | March 6, 2000 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma, Masayoshi Arai |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism having ability to produce FKI-0076 substance represented by the following formula [I] is cultured in a medium allowing for the accumulation of FKI-0076 substance in the culture liquid. The FKI-0076 substance from can then be isolated the cultured mass. Since the substance has the ability to enhance azole antifungal agents, it provides an action against various fungal infections such as deep-seated mycosis and other fungal infections in low concentration and within a short term. Consequently, the FKI-0076 is useful for reducing the frequency of appearance of resistant microorganisms. Further, usefulness for overcoming resistance is expected. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 45/88 |
| Publication No: | US 6605595 B1 |
| Title: | Avermectin derivatives |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 12, 2003 |
| Filing Date: | February 9, 2000 |
| Inventors: | Satoshi Omura, Toshiaki Sunazuka, Andreas Turberg, Georg von Samson-Himmelstjerna, Olaf Hansen, Achim Harder |
| Assignee: | Kitasato Institute |
| Abstract: | Avermectin derivatives represented by the general formula (I) or salts thereof: wherein —X----Y— represents —CH═CH—, —CH2—C(═O)—, —CH2—CH2—, or —CH2—CH(R13)—; for example, 1) when —X----Y— represents —CH═CH—, R1 represents (R11)(R12)C [wherein R11 represents a substituted or unsubstituted lower alkyl group; a formyl group; a lower alkoxylcarbonyl group etc.; and R12 represents a hydrogen atom or a lower alkyl group]; when the bond between R2 and a carbon atom at the 5-position is a single bond, R2 represents a hydroxyl group or a tri(lower alkyl)silyloxy group; or R2 forms a carbonyl group or a hydroxime group together with the carbon atom at the 5-position; 2) when —X----Y— represents —CH2—C(═O)—, R1 represents (R11a)(R12a)C [wherein R11a represents a lower alkoxycarbonyl group, or —COOCH2CH═CH2; and R12a represents a hydrogen atom]; and R2 represents a hydroxyl group or a tri(lower alkyl)silyloxy group. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 46/88 |
| Publication No: | DE 60127948 D1 |
| Title: | PROCESS FOR THE PREPARATION OF AVERMECTIN DERIVATIVES |
| Publication Type: | German Patent |
| Publication Date: | May 31, 2007 |
| Filing Date: | February 23, 2001 |
| Inventors: | Hirofumi Endo, Hiroyuki Yamaguchi, Yutaka Kanda, Shinichi Hashimoto, Satoshi Omura, Haruo Ikeda |
| Assignee: | Kitasato Institute |
| Abstract: | According to the present invention, 22,23-dihydroavermectin B1a, which is useful as a medicine, a veterinary drug, and a pesticide, can be directly fermented and produced. This can obviate the need for the complicated and difficult conventional processes for purifying avermectin B1a at an industrial level and for chemically modifying avermectin B1a and can significantly decrease cost and time required in the industrial production of 22,34-dihydroavermectin B1a. The production of the formulation containing only 22,23-dihydroavermectin B1a, which is highly effective as a medicine, is also realized. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 47/88 |
| Publication No: | US 6608185 B1 |
| Title: | Substances KF-1040T4A,KF-1040T4B, KF-1040T5A, and KF-1040T5B, and process for producing same |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 19, 2003 |
| Filing Date: | March 25, 1999 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism which belongs to the genus Gliocladium and has the ability to produce stereoisomers KF-1040T4A and KF-1040T4B which are compounds represented by the following formula [I],and stereoisomers KF-1040T5A and KF-1040T5B which are compounds represented by the following formula [II],is cultivated in a culture medium to accumulate KF-1040T4A and/or KF-1040T4B and/or KF-1040T5A and/or KF-1040T5B in the culture medium, and the substance KF-1040T4A and/or KF-1040T4B and/or KF-1040T5A and/or KF-1040T5B are harvested from the culture medium. The obtained substances are useful for the prevention and treatment of the diseases relating to arteriosclerosis, obesity, thrombosis, inflammations and immunofunctional disorders. |
| Representative Figure: | |
  | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 48/88 |
| Publication No: | DE 69932746 D1 |
| Title: | SUBSTANCES WK-5344A AND Wk-5344B AND METHOD FOR THE PRODUCTION THEREOF |
| Publication Type: | German Patent |
| Publication Date: | September 21, 2006 |
| Filing Date: | March 8, 1999 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Yoko Takahashi |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to novel substance having inhibitory action on cholesteryl ester transfer protein, WK-5344A substance and WK-5344B substance, and process for production thereof. A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 49/88 |
| Publication No: | TW 526201 B |
| Title: | Novel FT-0554 substance and its production |
| Publication Type: | Taiwanese Patent |
| Publication Date: | April 1, 2003 |
| Filing Date: | November 3, 1998 |
| Inventors: | Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Yuzuru Iwai |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to fungi having producing activity of FT-0554 substance represented by the following formula [I] subjected to accumulation of FT-0554 substance in the cultured medium, and isolating FT-0554 substance from the said cultured mass. The medicament useful for treatment of parasitic infection, specifically helminthiasis can be obtained. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 50/88 |
| Publication No: | US 6077943 A |
| Title: | Method of producing erythromycin derivative |
| Publication Type: | United States Utility Patent |
| Publication Date: | June 20, 2000 |
| Filing Date: | August 28, 1998 |
| Inventors: | Satoshi Omura, Masayasu Kato, Miichiro Arita |
| Assignee: | Takeda Chemical Industries, Ltd., Kitasato Institute |
| Abstract: | A method of producing an N-demethyl-N-isopropyl-8,9-anhydroerythromycin A-6,9-hemiacetal or a salt thereof, characterized in that an N-demethylerythromycin A or a salt thereof is reacted with an isopropylating agent and subsequently treated under acidic conditions, and a method of producing a substantially pure crystal of an 8,9-anhydroerythromycin A-6,9-hemiacetal derivative represented formula (VI): ##STR1## wherein R1 and R2, whether identical or not, represent an alkyl having 1 to 6 carbon atoms, an alkenyl having 2 to 6 carbon atoms or an alkynyl having 2 to 6 carbon atoms; R3 represents hydrogen or a hydroxyl group; one of R4 and R5 represents hydrogen and the other represents a hydroxyl group, or R4 and R5 bind together to represent O═; R6 represents hydrogen or a hydroxyl group that may be substituted for; R7 represents hydrogen or a hydroxyl group; or a salt thereof, characterized in that a crude crystal of said 8,9-anhydroerythromycin A-6,9-hemiacetal derivative or a salt thereof is recrystallized as a solvation product from hydrated isopropanol. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 51/88 |
| Publication No: | CA 2315796 C |
| Title: | Novel substances kf-1040 and process for producing the same |
| Publication Type: | United States Utility Patent |
| Publication Date: | March 9, 2004 |
| Filing Date: | February 16, 1998 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma |
| Assignee: | Kitasato Institute |
| Abstract: | A process for producing a substance KF-1040A represented by formula (I), and another substance KF-1040B represented by formula (II), which comprises culturing microorganisms capable of producing the substances KF-1040A and KF-1040B, thus accumulating these KF-1040A and/or KF-1040B in the liquid culture and harvesting the same from the culture. Because of the activities of inhibiting diacyloglycerol transferase and sphingomyelinase, the above substances are useful in preventing and treating arteriosclerosis, obesity, thrombus, inflammation and immune function-related diseases. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 52/88 |
| Publication No: | US 5869675 A |
| Title: | Lactacystin derivatives |
| Publication Type: | United States Utility Patent |
| Publication Date: | November 28, 1997 |
| Filing Date: | February 9, 2000 |
| Inventors: | Satoshi Omura, Toshiaki Sunazuka, Haruo Tanaka |
| Assignee: | Kitasato Institute |
| Abstract: | Novel lactacystin derivatives other than lactacystin per se, with superior activity for the genesis of neurites and highly selective toxicity and low cytotoxicity as compared with known lactacystin have been prepared, of the formula ##STR1## wherein R is lower alkoxy, --S--(CH2)n R1 or --S--(CH2) n --CH(R2)-(R3), in which R1 is branched or straight-chain lower alkyl, hydroxy, carboxyl, lower alkoxycarbonyl, optionally substituted phenyl, substituted or unsubstituted amino or pyridyl, R2 is substituted or unsubstituted amino, lower alkyl or amino acid residue, R3 is carboxyl, lower alkoxycarbonyl, lower alkenyloxycarbonyl or amino acid residue, and n is 0-4, or a pharmacologically acceptable salt thereof. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 53/88 |
| Publication No: | US 5756320 A |
| Title: | Bioactive substances K93-0711 I-1 and I-2 and process for production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | May 26, 1998 |
| Filing Date: | January 21, 1997 |
| Inventors: | Satoshi Omura, Kanki Komiyama, Masahiko Hayashi, Satoshi Takamatsu |
| Assignee: | Kitasato Institute |
| Abstract: | Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium. These bioactive substances K93-0711 I-1 and I-2 are then isolated therefrom. The substances are effective for treatment of IL-6-involving diseases such as cancer cachexia, multiple myeloma and rheumatoid arthritis. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 54/88 |
| Publication No: | US 5807721 A |
| Title: | Compound FO-1289, process of production with aspergillus and strain |
| Publication Type: | United States Utility Patent |
| Publication Date: | September 21, 2006 |
| Filing Date: | December 4, 1995 |
| Inventors: | Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma |
| Assignee: | Kitasato Institute |
| Abstract: | A FO-1289 substance of the formula ##STR1## wherein R1, R2, R3 and R4 are hydrogen or acyl. A process for the production thereof comprises culturing the novel microorganism Aspergillus sp. FO-1289 FERM BP-4242 in a nutrient medium, accumulating the FO-1289 substance thus produced in the medium, and isolating the FO-1289 substance therefrom. Particular species of the FO-1289 substance comprise FO-1289A, in which R1, R2 and R3 are acetyl and R4 is hydrogen; FO-1289B, wherein R1 is propionyl, R2 and R3 are acetyl and R4 is hydrogen; FO-1289C, wherein R1 and R3 are acetyl, R2 is propionyl and R4 is hydrogen; and FO-1289D, wherein R1 and R2 are acetyl, R3 is propionyl and R4 is hydrogen. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 55/88 |
| Publication No: | AU 664437 C |
| Title: | FO-1289 substance and its production |
| Publication Type: | Australian Patent |
| Publication Date: | October 15, 1995 |
| Filing Date: | March 26, 1993 |
| Inventors: | Rokuro Masuma, Satoshi Omura, Hiroshi Tomoda |
| Assignee: | Kitasato Institute |
| Abstract: | FO-1289 substance comprising FO-1289A substance, FO-1289B substance, FO-1289C substance and FO-1289D substance, which has inhibitory activity for acylcoenzyme A cholesterol acyltransferase is produced by culturing $i(Aspergillus) Sp. FO-1289. The substance is useful for treatment and prevention of a disease attributed by accumulation of cholesterol. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 56/88 |
| Publication No: | US 5336783 A |
| Title: | Calpain inhibitor cystamidin A and its production |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 9, 1994 |
| Filing Date: | March 23, 1993 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Kazuro Shiomi, Jing R. Liu |
| Assignee: | Takeda Chemical Industries, Ltd., Kitasato Institute |
| Abstract: | A novel calpain inhibitory active and low molecular weight substance, cystamidin A and its production are provided. Cystamidin A of the following formula [I] was produced by culturing Streptomyces sp. KP-1241 FERM BP-41 71 in a nutrient medium and isolating the active substance from the cultured mass. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 57/88 |
| Publication No: | US 5369021 A |
| Title: | Microorganism for selective production of a specific compound of avermectin and a method for selective production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | November 29, 1994 |
| Filing Date: | December 30, 1992 |
| Inventors: | Omura Satoshi, Ikeda Haruo |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism for selective production of a specific compound of avermectin having one or more of the following properties: specific accumulation of avermectin compound "a", effective incorporation of isoleucine or its keto acid (3-methyl-2-oxovaleric acid) into avermectin molecule, and markedly suppressed incorporation of valine or its keto acid (2-oxoisovaleric acid) into avermectin molecule. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 58/88 |
| Publication No: | US 5175150 A |
| Title: | Erythromycin derivative |
| Publication Type: | United States Utility Patent |
| Publication Date: | December 29, 1992 |
| Filing Date: | December 17, 1990 |
| Inventors: | Satoshi Omura, Zen Itoh |
| Assignee: | Kitasato Institute |
| Abstract: | Disclosed are novel erythromycin derivatives, or salts thereof, represented by the following general formula: ##STR1## and processes for preparing the same. The erythromycin derivatives described above have an excellent effect of stimulating the gastrointestinal contractile motion and have low toxicity, and the preparations containing these compounds can be advantageously used as digestive tract contractile motion stimulants. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 59/88 |
| Publication No: | AU 629966 C |
| Title: | A microorganism for selective production of specific component of avermectin and a method for selective production thereof |
| Publication Type: | Australian Patent |
| Publication Date: | May 7, 1992 |
| Filing Date: | August 6, 1990 |
| Inventors: | Haruo Ikeda, Satoshi Omura |
| Assignee: | Kitasato Institute |
| Abstract: | A microorganism for selective production of a specific compound of avermectin having one or more of the following properties: specific accumulation of avermectin compound "a", effective incorporation of isoleucine or its keto acid (3-methyl-2-oxovaleric acid) into avermectin molecule, and markedly suppressed incorporation of valine or its keto acid (2-oxoisovaleric acid) into avermectin molecule. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 60/88 |
| Publication No: | US 4948782 A |
| Title: | A method of promoting the growth of domestic animals with erythromycin derivative containing composition |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 14, 1990 |
| Filing Date: | February 18, 1988 |
| Inventors: | Satoshi Omura, Zen Itoh |
| Assignee: | Kitasato Institute |
| Abstract: | A growth promoting composition for animals containing an erythromycin derivative wherein a dimethylamino radical of the 3'-position is converted into a primary amino radical, a secondary amino radical, a tertiary amino radical other than the dimethyl amino radical, or a quaternary ammonio radical. This composition does not exhibit the antimicrobial activity at all or show the extremely decreased antimicrobial activity, and has the excellent effect to improve the feed efficiency of domestic animals. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 61/88 |
| Publication No: | DE 3788389 T2 |
| Title: | CERVINOMYCIN COMBS AS ANTIBIOTICS AND THEIR PRODUCTION PROCESS. |
| Publication Type: | German Patent |
| Publication Date: | June 23, 1994 |
| Filing Date: | February 17, 1987 |
| Inventors: | Satoshi - Omura, Akira Sumiyoshi Jutak Nakagawa, Yuzuru - Iwai |
| Assignee: | Kitasato Institute |
| Abstract: | Cervinomycin derivs. of formula (I) are new: where at least one of R1, R2 and R3 is acyl or alkyl and the rest are H; R4 is H or alkyl; B is a ring moiety of formula (II) or (III). Reaction of cervinomycin A2 (I, R1 = R4 = H, B is (II)) or cervinomycin A1 (I, R1 = R2 = R3 = R4 = H, B is (III)) with an alkylating or acylating agent. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 62/88 |
| Publication No: | DE 3650020 D1 |
| Title: | Stimulus for the contraction movement of the digestive tract. |
| Publication Type: | German Patent |
| Publication Date: | September 15, 1994 |
| Filing Date: | August 28, 1986 |
| Inventors: | Satoshi Omura, Zen Itoh |
| Assignee: | Takeda Chemical Industries, Ltd., Kitasato Institute |
| Abstract: | Disclosed are digestive tract contractile motion stimulants containing compounds, or salts thereof, represented by the following general formula: ##STR1## The compounds described above have an excellent effect of stimulating the gastrointestinal contractile motion, and the preparation of the present invention containing these compounds can be advantageously used as digestive tract contractile motion stimulants. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 63/88 |
| Publication No: | EP 0215355 B1 |
| Title: | Erythromycin derivative and process for preparing the same |
| Publication Type: | European Patent |
| Publication Date: | April 6, 1994 |
| Filing Date: | August 28, 1986 |
| Inventors: | Satoshi Omura, Zen Itoh |
| Assignee: | Kitasato Institute |
| Abstract: | Disclosed are novel erythromycin derivatives, or salts thereof, represented by the following general formula: |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 64/88 |
| Publication No: | CA 1312862 C |
| Title: | Erythromycin derivative and process for preparing the same |
| Publication Type: | Canadian Patent |
| Publication Date: | January 19, 1993 |
| Filing Date: | August 27, 1986 |
| Inventors: | Satoshi Omura, Zen Itoh |
| Assignee: | Kitasato Institute |
| Abstract: | Abstract of the Disclosure Disclosed are novel erythromycin derivatives, or salts thereof, represented by the following general formula: and processes for preparing the same. The erythromycin derivatives described above have an excellent effect of stimulating the gastrointestinal contractile motion and have low toxicity, and the preparations containing these compounds can be advantageously used as digestive tract contractile motion stimulants. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 65/88 |
| Publication No: | US 4677097 A |
| Title: | Compositions for inducing contractile motility of the gastrointestinal tract |
| Publication Type: | United States Utility Patent |
| Publication Date: | June 30, 1987 |
| Filing Date: | October 4, 1985 |
| Inventors: | Satoshi Omura, Zen Itoh |
| Assignee: | Kitasato Institute |
| Abstract: | A pharmaceutical composition for inducing contractile motility of the gastrointestinal tract in humans and animals, comprising as active ingredient 8,9-anhydroerythromycin 6,9-hemiketals, anhydroerythromycins, derivatives thereof and/or pharmaceutically acceptable salts thereof, in association with a pharmaceutically acceptable carrier or excipient. The active compounds may be produced by chemical modification of erythromycin and exhibit no or little antimicrobial activity. By administering the present composition to humans and animals, contractile motility of the gastrointestinal tract similar to the motility occurring naturally under normal conditions may be effectively induced. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 66/88 |
| Publication No: | US 4626547 A |
| Title: | Antibiotic AM-2604-A, an anti-trichomonas agent, anti-caccidium agent, anti-viral agent and anti-fungal agent containing the same and methods of use of the same |
| Publication Type: | United States Utility Patent |
| Publication Date: | December 2, 1986 |
| Filing Date: | November 15, 1984 |
| Inventors: | Satoshi Omura, Hideki Shimizu |
| Assignee: | Kitasato Institute |
| Abstract: | An antibiotic substance designated as AM-2604-A is described, and is obtained by cultivating an antibiotic AM-2604-A substance-producing strain belonging to the genus Streptomyces in a nutrient medium and recovering the desired substance from the culture broth. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 67/88 |
| Publication No: | US 4666715 A |
| Title: | Antibiotic AM-5344-A2 substance and process for the production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | May 19, 1987 |
| Filing Date: | June 24, 1983 |
| Inventors: | Satoshi Omura, Yuzuru Iwai, Kiyoizumi Hinotozawa, Atsushi Hirano |
| Assignee: | Takeda Chemical Industries, Ltd., Kitasato Institute |
| Abstract: | An antibiotic AM-5344-A2 substance, and a process for the preparation of the antibiotic AM-5344-A2 substance are described. The antibiotic AM-5344-A2 substance is prepared by cultivating an AM-5344-A2 substance-producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. Am-5344 in a nutrient medium, and recovering the Am-5344-A2 substance from the culture. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 68/88 |
| Publication No: | US 4493845 A |
| Title: | Antibiotic AM-3603 |
| Publication Type: | United States Utility Patent |
| Publication Date: | January 15, 1985 |
| Filing Date: | October 18, 1982 |
| Inventors: | Satoshi Omura, Yoshitake Tanaka, Yuzuru Iwai, Yoko Takahashi, Akira Nakagawa |
| Assignee: | Kitasato Institute |
| Abstract: | Antibiotic AM-3603 which is also designated as irumamycin is represented by the following formula: ##STR1## This substance is active upon certain Gram-positive bacteria, phytopathogenic fungi and dermatophytes, and is of interest in treating various diseases of humans and animals caused by infectious bacteria and fungi and also useful for agricultural purposes. Antibiotic AM-3603 may be prepared by fermentation, in which a microorganism capable of producing AM-3603 is cultured in a medium to accumulate AM-3603 in the cultured broths, from which AM-3603 is recovered. A preferred strain is Streptomyces sp. AM-3603 (FERM-P 5619; NRRL 12518). |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 69/88 |
| Publication No: | US 4353986 A |
| Title: | Process for producing antibiotic nanaomycin E |
| Publication Type: | United States Utility Patent |
| Publication Date: | October 12, 1982 |
| Filing Date: | June 22, 1981 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Itaru Takahashi, Shinzo Ishii, Kazuyuki Mineura, Kunikatsu Shirahata, Masaji Kasai |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting material for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 70/88 |
| Publication No: | US 4533547 A |
| Title: | Antiviral antibiotic substance AM-2722 and process for production thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 6, 1985 |
| Filing Date: | May 11, 1981 |
| Inventors: | Satoshi Omura, Akira Nakagawa, Hiroshi Hashimoto, Yasuhiko Kojima, Yuzuru Iwai, Ruiko Oiwa, Atsushi Hirano |
| Assignee: | Kitasato Institute |
| Abstract: | A novel antiviral antibiotic AM-2722 is described represented by the molecular formula C19 H26 NO3 Cl, and having the following physicochemical properties: (1) specific rotary power: [α]D 20 -0.5 (C-1, chloroform); (2) the UV spectrum shown in FIG. 1; and (3) the IR spectrum shown in FIG. 2. Also described is a process for producing the antiviral antibiotic AM-2722, wherein a microorganism of Streptomyces which has the ability to produce the antibiotic AM-2722 is cultured aerobically in a nutrient medium and the antibiotic AM-2722 accumulated in the medium and the microorganism cells is recovered. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 71/88 |
| Publication No: | US 4324728 A |
| Title: | Compound nanaomycin A and derivatives thereof and a process for producing the same |
| Publication Type: | United States Utility Patent |
| Publication Date: | April 13, 1982 |
| Filing Date: | June 11, 1979 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A), (b) R is H and R' is NH2 (nanaomycin C), (c) R is COCH3 and R' is OH (acetylnanaomycin A), and (d) R is H and R' is OCH3 (nanaomycin A methyl ester). Nanaomycin A is a new compound of quinone type and its acute toxicity (LD50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 72/88 |
| Publication No: | US 4308210 A |
| Title: | Nanaomycin B and therapeutic compositions containing same |
| Publication Type: | United States Utility Patent |
| Publication Date: | December 29, 1981 |
| Filing Date: | May 25, 1979 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD50, intra-penetrial injection) in mice of this compound is 169 mg/Kg. Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 73/88 |
| Publication No: | DE 2961285 D1 |
| Title: | Frenolicin b, process for preparation thereof and pharmaceutical compositions containing it |
| Publication Type: | German Patent |
| Publication Date: | January 14, 1982 |
| Filing Date: | January 30, 1979 |
| Inventors: | Satoshi Omura, Yuzura Iwai, Juichi Awaya, Yoko Takahashi, Ruiko Oiwa |
| Assignee: | Kitasato Institute |
| Abstract: | A novel compound frenolicin B of the formula: ##STR1## is prepared by cultivating a microorganism belonging to genus Streptomyces, e.g. Streptomyces roseofulvus AM-3867, in a culture medium and isolating the compound formed and accumulated in the medium from the cultured product. Said frenolicin B is useful as an antibiotic. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 74/88 |
| Publication No: | US 4226879 A |
| Title: | Antibiotic composition |
| Publication Type: | United States Utility Patent |
| Publication Date: | October 7, 1980 |
| Filing Date: | September 1, 1978 |
| Inventors: | Kyowa Hakko Kogyo Kabushiki Kaisha, The Kitasato Institute |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 75/88 |
| Publication No: | US 4194064 A |
| Title: | Production of nanaomycin B |
| Publication Type: | United States Utility Patent |
| Publication Date: | March 18, 1980 |
| Filing Date: | December 7, 1977 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD50, intra-penetrial injection) in mice of this compound is 169 mg/kg. Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 76/88 |
| Publication No: | US 4196266 A |
| Title: | Production of nanaomycin A and derivatives thereof |
| Publication Type: | United States Utility Patent |
| Publication Date: | April 1, 1980 |
| Filing Date: | December 1, 1977 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Juichi Awaya, Toju Hata |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A), (b) R is H and R' is NH2 (nanaomycin C), (c) R is COCH3 and R' is CH (acetylnanaomycin A), and (d) R is H and R' is OCH3 (nanaomycin A methyl ester). Nanaomycin A is a new compound of quinone type and its acute toxicity (LD50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 77/88 |
| Publication No: | DE 2754326 C2 |
| Title: | Antibiotic AM 2282, its manufacture and pharmaceuticals |
| Publication Type: | German Patent |
| Publication Date: | October 21, 1982 |
| Filing Date: | December 6, 1977 |
| Inventors: | Atsushi Hasuda Saitama Hiramo, Yuzuru Narita Chiaba Iwai, Satoshi Tokio Omura |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to a new compound designated as AM-2282, having antibiotic activity and pharmacological activity, and a process of preparing same. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 78/88 |
| Publication No: | US 3995028 A |
| Title: | Antibiotic OS-3256-B |
| Publication Type: | United States Utility Patent |
| Publication Date: | November 30, 1976 |
| Filing Date: | August 21, 1975 |
| Inventors: | Satoshi Omura, Iwao Umezawa, Keiki Satoh, Juichi Awaya, Kanki Komiyama, Ruiko Oiwa |
| Assignee: | Kitasato Institute |
| Abstract: | The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 79/88 |
| Publication No: | US 3974273 A |
| Title: | Compound NA-337 and a process for producing the same by fermentation |
| Publication Type: | United States Utility Patent |
| Publication Date: | August 10, 1976 |
| Filing Date: | March 14, 1975 |
| Inventors: | Satoshi Omura, Haruo Tanaka, Juichi Awaya, Yaeko Konda, Yoshitsugu Narimatsu, Masayuki Onda |
| Assignee: | Kitasato Institute |
| Abstract: | This invention relates to a new compound NA-337 and a process for producing the same by fermentation. NA-337 is positive in Dragendorff's reagent. NA-337 is confirmed to be a new compound having a fat-clearing activity. This compound is produced by fermentation, in which an NA-337-producing strain is cultured aerobically in a medium and the accumulated NA-337 is recovered from the cultured matters. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 80/88 |
| Publication No: | DE 2510868 C3 |
| Title: | Nanaomycin A and process for the preparation of the antibiorica nanaomycin A and nanaomycin B. |
| Publication Type: | German Patent |
| Publication Date: | February 14, 1980 |
| Filing Date: | March 13, 1975 |
| Inventors: | Juichi Souka Saitama Awaya, Toju Tokio Hata, Satoshi Tokio Omura, Haruo Maschida Tokio Tanaka |
| Assignee: | Kitasato Institute |
| Abstract: | Novel antibiotic, OS-3966-A (I) is produced by aerobic culture of Streptomyces rosa var. notoensis (FERM-P2209). In an example, microorganism was cultured on a medium (pH 7.0) contg. glycerol 2.0, soybean powder 2.0, and NaCl 0.3% at 27 degrees C for 4 days. (I) in the culture filtrate was extracted with BuOAc at pH 2.0, transferred to 1% NaHCO3, extracted with EtOAc at pH 2.0, concd., and ppted. by addn. of petroleum ether. The yellowish brown powder was purified by a silica gel chromatography yielding 317 mg. crystals from 20 l. broth. (I) had molecular formula C16H14O6, m.pt. 178-180 degrees C, and alpha 26d = -27.5 degrees. (I) was soluble in MeOH, EtOH, EtOAc, CHCl3, Me2CO, and Et2O and insoluble in hexane, petroleum ether, and water. (I) was +ve to FeCl3 and reductive catalysts reactions and -ve to ninhydrin, Sakaguchi's, Ehrlich's, Fehling's, and Molish's reactions. (I) was effective against Mycoplasma, Gram-positive bacteria, and Trichophyton. (I) had an LD50 for mice of 282 mg./-kg. mice by i.p. injection. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 81/88 |
| Publication No: | CA 1026351 A |
| Title: | Macrocyclic lactone and its production |
| Publication Type: | Canadian Patent |
| Publication Date: | February 14, 1978 |
| Filing Date: | September 19, 1974 |
| Inventors: | Satoshi Omura, Akira Nakagawa |
| Assignee: | Kitasato Institute |
| Abstract: | No Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 82/88 |
| Publication No: | US 3956487 A |
| Title: | Novel antifungal antibiotic substance, and agricultural and horticultural fungicidal composition containing said substance |
| Publication Type: | United States Utility Patent |
| Publication Date: | May 11, 1976 |
| Filing Date: | March 20, 1974 |
| Inventors: | Toju Hata, Satoshi Omura, Michiko Katagiri, Juichi Awaya, Shimpei Kuyama, Shizuo Higashikawa, Kazuomi Yasui, Haruko Terada |
| Assignee: | Kitasato Institute |
| Abstract: | The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 83/88 |
| Publication No: | US 3956276 A |
| Title: | Novel antifugal antibiotic substance, process for production of the same, and agricultural and horticultural fungicidal composition containing said substance |
| Publication Type: | United States Utility Patent |
| Publication Date: | May 11, 1976 |
| Filing Date: | March 20, 1974 |
| Inventors: | Toju Hata, Satoshi Omura, Michiko Katagiri, Juichi Awaya, Shimpei Kuyama, Shizuo Higashikawa, Kazuomi Yasui, Haruko Terada |
| Assignee: | Kitasato Institute |
| Abstract: | The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 84/88 |
| Publication No: | DE 2231979 C3 |
| Title: | Antifungal antibiotic compound, processes for their preparation and fungicides |
| Publication Type: | German Patent |
| Publication Date: | September 4, 1975 |
| Filing Date: | June 29, 1972 |
| Inventors: | Juichi Soka Saitama Awaya, Tojiu Dr. Hata, Shizuo Higashikawa, Michiko Katagiri, Shimpei Dr. Kuyama, Satoshi Dr. Omura, Haruko Terada, Kazuomi Yasui |
| Assignee: | Kitasato Institute |
| Abstract: | The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 85/88 |
| Publication No: | CA 874952 A |
| Title: | Process for the manufacture of new antibiotics |
| Publication Type: | Canadian Patent |
| Publication Date: | October 12, 1980 |
| Filing Date: | April 13, 1978 |
| Inventors: | Hata Toju, Matsumae Akihiro, Omura Satoshi, Abe Jinnosuke, Watanabe Tetsuo |
| Assignee: | Kitasato Institute |
| Abstract: | No Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 86/88 |
| Publication No: | US 3630846 A |
| Title: | Antibiotic production using streptomyces kitasatoensis |
| Publication Type: | United States Utility Patent |
| Publication Date: | December 28, 1971 |
| Filing Date: | October 7, 1969 |
| Inventors: | Toju Hata, Akihiro Matsumae, Satoshi Omura, Jinnosuke Abe, Tetsuo Watanabe |
| Assignee: | Kitasato Institute |
| Abstract: | Manufacture of new antibiotic substances by the cultivation of a micro-organism belonging to Streptomyces kitasatoensis. The antibiotic of the invention has the general structural formula: WHEREIN WHEN R1 represents hydrogen, R2 represents acetyl, propionyl, butyryl or where when R1 represents acetyl, R2 represents acetyl, propionyl, butyryl or isovaleryl. |
| Representative Figure: | |
 | |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 87/88 |
| Publication No: | DE 1617585 C3 |
| Title: | Leucomycin antibiotics A3 to A9 |
| Publication Type: | German Patent |
| Publication Date: | October 12, 1980 |
| Filing Date: | September 4, 1967 |
| Inventors: | Jinnosuke Shizuoka Abe, Toju Hata, Akihiro Matsumae, Satoshi Omura, Tetsuo Musashino Tokio Watanabe |
| Assignee: | Kitasato Institute |
| Abstract: | No Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 88/88 |
| Publication No: | US 3535309 A |
| Title: | Antibiotics and their production |
| Publication Type: | United States Utility Patent |
| Publication Date: | October 20, 1970 |
| Filing Date: | September 1, 1967 |
| Inventors: | Toju Hata, Akihiro Matsumae, Satoshi Omura, Jinnosuke Abe, Tetsuo Watanabe |
| Assignee: | Kitasato Institute |
| Abstract: | No Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
Discover Your Abilities and Aspirations!
$10 $25 $50 $100 Other
Tax Exempt 501(c)3 Non-Profit Organization
Any Currency
“One comes to be of just such stuff as that on which the mind is set” - Maithri Upanishath, VI.34:3
“…the peace that is found in libraries and laboratories…” - Louis Pasteur
“…the peace that is found in libraries and laboratories…” - Louis Pasteur
Contact Us E-Mail: info@GangaLib.org
Ganga library non-profit 501(c)(3) org. Contributions tax deductible. IRS Tax ID 46-2892728
Copyright © 2023 Ganga Library Inc. All Rights reserved.;
Copyright © 2023 Ganga Library Inc. All Rights reserved.;
Photo Bengt Nyman, Wiki. Painting Tim Tompkins PaintHistory.com
Name: Satoshi ÅŒmura
Birth: 12 July 1935, Yamanashi Prefecture, Japan
Residence: Kitasato University, Tokyo, Japan
Award: "for their discoveries concerning a novel therapy against infections caused by roundworm parasites."
Portion of Cash: 1/3
Nobel Prize Cash & Philanthropy
Patents