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Herbert C Brown Ph.D.

The Nobel Prize in Chemistry 1979
The President's National Medel of Sciences - Physical Sciences, 1969

Organic Chemist. Development of use of boron into important reagents in organic synthesis. School, advanced several times, graduating at 12; refused further advancement, avoiding being sister's classmate.

Graduating, Depression years, future wife Sarah gave him gift, Stock's 'Hydrides of Boron and Silicon' because cheapest chemistry book! Led to Nobel Prize!

Patents

Publication:1/102
Publication No:WO 8704438 A1
Title:Novel optically active alkali metal mono- and diorganylborohydrides and boranes and process for preparing and using same
Publication Type:Application
Publication Date:Jul 30, 1987
Filing Date:Jan 21, 1987
Inventors:Brown, Herbert C.
Assignee:Aldrich Boranes Inc
Abstract:Treatment of boronic esters of very high optical purity with alkali metal aluminum hydride and treatment of borinic esters of very high optical purity with alkali metal monoalkoxyaluminohydride provides novel, quantitative synthesis of novel alkali metal monoorganyl- and diorganylborohydrides containing boron directly attached to the asymmetric center or centers of essentially 100% optical purity. These optically active mono- and diorganylborohydrides provide new, useful optically active reducing agents and convenient sources for optically active mono- and diorganylboranes.
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Publication:2/102
Publication No:US 6248885 B1
Title:Borane-trialkylamine hydroboration agents
Publication Type:Grant
Publication Date:Jun 19, 2001
Filing Date:Apr 7, 1998
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:Borane-trialkylamines of the formula H3B.NRR1R2 wherein R is a tertiary alkyl group having 4 to 8 carbon atoms, and R1 and R2 are the same or different straight or branched chain alkyl from 1 to 4 carbon atoms are provided. The compounds are new hydroboration agents.
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Publication:3/102
Publication No:US 6204405 B1
Title:Borane-trialkylamine hydroboration agents
Publication Type:Grant
Publication Date:Mar 20, 2001
Filing Date:Dec 22, 1999
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:New, economical and convenient procedures for the preparation of catecholborane in high chemically pure form using tri-O-phenylene bis borate readily prepared from the reaction of catechol with boric acid, and diborane or borane-Lewis base complexes.
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Publication:4/102
Publication No:US 6008414 A
Title:Dioxane-monochloroborane and dioxane-dichloroborane
Publication Type:Grant
Publication Date:Dec 28, 1999
Filing Date:Feb 16, 1999
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:Highly reactive hydroborating agents dioxane-monochloroborane and dioxane-dichloroborane are provided. Also provided by this invention are methods for producing dioxane-monochloroborane, dioxane-dichloroborane and methods for hydroborating olefins with these reagents.
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Publication:5/102
Publication No:US 5567849 A
Title:Borane-sulfide hydroboration agents
Publication Type:Grant
Publication Date:Oct 22, 1996
Filing Date:May 9, 1995
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A borane-sulfide represented by the formula BH3.SR1 R2 wherein B is boron, H is hydrogen, R1 and R2 each are straight or branched chain alkyl or alkoxy with at least one R being a branched chain when both R1 and R2 are alkyl, and S is sulfur. The compounds are hydroboration agents
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Publication:6/102
Publication No:US 5543569 A
Title:Borane-N,N-dialkylaniline hydroboration agents
Publication Type:Grant
Publication Date:Aug 6, 1996
Filing Date:May 9, 1995
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:Borane-N,N-dialkylanilines represented by the formula H3 B. C6 H5 NRR' wherein N is nitrogen, R is isobutyl or isopropyl and R' is straight or branched chain lower alkyl. The compounds are useful as hydroboration agents and for generating diborane.
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Publication:7/102
Publication No:US 5504240 A
Title:Borane-hydroxydialkylsulfide borates
Publication Type:Grant
Publication Date:Apr 2, 1996
Filing Date:May 9, 1995
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:Novel borane adducts of hydroxydialkylsulfide borate esters represented by formula ##STR1## wherein R is straight or branched chain alkyl or alkoxy having from 2 to 5 carbon atoms and n is 1 to 3 inclusive. The compound are new hydroboration agents.
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Publication:8/102
Publication No:US 5481038 A
Title:Borane-N,N-diisopropylalkylamine hydroboration agents
Publication Type:Grant
Publication Date:Jan 2, 1996
Filing Date:May 9, 1995
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:Borane-N,N-diisopropylalkylamines as represented by the formula: H3 B.NPrzi 2 R wherein Pri is isopropyl, R is branched-chain alkyl or cycloalkyl having 3 to 6 carbon atoms and B is boron are provided. The compounds are new hydroboration agents.
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Publication:9/102
Publication No:US 5380940 A
Title:Bis(bicyclo(2.2.2)octyl)haloboranes
Publication Type:Grant
Publication Date:Jan 10, 1995
Filing Date:Jun 26, 1992
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A novel class of enolboration reagents represented by the formula R2 BX/R'3 N wherein each R is the same or different alkyl or cycloalkyl, B is boron, X is halo, R' is lower alkyl and / indicates that R2 BX is preferably employed in the presence of R'3 N are disclosed. Methods of enolborating a wide variety of organic carbonyl compounds are also provided. Further, new bis(bicyclo[2.2.2.]octyl)haloboranes are efficacious for enolboration.
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Publication:10/102
Publication No:US 5276195 A
Title:Process for producing dimethylorganoboranes
Publication Type:Grant
Publication Date:Jan 4, 1994
Filing Date:Jul 14, 1993
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A process for preparing a dimethylorganoborane represented by the formula R*BMe2 wherein R* is a chiral organyl group attached to the boron, B is boron and Me is methyl comprising treating a chiral boronic ester R*B(OR')2 with amethyl magnesium salt or trimethylaluminum wherein R* is the same chiral organyl group and R' is alkyl.
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Publication:11/102
Publication No:US 5220072 A
Title:Process of synthesizing chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes
Publication Type:Grant
Publication Date:Jun 15, 1993
Filing Date:Mar 23, 1992
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A chemically and optically pure B-halodiiso-2-ethylapopinocampheylborane of essentially 100% ee represented by the formula: ##STR1## wherein B is borane and X is halo and a process for preparing.
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Publication:12/102
Publication No:US 5214209 A
Title:Method of producing primary amines in high yields and novel intermediates therefor
Publication Type:Grant
Publication Date:May 25, 1993
Filing Date:Mar 26, 1990
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral organo group,attached to boron, B is boron and Me is methyl.
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Publication:13/102
Publication No:US 5210310 A
Title:Optically active dimethylorganoboranes
Publication Type:Grant
Publication Date:May 11, 1993
Filing Date:Mar 26, 1990
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMe2 wherein R is an organo group, R* is a chiral organo group, attached to boron, B is boron and Me is methyl.
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Publication:14/102
Publication No:US 5202502 A
Title:Process for producing optically active alcohols
Publication Type:Grant
Publication Date:Apr 13, 1993
Filing Date:Mar 23, 1992
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A chemically and optically pure B-halodiiso-2- ethylapopinocampheylborane of essentially 100% ee represented by the formula: ##STR1## wherein B is borane and X is halo, and a process of using such for the production of optically active alcohols.
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Publication:15/102
Publication No:US 5175378 A
Title:Synthesis of optically pure forms of ipsdienol
Publication Type:Grant
Publication Date:Dec 29, 1992
Filing Date:Mar 16, 1992
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:An improved process for preparing either optically pure enantiomer of the bark beetle pheromones ipsenol and ipsdienol is provided. The process is also applicable to the condensation of aldehydes of widely varying properties to the corresponding chiral alcohol.
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Publication:16/102
Publication No:US 5175371 A
Title:Synthesis of optically pure forms of ipsenol
Publication Type:Grant
Publication Date:Dec 29, 1992
Filing Date:Mar 16, 1992
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:An improved process for preparing either optically pure enantiomer of the bark beetle pheromones ipsenol and ipsdienol is provided. The process is also applicable to the condensation of aldehydes of widely varying properties to the corresponding chiral alcohol.
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Publication:17/102
Publication No:US 5159116 A
Title:Chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes
Publication Type:Grant
Publication Date:Oct 27, 1992
Filing Date:Jul 15, 1991
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A chemically and optically pure B-halodiiso-2-ethylapopinocampheylborane of essentially 100% ee represented by ##STR1## wherein B is borane and X is halo.
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Publication:18/102
Publication No:US 5103063 A
Title:Intermediates useful for the chiral isoprenylation of aldehydes
Publication Type:Grant
Publication Date:Apr 7, 1992
Filing Date:Aug 3, 1990
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:An improved process for preparing either optically pure enantiomer of the bark beetle pheromones ipsenol and ipsdienol is provided. The process is also applicable to the condensation of aldehydes of widely varying properties to the corresponding chiral alcohol. This invention also concerns novel intermediates R'2 B(2'-isoprenyl) wherein R' is isopinocampheyl, 2-isocaranyl and 4-isocaranyl.
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Publication:19/102
Publication No:US 5087700 A
Title:Method of producing primary amines in high yields
Publication Type:Grant
Publication Date:Feb 11, 1992
Filing Date:Mar 26, 1990
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMez2 or R*BMe2 wherein R is an organo group, R* is a chiral organo group, attached to boron, B is boron and Me is methyl.
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Publication:20/102
Publication No:US 5068432 A
Title:Process for producing optically pure 2-phenoxyphenylalkylamines
Publication Type:Grant
Publication Date:Nov 26, 1991
Filing Date:Feb 1, 1991
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
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Publication:21/102
Publication No:US 5043479 A
Title:Chemically and optically pure diisopinocampheylhaloboranes
Publication Type:Grant
Publication Date:Aug 27, 1991
Filing Date:Sep 1, 1989
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:Novel chemically pure diisopinocampheylhaloboranes of essentially 100% ee, represented by the formula Ipc2 BX wherein Ipc is isopinocampheyl and X is halo.
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Publication:22/102
Publication No:US 4978794 A
Title:Novel β-(2-alkenyl)bis(2-isocaranyl)boranes
Publication Type:Grant
Publication Date:Dec 18, 1990
Filing Date:Mar 26, 1990
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:2-Alkenylbis(2-isocaranyl)boranes represented by the formula: ##STR1## wherein R is 2-alkenyl. The compounds undergo asymmetric 2-alkenylboration with a variety of aldehydes and afford the corresponding alcohols in 94-99% ee.
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Publication:23/102
Publication No:US 4950791 A
Title:Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
Publication Type:Grant
Publication Date:Aug 21, 1990
Filing Date:Jun 12, 1989
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
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Publication:24/102
Publication No:US 4918246 A
Title:Process for preparing optically active haloalcohols
Publication Type:Grant
Publication Date:Apr 17, 1990
Filing Date:Jun 12, 1989
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
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Publication:25/102
Publication No:US 4918242 A
Title:Novel optically 1,3-phenoxypropylhalides
Publication Type:Grant
Publication Date:Apr 17, 1990
Filing Date:Jun 12, 1989
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A process for producing the optically pure (+)- or (-)-isomer of a phenyl- or substituted-phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
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Publication:26/102
Publication No:US 4918229 A
Title:Method of producing primary amines in high yields and novel intermediates therefor
Publication Type:Grant
Publication Date:Apr 17, 1990
Filing Date:Jul 29, 1988
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A novel process for producing hindered and unhindered primary amines represented by the formula RNH2 and R*NH2 in high yields from novel intermediates RBMe2 or R*BMBe2 wherein R is an organo group, R* is a chiral organo group attached to boron, B is boron and Me is methyl.
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Publication:27/102
Publication No:US 4918207 A
Title:Novel optically active halo-substituted tetrahydrofurans
Publication Type:Grant
Publication Date:Apr 17, 1990
Filing Date:Jun 12, 1989
Inventors:Brown, Herbert C.
Assignee:Sigma-Aldrich Co.
Abstract:A process for producing the optically pure (+)- or (-) isomer of a pheynl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
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Publication:28/102
Publication No:US 4895996 A
Title:Synthesis of alkenes from enamines via hydroboration
Publication Type:Grant
Publication Date:Jan 23, 1990
Filing Date:Oct 17, 1988
Inventors:Christian T. Goralski, Bakthan Singaram, Herbert C. Brown
Assignee:Purdue Research Foundation, The Dow Chemical Company
Abstract:Alkenes are prepared by the hydroboration of enamines followed by an elimination reaction to form the alkene. This process has wide applicability and is useful for the stereospecific synthesis of [Z] isomers. It is preferred to use 9-borabicyclo[3.3.1 nonane as the hydroborating agent and to use methanol to catalyze the elimination reaction.
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Publication:29/102
Publication No:US 4886924 A
Title:Stereospecific synthesis of [E]-alkenes from enamines via hydroboration
Publication Type:Grant
Publication Date:Dec 12, 1989
Filing Date:Oct 17, 1988
Inventors:Christian T. Goralski, Bakthan Singaram, Herbert C. Brown
Assignee:The Dow Chemical Company
Abstract:A process for the stereospecific synthesis of [E] alkenes from enamines comprising the steps of hydroborating the enamine; esterifying the organoborane so formed and oxidizing the boronic ester in the presence of hydrogen peroxide and in the absence of added base under conditions sufficient to form the [E] alkene in high yield.
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Publication:30/102
Publication No:US 4870212 A
Title:Process for synthesizing lithium mono- and diorganylborohydrides
Publication Type:Grant
Publication Date:Sep 26, 1989
Filing Date:Dec 17, 1987
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:Improved processes for liberating boronic, RB(OR')2, and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided.
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Publication:31/102
Publication No:US 4870177 A
Title:Process for synthesizing lithium mono- and diorganylborohydrides
Publication Type:Grant
Publication Date:Sep 26, 1989
Filing Date:Dec 17, 1987
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:Improved processes for liberating boronic, RB(OR')2, and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided.
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Publication:32/102
Publication No:US 4868344 A
Title:Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
Publication Type:Grant
Publication Date:Sep 19, 1989
Filing Date:Mar 30, 1988
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resoltuion processes ad novel intermediates useful in the process including optically pure haloalcohols are provided.
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Publication:33/102
Publication No:US 4868337 A
Title:Optically active borinic esters and ketones
Publication Type:Grant
Publication Date:Sep 19, 1989
Filing Date:Dec 17, 1987
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:A process for synthesizing an optically pure ketone comprising the steps of: treating an appropriate optically pure boronic ester with an organolithium compound at -78° C. to obtain the "ate" complex, separating the optically pure borinic ester from the complex and converting said borinic ester into an optically pure ketone represented by the formulae: R*COR1 and R*COC.tbd.CR1 wherein R* is a chiral organyl moiety and R1 is an achiral organyl moeity.
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Publication:34/102
Publication No:US 4866181 A
Title:Process for producing optically active alcohols
Publication Type:Grant
Publication Date:Sep 12, 1989
Filing Date:Dec 17, 1987
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:A process for preparing optically active alcohols by reducing ketones using mono- or diisopinocampheylhaloboranes as reducing agents
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Publication:35/102
Publication No:US 4855506 A
Title:Process for lithium mono- and diorganylborohydrides
Publication Type:Grant
Publication Date:Aug 8, 1989
Filing Date:Dec 17, 1987
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:Improved processes for liberating boronic, RB(OR')2' and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided.
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Publication:36/102
Publication No:US 4795821 A
Title:Optically active borinic esters and ketones
Publication Type:Grant
Publication Date:Jan 3, 1989
Filing Date:Aug 29, 1986
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:A process for synthesizing an optically pure ketone comprising the steps of: treating an appropriate optically pure boronic ester with an organolithium compound at -78° C. to obtain the "ate" complex, separating the optically pure borinic ester from the complex and converting said borinic ester into an optically pure ketone represented by the formulae: R*COR1 and R*COC.tbd.CR1 wherein R* is a chiral organyl moeity and R1 is an achiral organyl moeity.
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Publication:37/102
Publication No:US 4772752 A
Title:Mono- and diisopinocampheylhaloboranes as new chiral reducing agents
Publication Type:Grant
Publication Date:Sep 20, 1988
Filing Date:Aug 29, 1986
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:Novel mono- and diisopinocampheylhaloboranes, represented by the formulae IpcBX2 and Ipc2 BX wherein Ipc is isopinocampheyl and X is halo, as well as processes for making and using same.
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Publication:38/102
Publication No:US 4772751 A
Title:Process for lithium mono- and diorganylborohydrides
Publication Type:Grant
Publication Date:Sep 20, 1988
Filing Date:Aug 29, 1986
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:Improved processes for liberating boronic, RB(OR')2, and borinic, RR'BOR', esters from their "ate" complexes, free of alcohol are provided. Pyrolysis of lithium organylborates LiRB(OR')3 and LiRR'BOR', wherein R is an organyl group and R' is straight or branched-chain lower alkyl, directly yields the relatively volatile boronic and borinic esters in high purity, leaving behind a residue of lithium alkoxide. Treatment of the lithium organylborates with an appropriate acid halide cleanly liberates either volatile or non-volatile boronic or borinic esters, readily separated from the lower alkyl ester produced as a by-product. The novel compound lithium dimethylborohydride is also provided.
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Publication:39/102
Publication No:US 4713380 A
Title:Production of optically pure organoboranes
Publication Type:Grant
Publication Date:Dec 15, 1987
Filing Date:Jan 16, 1985
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:A process for upgrading to essentially 100% enantiomeric excess the optical purity of an organoborane intermediate represented by the formulae: IcpBHR* or Icp2 BR* wherein Icp is isopinocampheyl and R* is a unsubstituted or substituted, acyclic or cyclic alkyl having from 4 to 30 carbon atoms, comprising the steps of hydroborating cis-alkene, a trans-alkene or a tertiary-alkene with monoisopinocampheylborane or diisopinocampheylborane, obtaining a solid organoborane and recrystallizing the solid organoborane to obtain an enantiomeric excess of essentially 100% ee of said organoborane.
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Publication:40/102
Publication No:US 4518798 A
Title:Preparing esters and carboxylic acids from lower olefins
Publication Type:Grant
Publication Date:May 21, 1985
Filing Date:Sep 30, 1982
Inventors:George M. Kramer, Walter Weissman, Herbert C. Brown, Rowland Pettit
Assignee:Exxon Research & Engineering Co.
Abstract:Esters or carboxylic acids are prepared from olefins containing at least two carbon atoms by reacting the olefin with carbon monoxide in the presence of:
(i) a first complex of a selected Lewis acid with the ester or carboxylic acid, whichever is the reaction product recovered;
(ii) a second complex of the Lewis acid with an alcohol, if an ester is being prepared, or with water, if a carboxylic acid is being prepared; and
(iii) a metal carbonyl compound containing a Group IB transition metal in the first oxidation state; and by recovering the reaction product(s).
The preferred olefin is propylene, the preferred ester to be prepared is methylisobutyrate, the preferred metal is copper and the preferred Lewis acid is boron trifluoride.
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Publication:41/102
Publication No:US 4320027 A
Title:Process for producing highly stabilized borane-tetrahydrofuran solutions
Publication Type:Grant
Publication Date:Mar 16, 1982
Filing Date:May 2, 1980
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:A process which comprises heating a stabilized solution of borane in tetrahydrofuran containing an organic sulfide and finely divided particles of sodium fluoroborate at an elevated temperature for a period of time sufficient to convert the sodium fluoroborate particles to a form which permits them to be readily removed from the solution such as by settling, filtration or centrifugation.
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Publication:42/102
Publication No:US 4298750 A
Title:Borane-1,4-thioxane
Publication Type:Grant
Publication Date:Nov 3, 1981
Filing Date:Feb 19, 1980
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:The novel borane-1,4-thioxane is synthesized by adding the calculated quantity of diborane to 1,4-thioxane. It is a stable liquid at 25° C. The neat liquid is approximately 8.0 M in borane. The product, in spite of the additional oxygen atom in the ring, exhibits the desirable hydroborating and reducing action of borane-methyl sulfide. However, it possesses a major advantage over the latter in that the donor component, 1,4-thioxane, in contrast to methyl sulfide, is readily soluble in water and can be washed out of typical reaction mixtures. This greatly facilitates the synthetic applications of borane-1,4-thioxane over borane-methyl sulfide.
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Publication:43/102
Publication No:US 4082810 A
Title:Bulky trialkylborohydrides
Publication Type:Grant
Publication Date:Apr 4, 1978
Filing Date:Oct 16, 1975
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:Borohydride hydrogenations using agents of the formula M[RR'R"BH] wherein M is a metal and R, R', and R" are each organic groups, at least one of them beinga secondary or tertiary alkyl group, are described herein. These compounds are active hydrogenating agents which are particularly useful because they permit steric control of the hydrogenation of carbonyl groups, they permit selective hydrogenation of functional groups or, where one of the R groups is optically active, they permit stereoselective hydrogenation.
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Publication:44/102
Publication No:US 3984479 A
Title:Preparation of 9-BBN
Publication Type:Grant
Publication Date:Oct 5, 1976
Filing Date:Nov 8, 1973
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:9-Borabicyclo (3.3.1) noname (9-BBN), a relatively stable solid dialkylborane, can be used to reduce a wide variety of reducible chemical compounds, including both organic and inorganic compounds. The stability of the reagent greatly reduces the operating difficulties encountered with other dialkylboranes having similar reduction properties, which are thermally and hydrolytically unstable.
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Publication:45/102
Publication No:US 3882037 A
Title:Stabilized borane-tetrahydrofuran solutions
Publication Type:Grant
Publication Date:May 6, 1975
Filing Date:Feb 22, 1973
Inventors:Brown, Herbert C.
Assignee:Aldrich-Boranes, Inc.
Abstract:The presence of an aliphatic, alicyclic, or cyclic sulfide stabilizes solutions of diborane in tetrahydrofuran, permitting the storage of such solutions for long periods of time at ambient temperatures. Such stabilized solutions can be prepared without handling diborane gas by treating a suspension of an ionic borohydride in tetrahydrofuran, containing an aliphatic, alicyclic, or cyclic sulfide, with boron trifluoride, followed by removal of the precipitated fluoroborate. Such solutions are excellent for hydroboration, and possess major advantages over borane-tetrahydrofuran solutions available previously in being highly stable.
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Publication:46/102
Publication No:US 3439046 A
Title:Process for oxidation of hydrocarbylborane compounds to alcohols
Publication Type:Grant
Publication Date:Apr 15, 1969
Filing Date:Apr 18, 1967
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:47/102
Publication No:US 3358034 A
Title:Selective hydroboration process
Publication Type:Grant
Publication Date:Dec 12, 1967
Filing Date:Mar 12, 1964
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:48/102
Publication No:US 3350454 A
Title:Process of producing amines
Publication Type:Grant
Publication Date:Oct 31, 1967
Filing Date:Sep 27, 1963
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:49/102
Publication No:US 3345418 A
Title:Catalytic process for preparing organoboron compounds from diborane
Publication Type:Grant
Publication Date:Oct 3, 1967
Filing Date:Aug 29, 1957
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:50/102
Publication No:US 3322686 A
Title:Hydrogenation of chemical compounds and catalysts therefor
Publication Type:Grant
Publication Date:May 30, 1967
Filing Date:Feb 5, 1963
Inventors:Brown, Herbert C.
Assignee:Brown Charles A, Brown Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:51/102
Publication No:US 3277178 A
Title:Preparation of aldehydes from acid halides
Publication Type:Grant
Publication Date:Oct 4, 1966
Filing Date:Feb 27, 1962
Inventors:Brown, Herbert C.
Assignee:Brown Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:52/102
Publication No:US 3254129 A
Title:Optically active organoboranes
Publication Type:Grant
Publication Date:May 31, 1966
Filing Date:Jan 17, 1961
Inventors:Brown, Herbert C.
Assignee:Brown Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:53/102
Publication No:US 3180710 A
Title:Gas generator
Publication Type:Grant
Publication Date:Apr 27, 1965
Filing Date:Feb 11, 1963
Inventors:Brown, Herbert C.
Assignee:Brown Charles A, Brown Herbert C
Abstract:No, Abstract
Representative Figure:
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Publication:54/102
Publication No:US 3173967 A
Title:Isomerization of internal olefins to terminal olefins
Publication Type:Grant
Publication Date:Mar 16, 1965
Filing Date:May 28, 1958
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:55/102
Publication No:US 3161686 A
Title:Novel organoboron compounds
Publication Type:Grant
Publication Date:Dec 15, 1964
Filing Date:Mar 30, 1960
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:56/102
Publication No:US 3147272 A
Title:Method of preparing partially reduced organic compounds
Publication Type:Grant
Publication Date:Sep 1, 1964
Filing Date:Aug 18, 1959
Inventors:Herbert C Brown, Richard F Mcfarlin, Rao Bookinkere C Subba
Assignee:Herbert C Brown, Richard F Mcfarlin, Rao Bookinkere C Subba
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:57/102
Publication No:US 3134823 A
Title:Process involving the reaction of group i-b metal compounds with an organoboron compound in the presence of a strong base
Publication Type:Grant
Publication Date:May 26, 1964
Filing Date:Dec 12, 1960
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:58/102
Publication No:US 3133961 A
Title:Method of producing organoboron products
Publication Type:Grant
Publication Date:May 19, 1964
Filing Date:May 3, 1961
Inventors:Herbert C Brown, Rao Bookinkeve Channakes Subba, Paul A Tierney
Assignee:Purdue Research Foundation
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:59/102
Publication No:US 3085112 A
Title:Preparation of hydrocarbon boron compounds
Publication Type:Grant
Publication Date:Apr 9, 1963
Filing Date:Dec 22, 1960
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:60/102
Publication No:US 3078313 A
Title:Selective hydroboration
Publication Type:Grant
Publication Date:Feb 19, 1963
Filing Date:Jun 15, 1961
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:61/102
Publication No:US 3078312 A
Title:Isomerization of organoboron compounds
Publication Type:Grant
Publication Date:Feb 19, 1963
Filing Date:Mar 30, 1960
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:62/102
Publication No:US 3078311 A
Title:Catalytic process for preparing organoboron compounds from diborane
Publication Type:Grant
Publication Date:Feb 19, 1963
Filing Date:Jan 21, 1960
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:63/102
Publication No:US 3078310 A
Title:Isomerization of primary, secondary or tertiary organoboron compounds into isomers threof
Publication Type:Grant
Publication Date:Feb 19, 1963
Filing Date:Dec 7, 1959
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:64/102
Publication No:US 3078309 A
Title:Preparation of organoboron compounds
Publication Type:Grant
Publication Date:Feb 19, 1963
Filing Date:Nov 6, 1959
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:65/102
Publication No:US 3078308 A
Title:Process for the production of organoboron compounds
Publication Type:Grant
Publication Date:Feb 19, 1963
Filing Date:Aug 31, 1959
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:66/102
Publication No:US 3026356 A
Title:Process for the preparation of organo boron compounds
Publication Type:Grant
Publication Date:Mar 20, 1962
Filing Date:Apr 25, 1958
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:67/102
Publication No:US 3026329 A
Title:Mono-and di-chloroborane etherates
Publication Type:Grant
Publication Date:Mar 20, 1962
Filing Date:Jul 11, 1957
Inventors:Herbert C Brown, Rao Bookinkeve Channakes Subba, Paul A Tierney
Assignee:Purdue Research Foundation
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:68/102
Publication No:US 2993933 A
Title:Simultaneous preparation of organoboron compounds and separation of internal olefinsfrom alpha-olefins
Publication Type:Grant
Publication Date:Jul 25, 1961
Filing Date:May 28, 1958
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:69/102
Publication No:US 2988513 A
Title:Stabilized boron trichloride compositions
Publication Type:Grant
Publication Date:Jul 25, 1961
Filing Date:Apr 25, 1958
Inventors:Herbert C Brown, Paul A Tierney
Assignee:Herbert C Brown, Paul A Tierney
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:70/102
Publication No:US 2964378 A
Title:Low temperature preparation of alkali metal borohydrides from metal hydrides and alkyl borates in solution
Publication Type:Grant
Publication Date:Dec 13, 1960
Filing Date:Jun 3, 1955
Inventors:Herbert C Brown, Paul A Tierney
Assignee:Herbert C Brown, Paul A Tierney
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:71/102
Publication No:US 2945886 A
Title:Method for reducing chemical compounds by reacting with alkali metal borohydrides
Publication Type:Grant
Publication Date:Jul 19, 1960
Filing Date:Feb 20, 1957
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:72/102
Publication No:US 2925441 A
Title:Method of preparing organoboron compounds
Publication Type:Grant
Publication Date:Feb 16, 1960
Filing Date:Oct 30, 1958
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:73/102
Publication No:US 2925438 A
Title:Method of converting unsaturated organic compounds to organoboron compounds
Publication Type:Grant
Publication Date:Feb 16, 1960
Filing Date:Feb 1, 1957
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:74/102
Publication No:US 2925437 A
Title:Method for converting unsaturated organic compounds to organoboron compounds
Publication Type:Grant
Publication Date:Feb 16, 1960
Filing Date:Oct 30, 1956
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:75/102
Publication No:US 2874165 A
Title:Reduction of carbonyl compounds with boron hydrides
Publication Type:Grant
Publication Date:Feb 17, 1959
Filing Date:Apr 25, 1955
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:76/102
Publication No:US 2856428 A
Title:Method for hydrogenating organic compounds by reacting with alkali metal borohydrides
Publication Type:Grant
Publication Date:Oct 14, 1958
Filing Date:Jul 13, 1955
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:77/102
Publication No:US 2819328 A
Title:Propylene polymerization with pf5
Publication Type:Grant
Publication Date:Jan 7, 1958
Filing Date:Apr 8, 1954
Inventors:Brown Herbert C, Higley Willard S
Assignee:Standard Oil Co
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:78/102
Publication No:US 2780626 A
Title:2, 6-alkylpyridines
Publication Type:Grant
Publication Date:Feb 5, 1957
Filing Date:Aug 13, 1953
Inventors:Kanner Bernard, Herbert C Brown
Assignee:Research Corp.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:79/102
Publication No:US 2767230 A
Title:Alkylation process
Publication Type:Grant
Publication Date:Oct 16, 1956
Filing Date:Mar 4, 1954
Inventors:Herbert C Brown, Willard S Higley
Assignee:Standard Oil Corp.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:80/102
Publication No:US 2762824 A
Title:Manufacture of silicon compounds
Publication Type:Grant
Publication Date:Sep 11, 1956
Filing Date:Jun 16, 1953
Inventors:Brown, Herbert C.
Assignee:Ethyl Corp.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:81/102
Publication No:US 2727929 A
Title:Aromatization of chlorine compounds
Publication Type:Grant
Publication Date:Dec 20, 1955
Filing Date:Dec 5, 1951
Inventors:Herbert C Brown, David D Humphreys
Assignee:Ethyl Corp.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:82/102
Publication No:US 2709704 A
Title:Carbinol production
Publication Type:Grant
Publication Date:May 31, 1955
Filing Date:Apr 7, 1954
Inventors:Brown, Herbert C.
Assignee:Brown, Herbert C.
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:83/102
Publication No:US 2683721 A
Title:Method of reducing and hydrogenating chemical compounds by reacting with alkali metal borohydrides
Publication Type:Grant
Publication Date:Jul 13, 1954
Filing Date:Jan 17, 1952
Inventors:Brown, Herbert C.
Assignee:Hermann I Schlesinger, Herbert C Brown
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:84/102
Publication No:US 2636886 A
Title:Uranium complexes of heterocyclic diketones
Publication Type:Grant
Publication Date:Apr 28, 1953
Filing Date:Jan 5, 1946
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Atomic Energy Commission
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:85/102
Publication No:US 2614113 A
Title:Uranium purification as complexes of esters of trifluoroacetoacetic acid
Publication Type:Grant
Publication Date:Oct 14, 1952
Filing Date:Jun 5, 1946
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:86/102
Publication No:US 2600370 A
Title:Uranium borohydride and method of making the same
Publication Type:Grant
Publication Date:Jun 10, 1952
Filing Date:Feb 4, 1946
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:
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Publication:87/102
Publication No:US 2599203 A
Title:Preparation of aluminum borohydride
Publication Type:Grant
Publication Date:Jun 3, 1952
Filing Date:Mar 22, 1946
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Atomic Energy Commission
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:88/102
Publication No:US 2596047 A
Title:Uranium-aroyl aldehyde complexes and method of making same
Publication Type:Grant
Publication Date:May 6, 1952
Filing Date:Oct 23, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Atomic Energy Commission
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:89/102
Publication No:US 2584112 A
Title:Organic phosphines
Publication Type:Grant
Publication Date:Feb 5, 1952
Filing Date:Aug 30, 1950
Inventors:Brown Herbert C
Assignee:Standard Oil Co
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:90/102
Publication No:US 2555512 A
Title:Organic phosphines
Publication Type:Grant
Publication Date:Jun 5, 1951
Filing Date:Nov 13, 1946
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:91/102
Publication No:US 2548585 A
Title:Alkylation of urea with olefins
Publication Type:Grant
Publication Date:Apr 10, 1951
Filing Date:Nov 12, 1948
Inventors:Brown, Herbert C.
Assignee:Standard Oil Co
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:92/102
Publication No:US 2545633 A
Title:Preparation of lithium borohydride
Publication Type:Grant
Publication Date:Mar 20, 1951
Filing Date:Oct 16, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:93/102
Publication No:US 2544472 A
Title:Preparation of diborane
Publication Type:Grant
Publication Date:Mar 6, 1951
Filing Date:Feb 6, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:94/102
Publication No:US 2543511 A
Title:Preparation of diborane
Publication Type:Grant
Publication Date:Feb 27, 1951
Filing Date:May 9, 1946
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:95/102
Publication No:US 2534533 A
Title:Methods of preparing alkali metal borohydrides
Publication Type:Grant
Publication Date:Dec 19, 1950
Filing Date:Nov 5, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:96/102
Publication No:US 2494968 A
Title:Alkoxy borohydrides and their method of preparation
Publication Type:Grant
Publication Date:Jan 17, 1950
Filing Date:Jul 17, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:97/102
Publication No:US 2461663 A
Title:Preparation of alkali metal borohydrides
Publication Type:Grant
Publication Date:Feb 15, 1949
Filing Date:Jan 11, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:98/102
Publication No:US 2461662 A
Title:Preparation of alkali metal compounds
Publication Type:Grant
Publication Date:Feb 15, 1949
Filing Date:Jan 9, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:99/102
Publication No:US 2461661 A
Title:Preparation of alkali metal compounds
Publication Type:Grant
Publication Date:Feb 15, 1949
Filing Date:Jan 9, 1945
Inventors:Brown Herbert C, Schlesinger Hermann I
Assignee:Brown Herbert C, Schlesinger Hermann I
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:100/102
Publication No:US 2326229 A
Title:Process of producing carboxylic acid chlorides
Publication Type:Grant
Publication Date:Aug 10, 1943
Filing Date:Dec 4, 1942
Inventors:Herbert C Brown, Morris S Kharasch
Assignee:Du Pont
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:101/102
Publication No:US 2326228 A
Title:Chemical process
Publication Type:Grant
Publication Date:Aug 10, 1943
Filing Date:Dec 4, 1942
Inventors:Herbert C Brown, Morris S Kharasch
Assignee:Du Pont
Abstract:No, Abstract
Representative Figure:No Figure
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Publication:102/102
Publication No:US 2302228 A
Title:Method of chlorination with sulphuryl chloride and production of monochloro-trimethyl acetic acid
Publication Type:Grant
Publication Date:Nov 17, 1942
Filing Date:Apr 2, 1940
Inventors:Herbert C Brown, Morris S Kharasch
Assignee:Du Pont
Abstract:No, Abstract
Representative Figure:No Figure
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Herbert Brown
Drawing: Newton Llorente

Name: Herbert Charles Brown
Birth: 22 May 1912, London, United Kingdom
Death: 19 December 2004, Lafayette, IN, USA
Institution: Purdue University, West Lafayette, IN, USA
Award: "for their development of the use of boron- and phosphorus-containing compounds, respectively, into important reagents in organic synthesis"
Subject: Organic chemistry
Portion of cash: 1/2
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