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Gertrude B. Elion M.S.[Chemisty]

The Nobel Prize in Physiology or Medicine 1988
National Medal of Science - Chemistry 1991

Chemist, Pharmacologist. Discovered principles for drug treatment; developed drugs - anticancer, immunosuppressive, antiviral, antibacterial, anti-gout, anti-malarial. Purines.

"I was a child with an insatiable thirst for knowledge. My beloved grandfather died of cancer when I was 15. I was highly motivated to discover a cure for this terrible disease".

Patents

Compiled by Marc Norman, Dec., 2014

Publication:1/40
Publication No:US 4315920 A
Title:Adenosine deaminase inhibitors
Publication Type:Grant
Publication Date:Feb 16, 1982
Filing Date:Jan 14, 1980
Inventors:Burroughs Wellcome Co.
Assignee:University of Delaware
Abstract:Pharmaceutical preparations containing compounds of the formula ##STR1## where R is alkyl of 1 to 11 carbons. The preparations are useful in inhibiting adenosine deaminase in mammals thereby providing a method for prolonging the effectiveness of pharamaceutical agents which are biologically degraded by adenosine deaminase and thus converted into other compounds.
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Publication:2/40
Publication No:US 4299824 A
Title:Substituted pyrazolo pyrimidine riboside compounds, pharmaceutical compositions and method of use
Publication Type:Grant
Publication Date:Nov 10, 1981
Filing Date:Jun 13, 1980
Inventors:Janet L. Rideout, Thomas A. Krenitsky, Gertrude B. Elion
Assignee:University of Delaware
Abstract:4-Alkenylthio-1-β-D-ribofuranosylpyrazolo[3,4-d]-pyrimidines are active against coccidia in vivo, and unlike the 4-methylthio analogue, are non-toxic. Methods for the preparation and use of the compounds, intermediates in the preparation and formulations of the compounds are also described.1
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Publication:3/40
Publication No:US 4299823 A
Title:Pyrazolo pyrimidine riboside compounds, pharmaceutical compositions and method of use
Publication Type:Grant
Publication Date:Nov 10, 1981
Filing Date:Jun 13, 1980
Inventors:Janet L. Rideout, Thomas A. Krenitsky, Gertrude B. Elion
Assignee:Burroughs Wellcome Co.
Abstract:4-Substituted alkyl-1-α-D-ribofuransylpyrazole-(3,4-d) pyrimidines are active against coccidia in vivo and unlike the 4-methylthio analogue, are non-toxic. Methods for preparing and using the compounds, intermediates in the preparation and compositions of the compounds are also described.
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Publication:4/40
Publication No:US 4136175 A
Title:Purine nucleotide antiveral composition and methods of use
Publication Type:Grant
Publication Date:Jan 23, 1979
Filing Date:Jun 16, 1976
Inventors:Janet E. Rideout, Richard L. Miller, Gertrude B. Elion
Assignee:Burroughs Wellcome Co.
Abstract:The nucleotide derivatives of certain 2,6 substituted purines have been discovered to have anti-viral activity. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 2,6 Diamino-9-(β-D arabinofuranosyl)-purine-5'-phosphate is an example of a more active compound of this invention.
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Publication:5/40
Publication No:US 4081534 A
Title:Amino purine nucleosides as autoimmune suppressant agents
Publication Type:Grant
Publication Date:Mar 28, 1978
Filing Date:Jul 26, 1976
Inventors:Gertrude B. Elion, Robert A. Strelitz
Assignee:Burroughs Wellcome Co.
Abstract:A method and composition of treating a mammal suffering from an autoimmune disease which comprises internally administering to the mammal an effective autoimmune suppressant amount of the compound of formula or its pharmaceutically acceptable salts ##STR1## where R1 is amino or lower alkylamino and R2 is amino or hydrogen, provided that when R1 is amino, R2 is amino.
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Publication:6/40
Publication No:US 4038479 A
Title:Amino purine derivatives
Publication Type:Grant
Publication Date:Jul 26, 1977
Filing Date:Sep 7, 1971
Inventors:Gertrude B. Elion, Robert A. Strelitz
Assignee:Burroughs Wellcome Co.
Abstract:Compounds of the formula ##STR1## where R1 is amino or lower alkylamino, R2 is amine or hydrogen and pharmaceutically acceptable salts thereof, provided that when R1 is amino, R2 is amino. The compounds are useful as immune suppressants and as antivirals.
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Publication:7/40
Publication No:US 4006235 A
Title:Treating CNS lymphoma
Publication Type:Grant
Publication Date:Feb 1, 1977
Filing Date:Feb 12, 1975
Inventors:Dwight R. Stickney, William S. Simmons, Charles A. Nichol, George H. Hitchings, Gertrude B. Elion
Assignee:Burroughs Wellcome Co.
Abstract:Method and pharmaceutical preparations for treating meningeal leukemia, CNS lymphoma and neoplasms in the brain which comprises treating an infected mammal such as a human with a dose of an effective treatment amount of acompound of Formula I ##STR1## where R is a straight or branched chain lower alkyl of 1 to 4 carbon atoms, and X is a halogen atom (fluorine, chlorine, bromine or iodine) and pharmaceutically acceptable salts thereof. Preferred compounds for treatment of the aforementioned diseases are 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methyl-pyrimidine and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethyl-pyrimidine.
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Publication:8/40
Publication No:US 4005204 A
Title:Treatment of neoplasms in the brain with diamino dichloroalkyl pyrimidine
Publication Type:Grant
Publication Date:Jan 25, 1977
Filing Date:Feb 12, 1975
Inventors:Dwight R. Stickney, William S. Simmons, Charles A. Nichol, George H. Hitchings, Gertrude B. Elion
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:9/40
Publication No:US 4005203 A
Title:Treatment of meningeal leukemia with diamino dichlorophenyl pyrimidine
Publication Type:Grant
Publication Date:Jan 25, 1977
Filing Date:Feb 12, 1975
Inventors:Dwight R. Stickney, William S. Simmons, Charles A. Nichol, George H. Hitchings, Gertrude B. Elion
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:10/40
Publication No:US 3956277 A
Title:Purine sugar derivatives
Publication Type:Grant
Publication Date:May 11, 1976
Filing Date:Nov 15, 1971
Inventors:Gertrude B. Elion, Janet E. Litster, Lowrie M. Beacham, III
Assignee:Burroughs Wellcome Co.
Abstract:This invention relates to purine sugar derivatives which are useful as suppressors of the immune response and as antiviral agents, and to methods of preparation thereof.
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Publication:11/40
Publication No:US 3862061 A
Title:Imidazole derivatives
Publication Type:Grant
Publication Date:Jan 21, 1975
Filing Date:Mar 23, 1973
Inventors:Iii Lowrie M Beacham, Paulo M S Demiranda, Gertrude B Elion
Assignee:Burroughs Wellcome Co.
Abstract:Compounds of formula (I) or a pharmaceutically acceptable salt thereof, WHEREIN R1 is a hydrogen atom, a lower alkyl group or a benzyl group; R2 is agroup OR5, NR5 or an amide linked amino acid residue, in which R5 is ahydrogen atom or a lower alkyl group optionally substituted with one or more amino and/or carboxylic groups; R3 is a hydrogen atom, a group AN AMIDE LINKED AMINO ACID RESIDUE OR A GROUP IN WHICH R4 is a t-butyl group, a benzyl group or a group CH2=CH; and a=1 or 2.
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Publication:12/40
Publication No:US 3758684 A
Title:Treating dna virus infections with amino purine derivatives
Publication Type:Grant
Publication Date:Sep 11, 1973
Filing Date:Sep 7, 1971
Inventors:Elion G, Strelitz R
Assignee:Burroughs Wellcome Co, Wellcome Found
Abstract:No Abstract
Representative Figure:No Figure
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Publication:13/40
Publication No:US 3666856 A
Title:Treating immune response with amino purine derivatives
Publication Type:Grant
Publication Date:May 30, 1972
Filing Date:Nov 17, 1969
Inventors:Gertrude B Elion, Robert A Strelitz
Assignee:Burroughs Wellcome Co, Wellcome Found
Abstract:Compounds of the formula WHERE R1 is amino or lower alkylamino, R2 is amino or hydrogen and pharmaceutically acceptable salts thereof, provided that when R1 is amino, R2 is amino. The compounds are useful as immune suppressants and as antivirals.
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Publication:14/40
Publication No:US 3271399 A
Title:5-acyloxyuracils and their preparation
Publication Type:Grant
Publication Date:Sep 6, 1966
Filing Date:Feb 10, 1964
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:15/40
Publication No:US 3242178 A
Title:2, 4-diamino-6-hydroxymethyl-7, 8-dihydropteridine
Publication Type:Grant
Publication Date:Mar 22, 1966
Filing Date:Aug 20, 1963
Inventors:Gertrude B Elion
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:16/40
Publication No:US 3238207 A
Title:6-oxyorganopurines and method of preparing them
Publication Type:Grant
Publication Date:Mar 1, 1966
Filing Date:Mar 1, 1960
Inventors:Gertrude B Elion, George H Hitchings, Goodman Irving
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:17/40
Publication No:US 3232938 A
Title:6-alkylmercaptopurines
Publication Type:Grant
Publication Date:Feb 1, 1966
Filing Date:Aug 2, 1962
Inventors:Gertrude B Elion, George H Hitchings, Goodman Irving
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:18/40
Publication No:US 3232937 A
Title:6-benzylmercaptopurines
Publication Type:Grant
Publication Date:Feb 1, 1966
Filing Date:Aug 2, 1962
Inventors:Gertrude B Elion, George H Hitchings, Goodman Irving
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:19/40
Publication No:US 3176005 A
Title:9-nucleoside-6-thioheterocycles and method of making
Publication Type:Grant
Publication Date:Mar 30, 1965
Filing Date:Feb 12, 1963
Inventors:Elion Gertrude B, Hitchings George H
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:20/40
Publication No:US 3163639 A
Title:4-thio-2'-deoxyuridine
Publication Type:Grant
Publication Date:Dec 29, 1964
Filing Date:Jan 22, 1963
Inventors:Gertrude B Elion, George H Hitchings, Bieber Samuel
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:21/40
Publication No:US 3149111 A
Title:Dinitrophenylmercaptopurines
Publication Type:Grant
Publication Date:Sep 15, 1964
Filing Date:Sep 29, 1961
Inventors:Gertrude B Elion, George H Hitchings, Lottie E Mackay
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:22/40
Publication No:US 3135754 A
Title:Purine derivatives
Publication Type:Grant
Publication Date:Jun 2, 1964
Filing Date:Aug 9, 1962
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:23/40
Publication No:US 3135753 A
Title:Purine derivatives
Publication Type:Grant
Publication Date:Jun 2, 1964
Filing Date:May 10, 1961
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:24/40
Publication No:US 3128274 A
Title:Purine derivatives
Publication Type:Grant
Publication Date:Apr 7, 1964
Filing Date:Jul 19, 1962
Inventors:Gertrude B Elion, George H Hitchings, Lottie E Mackay
Assignee:Burroughs Wellcome Co.
Abstract:No Abstract
Representative Figure:No Figure
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Publication:25/40
Publication No:US 3098074 A
Title:6-thiocarboxamidopurine
Publication Type:Grant
Publication Date:Jul 16, 1963
Filing Date:Nov 18, 1959
Inventors:Gertrude B Elion, George H Hitchings, Lottie E Mackay
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:26/40
Publication No:US 3056785 A
Title:Purine derivatives
Publication Type:Grant
Publication Date:Oct 2, 1962
Filing Date:Mar 21, 1960
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Weilcome & Co U S A
Abstract:No Abstract
Representative Figure:No Figure
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Publication:27/40
Publication No:US 3050517 A
Title:Purine 6-thio-glycosides
Publication Type:Grant
Publication Date:Aug 21, 1962
Filing Date:Oct 11, 1957
Inventors:Elion Gertrude B, Hitchings George H, Irving Goodman
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:28/40
Publication No:US 3019224 A
Title:6-thiocyanopurines and method of their preparation
Publication Type:Grant
Publication Date:Jan 30, 1962
Filing Date:Nov 18, 1959
Inventors:Gertrude B Elion, George H Hitchings, Lottie E Mackay
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:29/40
Publication No:US 2933498 A
Title:7-aminothiazolo-(5,4-d) pyrimidine
Publication Type:Grant
Publication Date:Apr 19, 1960
Filing Date:Dec 28, 1954
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:30/40
Publication No:US 2884667 A
Title:2-amino-6-mercaptopurine
Publication Type:Grant
Publication Date:May 5, 1959
Filing Date:Jun 20, 1955
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:31/40
Publication No:US 2832781 A
Title:6-chloropurine
Publication Type:Grant
Publication Date:Apr 29, 1958
Filing Date:Jan 4, 1956
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:32/40
Publication No:US 2830053 A
Title:6-substituted purine compounds and method of making
Publication Type:Grant
Publication Date:Apr 8, 1958
Filing Date:Jul 18, 1955
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:33/40
Publication No:US 2815346 A
Title:Novel 6-chloropurine compounds and method of preparing them
Publication Type:Grant
Publication Date:Dec 3, 1957
Filing Date:May 25, 1955
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:34/40
Publication No:US 2807616 A
Title:Oxazolopyrimidines and method of preparing same
Publication Type:Grant
Publication Date:Sep 24, 1957
Filing Date:Oct 9, 1952
Inventors:Gertrude B Elion, Elvira A Falco, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:35/40
Publication No:US 2800473 A
Title:Method of making 6-mercaptopurine
Publication Type:Grant
Publication Date:Jul 23, 1957
Filing Date:Sep 12, 1955
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:36/40
Publication No:US 2724711 A
Title:Method for the manufacture of 6-mercaptopurine
Publication Type:Grant
Publication Date:Nov 22, 1955
Filing Date:Dec 28, 1954
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:37/40
Publication No:US 2721866 A
Title:Process of manufacture of 6-mercapto purine and intermediate therefor
Publication Type:Grant
Publication Date:Oct 25, 1955
Filing Date:Apr 22, 1954
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:38/40
Publication No:US 2697709 A
Title:Mercapto heterocycles and method of making
Publication Type:Grant
Publication Date:Dec 21, 1954
Filing Date:Jun 11, 1952
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:39/40
Publication No:US 2691654 A
Title:Amino heterocycles and method of making
Publication Type:Grant
Publication Date:Oct 12, 1954
Filing Date:Jun 11, 1952
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Publication:40/40
Publication No:US 2628235 A
Title:8-arylpurine derivatives and process of preparing same
Publication Type:Grant
Publication Date:Feb 10, 1953
Filing Date:Feb 15, 1950
Inventors:Gertrude B Elion, George H Hitchings
Assignee:Burroughs Wellcome Co
Abstract:No Abstract
Representative Figure:No Figure
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Elion
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Name: Gertrude Belle Elion
Birth: 23 January 1918, New York, NY, USA
Death: 21 February 1999, Chapel Hill, NC, USA
Institution: Wellcome Research Laboratories, Research Triangle Park, NC, USA
Award: "for their discoveries of important principles for drug treatment"
Subject: Pharmacology
Portion of cash: 1/3
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