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History of Discovery

Edward Calvin Kendall Ph.D.

The Nobel Prize in Physiology or Medicine 1950
Nobel Co-recipients Tadeus Reichstein, Phillip S.Hench

Chemist. Adrenal cortex hormones including cortisone: structure, biological effects. Thyroid hormone thyroxine: isolated. Glutathione: crystallized, established structure.

What physiologic processes are modified by cortisone and how this influence is exerted are matters still locked within this hormone. Said Shakespeare's soothsayer, "In Nature's infinite book of secrecy a little I can read."

History of Discovery

Excerpt from Nobel Lecture, December 11, 1950

"To chemists, physiologists, and clinicians the results have brought assurance and stimulation. For many patients hope has displaced despair. Progress in the manufacture of cortisone can be illustrated by its price. In July, 1949 the price per gram was $200.00 and this continued until after January, 1950. Since that time the price has been reduced five times: to $150.00, $135.00, $95.00, $50.00, and on November 1, 1950, to $35.00. Furthermore, in 1949 the supply of cortisone was allocated by a committee appointed by the National Academy of Sciences, but today it is available to every physician in the United States."

The Quest for Cortisone
Thom Rooke
MSU Press, 2012
1609173260, 9781609173265
192 pages
Science Life Sciences Biology

Summary: In 1948, when "Mrs. G.," hospitalized with debilitating rheumatoid arthritis, became the first person to receive a mysterious new compound-cortisone-her physicians were awestruck by her transformation from enervated to energized. After eighteen years of biochemical research, the most intensively hunted biological agent of all time had finally been isolated, identified, synthesized, and put to the test. And it worked. But the discovery of a long-sought "magic bullet" came at an unanticipated cost in the form of strange side effects. This fascinating history recounts the discovery of cortisone and pulls the curtain back on the peculiar cast of characters responsible for its advent, including two enigmatic scientists, Edward Kendall and Philip Hench, who went on to receive the Nobel Prize. The book also explores the key role the Mayo Clinic played in fostering cortisone's development, and looks at drugs that owe their heritage to the so-called "King of Steroids."

Scribners Scientific Memiors
Edward Calvin Kendall
Scribner, 1071
175 pages
Science Life Sciences Biochemistry
ACTH and Cortisone,a New Era in Medicine: An NBC Radio Discussion: Including the Story of Compound E
John Symonds, Lyon Browne, Edward Calvin Kendall, Alan Titsworth Kenyon
University of Chicago, 1049
16 pages

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Name: Edward Calvin Kendall
Birth: 8 March 1886, South Norwalk, CT, USA
Death: 4 May 1972, Princeton, NJ, USA
Affiliation at the time of the award: Mayo Clinic, Rochester, MN, USA
Prize motivation: ""for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects"
Field Biochemistry, endocrinology
Prize share: 1/3
History of Discovery